451 patents
Page 4 of 23
Utility
Solid forms of 7-[[(1S)-1-[4-[(1S)-2-cyclopropyl-1-(4-prop-2-enoylpiperazin-1-yl)ethyl]phenyl]ethyl]amino]-1-ethyl-4H-pyrimido[4,5-d][1,3]oxazin-2-one
5 Sep 23
Solid forms including 7-[[(1S)-1-[4-[(1S)-2-cyclopropyl-1-(4-prop-2-enoylpiperazin-1-yl)ethyl]phenyl]ethyl]amino]-1-ethyl-4H-pyrimido[4,5-d][1,3]oxazin-2-one and a dihydroxybenzoic acid selected from 2,5-dihydroxybenzoic acid, 2,4-dihydroxybenzoic acid, and 2,3-dihydroxybenzoic acid are provided, as well as pharmaceutical compositions including the solid forms, methods for using the solid forms in treating cancer patients, and methods of making the solid forms.
David Andrew Coates, Yizheng Cao
Filed: 12 Aug 22
Utility
Electrochemical Immunosensor for Detection of Calprotectin
31 Aug 23
An electrochemical biosensor for detection of a calprotectin antigen in a sample solution.
Muhammad Ashraful ALAM, Marco FRATUS, Rahim RAHIMI, Vidhya SELVAMANI, Mohit Singh VERMA, Jiangshan WANG
Filed: 11 Aug 21
Utility
Physiological Data Monitoring System
31 Aug 23
In some embodiments, a method may include providing a system, where the system includes one or more physiological sensors and a micro-server that includes a communication interface, memory storing instructions, and a processor.
Iraklis KOURTIS, Lampros KOURTIS, Brian Ellis WINGER, Jian YANG
Filed: 18 Aug 21
Utility
Secured medication transfer system
22 Aug 23
A vial adaptor and needle assembly are disclosed for use with a vial containing a medication, such as insulin.
Keith Daniel Alsberg, Christopher John DeMaria, Kenneth James Micklash, II, Gary Harlan Paulsen
Filed: 18 Aug 17
Utility
KRas G12C inhibitors
22 Aug 23
Serge Louis Boulet, Kevin Charles Fortner, Deqi Guo, David Michael Hyman, Sheng-Bin Peng, Chong Si
Filed: 4 Dec 20
Utility
Endotoxin Detection
17 Aug 23
Provided herein are methods and compositions for overcoming Low Endotoxin Recovery (LER) and unmasking endotoxins.
Matthew Christopher Bedwell, Ned Michael Mozier, Tammy Thurman, Robert Erwin Warburton, JR.
Filed: 18 Dec 20
Utility
Drive Ribbon for Moving Piston Within Container
17 Aug 23
A medical delivery device for advancing a piston in a medicament container to expel a medicament.
Jared Alden JUDSON, Timothy L. MOULTON
Filed: 25 Apr 23
Utility
Compounds and Methods Targeting Human and Mouse INSL5
17 Aug 23
The present invention provides compounds and methods targeting insulin-like peptide-5 (INSL5), including antibodies, cells and vectors comprising DNA encoding the same, and methods for producing the antibodies.
Petra VERDINO, Hsiu-Chiung YANG
Filed: 3 Aug 21
Utility
Drug Delivery Device Cassette
17 Aug 23
A drug delivery device may include a cassette with a needle assembly and a cartridge.
Murat GÜNAY, Jared Alden JUDSON, Russell Wayne PERKINS, Anthony Lawrence SCHAFF
Filed: 19 Aug 22
Utility
Combination Therapy with a Mutant IDH1 Inhibitor, a Deoxyadenosine Analog, and a Platinum Agent
17 Aug 23
The present invention relates to combination therapy with (a) a mutant IDH1 inhibitor, or a pharmaceutically acceptable salt thereof, (b) a deoxyadenosine analog, or a pharmaceutically acceptable salt thereof, and (c) a platinum agent, for the treatment of a solid tumor cancer.
David Michael HYMAN
Filed: 20 Jul 21
Utility
Processes and Intermediate for the Large-scale Preparation of 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE Hemisuccinate, and Preparation of 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE Acetate
10 Aug 23
The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms made by these processes.
Aktham Aburub, David Andrew Coates, Scott Alan Frank, Mark Steven Kerr, Roger Ryan Rothhaar, Radhe Krishan Vaid
Filed: 14 Apr 23
Utility
Processes and Intermediate for the Large-scale Preparation of 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE Hemisuccinate, and Preparation of 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE Acetate
10 Aug 23
The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms made by these processes.
Aktham Aburub, David Andrew Coates, Scott Alan Frank, Mark Steven Kerr, Roger Ryan Rothhaar, Radhe Krishan Vaid
Filed: 14 Apr 23
Utility
Glucagon-like PEPTIDE1 Receptor Agonists
10 Aug 23
David Andrew COATES, Todd FIELDS, Joseph Daniel HO, Fucheng QU
Filed: 31 Mar 23
Utility
Multispecific Binding Proteins and Methods of Developing the Same
3 Aug 23
Multispecific binding proteins that bind a first antigen and a second antigen and methods of purifying multispecific binding proteins.
Qing CHAI, Xiufeng WU
Filed: 18 Mar 21
Utility
Processes for the Preparation of Selective Estrogen Receptor Degraders
3 Aug 23
Alonso Jose ARGUELLES DELGADO, Boris Arnoldovich CZESKIS, Mai Khanh Nguyen HAWK, Douglas Patton KJELL, Yu LU, Nicholas Andrew MAGNUS, David Michael REMICK
Filed: 27 Jan 23
Utility
Insulin Delivery Systems, Methods, and Devices
27 Jul 23
A system includes a controller that is in communication with a medication delivery device and that includes control logic.
Ahmad Mohamad HAIDAR
Filed: 20 May 21
Utility
Subcutaneous Absorption and Bioavailability of Antibodies
27 Jul 23
Provided herein are methods of selecting antibodies suitable for subcutaneous administration; methods of improving subcutaneous absorption and bioavailability of antibodies; and methods of administering an antibody to a subject subcutaneously.
Selina Alyssa Lynette Estwick, Amita Datta-Mannan
Filed: 16 Apr 21
Utility
Selective Estrogen Receptor Degraders
27 Jul 23
Jolie Anne BASTIAN, Jeffrey Daniel COHEN, Almudena RUBIO, Daniel Jon SALL, Jennifer Anne MCMAHON
Filed: 15 Mar 23
Utility
Carboxy Substituted Glucocorticoid Receptor Agonists
20 Jul 23
Ryan Edward STITES, Jacqueline Mary WURST
Filed: 28 Feb 23
Utility
Methods and Apparatus for Visual-aware Hierarchy-based Object Recognition
13 Jul 23
The techniques described herein relate to computerized methods and apparatus for grouping images of objects based on semantic and visual information associated with the objects.
Edward John DELP, III, Jiangpeng HE, Runyu MAO, Zeman SHAO, Sri Kalyan YARLAGADDA, Fengqing Maggie ZHU
Filed: 28 Apr 21