779 patents
Page 20 of 39
Utility
Dosage Regimen For MAdCAM Antagonists
21 Oct 21
The present invention provides a method for the treatment of a patient comprising administering to the patient an initial dose of between about 1 mg and about 150 mg of a MAdCAM antagonist antibody.
Fabio CATALDI, Robert A. CLARE, Gail M. COMER, Vivekananda PRADHAN, Alaa AHMAD, Mina HASSAN-ZAHRAEE, Mera Krishnan TILLEY, Weidong ZHANG, Anindita BANERJEE, Karen Michelle PAGE, Michael Steven VINCENT, David J. VON SCHACK
Filed: 30 Nov 20
Utility
Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
19 Oct 21
The present invention is directed to antibodies, and antigen-binding portions thereof, engineered to introduce amino acids for site-specific conjugation.
Kimberly Marquette, Eric Bennett, Lioudmila Tchistiakova, L. Nathan Tumey, Jack Bikker, Valerie Calabro, Edmund Graziani
Filed: 19 Dec 12
Utility
Immunogenic compositions and uses thereof
19 Oct 21
The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B Streptococcus (GBS), conjugated to a carrier protein, and optionally including an aluminum-based adjuvant.
Annaliesa Sybil Anderson, Leena Shriram Bagle, Amardeep Singh Bhupender Bhalla, Miguel Angel Garcia, Lei Hu, Lakshmi Khandke, Avvari Krishna Prasad, Cindy Xudong Yang
Filed: 4 Aug 20
Utility
Solid Dosage Forms of Palbociclib
14 Oct 21
The present invention relates to solid dosage forms of palbociclib comprising a water-soluble acid.
Fady Makram Louiz Ibrahim, Matthew Patrick Mullarney, Ravi M. Shanker, Barbara Rodriguez Spong, Jian Wang
Filed: 17 Jun 21
Utility
Azalactam compounds as HPK1 inhibitors
12 Oct 21
Rebecca Anne Gallego, Sajiv Krishnan Nair, Robert Steven Kania, Omar Khaled Ahmad, Ted William Johnson, Jamison Bryce Tuttle, Mehran Jalaie, Michele Ann McTigue, Dahui Zhou, Matthew L. Del Bel, Ru Zhou, Mingying He, Anne-Marie Dechert Schmitt
Filed: 11 Nov 19
Utility
Heteroaryl Sulfone-based Conjugation Handles, Methods for Their Preparation, and Their Use In Synthesizing Antibody Drug Conjugates
7 Oct 21
Russell George DUSHIN, Daniel P. UCCELLO, Jeremy STARR, Ye CHE, Mark FLANAGAN, Jeffrey M. CASAVANT, Christopher John O'DONNELL, Gary Frederick FILZEN, Jennifer YOUNG, Joseph A. ABRAMITE, Lawrence N. TUMEY, Ludivine MOINE, Adam Matthew GILBERT, Lee R. ROBERTS
Filed: 31 Jul 17
Utility
Substituted 3-AZABICYCLO[3.1.0]HEXANES As Ketohexokinase Inhibitors
7 Oct 21
Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
Matthew Dowling, Dilinie Fernando, Kentaro Futatsugi, Kim Huard, Thomas Victor Magee, Brian Raymer, Andre Shavnya, Aaron Smith, Benjamin Thuma, Andy Tsai, Meihua Tu
Filed: 23 Mar 21
Utility
Diacylglycerol Acyl Transferase 2 Inhibitors
7 Oct 21
Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.
Markus Boehm, Shawn Cabral, Matthew S. Dowling, Kentaro Futatsugi, Kim Huard, Esther Cheng Yin Lee, Allyn T. Londregan, Jana Polivkova, David A. Price, Qifang Li
Filed: 11 Jun 21
Utility
5,7-DIHYDRO-PYRROLO-PYRIDINE Derivatives
7 Oct 21
Lei Zhang, Christopher Ryan Butler, Elizabeth Mary Beck, Michael Aaron Brodney, Matthew Frank Brown, Laura Ann McAllister, Erik Alphie LaChapelle, Adam Matthew Gilbert
Filed: 1 Jun 21
Utility
Heterocyclic Spiro Compounds As MAGL Inhibitors
7 Oct 21
Michael Aaron Brodney, Christopher Ryan Butler, Laura Ann McAllister, Steven Victor O'Neil
Filed: 10 Jul 19
Utility
Soluble Fibroblast Growth Factor Receptor 3 (SFGFR3) Polypeptides and Uses Thereof
7 Oct 21
The invention features soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides.
Elvire Gouze, Stéphanie Garcia
Filed: 20 Apr 21
Utility
Immunogenic compositions for use in pneumococcal vaccines
5 Oct 21
An object of the present invention is to provide immunogenic compositions for protection against S. pneumoniae, in particular against S. pneumoniae serogroup 9, while limiting the number of conjugates.
David Cooper, Kathrin Ute Jansen, Michael William Pride
Filed: 9 Apr 20
Utility
Heteroaromatic Compounds and Their Use As Dopamine D1 Ligands
30 Sep 21
Michael Aaron Brodney, Jennifer Elizabeth Davoren, Amy Beth Dounay, Ivan Viktorovich Efremov, David Lawrence Firman Gray, Michael Eric Green, Jaclyn Louise Henderson, Chewah Lee, Scot Richard Mente, Steven Victor O'Neil, Bruce Nelsen Rogers, Lei Zhang
Filed: 17 Mar 21
Utility
CorrectedQuinazoline Analogs As Receptor Tyrosine Kinase Inhibitors
16 Sep 21
The invention includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Eli Wallace, George Topalov, Joseph Lyssikatos, Alexandre Buckmelter, Qian Zhao
Filed: 31 Jan 19
Utility
Process for Preparing Pneumococcal Polysaccharide-protein Conjugates
16 Sep 21
An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described.
William P. Hausdorff, George Rainer Siber, Peter R. Paradiso
Filed: 24 May 21
Utility
Immunogenic compositions for the prevention and treatment of meningococcal disease
14 Sep 21
The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.
Gary W. Zlotnick, Leah D. Fletcher, John E. Farley, Liesel A. Bernfield, Robert J. Zagursky, Benjamin J. Metcalf
Filed: 7 Jan 20
Utility
Dispensing device
14 Sep 21
A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.
Peter J. Houzego, John Kelshaw Conway, Martin Douglas Pearl, Andrew Mark Bryant
Filed: 7 Nov 18
Utility
Glycoconjugation process
14 Sep 21
The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.
Mingming Han, Rajesh Kumar Kainthan, Jin-Hwan Kim, Avvari Krishna Prasad
Filed: 8 Jul 20
Utility
Liquid Bendamustine Pharmaceutical Compositions
9 Sep 21
Concentrated liquid pharmaceutical compositions comprising a) a pharmaceutically effective amount of bendamustine or a pharmaceutically acceptable salt thereof, b) a non-aqueous solvent, and c) at least about 2% water, suitable, after dilution, for administration to a mammal by injection are provided.
Andrew Malcolm Knill, Noel Norris
Filed: 14 Aug 19
Utility
Prostate-associated antigens and vaccine-based immunotherapy regimens
7 Sep 21
The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.
Joseph John Binder, Helen Kim Cho, Michael Robert Dermyer, Karin Ute Jooss, Brian Gregory Pierce, Joyce Tsi Tan, Van To Tsai, James Richard Merson
Filed: 8 Aug 18