103 patents
Page 5 of 6
Utility
Antibodies to TGF-β
21 Sep 20
The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof.
Steven R. Ledbetter, Celia Patricia Hart, Robert G. Holgate, Lutz U. Jermutus, Catriona L. Buchanan, Alexander R. Duncan, Donna K. Finch
Filed: 20 Nov 18
Utility
Variant RNAi
31 Aug 20
Provided herein are RNAi molecules including a first strand containing a guide sequence and a second strand comprising a non-guide sequence where the non-guide sequence contains a bulge opposite the seed region of the guide sequences; e.g., opposite the cleavage sequence.
Lisa M. Stanek, Adam Palermo, Brenda Richards, Sergio Pablo Sardi, Catherine O'Riordan, Antonius Song
Filed: 9 Sep 19
Utility
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17 Aug 20
This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject.
James Dodge, Lamya Shihabuddin, Marco Passini, Seng H. Cheng, Catherine O'Riordan
Filed: 1 Nov 07
Utility
lqtiac7ggn3ecdcyfxw9zxfz
3 Aug 20
Antibodies or antigen-binding fragments thereof are engineered to bind Transforming Growth Factor-β (TGFβ).
Ronnie Wei, Aaron Moulin, Magali Mathieu, Clark Pan, Sunghae Park, Huawei Qiu
Filed: 6 Aug 17
Utility
ffz4h8juoq7c1e10asequ33cfmmovskql7vm1g2neqepp
13 Jul 20
Provided herein are integrated continuous biomanufacturing processes for producing a therapeutic protein drug substance.
Konstantin Konstantinov, Rahul Godawat, Veena Warikoo, Sujit Jain
Filed: 20 Apr 17
Utility
khyjyz3h05bb01dkcl8dkx83k2jxj9m58o6bnto
29 Jun 20
Provided herein are methods for the purification of recombinant adeno-associated virus (rAAV) vectors that can be used for gene transfer and specifically for gene therapy or vaccination.
Paulene Mclean Quigley Sheldon, Peter S. Gagnon, Gina Nichols, Barbara A. Thorne
Filed: 11 Jun 18
Utility
c328rgpwx9m8bot3o4nwby1djk3 9cxevda4uj2ey6
15 Jun 20
The present disclosure relates to antisense oligonucleotides (AONs) for modulating the expression of glycogen synthase.
Carol A. Nelson, Bruce M. Wentworth, Ronald K. Scheule, Timothy E. Weeden, Nicholas P. Clayton
Filed: 24 May 18
Utility
cl9053ww5peeql6sn5su8y
11 May 20
Disclosed herein are methods that have been developed to control the formation of disulfide bonds between polypeptides of a multimeric protein produced by a bioprocess.
Kevin P. Brower, Chris Hwang, Rao Koduri, Konstantin B. Konstantinov, Veena Warikoo, Marcella Yu, Jin Yin
Filed: 24 Mar 15
Utility
02d83i3hryiqf8gzy190iy4d1hw6 pm4yh8rn1eh
11 May 20
A method for identifying a patient that is at risk for developing a thyroid disorder that occurs subsequent to treatment with a regimen that depletes lymphocytes, comprising determining whether antibodies directed against thyroid peroxidase or thyroid microsomes are present in the patient, wherein if the antibodies are present in the patient then the patient is at increased risk for developing a thyroid disorder.
David H. Margolin
Filed: 9 May 17
Utility
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4 May 20
Compositions and methods for treating macular degeneration are disclosed.
Samuel Wadsworth, Abraham Scaria, Chi-Chao Chan
Filed: 16 Apr 14
Utility
v33gfbcxpoxa9vs d081df0wy8m5oepp2oacg13hy5396dslpynr03cjlw32
27 Apr 20
The disclosure pertains to methods and compositions for treating disorders affecting the central nervous system (CNS).
Marco A. Passini, James Dodge
Filed: 1 Nov 07
Utility
hghmujgi82flmuzrzbqwjilgxvo4e3 aipdhidt0
27 Apr 20
Disclosed herein is a method of treating a patient suffering a myocardial infarction, particularly an acute myocardial infarction, or of reducing an adverse consequence of a myocardial infarction in a patient comprising administering an antagonist of TGF-β to the patient during the acute stage of the myocardial infarction.
Geoffrey Y. Akita, Scott Lonning, Richard C Gregory, Jr., Amelia B Kudej
Filed: 11 Dec 16
Utility
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30 Mar 20
The invention relates to a method of preparing inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
Craig S. Siegel, Rayomand Gimi, Michael Reardon, Jin Zhao
Filed: 31 Jul 18
Utility
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9 Mar 20
The present invention relates to non-mercurial preservatives, including antimicrobial polyamide polymers and octenidine, and to methods of use thereof to produce preservative-containing multi-dose formulations.
Guillaume Rigaut, Celine Loss-Dunod, Alexis Guy Andre Lucien Parisot, Pradeep K. Dhal
Filed: 12 Apr 17
Utility
xi75gbivlojrtcsex06ov2bdtxrpafi87q d0s0e1vua38exbtwxxbbzi
2 Mar 20
Provided herein are methods of perfusion culturing an adherent mammalian cell using a shake flask and a plurality of microcarriers, and various methods that utilize these culturing methods.
Jianguo Yang, Yang Yang, Jennifer Tengtrakool, Weichang Zhou
Filed: 17 Jan 18
Utility
mbw8zv30zjltpf26apms0d1x26wc2o6p8bjzny93ozkz ew9okx3b954p
24 Feb 20
Provided herein are seed train processes and methods of producing a recombinant protein that include the use of these seed train processes.
Michael Bruninghaus, Konstantin Konstantinov, Benjamin Wright, Weichang Zhou
Filed: 7 Jun 15
Utility
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16 Dec 19
The invention provides compositions and methods for treating breast cancer.
Jay Harper, Scott Lonning, Frank Hsu
Filed: 8 Jan 17
Utility
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16 Dec 19
An scFv-Fc dimer binds and neutralizes TGFβ1 selectively and with high affinity and avidity.
Huawei Qiu, Clark Pan, Julie Bird
Filed: 2 Mar 16
Utility
886vkzm5uxaak0o2q84naw
2 Dec 19
Provided are binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof, comprising a CH1 domain (e.g., a human IgG1 CH1 domain), wherein the CH1 domain has an engineered N-linked glycosylation site at amino acid position 114, according to Kabat numbering.
Clark Pan, Huawei Qiu, Pradeep Dhal, Bo Chen, Diego Gianolio
Filed: 4 Jun 17
Utility
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4 Nov 19
Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI.
Luis Z. Avila, Clark Q. Pan, Patrick Finn, John Harrahy, Qun Zhou, Yunxiang Zhu, Paul A. Konowicz, Duncan E. Paterson, Andreas Peer, Joseph P. Kutzko, Michael R. Reardon, James E. Stefano, Xiaoyang Zheng, Robert J. Miller, Lauren Young
Filed: 6 Oct 16