471 patents
Page 7 of 24
Utility
PYRAZOLO[1,5-A]PYRAZIN-4-YL Derivatives
9 Feb 23
Matthew Frank BROWN, Alpay DERMENCI, Andrew FENSOME, Brian Stephen GERSTENBERGER, Matthew Merrill HAYWARD, Dafydd Rhys OWEN, Stephen Wayne WRIGHT, Li Huang XING, Xiaojing YANG
Filed: 7 Sep 22
Utility
Combination Therapy
9 Feb 23
This disclosure provides a dosage regimen for co-administration of enzalutamide and a strong CYP3A4 inducer.
Jacqueline Gibbons, Joyce Mordenti, Michiel De Vries, Walter Krauwinkel, Taoufik Ouatas
Filed: 4 Oct 22
Utility
rchse4qakldkssiwnskd660h0
9 Feb 23
The invention provides solid forms of 2-((4-((S)-2-(5-chloropyridin-2-yl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((S)-oxetan-2-yl)methyl)-1H-benzo[d]imidazole-6-carboxylic acid, 1,3-dihydroxy-2-(hydroxymethyl)propan-2-amine salt for example, a hydrate (e.g. a monohydrate) crystalline form (e.g.
Gary E. Aspnes, Scott W. Bagley, Wesley Dewitt Clark, John M. Curto, David James Edmonds, Mark E. Flanagan, Kentaro Futatsugi, David Andrew Griffith, Kim Huard, Yajing Lian, Chris Limberakis, Allyn T. Londregan, Alan M. Mathiowetz, David Walter Piotrowski, Roger B. Ruggeri
Filed: 7 Dec 20
Utility
dxzrjdwgludjaa0vieii2mf786ny97dcnoq4favb0h
9 Feb 23
Provided herein are pharmaceutical combinations comprising (a) a B-Raf inhibitor, or a pharmaceutically acceptable salt thereof, (b) at least one mitogen activated protein kinase (MEK) inhibitor, or a pharmaceutically acceptable salt thereof, and (c) an epidermal growth factor receptor (EGFR) inhibitor or a pharmaceutically acceptable salt thereof; and optionally at least one pharmaceutically acceptable carrier; methods for preparing the pharmaceutical combinations, and the uses of the pharmaceutical combinations in the treatment of proliferative diseases, such as cancer.
Giordano Caponigro, Zhu Alexander Cao
Filed: 16 May 22
Utility
h2rsldzb8fsk6fr9aflvctl0lwshjdf
2 Feb 23
The present invention relates to the field of pharmaceutical formulations of antibodies.
Thomas Joseph Crowley, Robert Lee Dufield, Jennifer Juneau
Filed: 10 Nov 20
Utility
n9a8ztmo0v3bxtnzdbevowc0b77vaba6zc4t
26 Jan 23
Mark Laurence BOYS, Bryan Daniel ELLIS, John Joseph GAUDINO, Erik James HICKEN, Ellen Ruth LAIRD, Nicholas Charles LAZZARA, Bradley Jon NEWHOUSE, Spencer Phillip PAJK
Filed: 29 Jun 21
Utility
smzcz9hcc00wohu9ferjqybt
26 Jan 23
Meng Li, Anthony William Tolcher
Filed: 4 Jan 21
Utility
zjj75r9lq16uqiuaeg8twsb 2d8rp5fotuyexqb70synsz21btojpsf6dyl
19 Jan 23
Christopher Ryan Butler, Michelle Renee Garnsey, Kevin Alexander Ogilvie, Jana Polivkova, Matthew Forrest Sammons, Aaron Christopher Smith, Qingyi Yang
Filed: 8 Jun 21
Utility
2xmcd w16hw70vakcnzrpv2v7ceu60rf8ar
19 Jan 23
Provided are compositions and methods for stabilizing a transfection cocktail containing DNA-cationic polymer complexes for an extended time, while maintaining high transfection efficiency.
Saurabh Kant Bhardwaj, Chia Hung Chu
Filed: 16 Dec 20
Utility
ad1labunvc7c2ehvyk9o04jnjdxzt
12 Jan 23
The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof.
Atli Thorarensen, Matthew Frank Brown, Agustin Casimiro-Garcia, Ye Che, Jotham Wadsworth Coe, Mark Edward Flanagan, Adam Matthew Gilbert, Matthew Merrill Hayward, Jonathan David Langille, Justin Ian Montgomery, Jean-Baptiste Telliez, Rayomand Jal Unwalla, John I. Trujillo
Filed: 4 Aug 21
Utility
43oynfls253qvrh1b1o975gu9iov027c rqz6wzdoivta
12 Jan 23
Ronald Jay Hinklin, Shelley Allen, Patrick Barbour, Adam Cook, Joshua Dahlke, John Gaudino, Ellen Laird, Oren T. McNulty, Qian Zhao
Filed: 15 Jul 21
Utility
ie9tkgd28jux1spdm3zc448a mtmfeao7nju4nv4pxhanrz
5 Jan 23
Thomas Allen Chappie, Nandini Chaturbhai Patel, Patrick Robert Verhoest, Christopher John Helal, Simone Sciabola, Erik Alphie LaChapelle, Travis T. Wager, Ramalakshmi Yegna Chandrasekaran
Filed: 12 Aug 22
Utility
uub6n9xoyo7zrpya9o2aipzq69s7y8hlfoahtvf f6jr8ddifyhiwe36t2
5 Jan 23
In one aspect, the invention relates to a polypeptide derived from E. coli and a fragment thereof, including compositions and methods thereof.
Annaliesa Sybil Anderson, Ye Che, Wei Chen, Laurent Oliver Chorro, Ling Chu, Robert G.K. Donald, Matthew Curtis Griffor, Jianxin Gu, Zeqiang Guan, Jin-Hwan Kim, Srinivas Kodali, Scott Ellis Lomberk, Jason Arnold Lotvin, Nishith Merchant, Justin Keith Moran, Rosalind Pan, Avvari Krishna Prasad, Mark Edward Ruppen, Suddham Singh, David Robert Stead, Karen Kiyoko Takane
Filed: 28 Oct 20
Utility
ved444kqsb0eurqv4135evb wdb2yotimx9w8v16wivfp4ycyfm6u0
5 Jan 23
The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70).
Siler Panowski, Tao Sai, Barbra Johnson Sasu, Surabhi Srivatsa Srinivasan, Thomas John Van Blarcom
Filed: 1 Jun 22
Utility
og4t2xftkezt17s0v62epyt6ro72rmm5h 0i0s69fp5734icq
22 Dec 22
Joyann Barber, Sujin Cho-Schultz, Matthew L. Del Bel, Rebecca Anne Gallego, Mingying He, Mehran Jalaie, Robert Steven Kania, Michele Ann McTigue, Sajiv Krishnan Nair, Anne-Marie Dechert Schmitt, Jamison Bryce Tuttle, Dahui Zhou, Ru Zhou
Filed: 30 Apr 21
Utility
pxu r1rk2837yf4odcc4
22 Dec 22
Annaliesa Sybil Anderson, John Lance Perez, Kathrin Ute Jansen, Paul Liberator, Cuiwen Tan, Thomas Richard Jones, Johannes Frederik Beeslaar, Judith Absalon, Jason Douglas Maguire, Shannon Lea Harris
Filed: 24 Sep 20
Utility
2n73gcxz1s9t868uww71uyzpn gry2ktej53f60
8 Dec 22
In part, the invention provides a new combination comprising (1) a GLP-1R agonist and (2) an ACC inhibitor or a DGAT2 inhibitor, or a KHK inhibitor or FXR agonist.
Gary E. Aspnes, Scott W. Bagley, John M. Curto, Matthew Dowling, David James Edmonds, Dilinie Fernando, Mark E. Flanagan, Kentaro Futatsugi, David Andrew Griffith, Kim Huard, Gajendra Ingle, Wenhua Jiao, Shawn M. LaCasse, Yajing Lian, Chris Limberakis, Allyn T. Londregan, Alan M. Mathiowetz, David Walter Piotrowski, Roger B. Ruggeri, Kristin Wiglesworth
Filed: 15 May 20
Utility
4h1pmd22canifor5tc1zou8vsf1rnqqni4oh94rl4aadtl13u99uliq1
8 Dec 22
The present invention relates to new conjugated capsular saccharide antigens (glycoconjugates), immunogenic compositions comprising said glycoconjugates and uses thereof.
Annaliesa Sybil Anderson, Caitlyn Gallagher, Jianxin Gu, Isis Kanevsky, Jin-Hwan Kim, Justin Keith Moran, Suddham Singh, Naveen Surendran
Filed: 25 May 22
Utility
w1wk03mh o3hnmlixnmzbpzh4ydgv1044bl50
8 Dec 22
The present invention provides antibodies, or antigen-binding fragment thereof, which specifically bind to tumor necrosis factor (TNF)-like ligand (TL1A).
Robert ARCH, Jun ZHANG, Michelle MADER, Tetsuya ISHINO, Joel BARD, William FINLAY, Orla CUNNINGHAM, Ciara REILLY, Peter BRAMS, Brigitte DEVAUX, Haichun HUANG, Karla HENNING
Filed: 28 Jul 22
Utility
dbgpn6ifbavmvn38mkgg1hbioiv7ko
8 Dec 22
The present invention relates to new conjugated capsular saccharide antigens (glycoconjugates), immunogenic compositions comprising said glycoconjugates and uses thereof.
Annaliesa Sybil Anderson, Caitlyn Gallagher, Jianxin Gu, Isis Kanevsky, Jin-Hwan Kim, Justin Keith Moran, Suddham Singh, Naveen Surendran
Filed: 25 May 22