779 patents
Page 19 of 39
Utility
Dispensing Device
2 Dec 21
A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.
Peter J. Houzego, John Kelshaw Conway, Martin Douglas Pearl, Andrew Mark Bryant
Filed: 13 Aug 21
Utility
Aminopyrimidinyl Compounds
2 Dec 21
Andrew FENSOME, Ariamala GOPALSAMY, Brian S. GERSTENBERGER, Ivan Viktorovich EFREMOV, Zhao-Kui WAN, Betsy PIERCE, Jean-Baptiste TELLIEZ, John I. TRUJILLO, Liying ZHANG, Li XING, Eddine SAIAH
Filed: 6 Aug 21
Utility
Glycoconjugation Process
2 Dec 21
The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.
Mingming Han, Rajesh Kumar Kainthan, Jin-Hwan Kim, Avvari Krishna Prasad
Filed: 12 Aug 21
Utility
Method for predicting response to breast cancer therapeutic agents and method of treatment of breast cancer
30 Nov 21
Methods for treating triple negative breast cancer with an androgen receptor inhibitor are provided, as well as methods for screening for the likelihood of the effectiveness of such treatment.
Amy Christian Peterson, Hirdesh Uppal
Filed: 10 Dec 18
Utility
Derivatives of relebactam and uses thereof
23 Nov 21
Derivatives of relebactam, therapeutic methods of using the derivatives of relebactam, particularly in combination with β-lactam antibiotics and pharmaceutical compositions thereof are disclosed.
Eric M. Gordon, Matthew A. J. Duncton, John Freund
Filed: 1 Oct 19
Utility
Sustained release pharmaceutical compositions
23 Nov 21
Eric Joel Benjamin, Wendy Ann Dulin, Yanning Lin, Kai Zhuang
Filed: 1 Nov 19
Utility
Compounds and Uses Thereof to Treat Tumors In a Subject
18 Nov 21
The present invention relates to compounds that can be used to induce immunogenic cell death (ICD).
Astrid Zimmermann, Maria Jesus Ortiz Ruiz, Heike Dahmen, Thomas Grombacher
Filed: 13 Mar 19
Utility
Novel IMIDAZO[4,5-C]QUINOLINE Derivatives As LRRK2 Inhibitors
18 Nov 21
Michael Aaron BRODNEY, Thomas Allen CHAPPIE, Jinshan Michael CHEN, Jotham Wadsworth COE, Karen Jean COFFMAN, Paul GALATSIS, Michelle Renee GARNSEY, Christopher John HELAL, Jaclyn Louise Henderson, Bethany Lyn KORMOS, Ravi G. KURUMBAIL, Luis Angel MARTINEZ-ALSINA, Martin Youngjin PETTERSSON, Matthew Richard REESE, Colin Richard ROSE, Antonia Friederike STEPAN, Patrick Robert VERHOEST, Travis T. WAGER, Joseph Scott WARMUS, Yuan ZHANG
Filed: 6 Mar 18
Utility
Combinations for Treating Cancer
18 Nov 21
Provided herein are methods and combinations for treating a subject having cancer by administering to the subject a PD-1/PD-L1 axis inhibitor, a CD-122-biased-cytokine agonist, and optionally a PARP inhibitor.
Christoffel Hendrik Boshoff, Rossano Cesari, Cristian Massacesi, Deborah Charych
Filed: 4 Nov 19
Utility
Vectors for expression of prostate-associated antigens
16 Nov 21
The present disclosure provides (a) vectors comprising a multi-antigen construct encoding two, three, or more immunogenic PAA polypeptides; (b) compositions comprising the vectors, (c) methods relating to uses of the vectors and compositions for eliciting an immune response or for treating prostate cancers.
Joseph John Binder
Filed: 23 Aug 18
Utility
Quinazoline analogs as receptor tyrosine kinase inhibitors
16 Nov 21
The invention includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Eli Wallace, George Topalov, Joseph Lyssikatos, Alexandre Buckmelter, Qian Zhao
Filed: 31 Jan 19
Utility
Combinations of Tgf-beta Inhibitors and CDK Inhibitors for Cancer Treatments
11 Nov 21
This invention relates to a method of treating breast cancer by administering a TGFβ inhibitor in combination with a CDK inhibitor to a patient in need therof.
Flavia Mercer PERNASETTI
Filed: 16 Sep 19
Utility
Pneumococcal dosing regimen
9 Nov 21
Methods of immunizing older adult subjects against Streptococcus pneumoniae infection are provided.
George Rainer Siber, Peter R. Paradiso, Jill Hackell, Stephen Paul Lockhart, William P. Hausdorff
Filed: 24 Jul 19
Utility
Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors
9 Nov 21
Steven W Andrews, James F Blake, Julia Haas, Yutong Jiang, Gabrielle R Kolakowski, David A Moreno, Li Ren, Shane M Walls
Filed: 18 Jan 18
Utility
Crystalline forms of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate
9 Nov 21
This invention relates to a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, and to pharmaceutical compositions thereof, to intermediates and methods for the production and isolation of such crystalline forms and compositions, and to methods of using such crystalline forms and compositions in the treatment of abnormal cell growth in mammals, especially humans.
Christopher Scott Seadeek
Filed: 25 Jul 19
Utility
Cyclic substituted imidazo[4,5-c]quinoline derivatives
2 Nov 21
Thomas Allen Chappie, Paul Galatsis, Michelle Renee Garnsey, Christopher John Helal, Jaclyn Louise Henderson, Bethany Lyn Kormos, Ravi G. Kurumbail, Luis Angel Martinez-Alsina, Martin Youngjin Pettersson, Antonia Friederike Stepan, Travis T. Wager
Filed: 1 Mar 18
Utility
Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
2 Nov 21
The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof.
Emilio Anthony Emini, Wendy Jo Watson, Avvari Krishna Prasad, Mingming Han, Jin-Hwan Kim, Jianxin Gu, Yu-ying Yang, Rajesh Kumar Kainthan, David Cooper, Michael William Pride, Kathrin Ute Jansen
Filed: 6 Oct 16
Utility
GLP-1 Receptor Agonists and Uses Thereof
28 Oct 21
Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
Gary Erik Aspnes, Scott W. Bagley, Edward L. Conn, John M. Curto, David J. Edmonds, Mark E. Flanagan, Kentaro Futatsugi, David A. Griffith, Kim Huard, Chris Limberakis, Alan M. Mathiowetz, David W. Piotrowski, Roger B. Ruggeri
Filed: 13 Jun 19
Utility
Therapeutic antibodies and their uses
26 Oct 21
The present invention relates to bispecific antibodies that specific bind to BCMA (B-Cell Maturation Antigen) and CD3 (Cluster of Differentiation 3).
Tracy Chia-Chien Kuo, Javier Fernando Chaparro Riggers, Wei Chen, Amy Shaw-Ru Chen, Edward Derrick Pascua, Thomas John Van Blarcom, Leila Marie Boustany, Weihsien Ho, Yik Andy Yeung, Pavel Strop, Arvind Rajpal
Filed: 21 Dec 20
Utility
IL-15 Variants and Uses Thereof
21 Oct 21
The present invention relates to human interleukin 15 (IL-15) variants that have therapeutic and diagnostic use, and methods for making thereof.
Yik Andy Yeung, Reid Martin Renny Feldman, Ling Hon Matthew Chu, Javier Fernando Chaparro Riggers, Ivana Djuretic, Laura Lin, Lidia Mosyak
Filed: 24 Jun 21