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New words:
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Removed:
abnormal, accrue, accumulate, andersen, apprise, approve, arthur, assist, assuming, auditing, automatic, automating, Balanced, barium, begin, Budget, called, centered, chain, chromosome, classify, closing, commence, consummation, contrast, conversion, converted, deadly, decline, deducting, deleted, demonstrate, depicting, detailed, diagram, double, ease, enema, Eric, fashion, Fearon, final, focusing, genome, Genzyme, HHS, hire, hired, house, imaging, importantly, inactivation, incorporation, indirect, individually, kit, lack, legally, lengthy, lifesaving, mandated, mismatch, nominal, notification, partnership, pathologic, PCR, perception, periodic, petitioned, PMA, polymerase, produce, qualify, radiographic, reaction, reagent, reimburse, reimbursing, repair, replication, representing, Roche, SAB, satisfaction, Secretary, simplify, simplifying, spring, Subcommittee, submission, submit, subsequent, surface, testified, theApc, treated, uncommon, virtually, vitro, whichever, widespread
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EXHIBIT 12.1
COMPUTATION OF RATIOS OF EARNINGS TO FIXED CHARGES AND EARNINGS TO
COMBINED FIXED CHARGES AND PREFERRED STOCK DIVIDENDS
(IN THOUSANDS, EXCEPT RATIO DATA)
| | Fiscal Year Ended December 31, | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| | 2004 | 2003 | 2002 | 2001 | 2000 | |||||||||||
| Loss before benefit for taxes on loss | $ | (18,523 | ) | $ | (28,340 | ) | $ | (29,883 | ) | $ | (23,485 | ) | $ | (11,883 | ) | |
| Add: fixed charges | 290 | 174 | 70 | 60 | 43 | |||||||||||
| Income before taxes and fixed charges | (18,233 | ) | (28,166 | ) | (29,813 | ) | (23,425 | ) | (11,840 | ) | ||||||
| Fixed charges: | ||||||||||||||||
| Estimated interest component of rental expense | 290 | 174 | 70 | 60 | 43 | |||||||||||
| Ratio of earnings before taxes and fixed charges to fixed charges | (1 | ) | (1 | ) | (1 | ) | (1 | ) | (1 | ),(2) | ||||||
- (1)
- During each of these periods, our earnings were less than our fixed charges. The amount of such deficiency was approximately $18.5 million, $28.3 million, $29.9 million, $23.5 million and $11.9 million for fiscal years 2004, 2003, 2002, 2001 and 2000, respectively.
- (2)
- During each of this period, our earnings were less than our combined fixed charges and preferred dividends. The amount of such deficiency was approximately $11.9 million for fiscal year 2000, as dividends were at the discretion of the board of directors, none of which were declared.