283 patents
Page 6 of 15
Utility
Stem cell derived islet differentiation
11 Oct 22
Provided herein are methods of producing β cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both.
Felicia J. Pagliuca, George Harb, Lillian Ye
Filed: 10 Sep 21
Utility
Processes for making modulators of cystic fibrosis transmembrane conductance regulator
11 Oct 22
Paul T. Angell, Cristian Harrison, Robert M. Hughes, Berenice Lewandowski, Benjamin J. Littler, Vito Melillo, William A. Nugent, David Andrew Siesel, David Smith, John Studley
Filed: 7 Dec 18
Utility
Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
6 Oct 22
This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.
Alexander Russell Abela, Corey Don Anderson, Brett C. Bookser, Brett B. Busch, Jeremy J. Clemens, Thomas Cleveland, Timothy Richard Coon, Bryan Frieman, Senait G. Ghirmai, Peter Grootenhuis, Anton V. Gulevich, Sara Sabina Hadida Ruah, Yoshihiro Ishihara, Haripada Khatuya, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Pierre, Andreas Termin, Sara E. Swift, Johnny Uy, Carl V. Vogel, Jinglan Zhou
Filed: 13 Aug 20
Utility
Materials and methods for treatment of pain related disorders
4 Oct 22
The present application provides materials and methods for treating a patient with one or more conditions associated with SCN9A whether ex vivo or in vivo.
Ante Sven Lundberg, Samarth Kulkarni, Lawrence Klein, Hari Kumar Padmanabhan
Filed: 6 Jul 17
Utility
Modulator of Cystic Fibrosis Transmembrane Conductance Regulator, Pharmaceutical Compositions, Methods of Treatment, and Process for Making the Modulator
29 Sep 22
Timothy Alcacio, Minson Baek, Peter Grootenhuis, Sara Sabina Hadida Ruah, Robert M. Hughes, Ali Keshavarz-Shokri, Rachel McAuley-Aoki, Jason McCartney, Mark Thomas Miller, Fredrick Van Goor, Beili Zhang, Corey Anderson, Thomas Cleveland, Bryan A. Frieman, Haripada Khatuya, Pramod Virupax Joshi, Paul John Krenitsky, Vito Melillo, Fabrice Jean Denis Pierre, Andreas P. Termin, Johnny Uy, Jinglan Zhou, Alexander Russell Abela, Brett Bradley Busch, Prasuna Paraselli
Filed: 20 Oct 21
Utility
Modulator of the cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
27 Sep 22
Alexander Russell Abela, Timothy Alcacio, Corey Anderson, Paul Timothy Angell, Minson Baek, Jeremy J. Clemens, Thomas Cleveland, Lori Ann Ferris, Peter Diederik Jan Grootenhuis, Raymond Stanley Gross, Anton V. Gulevich, Sara Sabina Hadida Ruah, Clara Kuang-Ju Hsia, Robert M. Hughes, Pramod Virupax Joshi, Ping Kang, Ali Keshavarz-Shokri, Haripada Khatuya, Paul John Krenitsky, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Jean Denis Pierre, Yi Shi, Muna Shrestha, David Andrew Siesel, Kathy Stavropoulos, Andreas P. Termin, Fredrick F. Van Goor, Johnny Uy, Timothy John Young, Jinglan Zhou
Filed: 17 Aug 20
Utility
Antiproliferation compounds and uses thereof
13 Sep 22
The present invention provides compounds of Formula I′, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).
Henry Yu, Michael Clark, Guy Bemis, Michael Boyd, Kishan Chandupatla, Philip Collier, Hongbo Deng, Huijun Dong, Warren Dorsch, Russell R. Hoover, Mac Arthur Johnson, Jr., Shashank Kukarni, Marina Penney, Steven Ronkin, Darin Takemoto, Qing Tang, Nathan D. Waal, Tiansheng Wang, David J. Lauffer, Pan Li
Filed: 27 Aug 20
Utility
Processes for preparing pyrrolidine compounds
6 Sep 22
Paul T. Angell, Robert M. Hughes, Berenice Lewandowski, Benjamin J. Littler, William A. Nugent, David Smith, John Studley
Filed: 2 Aug 18
Utility
Modulators of cystic fibrosis transmembrane conductance regulator
30 Aug 22
Mark Thomas Miller, Corey Anderson, Vijayalaksmi Arumugam, Brian Richard Bear, Hayley Marie Binch, Jeremy J. Clemens, Thomas Cleveland, Erica Conroy, Timothy Richard Coon, Bryan A. Frieman, Peter Diederik Jan Grootenhuis, Raymond Stanley Gross, Sara Sabina Hadida-Ruah, Haripada Khatuya, Pramod Virupax Joshi, Paul John Krenitsky, Chun-Chieh Lin, Gulin Erdogan Marelius, Vito Melillo, Jason McCartney, Georgia McGaughey Nicholls, Fabrice Jean Denis Pierre, Alina Silina, Andreas P. Termin, Johnny Uy, Jinglan Zhou
Filed: 31 Mar 20
Utility
Materials and methods for treatment of myotonic dystrophy type 1 (DM1) and other related disorders
30 Aug 22
The present application provides materials and methods for treating a patient with one or more conditions associated with DMPK whether ex vivo or in vivo.
Ante Sven Lundberg, Samarth Kulkarni, Lawrence Klein, Hari Kumar Padmanabhan
Filed: 27 Jun 17
Utility
Pharmaceutical Compositions for Treating Cystic Fibrosis
18 Aug 22
Cathy Chu, Varsha Dhamankar, Eleni Dokou, Eric L. Haseltine, Samuel Moskowitz, Sarah Robertson, David Waltz, Weichao George Chen
Filed: 15 Sep 21
Utility
Materials and Methods for Treatment of Hemoglobinopathies
18 Aug 22
Materials and methods for treating a patient with hemoglobinopathy, both ex vivo and in vivo and materials and methods for deleting at least a portion of a human beta globin locus on chromosome 11 in a human cell by genome editing and thereby increasing the production of fetal hemoglobin (HbF).
Tirtha Chakraborty, Bibhu Prasad Mishra
Filed: 26 Jan 22
Utility
Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
16 Aug 22
This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis by administering such modulators and pharmaceutical compositions, and processes for making such modulators.
Alexander Russell Abela, Jeremy J. Clemens, Peter Diederik Jan Grootenhuis, Sara Sabina Hadida Ruah, Yoshihiro Ishihara, Haripada Khatuya, Jason McCartney, Mark Thomas Miller, Fabrice Jean Denis Pierre, Joe Anh Tran, Jinglan Zhou
Filed: 12 Apr 19
Utility
Method for Treating Cancer Using a Combination of CHK1 and Atr Inhibitors
11 Aug 22
Thomas HELLEDAY, Kumar SANJIV
Filed: 20 Sep 21
Utility
Pharmaceutical Composition and Administrations Thereof
4 Aug 22
The present invention relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.
Eleni DOKOU, Shahla JAMZAD, John P. CAESAR, JR., Majed FAWAZ, Laura DAS, Chong-Hui GU, Patricia Nell HURTER, Meghna Jai ISRANI, Meghan M. JOHNSTON, Dragutin KNEZIC, Andrew G. KUZMISSION, HongRen WANG
Filed: 15 Sep 21
Utility
Compounds Useful As Inhibitors of Atr Kinase and Combination Therapies Thereof
28 Jul 22
John Robert POLLARD, Philip Michael Reaper, Mohammed Asmal
Filed: 3 Aug 21
Utility
Enhanced Differentiation of Beta Cells
28 Jul 22
Provided herein are methods of manufacturing β cells in vitro.
Bryce CAREY
Filed: 23 Dec 21
Utility
Pancreatic Differentiation
28 Jul 22
In some aspects, disclosed herein are methods and compositions for generating enterochromaffin cells.
George HARB, Lillian YE
Filed: 11 Feb 22
Utility
Compositions and Methods for Editing Beta-globin for Treatment of Hemaglobinopathies
21 Jul 22
The disclosure features systems and methods for correcting a mutation in the human beta-globin (HBB) gene in a cell or population of cells.
Sanjay D'SOUZA, Jason WEST, Brenda K. EUSTACE, Sudipta MAHAJAN
Filed: 17 Dec 21
Utility
Crystalline forms of C
19 Jul 22
Gary DeCrescenzo, Dean Welsch, Petinka I. Vlahova, Stephan X. M. Boerrigter, Alexander Aronov, Ali Keshavarz-Shokri, Alexander N. Scangas, Kathy Stavropoulos, Benjamin Littler, Irina Nikolaevna Kadiyala, Rossitza Gueorguieva Alargova
Filed: 7 Jul 20