179 patents
Page 7 of 9
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Systems and Methods for Assessing Colorectal Cancer Molecular Subtype and Risk of Recurrence and for Determining and Administering Treatment Protocols Based Thereon
18 Mar 21
Products, systems, and methods for classifying human colorectal cancer into a consensus molecular subtype (CMS) and for assessing risk of recurrence based on CMS scores and based on risk scores derived from abbreviated gene expression profiles, for determining suitable treatment protocols for human colorectal cancer patients based on the determined CMS classification and based on the determined risk of recurrence, and for administering the suitable treatment protocols.
Steven Buechler
Filed: 7 Mar 19
Utility
Covalent heterobivalent antibody inhibitors and ligands
16 Mar 21
The invention provides a strategy for site specific covalent modification of antibodies using a specialized targeting covalent heterobivalent ligand (cHBL), and corresponding design for a covalent heterobivalent inhibitor (cHBI) that can be used to prevent Immunoglobulin E (IgE) mediated allergic reactions triggered by drug molecules, according to one embodiment.
Zihni Basar Bilgicer, Peter Edward Deak, Tanyel Kiziltepe Bilgicer, Michael William Handlogten, Jonathan Darryl Ashley
Filed: 19 Dec 16
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Electricity generation from low grade waste heat
2 Mar 21
Systems and methods for generating electricity from low grade heat.
Tengfei Luo, Shirui Luo
Filed: 22 Mar 19
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Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection
16 Feb 21
Described herein are compounds and compositions, and methods of making and their use as effective agents against mycobacterial infections.
Marvin J. Miller, Garrett C. Moraski
Filed: 19 Sep 16
Utility
Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same
9 Feb 21
Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same.
Marvin J. Miller, Garrett C. Moraski, Lowell D. Markley, George E. Davis
Filed: 5 Feb 18
Utility
Closed bipolar electrode-enabled electrochromic detector for chemical sensing
2 Feb 21
The described BPE-enabled device includes two separated chambers which perform detection and reporting independently.
Paul W. Bohn, Wei Xu, Kaiyu Fu, Chaoxiong Ma
Filed: 11 Aug 17
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Optical-quality Surface That Imparts Spatial Control of Macrophage Fusion
28 Jan 21
Methods to form a surface coating and surface pattern, which are based on adsorption of hydrocarbon chains that can be used with imaging optics to visualize macrophage fusion and multinucleated giant cell formation with living specimens are described.
James Faust, Tatiana Ugarova, Robert Ros, Wayne Christenson, Kyle Doudrick
Filed: 5 Oct 20
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Deuterated Imidazopyridines
14 Jan 21
A series of imidazopyridine and pyrazolopyridine compounds is provided in which carbon hydrogen bonds have been replaced with isotopic carbon-deuterium bonds, syntheses thereof, compositions thereof, and methods of using such compounds and compositions.
Rui LIU, Marvin J. MILLER, Garrett C. MORASKI
Filed: 11 Mar 19
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Representation Learning for Wearable-sensor Time Series Data
14 Jan 21
Presented herein are embodiments for analysis of and representation learning for wearable sensor time series data.
Nitesh V. Chawla, Xian Wu
Filed: 10 Apr 20
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Catalysts and Methods for Producing Acetic Acid from Methane, Carbon Monoxide, and Oxygen
14 Jan 21
Catalysts for producing one or more oxygenated products from methane are provided.
Franklin Tao, Weixin Huang, Yu Tang, Yuting Li
Filed: 26 Mar 19
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Additive manufacturing device for biomaterials
12 Jan 21
An additive manufacturing (AM) device for biomaterials comprises a reservoir, a shaft, and a material delivery head.
David J. Hoelzle
Filed: 11 May 17
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Ionic liquids comprising heteraromatic anions
12 Jan 21
Some embodiments described herein relate to ionic liquids comprising an anion of a heteraromatic compound such as optionally substituted pyrrolide, optionally substituted pyrazolide, optionally substituted indolide, optionally substituted phospholide, or optionally substituted imidazolide.
William F. Schneider, Joan F. Brennecke, Edward J. Maginn, Elaine Vazquez, Burcu Gurkan, Erica Price, Brett Goodrich
Filed: 4 Sep 18
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Exosomal biomarkers diagnostic of tuberculosis
12 Jan 21
A method for diagnosing an active Mycobacterium tuberculosis infection by detecting certain RNA biomarkers present in secreted extracellular vesicles isolated from a bodily fluid.
Jeffrey S. Schorey, Prachi Pratap Singh, Yong Cheng
Filed: 21 Nov 19
Utility
Assessing Colorectal Cancer Molecular Subtype and Uses Thereof
30 Dec 20
Disclosed are genetic methods and tools for colon cancer disease classification in disease subtypes, CMS1, CMS2, CMS3, CMS4, as well as improved methods for rapid, more accurate, and more reliably reproducible disease subtype determination.
Steven Buechler
Filed: 7 Sep 20
Utility
Nanoallergens and uses thereof
28 Dec 20
Embodiments of the present disclosure provide a nanoparticle based platform, and nanoallergens for identifying, evaluating and studying allergen mimotopes as multiple copies of a single mimotope or various combinations on the same particle.
Zihni Basar Bilgicer, Peter Edward Deak, Tanyel Kiziltepe Bilgicer, Jared Francis Stefanick, Jonathan Darryl Ashley
Filed: 25 Sep 16
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Systems and Method for Electrophoretic Fractionation of the Microbiome
9 Dec 20
A system and methods of characterizing a population of a virus, bacteriophage, or other microbes in a microbiome that includes the steps of separating a sample of microbiota into more than one fraction by continuous capillary zone electrophoresis based on the physiochemical properties of the microbes in the microbiota using a constant voltage applied to the sample during the continuous zone electrophoresis.
Norman DOVICHI, Bonnie JASKOWSKI HUGE, Matthew CHAMPION
Filed: 5 Aug 20
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Methods and Apparatus for Determining Electromagnetic Exposure Compliance of Multi-antenna Devices
25 Nov 20
A method of determining electromagnetic exposure values for radiative compliance tests a transmitting device with multiple transmitters or antenna.
Bertrand Hochwald, Arash Ebadi Shahrivar
Filed: 10 Jan 19
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Mitigating beam squint in millimeter wave wireless communication systems
26 Oct 20
A method for managing beam squint in a phased antenna array system operating at millimeter wavelengths using carrier aggregation includes determining a minimum array gain threshold, determining an upper bound for a fractional bandwidth for a fixed number of antennas, and constructing a codebook with a predetermined coverage range based on at least one of an angle of arrival or an angle of departure and further based on the upper bound.
Mingming Cai, J. Nicholas Laneman, Bertrand Hochwald
Filed: 3 Dec 18
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Antibacterial Monobactams
21 Oct 20
Bromine induced lactamization of vinyl acetohydroxamates facilitated syntheses of monocyclic β-lactams suitable for incorporation of a thiomethyl and extended functionality at the C(4) position.
Marvin J. MILLER, Serena CAROSSO, Rui LIU, Patricia MILLER
Filed: 1 Oct 18
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Super-resolution Fluorescence Microscopy by Stepwise Optical Saturation
21 Oct 20
A microscopy method and system includes obtaining a plurality of raw fluorescence images, respective ones of the plurality of raw fluorescence images obtained by exciting a sample using a light source at a respective irradiance value in a weak saturation region of the sample, and capturing the respective raw fluorescence image; applying a plurality of weights to the plurality of raw fluorescence images in a one-to-one correspondence so as to generate a plurality of weighted fluorescence images, wherein a respective weight is based on the respective irradiance value at which the corresponding raw fluorescence image was obtained; and linearly combining the plurality of weighted fluorescence images, thereby generating the output image having a resolution greater than a diffraction limit.
Scott S. HOWARD, Yide ZHANG, Cody J. SMITH
Filed: 27 Dec 18