275 patents
Page 4 of 14
Utility
Incretin Analogs and Uses Thereof
29 Jun 23
Incretin analogs are provided that have activity at each of the GIP, GLP-1 and glucagon receptors.
Jorge Alsina-Fernandez, Tamer Coskun, Lili Guo, Hongchang Qu
Filed: 21 Nov 22
Utility
Pharmaceutical Preparation for Improving Absorption and Postprandial Hypoglycemic Action of Insulin
25 May 23
The present disclosure relates to compositions and combinations comprising one or more insulin(s) and one or more vasoactive agent(s), and use thereof for increasing subcutaneous insulin absorption and/or treating diabetes and/or treating or preventing hyperglycemia or complications in a patient in need thereof.
Jean-luc ARDILOUZE, Maude GAGNON-AUGER, Fernand GOBEIL, Julie MENARD, Jean-Patrice BAILLARGEON, Pascal BRASSARD
Filed: 19 Jan 23
Utility
Three Resin Reactors In Series Peptide Synthesizer
25 May 23
A Solid Phase Peptide Synthesis (SPPS) device and method of using the same for manufacturing peptides is taught herein.
Martin D. Johnson, Michael E. Kopach, Mark R. Berglund, Stephen Robert GROSKREUTZ, Jingyao WANG, Luke P. Webster
Filed: 29 Jan 21
Utility
Ahr Agonists
25 May 23
The present invention relates to certain substituted AHR agonist compounds, to pharmaceutical compositions comprising the compounds and to methods of using the compounds to treat immune-mediated diseases.
Lacie Marie CHAUVIGNE-HINES, Christian Alexander CLARKE, Douglas Linn GERNERT, Steven James GREEN, Brian Morgan WATSON
Filed: 13 Sep 22
Utility
Anti-CGRP Antibody Formulation
25 May 23
Pharmaceutical formulations for anti-CGRP antibodies, and methods of using the same, are provided which are useful as treatment for migraines, episodic headaches, chronic headaches, chronic cluster headaches, and episodic cluster headaches.
Anant Sharma
Filed: 8 Aug 22
Utility
Pan-elr+ CXC Chemokine Antibodies for the Treatment of Respiratory Disease
25 May 23
Provided herein are methods and uses of antibodies that bind all seven human ELR+CXC chemokines with high affinity for preventing and/or treating respiratory diseases, e.g., acute respiratory distress syndrome (ARDS).
Dipak R Patel, Derrick Ryan Witcher, Michael Edward Woodman
Filed: 16 Apr 21
Utility
Combination Therapy with a Mutant Idh Inhibitor
11 May 23
Nathan Arthur BROOKS, Raymond GILMOUR
Filed: 22 Mar 21
Utility
Conjugates for Selective Responsiveness to Vicinal Diols
4 May 23
Embodiments of the present disclosure relate to sensors that can selectively bind to specific vicinal diols in the presence of other diols.
Alborz MAHDAVI, Ryan Kelly SPENCER, Jack Joseph STEELE, JingXin LIANG, Mirna Ekram Anwar SHAKER, Diao CHEN, Sachitanand MALI
Filed: 31 Mar 21
Utility
Combination Therapy with a Mutant Idh Inhibitor and a BCL-2 Inhibitor
4 May 23
Nathan Arthur BROOKS, Courtney DINARDO, Raymond GILMOUR, Marina KONOPLEVA, Vivian SALAMA
Filed: 22 Mar 21
Utility
Substituted 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE Derivatives
4 May 23
Thomas John BLEISCH, Douglas Linn GERNERT, Freddie Craig STEVENS
Filed: 5 Feb 21
Utility
Processes and Intermediate for the Large-scale Preparation of 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE Hemisuccinate, and Preparation of 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE Acetate
4 May 23
The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-tri-fluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms made by these processes.
Aktham Aburub, David Andrew Coates, Scott Alan Frank, Mark Steven Kerr, Roger Ryan Rothhaar, Radhe Krishan Vaid
Filed: 6 Jul 20
Utility
Crystallization of Antibodies or Antigen-Binding Fragments
4 May 23
Provided herein are methods and compositions for improving the crystallization of antibodies, antigen-binding fragments, e.g., Fab or Fab′, or fusion proteins, and Fab/Fab′/mAb:Antigen complexes.
Shane Krummen Atwell, Ricky Long Lieu
Filed: 9 Feb 21
Utility
Ahr Agonists
27 Apr 23
The present invention relates to certain substituted AHR agonist compounds, to pharmaceutical compositions comprising the compounds and to methods of using the compounds to treat immune-mediated diseases.
Cheryl Ann CARSON, Christian Alexander CLARKE, Douglas Linn GERNERT, Steven James GREEN, William Glen HOLLOWAY
Filed: 13 Sep 22
Utility
Dose Detection and Drug Identification for a Medication Delivery Device
20 Apr 23
The present disclosure relates to a dose detection system for use in combination with a medication delivery device.
Roy Howard BYERLY, Russell Wayne PERKINS, Rossano Claudio MASSARI, Patrick Kevin MURPHY, Davide PACCIORETTI, Sean Matthew PSZENNY, Oliver Brian REGELE
Filed: 20 Dec 22
Utility
Dose Detection Module for a Medication Delivery Device
13 Apr 23
The present disclosure relates to a dose detection system for use with a medication delivery device in which a dose setting member rotates relative to an actuator during dose delivery.
Matthew Thomas ANTONELLI, William Churchill Taliaferro BURKE, Roy Howard BYERLY, Christopher Robert MCCASLIN, Ethan Edward PEASE, Kenneth Alan RITSHER
Filed: 13 Dec 22
Utility
FGFR3 Inhibitor Compounds
30 Mar 23
Adedoyin David ABRAHAM, Desta Doro BUME, Kevin Ronald CONDROSKI, Robert Alan HAZLITT, Timothy Scott KERCHER, Andrew Terrance METCALF, Kaveri Balan URKALAN, Shane Michael WALLS, Andrew Karl DILGER
Filed: 3 Mar 22
Utility
CGRP Antigonists Useful As Tracer Compounds for Positron Emission Tomography
30 Mar 23
Mark Donald CHAPPELL, Miles Goodman SIEGEL
Filed: 4 Dec 20
Utility
SSTR4 Agonist Salts
30 Mar 23
The present invention relates to specific salts of (1S,5R)-(1α,5α,6α)-N-[1,1-dimethyl-2-[(3-methyl-2-pyridyl)oxy]ethyl]-3-azabicyclo[3.1.0]hexane-6-carboxamide, to pharmaceutical compositions comprising said salts, to methods of using said salts to treat physiological disorders, and to intermediates useful in the synthesis of the salts.
David Andrew COATES, David Michael REMICK
Filed: 14 Sep 22
Utility
Therapeutic Uses of Dulaglutide
23 Mar 23
The present invention relates to methods for treating, preventing or delaying disorders relating to cognition, such as cognitive decline, cognitive impairment or dementia in a patient.
Hertzel Chaim GERSTEIN
Filed: 22 Jan 21
Utility
Gripping Attachment for a Bottle
16 Mar 23
A gripping attachment (10) is disclosed which facilitates the handling of a medication bottle (12).
Tonya Lee Chalfant, Carrie Jannean Page, Tony Y. Zhang, Robert Louis Ternik, Matthew Scott Thomas, Jacob Luisi, Michael P. Squillace
Filed: 23 Nov 22