471 patents
Page 8 of 24
Utility
1-(((2S,3S,4S)-3-ETHYL-4-FLUORO-5-OXOPYRROLIDIN-2-YL)METHOXY)-7-METHOXYISOQUINOLINE-6-CARBOXAMIDE Combinations and Oral Dosage Forms
1 Dec 22
The present invention is related to the discovery of new oral dosage formulations and combination therapies for 1-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide, or a pharmaceutically acceptable salt thereof, for treating conditions ameliorated by inhibition of IRAK4.
Allan Joseph Hutchins, Bruce Clinton MacDonald, Vikram Rama Rao, Degui Tang, Weili Yu
Filed: 11 Nov 20
Utility
Streptococcus Pneumoniae Capsular Polysaccharides and Conjugates Thereof
1 Dec 22
The invention relates to activated Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides and processes for their preparation.
Jianxin Gu, Rajesh Kumar Kainthan, Jin-Hwan Kim, Avvari Krishna Prasad, Yu-Ying Yang
Filed: 22 Jul 22
Utility
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1 Dec 22
Methods for providing a carboxamide compound and intermediates used in the preparation of the carboxamide compound are provided.
Vadali Lakshmana Rao, Saidugari Swamy, Nagaraju Mittapelly, Dasari Srinivasa Rao, Sarah Haycock Lewandowski, Alan Pettman
Filed: 24 Jun 20
Utility
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1 Dec 22
The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to GDF15, as well as methods and uses for the antibodies.
Kevin Charles Beaumont, Danna M. Breen, Matthew Allister Lambert, Jeffrey Raymond Chabot, Tao He, Ksenya Shchors, James R. Apgar
Filed: 1 Aug 22
Utility
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24 Nov 22
The present disclosure describes combination therapies and uses thereof for the treatment of cancer.
Shih-Hsun CHEN, Luca MICCI, Cecilia Marianne ODERUP, Shahram SALEK-ARDAKANI, Jie WEI
Filed: 18 Dec 19
Utility
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24 Nov 22
A filling head (20) for filling a container (22) includes a receptacle (24).
Simon Cooper, Bruce MacMichael, Peter Houzego
Filed: 24 Jun 20
Utility
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17 Nov 22
Samit Kumar Bhattacharya, Christopher Ryan Butler, Kevin James Filipski, Bethany Lyn Kormos, Luis Angel Martinez-Alsina, Russell Alan Miller, Kiyoyuki Omoto, Brian Raymer, Matthew Richard Reese, Rachel Jane Roth Flach, Yuan Zhang
Filed: 24 Jun 20
Utility
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17 Nov 22
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines comprising polynucleotide molecules encoding one or more influenza antigens, such as hemagglutinin antigens.
Philip Ralph Dormitzer, Advait Vijay Badkar, Christina Van Geen Hoven, Kathrin Ute Jansen, Pirada Suphaphiphat Allen, Ramin Darvari, Mark Duda
Filed: 29 Apr 22
Utility
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10 Nov 22
A combination of temsirolimus and trastuzumab in the treatment of cancer is provided.
Laurence Moore, Charles Michael Zacharchuk, Sridhar Krishna Rabindran
Filed: 10 Dec 21
Utility
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3 Nov 22
Ariamala Gopalsamy, Shawn Cabral, Agustin Casimiro-Garcia, Ming Zhu Chen, Chulho Choi, Robert Lee Dow, Olugbeminiyi Omezia Fadeyi, David Hepworth, Jayasankar Jasti, Lyn Howard Jones, Arjun Venkat Narayanan, Mihir Dineshkumar Parikh, David Walter Piotrowski, Lee Richard Roberts, Ralph Pelton Robinson, Jr., Hatice Gizem Yayla
Filed: 12 Apr 21
Utility
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27 Oct 22
The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen).
Tracy Chia-Chien KUO, Bijan Andre Boldajipour, Javier Fernando Chaparro Riggers, Philippe Duchateau, Roman Galetto, Alexandre Juillerat, Thomas Charles Pertel, Arvind Rajpal, Barbra Johnson Sasu, Cesar Adolfo Sommer, Julien Valton, Thomas John Van Blarcom
Filed: 15 Mar 22
Utility
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13 Oct 22
The present disclosure provides (i) isolated immunogenic TAA polypeptides (i.e., an immunogenic MUC1 polypeptides, an immunogenic MSLN polypeptides, and an immunogenic TERT polypeptides), (ii) isolated nucleic acid molecules encoding one or more immunogenic TAA polypeptides, (iii) compositions comprising an immunogenic TAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic TAA polypeptide, and (iv) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions.
Joseph John Binder, Paul Jason Cockle, Derek John Falconer, Siradanahalli Guru, Karin Ute Jooss, Marianne Marcela Andrea Martinic, Kenneth Nelson Wills, Helen Kim Cho
Filed: 13 May 21
Utility
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13 Oct 22
Shelley ALLEN, Patrick Michael DOERNER BARBOUR, James Francis BLAKE, Sydney Taylor BLANCHE, Mark Laurence BOYS, Wesley Dewitt CLARK, Connor James COWDREY, Joshua Ryan DAHLKE, Alex Andrew KELLUM, Ellen Margaret KNAPP, David Austin MORENO, Jacob Matthew O'LEARY, Li REN, Faith Elizabeth WITKOS
Filed: 30 Mar 22
Utility
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13 Oct 22
Douglas Carl Behenna, Ping Chen, Kevin Daniel Freeman-Cook, Robert Louis Hoffman, Mehran Jalaie, Asako Nagata, Sajiv Krishnan Nair, Sacha Ninkovic, Martha Alicia Ornelas, Cynthia Louise Palmer, Eugene Yuanjin Rui
Filed: 15 Jun 22
Utility
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13 Oct 22
The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a VEGFR inhibitor, and the use of the combination therapies for the treatment of cancer, and in particular for treating cancers that express PD-L1.
Jean-Francois Andre MARTINI, Jamal Christo Tarazi, Rodolfo Fleury Perini, David J. Mauro
Filed: 20 Apr 22
Utility
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6 Oct 22
The invention relates to a Protein A chromatography step of a purification process for a therapeutic protein, wherein a load solution including the therapeutic protein is applied onto a Protein A chromatography medium.
Russell Ian SHPRITZER
Filed: 9 Jun 20
Utility
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6 Oct 22
Steven W. ANDREWS, Sean ARONOW, James F. BLAKE, Barbara J. BRANDHUBER, James COLLIER, Adam COOK, Julia HAAS, Yutong JIANG, Gabrielle R. KOLAKOWSKI, Elizabeth A. MCFADDIN, Megan L. MCKENNEY, Oren T. MCNULTY, Andrew T. METCALF, David A. MORENO, Ginelle A. RAMANN, Tony P. TANG, Li REN, Shane M. WALLS
Filed: 1 Dec 20
Utility
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29 Sep 22
Ketan Satish GAJIWALA, Chan Woo HUH, Mehran JALAIE, Ryan Lloyd PATMAN, Eugene Yuanjin RUI, Jianmin SUN, Martin James WYTHES
Filed: 11 Mar 22
Utility
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15 Sep 22
Patrick Michael DOERNER BARBOUR, Tanna Marie BETTENDORF, Dean Russell KAHN, Alex Andrew KELLUM, Ellen Ruth LAIRD, David Austin MORENO, Li REN
Filed: 4 Jun 21
Utility
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15 Sep 22
Patrick Michael BARBOUR, Katie Keaton BROWN, Adam Wade COOK, Erik James HICKEN, Dean Russell KAHN, Ellen Ruth LAIRD, Andrew Terrance METCALF, David Austin MORENO, Bradley Jon NEWHOUSE, Spencer Phillip PAJK, Brett Joseph PRIGARO, Li REN, Eugene TARLTON
Filed: 16 May 22