46 patents
Page 2 of 3
Utility
Plunger pumping arrangement for a hollow fiber filter
30 Aug 22
A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel.
Rudolf Pavlik
Filed: 8 Sep 20
Utility
Methods and systems for removing pressure and air from chromatography columns
19 Jul 22
Methods and systems for removing gases and/or pressure formed during the sterilization, e.g., the gamma irradiation, of prepacked chromatography systems (column plus attached tube and valve set) are described.
Alan Kit Ho Chan, James Ronald Peyser
Filed: 20 Sep 18
Utility
Encapsulated system for pressurized fluid processes
12 Jul 22
Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing.
Michael C. Gagne, Dean C. Richards, Steven V. Cates
Filed: 14 Aug 20
Utility
Alternating tangential flow rapid harvesting
24 May 22
Methods and systems of harvesting a cell product from a cell culture by culturing cells in a fluid medium until the cells have produced a cell product at a harvest concentration are disclosed.
Shashi Kiran Kudugunti, WengLong Roy Lin, John Bonham-Carter, James R. Rusche
Filed: 25 Jul 17
Utility
Micro alternating tangential flow perfusion filter, micro bioreactor, and methods of use thereof
24 May 22
A micro alternating tangential flow (microATF) perfusion filter includes a hollow cylinder having a proximal end and a distal end.
Michael Bransby, Philip Yuen
Filed: 26 Oct 18
Utility
Fluid flow monitoring assembly including a flow sensor housing removably secured to a flexible conduit that encapsulates the removable sensor
15 Mar 22
A method of using a fluid monitoring assembly for measuring the flow rate of a fluid through a flexible conduit comprising a wall that defines a lumen through which the fluid passes.
Michael C. Gagne, Dean C. Richards, Steven V. Cates
Filed: 17 Dec 19
Utility
Affinity chromatography media and chromatography devices
25 Jan 22
Chromatography media and devices containing chromatography media are disclosed.
Feng Gu, Surya Kiran Chodavarapu, James Bogdanor, Dennis McCreary, James Neil Pryor, James Rusche, James Peyser, Thomas Pauly
Filed: 15 Jan 15
Utility
Flexible tubing management system for pharmaceutical, bioprocess applications, and food/dairy applications
25 Jan 22
A system for managing flexible conduit or tubing used in pharmaceutical, bioprocess, or food/dairy applications includes a segment of flexible conduit or tubing and a plurality of conduit tracks, each conduit track including a conduit channel disposed on a first side thereof and extending along the length of each respective conduit track and dimensioned to receive the segment of flexible conduit or tubing therein, each conduit track further including a connector channel disposed on a second, opposing side and extending along the length of each respective conduit track and containing the one or more connectors that connect adjacent conduit tracks.
Michael C. Gagne, Dean C. Richards, Steven V. Cates, Scott Bendon
Filed: 18 Feb 20
Utility
Enclosed filtration system processes
18 Jan 22
A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired.
Jerry Shevitz
Filed: 24 Sep 18
Utility
Disposable alternating tangential flow filtration units
26 Oct 21
Disclosed herein are robust disposable alternating tangential flow (ATF) housing and diaphragm pump units and associated methods of manufacturing, testing, wetting, and using the same.
Travis R. Ward, Steven R. Pearl, Adam Malone, Tim Erlandson
Filed: 26 Aug 16
Utility
Slope spectroscopy standards
12 Oct 21
The present invention relates generally to a slope spectroscopy standards and methods of making slope spectroscopy standards, specifically standards and methods of developing standards specifically for variable pathlength (slope) measurements.
Mark Salerno, I-Tsung Shih, Craig Harrison
Filed: 9 Nov 20
Utility
Flexible tubing management system for pharmaceutical, bioprocess applications, and food/dairy applications
7 Sep 21
A system for managing flexible conduit or tubing used in pharmaceutical, bioprocess, or food/dairy applications includes a segment of flexible conduit or tubing and a plurality of conduit tracks, each conduit track including a conduit channel disposed on a first side thereof and extending along the length of each respective conduit track and dimensioned to receive the segment of flexible conduit or tubing therein, each conduit track further including a connector channel disposed on a second, opposing side and extending along the length of each respective conduit track and containing the one or more connectors that connect adjacent conduit tracks.
Michael C. Gagne, Dean C. Richards, Steven V. Cates, Scott Bendon
Filed: 18 Feb 20
Utility
Methods, devices and systems for 3-stage filtration
8 Jun 21
The present disclosure pertains to filtration methods comprising: passing a first fluid that comprises cells, cell debris and targeted product produced by the cells through a first filter thereby separating the first fluid into a first retentate comprising cells and a first permeate comprising targeted product and cell debris; combining resin beads having affinity for targeted product with the first permeate to form a second fluid containing resin beads with bound target product and cell debris; passing the second fluid through a second filter thereby separating the second fluid into a second retentate comprising resin beads with bound target product and a second permeate comprising cell debris; combining an elution buffer with the second retentate to form a third fluid that comprises a mixture of resin beads and unbound targeted product; and passing the third fluid through a third filter thereby separating resin beads from targeted product.
Michael Bransby
Filed: 7 May 18
Utility
Encapsulated valve system and method of use
1 Jun 21
An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface.
Michael C. Gagne, Steven V. Cates
Filed: 5 Feb 19
Utility
Tangential flow depth filtration systems and methods of filtration using same
1 Jun 21
The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
Michael Bransby, Derek Carroll
Filed: 5 Aug 20
Utility
Alkaline stable Fc-binding proteins for affinity chromatography
25 May 21
The present invention relates to Fc binding proteins comprising one or more Fc binding domains wherein at least one domain comprises of an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-6 or 21.
Paul Knick, Erik Fiedler, Ulrich Haupts, Maren Meysing
Filed: 7 Aug 17
Utility
Fluid monitoring assembly with replaceable sensor functionality
25 May 21
A fluid monitoring assembly includes a conduit having a wall defining a lumen for carrying fluid.
Michael C. Gagne, Steven V. Cates, Dean Richards, Scott Bendon
Filed: 13 Sep 19
Utility
Fluid plug for sterile processes and methods of using the same
9 Feb 21
A fluid plug for use with sterile processes such as the manufacture or production of pharmaceuticals and biologics is disclosed.
Michael C. Gagne
Filed: 3 Aug 16
Utility
Slope spectroscopy standards
9 Nov 20
The present invention relates generally to a slope spectroscopy standards and methods of making slope spectroscopy standards, specifically standards and methods of developing standards specifically for variable pathlength (slope) measurements.
Mark Salerno, I-Tsung Shih, Craig Harrison
Filed: 18 Jun 19
Utility
Plunger pumping arrangement for a hollow fiber filter
12 Oct 20
A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel.
Rudolf Pavlik
Filed: 27 Dec 17