118 patents
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Utility
Solid State Forms of N-[2-(2-{4-[2-(6,7-DIMETHOXY-3,4-DIHYDRO-2(1H)-ISOQUINOLINYL)ETHYL]PHENYL}-2H-TETRAZOL-5-YL)-4,5- DIMETHOXYPHENYL]-4-OXO-4H-CHROMENE-2-CARBOXAMIDE and of Its Mesylate Salt
5 May 22
The present disclosure relates to solid state forms of Encequidar (previously referred to as HM-30181A) base, Encequidar ((HM-30181A) mesylate, co-crystals of Encequidar (HM-30181A) mesylate, processes for preparation thereof, as well as pharmaceutical compositions including the same.
Petar BibuliƧ, Dijana Skalec Samec, Marina Marinkovic, Jasna Dogan
Filed: 14 Feb 20
Utility
Crystalline Solid Forms of Baricitinib
5 May 22
The present disclosure relates to cocrystals/salts of baricitinib, processes for preparation thereof as well as a pharmaceutical composition comprising the same.
Ivana Landeka, Dijana Skalec Samec, Lorena Kordic
Filed: 5 Feb 20
Utility
Solid State Forms of Lumateperone Ditosylate Salt
28 Apr 22
Disclosed are solid state forms of lumateperone ditosylate, uses thereof, and pharmaceutical compositions thereof.
Ariel MITTELMAN, Ido FUCHS, Sharona SHACHANTOV, Doron RUDIK, Rotem SELLA-EREZ
Filed: 7 Jan 22
Utility
Treating Refractory Migraine
31 Mar 22
Disclosed herein are methods of treating or reducing incidence of migraine and/or at least one secondary symptom associated with refractory migraine in a subject having refractory migraine comprising administering to the subject a monoclonal antibody that modulates the CGRP pathway.
Marcelo Bigal, Ernesto Aycardi
Filed: 5 May 21
Utility
Pharmaceutical Composition for the Treatment of Parkinson's Disease
3 Mar 22
Disclosed is a pharmaceutical composition comprising i) a dopamine agonist and ii) a L-DOPA derivative in combination in form of a liquid preparation.
Rudolf-Giesbert Alken, Frank Schneider
Filed: 16 Jul 21
Utility
Antagonist Antibodies Directed Against Calcitonin Gene-Related Peptide and Methods Using Same
24 Feb 22
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody.
Joerg Zeller, Kristian T. Poulsen, Yasmina Noubia Abdiche, Jaume Pons, Sierra Jones Collier, Arnon Rosenthal
Filed: 16 Mar 21
Utility
Preventing, Treating, and Reducing (Persistent) Post-traumatic Headache
17 Feb 22
Disclosed herein are methods of treating or reducing incidence of post-traumatic headache and/or at least one secondary symptom associated with post-traumatic headache in a subject comprising administering to the subject a monoclonal antibody that modulates the CGRP pathway.
Marcelo Bigal
Filed: 5 Apr 21
Utility
Solid State Forms of Lumateperone Salts and Processes for Preparation of Lumateperone and Salts Thereof
27 Jan 22
Nikolina Janton, Helena Ceric, Sanja Matecic Musanic, Natasa Mrsic, Lidija Lerman, Tina D. Momcilovic, Ivana Sagud, Alexandr Jegorov
Filed: 27 Nov 19
Utility
Methods of Treating Inflammatory Pain
20 Jan 22
The invention relates to an anti-CGRP antibody for use in the prevention and/or treatment of inflammatory pain and/or symptoms of inflammatory pain, and to a method of treating and/or preventing inflammatory pain and/or symptoms of inflammatory pain using an anti-CGRP antibody.
Kristian Todd Poulsen, David Louis Shelton, Joerg Zeller, Ian Machin, Laura Corradini
Filed: 24 Feb 21
Utility
Solid State Forms of Reproxalap
13 Jan 22
The present disclosure relates to solid state forms of Reproxalap salts, processes for the preparation thereof, pharmaceutical formulations/compositions thereof, and methods of use thereof.
Anantha Rajmohan Muthusamy, Sundara Lakshmi Kanniah, Rahul Kumar Reddy Putikum, Sudhanshu Saxena, Amol Bandal
Filed: 12 Dec 19
Utility
Inhaler System
6 Jan 22
A system may include a plurality of inhalers, where each inhaler comprising medicament, a processor, memory, and a transmitter, multiple processing modules that may reside at least partially on a user device, a digital health platform (DHP) that is configured to receive and aggregate inhaler data from inhalers that are associated with a plurality of different users and a plurality of different medicament types.
Eric Chan, John Macey, Jon Cody Goldberg, Jenna-Leigh Meola
Filed: 2 Jul 21
Utility
Inhalation Monitoring System and Method
30 Dec 21
An inhalation monitoring system includes an inhaler having a medicament delivery apparatus configured to deliver medicament to a user during an inhalation of the user; inhalation monitoring apparatus, configured to, during the inhalation, gather data for determining a measure of the user's lung function and/or lung health; and a processor configured to receive the data from the inhalation monitoring apparatus and, using the data, determine a measure of the user's lung function and/or lung health.
Mark Milton-Edwards, Henry Chrystyn, Mark Steven Morrison, Douglas E. Weitzel
Filed: 8 Sep 21
Utility
Inhaler System
23 Dec 21
Provided is a system comprising an inhaler.
Amir Zur, Xinyu Liu, Mark Milton-Edwards
Filed: 19 Jun 20
Utility
Inhaler System
23 Dec 21
Provided is a system comprising a plurality of inhalers that each include a processor configured to determine a value of a usage parameter relating to use of the respective first inhaler, encrypt data based on the value, and transmit the encrypted data.
Xinyu Liu, Jenna-Leigh Meola, Cody Goldberg, Jinn Kim, Sunil Kumar Mishra, Vered Ben-Anat
Filed: 19 Jun 20
Utility
New Crystalline Polymorphs of Rigosertib Sodium
23 Dec 21
The present disclosure encompasses crystalline polymorphs of Rigosertib Sodium, processes for preparation thereof, and pharmaceutical compositions thereof.
Pavel Kolesa, Roman Gabriel, Alexandr Jegorov
Filed: 24 Oct 19
Utility
Blister Pack and Inhaler Comprising the Same
16 Dec 21
Provided is a blister pack for a dry powder inhaler, which dry powder inhaler is configured to deliver a first powder medicament and a second powder medicament different from the first powder medicament.
Peter John Crowley, Jan Geert Hazenberg, Daniel Buck, Christopher David Edlin, Hardik Kirtikumar Shah
Filed: 2 Jul 21
Utility
Solid State Forms of Voclosporin
16 Dec 21
Pavel Kolesa, Ladislav Cvak, Alexandr Jegorov, Katerina Ondruszova
Filed: 21 Oct 19
Utility
Solid State Forms of Daprodustat and Process for Preparation Thereof
16 Dec 21
Dijana S. Samec, Ivana Landeka, Valentina Travancic
Filed: 13 Nov 19
Utility
Solid State Forms of Pemafibrate
9 Dec 21
The present disclosure relates to solid state forms of Pemafibrate processes for preparation thereof and pharmaceutical compositions thereof.
Pavel Kolesa, Andrea Colombo, Ettore Marzorati
Filed: 21 Dec 18
Utility
Application of Raman Spectroscopy for the Manufacture of Inhalation Powders
2 Dec 21
The present invention generally relates to improved methods for the manufacture of inhalation powders.
Hardik Kirtikumar SHAH
Filed: 20 Jul 21