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PLD with Phase AML patients Taylor I the will some trial a/b in color abstract As last in week's first provide MDS. on cancer. with combination ovarian from combination our XXX patients and our an investigating then update and I data in Phase higher-risk investigating ASH trial provide outlined, platinum-resistant Ib with in azacitidine from XXX in with
in Phase combination XXX cancer. platinum-resistant Ib with ongoing our with trial clinical start ovarian Let's of patients
into cutoff As patients data with study. XX, been cancer platinum-resistant date this of of have the October XX XXXX, ovarian enrolled
profile, with the the X.X lines prior of PLD an profile of of median which systemic acceptable plus consistent a XXX individual agents. have patients was therapy. safety These safety had
For adverse event was XXX, common the most grade reaction, mostly X X. drug-related infusion-related or
for October partial response XXXX, responses, X patients XX efficacy. of the and partial evaluable X responses. were XX, of data unconfirmed confirmed X partial observed cutoff As We date
November date of response reached XXXX, and both have confirmatory not stable disease response partial assessment. X of of best had the are study with X, patients on a unconfirmed responses patients patients still As Four and progressive disease. had
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response JAVELIN monotherapy with the overall for treated rate the In patients PLD trial, was X%.
X date, in patients with cm of Additionally, proportion A disease higher which in poor prognostic are enrolled bulky diameter bevacizumab, trials have factors. pretreatment and to both measuring of over our
and the to We expect additional data quarter midyear this response cohort expansion response end durability from and provide XXXX. of by full the cohorts
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XXXX. expect combination are in dosing cancer. data also XXX enrollment Enrollment from trial Phase soravtansine, midyear report in initial platinum-resistant quickly, continuing progressing mirvetuximab We our and combination we to in Ib are of with this ovarian trial
activity are I AML with of monotherapy pharmacokinetics I our trial MDS. standard current -- the and clinical have made antitumor pharmacodynamic us Phase both to XXX a/b progress evaluating of trial, in in safety high-risk azacitidine care. In Let as the tolerability in and now we effects and we turn this combination
therapy. azacitidine. of cutoff combination XX As as with are XXXX. XX cohort described XX, There adult data May relapsed/refractory monotherapy in primarily X date our in in of XXX and abstract have received of or patients the or a combination as with of had the patients AML These in ASH patients median high-risk cohort lines XX MDS prior the monotherapy patients
In safety profile in this a acceptable combination. trial, XXX monotherapy had as and an
X. a the state a For XXX, drug-related targeted subsequently relapsed/refractory reported mostly a allogeneic Monotherapy and patient TPXX by CDXX common reaction, response grade infusion-related heavily remains event were responses in relapsed/refractory and not to with we was to was a patient. XXX taken agents pretreated adverse mutant pretreated free. been monotherapy AML patients. particularly encouraged or This have AML achieved most in Consequently, leukemia-free heavily X morphologic leukemia response monotherapy, had transplant rapid
activity observed Additionally, the reduction. in patients, we form in of antileukemic blast count other also
patients in the included several We mutant dose untreated enrolled previously are trial. abstract. TPXX MDS the escalation in portion high-risk also ASH data of These our
high-risk disease, had whom marrow-complete and study high-risk on As has with combination MDS. data complete XXXX, a July mutant best bone of marrow patient cutoff X, observed azacitidine We in treatment-related mutan in of stable a to response TPXX evaluable in of to X patient who response taken the was was X transplant. remains date X in who transplant. Two previously patients MDS taken risk X response antitumor TPXX untreated observed of patients with X activity
mechanism Overall, of action growing its patients unmet encouraged data body of XXX higher-risk the the of unique of and MDS. to and with we needs therapeutic address are by AML potential validates that the
and Our both data driven marrow. evidence blood to continue bone CDXX peripheral show pharmacodynamic in of activity,
both ASH durability company-sponsored and the system next terms may improved CDXX and the is the indications in during refractory rate data of dose frontline and We believe event immune involvement sharing and important of blockade to of response activation ASH CDXX complete at adaptive to of the relapsed forward We that of meeting the month. the in resulting look the cohort from response. time [indiscernible] patients data around portion provide the presenting improvement a of escalation trial initial expansion significant
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