34 patents
Page 2 of 2
Utility
In situ detection of nucleotide variants in high noise samples, and compositions and methods related thereto
3 Aug 21
The invention relates to methods of in situ detection of a nucleic acid variation of a target nucleic acid in a sample, including single nucleotide variations, multi-nucleotide variations or splice sites.
Yuling Luo, Xingyong Wu, Liuliu Pan, Xiaoming Wang, Xiao-Jun Ma, Nan Su, Steve Chen
Filed: 11 Oct 16
Utility
Wnt/sFRP complexes, Wnt-containing compositions, Wnt-expressing cells, and methods of making, purifying, and using same
29 Jun 21
This disclosure describes isolated protein complexes including a Wnt and a sFRP; compositions including a Wnt; a cell overexpressing a Wnt and a sFRP; compositions including a cell overexpressing a Wnt and a cell overexpressing a sFRP; methods of making the protein complexes, compositions, and cells; and methods of using the isolated protein complexes, compositions, and cells.
Anthony Person, Liwen Xiong, Ming Bi, Camrin Tracy
Filed: 9 Oct 18
Utility
Hybridoma Clones, Monoclonal Antibodies to VSIG-4, and Methods of Making and Using
25 Mar 21
Described herein are monoclonal antibodies that bind to VSIG-4 including antibodies that block the binding of VSIG-4 to SIGLEC-7, compositions including the monoclonal antibodies, and methods of making and using those antibodies and compositions.
Birte Aggeler, Christine Goetz, Jody Bonnevier, Christopher Carlin Valley, Christopher Hammerbeck, Ernesto Ruben Resnik
Filed: 19 Aug 20
Utility
Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations
4 Feb 21
Methods of detecting multiple nucleic acid targets in single cells through indirect capture of labels to the nucleic acids are provided.
Yuling Luo, Shiping Chen, Huei-Yu Fay Wang, John James Flanagan
Filed: 18 Aug 20
Utility
Methods to Further Enhance Signal Amplification for the In Situ Detection of Nucleic Acids
4 Feb 21
The present invention relates to detection of nucleic acids and provides a composition comprising a Signal Generating Complex, wherein the composition comprises: (A) a pair of target probes (TPs), wherein a first TP of the pair of TPs comprises a nucleic acid sequence comprising two segments; (B) a pair of base PPAs comprising the first and second base PPAs, wherein the first base PPA comprises a nucleic acid sequence comprising three segments; (C) a set of extension PPAs comprising the first and second extension PPAs, wherein the first extension PPA comprises a nucleic acid sequence comprising two segments; (D) a plurality of pre-amplifiers (PAs), wherein the PAs comprise a nucleic acid sequence comprising three segments; (E) a plurality of amplifiers (AMPs), wherein the AMPs comprise a nucleic acid sequence comprising two segments; and (F) a plurality of label probes (LPs), wherein the LPs comprise a nucleic acid sequence comprising two segments.
Yuling LUO, Xiao-Jun MA, Steve CHEN, Nan SU, Emerald DOOLITTLE, Bingqing ZHANG, Xiaoming WANG, Xingyong WU, Xiao Yan PIMENTEL, Helen JARNAGIN
Filed: 8 Apr 19
Utility
Methods and kits for assaying endoglycosidase activity
12 Jan 21
A method for assaying endoglycosidase activity includes providing a proteoglycan having a glycosaminoglycan chain with a non-reducing end; treating the proteoglycan with a glycosyltransferase to incorporate a carbohydrate into the non-reducing end of the glycosaminoglycan chain, wherein the carbohydrate includes a click chemistry moiety; adding a label to the proteoglycan, wherein the label includes a click chemistry moiety that reacts to the click chemistry moiety of the carbohydrate such that the label attaches to the carbohydrate to form a labeled proteoglycan; immobilizing the labeled proteoglycan on a multi-well plate, wherein the multi-well plate includes a specific anti-proteoglycan antibody for binding the labeled proteoglycan; treating the labeled proteoglycan with an endoglycosidase specific to the glycosaminoglycan chain; and detecting the labeled proteoglycan.
Zhengliang L. Wu, Xinyi Huang, Cheryl M. Ethen
Filed: 5 Oct 17
Utility
Methods of Detecting Nucleic Acids In Individual Cells and of Identifying Rare Cells from Large Heterogeneous Cell Populations
30 Dec 20
Methods of detecting multiple nucleic acid targets in single cells through indirect capture of labels to the nucleic acids are provided.
Yuling Luo, Shiping Chen
Filed: 3 Sep 20
Utility
Methods of Detecting Nucleic Acid Sequences with High Specificity
23 Dec 20
The invention relates to methods of detecting nucleic acids, including methods of detecting one or more target nucleic acid sequences in multiplex branched-chain DNA assays, are provided.
Yuling LUO, John James FLANAGAN, Nan SU, Huei-Yu Fay WANG
Filed: 3 Jun 20
Utility
Compounds That Modulate the Interaction of Vista and VSIG3 and Methods of Making and Using
18 Nov 20
Described herein are polyclonal and monoclonal antibodies that binds to VSIG3, compounds that modulate the interaction of VISTA and VSIG3, and methods of making and using the polyclonal and monoclonal antibodies and compounds.
Christine Goetz, Christopher Hammerbeck, Christopher Valley, Jody Bonnevier, Birte Aggeler, Jinghua Wang, Guoping Wu, Vassilios Kalabokis, Jose Fernando Bazan
Filed: 31 Jan 19
Utility
Hybridoma clones, monoclonal antibodies to VSIG-4, and methods of making and using
24 Aug 20
Described herein are monoclonal antibodies that bind to VSIG-4 including antibodies that block the binding of VSIG-4 to SIGLEC-7, compositions including the monoclonal antibodies, and methods of making and using those antibodies and compositions.
Birte Aggeler, Christine Goetz, Jody Bonnevier, Christopher Carlin Valley, Chris Hammerbeck, Ernesto Ruben Resnik
Filed: 25 Jun 18
Utility
Dual chamber storage device
4 May 20
A dual chamber storage device includes a first chamber having a base and a hollow body for storing a first material.
Paul V. McGrath, Thomas M. Pizza, Jerry W. Westwood, Steven L. Hjelm, Keith M. Simeone
Filed: 11 Jun 18
Utility
Dual chamber storage device
4 May 20
A dual chamber storage device includes a first chamber having a base and a hollow body for storing a first material.
Paul V. McGrath, Thomas M. Pizza, Jerry W. Westwood, Steven L. Hjelm, Keith M. Simeone
Filed: 29 Jul 19
Utility
IL-37 Fusion Protein and Methods of Making and Using Same
19 Feb 20
The disclosure provides interleukin 37 (IL-37) fusion proteins, methods of making IL-37 fusion proteins including constructs used to express IL-37 fusion proteins, and methods of using IL-37 fusion proteins.
Vassilios Kalabokis, Charles A. Dinarello
Filed: 19 Mar 18
Utility
Dual Chamber Storage Device
20 Nov 19
A dual chamber storage device includes a first chamber having a base and a hollow body for storing a first material.
Paul V. McGrath, Thomas M. Pizza, Jerry W. Westwood, Steven L. Hjelm, Keith M. Simeone
Filed: 29 Jul 19