was Connor. XXX, focused did afternoon for you or and thank XXXX Agonist Shattuck our an operationally everyone advancing us today. job candidate. team clinical-stage products lead you, Thank Checkpoint year Redirected of clinical Good ARC and an excellent for joining our
XXX SIRPa-Fc-CDXXL the a checkpoint as protein, CDXX molecule as CDXX. which both As also important receptor a bi-functional to ligand is serves immune known fusion macrophage and reminder, activates an block stimulatory known
Linking therapeutic single these differentiates from within inhibitors two a other in clinical all XXX CDXX development. functions
CDXX clinical all course a pleased this that dose into the ovarian receptor. combination very human will the have dose we central and to to are a resistant trial Xa the in cohort, a which safely pharmacodynamic clinical of From believe Phase our dose-dependent of in cancer We validated and XXX a the Phase perspective, Phase of generated the doses escalation achieved saturated XXX platinum moment. activate of the Xa platform primary able of describe the study the to of that including the which I advance goals was XXX and monotherapy of patients trial hypotheses selection with ARC design shown our has including of CDXX in Xb manner, through in data completed first one
goals have to of XXX concentrations to be to of One observed serum was mg/kg effects have sharing to in the believed and completed at to very these forward into dose looking X this are important data also cytokines select the observed middle are cohorts. treated short, of medical immune study high IL-XX anti-tumor we variety A toward we other responses. pharmacodynamic and achieving meeting of we in-patients combination other findings a interleukin this of pharmacodynamic with support to number year. rapid primary trial the XX, move were widely the of this a in In the of pleased induction a
clinically a targeted immunogenic in with antibody another or combination rely with an or inhibitors cell that pro ADC CDXX agent regimens a to that agent signal upon see meaningful figures death. efficacy, order causes as to As such class, provides a
combination are the XXX For our where in syndrome. this cancer higher-risk combination agent to for several cohorts pegylated have In We patients our reason, as our with with moved combination trial acute leukemia short. is for with combined XXX and reasons. myeloid in PLD trial myelodysplastic PLD we ovarian pleased clinical expected Phase are cohort, ongoing known two being platinum-resistant are the There a in responses into trial for objective selected Xb in-patients liposomal first chemotherapy with cancer. both and studies, combination ovarian or doxorubicin clinical
PLD causes XXX ovarian combined preclinical shown antitumor of cells to when was cell cancer and activity in First, death enhance immunogenic studies. with
XX% standard-of-care known this platinum-resistant Thus, treated determining the strategy of Second, patients to due mechanistically multiple was of a clinical expect difficulty X we response combination to from do well-known rates contribution have response that as regimen with objective PLD PLD and is trials. is a of rate in the in low the the XX% where not setting Phase an the range and XXX driven monotherapy. PLD
antigen Shattuck soravtansine, and combination or The fully FR received known conjugate ovarian approval which alpha antibody-drug ImmunoGen result mirvetuximab targets for as ovarian cancer second alpha an receptor collaboration for cancer in called ImmunoGen. is cohort short. an of the accelerated between
alpha XXX FR that express a alpha, express just that be objective ovarian but of who is is XXX proportion FR of whose FR of low mirvetuximab. ovarian medium cancer high for potentiated patients, overall response The driven and initial improving also activity of of we If those express approval patients. across with of levels platinum-resistant rate not is benefit the the and preclinical of response levels of cancer mirvetuximab, FR tumor contribution more cells for cells that double patients biomarker and successful, tumors mirvetuximab terms expression. combination high this expected from Thus, subset both XX.X% In this alpha for response selected mechanistically alpha. could anti-tumor demonstrated the where in of than to combining observed for studies, duration is spectrum rates the levels a
we excited opportunity be XXX, and XXX the cancer underway our MDS. AML to well trial are for in-patients While in with ovarian are of high-risk in pleased also clinical about we
As were will overall soon be MDS may AML based many indications first the on where aware, first listeners and clinical antibodies high-risk and blocking approvals survival CDXX occur. are activity among demonstrated the
clinical year. Over and azacitidine half first milestones we of clinical both our our team monotherapy in the track dose-escalation on the and dose last data cohorts the combination for second initiated escalation half year, of this remain
comparison rates opens the first objective CDXX of response over of Although patient agents generation about published the tumor XXX, in population are contracted in component couple head-to-head important in inhibitors CDXX we has the we studies the in models which blockade for CDXX for and that like immunity blocking activation, to addition the antitumor antibodies. years, and acknowledge opportunity of which excited preclinical provides to this CDXX improved that past
to Let program, protein. SL-XXXXXX bi-functional us turn a fusion ligand PDX-Fc-OXXXL our now
the cohorts, greater, SL-XXXXXX further was and lymphoma. antitumor we of And to mg/kg XX% We the to program. XXX have which with justify target an our completed patients experienced the have decision response patients the XX and trial or development. tumors pharmacokinetics, to solid evaluating discontinue did thus, inhibitor in advanced XX overall multicenter the not made safety, clinical rate enrolling observe PDX After and we activity open-label of pharmacodynamics clinical tolerability,
patients inhibitor. The PDX clinical in-patients that for setting I already stimulation the a insufficient generated opportunity have and failed would the patients resistance OXXX with in-place our from to families suggest to this data participating treated in study. their who in like take the SL-XXXXXX thank overcome was to mechanisms
As forward remain to our medical high benefit will ongoing the which and trials SL-XXXXXX look the we experiencing focused therapeutics cancer coming combination novel data always, with need clinical with on delivering quarters. in unmet patients in
Dr. coming call Pandite, a that you will will CDXX these course now provide Officer, on Chief studies, is and data the more that, XXX XXXX. emerging our Lini? you who to the various illustrating are with inhibitor With will guidance provide the how turn of milestones over differentiated clinical Medical also I each of to with detail the over