463 patents
Utility
Therapeutic DNP Derivatives and Methods Using Same
18 Jan 24
The present invention includes DNP derivatives that are useful for preventing or treating a metabolic disease or disorder in a subject in need thereof.
Gerald I. Shulman, David A. Spiegel
Filed: 11 Jan 23
Utility
a Gene Associated with Human Reading Performance
18 Jan 24
Disclosed herein are kits and methods for assessing the risk of poor reading performance in an individual by detecting and identifying single nucleotide polymorphisms in chromosome 19, e.g. in the KIAA0355 (GARRE1) gene.
Jeffrey R. Gruen, Andrew Adams, Dongnhu Truong, Jan Frijters, Joan Bosson-Heenan
Filed: 8 Oct 20
Utility
Compositions and Methods for Inhibiting Group II Intron Rna
18 Jan 24
The present invention provides compositions and methods for inhibiting group II intron splicing for treating or preventing a disease or disorder associated with an organism harboring an active group II intron.
Anna Marie Pyle, Olga Fedorova, Erik Jagdmann, Michael Van Zandt, Lin Yuan, Albert DeBerardinis
Filed: 28 Aug 23
Utility
Method of Manipulating Pluripotency In Cells
18 Jan 24
Described herein is a method of maintaining pluripotency in a cell.
Valentyna Kostiuk, Mustafa Khokha
Filed: 12 Jul 23
Utility
N-Linked Glycosylation Inhibitors and Methods of Using Same
11 Jan 24
The present disclosure includes compounds, compositions, and methods for preventing, ameliorating, and/or treating diseases associated with N-linked glycosylation and/or oligosaccharyltransferase function in a subject in need thereof.
Joseph N. Contessa, Michael Van Zandt
Filed: 31 Aug 21
Utility
Compositions and Methods for Treating, Ameliorating, And/or Preventing Diseases or Disorders Caused by or Associated with DNASE1 And/or DNASE1L3 Deficiency
28 Dec 23
The present disclosure includes novel DNAse1 and/or DNAse1L3 constructs with improved in vivo half-lives, enzymatic stability, and/or developability properties.
Paul Stabach, Demetrios Braddock
Filed: 18 Jul 23
Utility
Nanobody Compositions and Methods of Use of the Same
28 Dec 23
The invention provides methods for identifying nanobodies that bind with high affinity to secreted proteins or extracellular proteins, as well and compositions comprising the identified nanobodies and methods of use thereof.
Aaron Ring, Feimei Liu
Filed: 20 Aug 21
Utility
Binding Proteins 1
21 Dec 23
The present disclosure relates to cell penetrating anti-DNA binding proteins.
James CAMPBELL, Valentina DUBLJEVIC, James HANSEN, Zahra RATTRAY, Jiangbing ZHOU
Filed: 3 Feb 23
Utility
Targeting Host-bacteria Interactions for the Treatment of Microbiota-mediated Diseases
21 Dec 23
The present invention generally relates to compositions and methods for modulating specific paired host protein-microbiota interactions and the use thereof for the prevention and treatment of diseases and disorders.
Connor Rosen, Noah Palm, Aaron Ring
Filed: 17 Nov 21
Utility
Patient-controlled Liquid Oral Medicine Dispenser and Deactivation System
14 Dec 23
Provided herein are patient-controlled oral liquid-medicine dispenser and deactivation systems.
Daniel Wiznia, Jinlei Li, Claudia See
Filed: 2 Jun 23
Utility
Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same
14 Dec 23
The present disclosure provides inhibitors of MIF tautomerase activity.
William L. Jorgensen
Filed: 26 Oct 21
Utility
Wearable Air Pollutant Monitoring Device
7 Dec 23
Wearable pollutant monitoring devices, associated methods of manufacture, and methods for pollution analysis are described herein.
Krystal Pollitt, Elizabeth Lin, Jeremy Koelmel
Filed: 3 Sep 21
Utility
Rapidly synthesized extracellular matrix-based gels and patterning techniques, from micro- to macro-scale
30 Nov 23
In some aspects, the present invention provides a method of forming crowded collagen based constructs, having the steps of providing a collagen solution in a buffer, providing a macromolecular bath solution, and delivering the collagen solution into the macromolecular bath solution to form crowded collagen constructs.
Michael Mak, Xiangyu Gong
Filed: 15 May 23
Utility
Compounds and Methods for Treating or Preventing Anterior Segment Ocular Disorders and/or Retinal Degenerations
30 Nov 23
The invention provides a method of treating retinal degenerations, such as but not limited to anterior segment ocular disorders and/or age-related macular degeneration (AMD), in a subject, the method comprising administering to the subject a pharmaceutical composition comprising an effective amount of a compound of formula (1) or formula (2).
Mark Fields, Lucian Del Priore, Huey Cai, Denton Hoyer
Filed: 12 Jun 23
Utility
Compositions and Methods of Treating or Preventing Fibrotic Lung Diseases
23 Nov 23
The invention includes a method of preventing or treating a fibrotic lung disease in a subject, comprising administering to the subject a thyroid receptor β-agonist.
Naftali Kaminski, Guoying Yu, Argyrios Tzouvelekis
Filed: 14 Apr 23
Utility
All-optical Visualization of Specific Molecules In the Ultrastructural Context of Brain Tissue
16 Nov 23
One aspect of the invention provides a method for preparing a biological sample.
Ons M'Saad, Joerg Bewersdorf
Filed: 4 Apr 23
Utility
Methods of Treating or Preventing Acute Respiratory Distress Syndrome
16 Nov 23
The invention includes a method of preventing or treating acute respiratory distress syndrome (ARDS) in a subject, comprising administering to the subject a thyroid hormone and/or a thyroid receptor β-agonist.
Naftali Kaminski, Patty Lee, Guoying Yu, Yi Zhang
Filed: 13 Jan 23
Utility
Compounds and Compositions for Disrupting Programmed Ribosomal Frameshifting
16 Nov 23
In one aspect, the present disclosure relates to a pyrrolidine substituted quinolone compound.
Junjie Guo, Yu Sun
Filed: 23 Aug 21
Utility
Selective Agonists of 5-HT2A Receptor and Methods of Use
16 Nov 23
In one aspect, the present disclosure describes tetrahydropyridine compounds of formula (I), which are 5-HT2A receptor agonists that exhibit selective binding to the 5-HT2A receptor over the 5-HT2B receptor.
Jonathan Ellman, Danielle Confair, Oh Sang Kweon, Bryan Roth, Kuglae Kim, Brian Shoichet, Anat Levit, John Irwin
Filed: 27 Sep 21
Utility
INTERLEUKIN-18 Variants and Methods of Use
9 Nov 23
The present invention provides compositions and methods comprising an activator of IL-18 activity for use in therapeutic and non-therapeutic applications.
Aaron Ring, Ting Zhou, Suzanne Fischer
Filed: 8 Mar 23