Nyxoah 6K Current report | NYXH 15 May 23

Exhibit 99.5

NAME: Legal form: Address: N°. Postal code: Town: Country: Register of legal persons - commercial court: Website : Company registration number 0817.149.675 DATE 10/10/2022 of filing the most recent document mentioning the date of publication of the deed of incorporation and of the deed of amendment of the articles of association. approved by the general meeting of 14/06/2023 regarding the period from 01/01/2022 to 31/12/2022 Preceding period from 01/01/2021 to 31/12/2021 The amounts for the preceding period are not NAT. Filing date N°. P. U. D. C-c 1 40 1 EUR ANNUAL ACCOUNTS AND OTHER DOCUMENTS TO BE FILED IN ACCORDANCE WITH THE BELGIAN COMPANIES AND ASSOCIATIONS CODE 0817.149.675 NV Belgium NYXOAH Rue Edouard Belin 1435 Mont-Saint-Guibert 12 are / Brabant Wallon identical to the ones previously published. IDENTIFICATION DETAILS (at the filing date) 1 2 3 ANNUAL ACCOUNTS IN EURO (2 decimals) Total number of pages filed: Numbers of the sections of the standard model form not filed because they serve no useful purpose: Signature (name and position) Signature (name and position) 47 6.2.2, 6.2.3, 6.2.4, 6.2.5, 6.3.1, 6.3.4, 6.4.2, 6.5.2, 6.8, 6.17, 6.20, 7, 8, 9, 11, 12, 13, 14, 15 Olivier Taelman Managing Director Optional mention. If necessary, change to currency in which the amounts are expressed. 1/47 1 2 3 Strike out what does not apply.

COMPLETE LIST with surname, first names, profession, place of residence (address, number, postal code and town) and position within the company LIST OF DIRECTORS, BUSINESS MANAGERS AND AUDITORS AND DECLARATION REGARDING A COMPLIMENTARY REVIEW OR CORRECTION ASSIGNMENT LIST OF DIRECTORS, BUSINESS MANAGERS AND AUDITORS N°. 0817.149.675 NYXOAH C-c 2.1 Taub Robert Title : Delegated director Mandate : 21/09/2020- 01/04/2025 Kleomenous 12, box TK, 10675 Athenes - Kolonaki, Greece Hambrecht Jürgen Title : Director Mandate : 21/09/2020- 01/04/2025 Römerweg 36, 6734 Neustadt, Germany Rakin Kevin Title : Director Mandate : 21/09/2020- 01/04/2025 Side Hill Road 14, CT06880 Westport, United States of America Ernst & Young Réviseurs d'Entreprises CALL 0446.334.711 Title : Auditor, Lidmaatschapsnummer : B00160 Mandate : 08/06/2022- 11/06/2025 De Kleetlaan 2, 1831 Diegem, Belgium Vertegenwoordigd door : D'Addario Carlo- Sébastien Company auditor, Lidmaatschapsnummer : A02506 De Kleetlaan 2 , 1831 Diegem, Belgium 1. Deyo Don Title : Director Mandate : 21/09/2020- 08/06/2022 Woodland Drive 598, MN55115 Mahomedi, United States of America Janssen Jan Title : Director Mandate : 21/09/2020- 08/06/2022 Killaeton Street 206, Saint I Nouvelles-Galles du Sud, Australia Gianello Pierre Title : Director Mandate : 21/09/2020- 01/04/2025 Avenue de la Rochefoucauld 9, 1330 Rixensart, Belgium JOHNSON-MILS Rita Title : Director Mandate : 27/08/2021- 01/04/2025 Governors Way 235, TN 3702 Brentwood, United States of America 2/47

Nr. C-c 2.1 LIST OF DIRECTORS, BUSINESS MANAGERS AND AUDITORS (continued from previous page) 0817.149.675 NYXOAH Taelman Olivier Title : Director Mandate : 21/09/2020- 01/04/2025 Stokstraat 43, 3800 Zepperen, Belgium Kirby Virginia M. Title : Director Mandate : 08/06/2022- 01/04/2025 West Bald Eagle Blvd 5636, 55110 White Bear Lake, United States of America Cohen Raymond W. Title : Director Mandate : 08/06/2022- 18/10/2022 Dean Martin Dr 4471, 89103 Las Vegas, United States of America 3/47

N°. 0817.149.675 C-c 2.2 DECLARATION REGARDING A COMPLIMENTARY REVIEW OR CORRECTION ASSIGNMENT NYXOAH The managing board declares that not a single audit or correction assignment has been given to a person not authorized to do so by law, pursuant to articles 34 and 37 of the law of 22 April 1999 concerning accounting and tax professions. If affirmative, should be mentioned hereafter: surname, first names, profession and address of each external accountant or company auditor and their membership number at their Institute, as well as the nature of their assignment: A. Bookkeeping of the company **, B. Preparing the annual accounts **, C. Auditing the annual accounts and/or D. Correcting the annual accounts. The annual accounts were / were not * or corrected by an external accountant or by a company auditor who is not the statutory If the tasks mentioned under A or B are executed by certified accountants or certified bookkeepers - tax experts, the following information can be mentioned hereafter: surname, first names, profession and address of each certified accountant or certified bookkeeper-tax expert and their membership number at the Institute of Accounting professionals and Tax Experts, as well as the nature of their assignment. auditor. Membership number Nature of the assignment (A, B, C and/or D) Surname, first names, profession and address Accountants & Tax Advisors BV 0472.250.042 50.037.549 B Title : External accountant Bosdellestraat 120 , box 14, 1933 Sterrebeek, Belgium Represented by : HEIRMAN Joël CPA Stenedorpstraat 15 , 8400 Oostende, Belgium 1. 10.628.469 * Strike out what does not apply. ** Optional mention. 4/47

N°. 0817.149.675 NYXOAH C-c 3.1 BALANCE SHEET AFTER APPROPRIATION Codes Period Preceding period ASSETS Tangible fixed assets FIXED ASSETS Intangible fixed assets FORMATION EXPENSES Land and buildings ...................................................... Plant, machinery and equipment ................................. Furniture and vehicles ................................................. Leasing and other similar rights .................................. Other tangible fixed assets ......................................... Assets under construction and advance payments .... Financial fixed assets 6.3 6.2 6.4 / 6.5.1 ................................................................... ..... .................................................. ...................... ...................................................... ....................................................... ...................................................... ............... 37.729.099,03 1.655.931,92 661.942,71 181.810,85 94.484,13 39.407.922,03 8.896.154,03 717.694,23 22.891,08 24.642.949,61 11.709.906,15 23.085.978,76 1.532.807,41 609.315,94 100.288,24 131.725,24 691.477,99 24.163,44 21/28 20 21 22/27 22 23 24 25 26 28 27 Notes ANNUAL ACCOUNTS 6.1 Affiliated Companies ................................................... Participating interests ........................................... Amounts receivable .............................................. Other companies linked by participating interests ....... Participating interests ........................................... Amounts receivable .............................................. Other financial fixed assets ......................................... Shares .................................................................. Amounts receivable and cash guarantees ............ 6.15 6.15 64,48 64,48 22.826,60 22.826,60 64,48 64,48 24.098,96 24.098,96 280/1 280 281 282/3 282 283 284/8 284 285/8 5/47

N°. 0817.149.675 NYXOAH C-c 3.1 Codes Period Preceding period CURRENT ASSETS Amounts receivable after more than one year Trade debtors ................................................................ Other amounts receivable ............................................. Stocks and contracts in progress Stocks ........................................................................... Raw materials and consumables ............................ Work in progress .................................................... Finished goods ....................................................... Goods purchased for resale ................................... Immovable property intended for sale .................... Advance payments ................................................. Contracts in progress ................................................... Amounts receivable within one year Trade debtors ................................................................ Other amounts receivable ............................................. Current investments Own shares ................................................................... Other investments ......................................................... Cash at bank and in hand Accruals and deferred income TOTAL ASSETS 6.5.1 / 6.6 6.6 .............................................................. ....... .................. .................. .................. ................. ..................................... ................................ ................................. ................................. .... ........................................................... .......... ................................................... .................. ........................................... .......................... ............................................................... ...... 93.898.353,40 881.980,97 881.980,97 498.585,30 99.541,00 283.854,67 2.539.182,76 1.575.658,95 963.523,81 76.968.116,35 76.968.116,35 12.250.184,30 1.258.889,02 142.202.429,46 133.871.124,53 345.998,00 345.998,00 83.440,00 262.558,00 632.770,46 228.045,25 404.725,21 131.247.463,30 1.644.892,77 170.223.980,29 29/58 29 290 291 3 30/36 30/31 32 33 34 35 36 37 40/41 40 41 50/53 50 51/53 54/58 490/1 20/58 Notes 6/47

N°. 0817.149.675 NYXOAH C-c 3.2 Codes Period Preceding period EQUITY AND LIABILITIES Reserves EQUITY Contributions Issued capital ........................................................ Uncalled capital .................................................. Legal reserve ........................................................ Financial support .................................................. Other .................................................................... Accumulated profits (losses) Deferred taxes ............................................................................. .................................................................... ............................ ............................................................................ ................... .................................(+)/(-) ................................................................... .. Untaxed reserves ........................................................ Available reserves ...................................................... Capital subsidies Advance to shareholders on the distribution of net assets ............................................................. ........... ............................................................................... ......... PROVISIONS AND DEFERRED TAXES ........................... ............................ ............................ .............. Provisions for liabilities and charges .............................. ............................... ............................... ..... 246.880.353,84 4.440.069,16 -112.185.344,99 10/15 10/11 100 101 12 13 130 1319 1313 132 14 15 19 16 160/5 Revaluation surpluses ..................................................... .................. 133 168 59.017,45 59.017,45 164.065.475,12 246.625.001,37 4.427.369,69 -82.559.526,25 11.646,57 11.646,57 134.695.008,85 Notes Pensions and similar obligations .................................. 160 Taxes ........................................................................... 161 Major repairs and maintenance ................................... 162 Environmental obligations ........................................... 163 Other liabilities and charges ........................................ 164/5 59.017,45 11.646,57 4 5 6.7.1 6.8 Capital ......................................................................... 10 4.440.069,16 4.427.369,69 Beyond capital ............................................................. Share premium account ........................................ Other ..................................................................... 11 1100/10 1109/19 242.440.284,68 242.440.284,68 242.197.631,68 242.197.631,68 Reserves not available ................................................. Reserves not available statutorily .......................... Purchase of own shares ....................................... 130/1 1311 1312 7/47 Amount to be deducted from the issued capital. Amount to be deducted from the other components of equity. 4 5

N°. 0817.149.675 NYXOAH C-c 3.2 Codes Period Preceding period AMOUNTS PAYABLE Amounts payable after more than one year Financial debts ............................................................ Advance payments on contracts in progress ............... Current portion of amounts payable after more than one year falling due within one year ............................. Taxes .................................................................... Other amounts payable ............................................... Accruals and deferred income TOTAL LIABILITIES .................... .................... .................... ........... ......................................................... ............................. Remuneration and social security ......................... Other amounts payable ............................................... Amounts payable within one year.................................... ................................ Financial debts ............................................................ Credit institutions ................................................... Other loans ........................................................... Trade debts ................................................................. Suppliers ............................................................... Bills of exchange payable ..................................... Advance payments on contracts in progress ............... Taxes, remuneration and social security ...................... 17/49 17 176 178/9 42/48 42 43 430/8 439 44 440/4 441 46 45 .......................................... ........................... ............................................................ ......... 450/3 454/9 47/48 492/3 10/49 7.448.403,16 923.471,64 6.253.118,45 343.347,53 4.039.150,08 1.528.161,10 183.463,36 1.344.697,74 342.459,74 271.813,07 142.202.429,46 170.223.980,29 6.146.858,60 1.275.843,36 3.866.733,08 442.999,99 2.470.069,73 2.470.069,73 566.583,99 6.469,85 560.114,14 387.079,37 1.004.282,16 Notes 170/4 923.471,64 1.275.843,36 4.039.150,08 6.9 6.9 6.9 6.9 Subordinated loans ............................................... Unsubordinated debentures .................................. Leasing and other similar obligations .................... Credit institutions .................................................. Other loans ........................................................... Trade debts ................................................................ Suppliers .............................................................. Bills of exchange payable ..................................... 170 171 172 173 174 175 1750 1751 923.471,64 1.275.843,36 8/47

N°. 0817.149.675 NYXOAH C-c 4 PROFIT AND LOSS ACCOUNT Codes Period Preceding period Operating charges Operating income Turnover ......................................................................... Produced fixed assets ..................................................... Other operating income ................................................... Goods for resale, raw materials and consumables .......... Purchases ................................................................. Stocks: decrease (increase) .............................(+)/(-) Services and other goods ............................................... Remuneration, social security and pensions ...........(+)/(-) Amounts written down on stocks, contracts in progress and trade debtors: additions (write-backs) ..............(+)/(-) Other operating charges .................................................. Operating charges reported as assets under restructuring costs ...................................................... (-) Operating profit (loss) 6.10 Stocks of finished goods and work and contracts in progress: increase (decrease) ............................(+)/(-) 6.10 Amortisations of and other amounts written down on formation expenses, intangible and tangible fixed assets .............................................................................. 6.10 Provisions for liabilities and charges: appropriations (uses and write-backs) ............................................(+)/(-) 6.10 6.10 .................................................(+)/(-) 18.950.378,54 3.095.389,42 37.397,67 15.402.040,49 415.550,96 51.500.499,90 1.198.786,05 1.697.371,35 -498.585,30 40.992.065,66 5.117.753,87 3.830.344,71 29.043,00 285.135,73 -32.550.121,36 11.636.219,97 862.859,70 290.563,15 9.502.672,00 980.125,12 39.461.322,49 303.484,73 303.484,73 39.737.035,55 3.931.747,52 3.046.551,74 21.386,82 -27.825.102,52 70/76A 70 630 62 71 72 74 60/66A 60 600/8 609 61 631/4 635/8 640/8 649 9901 Notes ................................................................. ............ ................................................................ ............. Non-recurring operating income ...................................... 6.12 76A 47.370,88 8.376,13 Non-recurring operating charges ...................................... 6.12 66A -7.587.260,00 6.10 9/47

N°. 0817.149.675 NYXOAH C-c 4 Codes Period Preceding period Taxes .............................................................................. Adjustment of income taxes and write-back of tax provisions ........................................................................ Profit (Loss) for the period before taxes Profit (Loss) of the period ....................(+)/(-) Transfer from deferred taxes ............................................... ....................... Transfer to deferred taxes.................................................... ................... Income taxes on the result.........................................(+)/(-) 6.13 ...........................................(+)/(-) Transfer from untaxed reserves .......................................... ............................. Transfer to untaxed reserves............................................... ........................ Profit (Loss) of the period available for appropriation ..............................................................(+)/(-) -29.610.197,80 15.620,94 35.558,27 19.937,33 -29.625.818,74 -29.625.818,74 -27.010.806,55 10.504,25 10.504,25 -27.021.310,80 9905 -27.021.310,80 689 780 680 67/77 670/3 77 9904 789 9903 Notes Income from financial fixed assets .............................. Income from current assets ........................................ Financial income Debt charges ............................................................. Amounts written down on current assets other than stocks, contracts in progress and trade debtors: additions (write-backs) .......................................(+)/(-) Other financial charges ............................................... .................................................................. ... .................................................................... ........ Other financial income ............................................... 6.11 Financial charges 6.11 305.556,01 736.983,10 6.043.723,10 3.021.339,03 82.614,15 77.096,55 1.424,22 3.591.140,66 305.016,86 731.480,24 75/76B 750 751 752/9 65/66B 650 651 652/9 7.086.262,21 3.669.661,43 4.146.338,65 2.855.365,46 Recurring financial income .............................................. 75 7.086.262,21 3.669.661,43 Non-recurring financial income ....................................... 76B Recurring financial charges ............................................. 65 3.103.953,18 1.036.497,10 Non-recurring financial charges ....................................... 66B 1.042.385,47 1.818.868,36 6.12 6.12 10/47

N°. 0817.149.675 C-c 5 Codes Period Preceding period APPROPRIATION ACCOUNT Profit (Loss) of the period available for appropriation ...................(+)/(-) to contributions ..................................................................................... Employees ............................................................................................. to legal reserve .................................................................................... Compensation for contributions .............................................................. Directors or managers ............................................................................ Transfers from equity Appropriations to equity .......................................................(+)/(-) Profit (loss) to be carried forward Shareholders' contribution in respect of losses Profit to be distributed Profit (Loss) to be appropriated Profit (Loss) of the preceding period brought forward ..................(+)/(-) ................................................................................. ............................................................................ ...................................................(+)/(-) ..................................... .................................. .............................................................................. ......................... to other reserves .................................................................................. -112.185.344,99 -29.625.818,74 -82.559.526,25 -112.185.344,99 -82.559.526,25 -27.021.310,80 -55.538.215,45 -82.559.526,25 9906 (9905) 14P 791/2 691/2 6921 (14) 794 6920 694 696 695 694/7 691 NYXOAH Other beneficiaries ................................................................................. 697 from contributions ................................................................................ from reserves ....................................................................................... 791 792 11/47

N°. 0817.149.675 C-c 6.1 Codes Period Preceding period NOTES ON THE ACCOUNTS New expenses incurred .......................................................................... Formation, capital increase or increase of contributions expenses, loan issue expenses and other formation expenses .............. Restructuring costs ................................................................................ Movements during the period Net book value at the end of the period ..................................................... ................... Of which Other .............................................................................................(+)/(-) Net book value at the end of the period Amortisation ........................................................................................... STATEMENT OF FORMATION, CAPITAL INCREASE OR INCREASE OF CONTRIBUTIONS EXPENSES, LOAN ISSUE EXPENSES AND RESTRUCTURING COSTS ..................................................... ................... xxxxxxxxxxxxxxx 11.709.906,15 2.813.752,12 8.896.154,03 8003 8004 (20) 200/2 204 20P 8002 NYXOAH 12/47

N°. 0817.149.675 C-c 6.2.1 Codes Period Preceding period Acquisitions, including produced fixed assets ........................................... Recorded .................................................................................................. Acquisition value at the end of the period Acquisition value at the end of the period Movements during the period Transfers from one heading to another .............................................(+)/(-) DEVELOPMENT COSTS Sales and disposals .................................................................................. ..................................................... ................... xxxxxxxxxxxxxxx ..................................................... ................... Amortisations and amounts written down at the end of the period ........... ............ ............ ............ ............ ............ ..... Written back ............................................................................................. Acquisitions from third parties ................................................................... Cancelled owing to sales and disposals .................................................... Amortisations and amounts written down at the end of the period ........... ............ ............ ............ ............ ............ ............ ............ .... NET BOOK VALUE AT THE END OF THE PERIOD xxxxxxxxxxxxxxx ......................................... ............................... Transferred from one heading to another ..........................................(+)/(-) STATEMENT OF INTANGIBLE FIXED ASSETS Movements during the period 35.717.922,37 15.402.040,49 51.119.962,86 12.631.943,61 758.920,22 13.390.863,83 37.729.099,03 8031 8041 8051 8121P 8071 8051P 8021 8091 8101 8081 8121 81311 8111 NYXOAH 13/47

N°. 0817.149.675 C-c 6.3.2 Codes Period Preceding period Acquisition value at the end of the period Acquisition value at the end of the period Movements during the period .................................................... .................... xxxxxxxxxxxxxxx .................................................... .................... Amortisations and amounts written down at the end of the period ............................................ ............................ Amortisations and amounts written down at the end of the period ............ ............ ............ ............ ............ ............ ............ ............ .... NET BOOK VALUE AT THE END OF THE PERIOD xxxxxxxxxxxxxxx PLANT, MACHINERY AND EQUIPMENT Revaluation surpluses at the end of the period Movements during the period Revaluation surpluses at the end of the period ........................................... ............................ Movements during the period xxxxxxxxxxxxxxx ......................................... ............................... ............. ............. ............. ............. ............. ............. ............. ........ 788.778,72 216.004,56 1.004.783,28 163.377,79 342.840,57 661.942,71 179.462,78 8172 8182 8192 8252P 8212 8192P 8162 8232 8242 8222 8322P 8272 8252 8282 8302 8312 8292 8322 (23) Acquisitions, including produced fixed assets ........................................... Transfers from one heading to another ............................................(+)/(-) Sales and disposals .................................................................................. Recorded .................................................................................................. Written back .............................................................................................. Acquisitions from third parties ................................................................... Cancelled owing to sales and disposals .................................................... Transferred from one heading to another ..........................................(+)/(-) Cancelled .................................................................................................. Recorded .................................................................................................. Acquisitions from third parties ................................................................... Transferred from one heading to another ..........................................(+)/(-) NYXOAH 14/47

N°. 0817.149.675 C-c 6.3.3 Codes Period Preceding period Acquisition value at the end of the period Acquisition value at the end of the period Movements during the period .................................................... .................... xxxxxxxxxxxxxxx ..................................................... ................... Amortisations and amounts written down at the end of the period ............................................ ............................ Amortisations and amounts written down at the end of the period ............. ............. ............. ............. ............. ............. ............. ........ NET BOOK VALUE AT THE END OF THE PERIOD xxxxxxxxxxxxxxx FURNITURE AND VEHICLES Revaluation surpluses at the end of the period Movements during the period Revaluation surpluses at the end of the period ..................................................... .................. Movements during the period xxxxxxxxxxxxxxx ......................................... ............................... ............. ............. ............. ............. ............. ............. ............. ........ 258.457,83 138.576,08 57.053,47 158.169,59 215.223,06 181.810,85 8173 8183 8193 8253P 8213 8193P 8163 8233 8243 8223 8323P 8273 8253 8283 8303 8313 8293 8323 (24) 397.033,91 Acquisitions, including produced fixed assets ........................................... Transfers from one heading to another ............................................(+)/(-) Sales and disposals .................................................................................. Recorded .................................................................................................. Written back .............................................................................................. Acquisitions from third parties ................................................................... Cancelled owing to sales and disposals .................................................... Transfers from one heading to another ............................................(+)/(-) Cancelled .................................................................................................. Recorded .................................................................................................. Acquisitions from third parties ................................................................... Transfers from one heading to another ............................................(+)/(-) NYXOAH 15/47

N°. 0817.149.675 C-c 6.3.5 Codes Period Preceding period Acquisition value at the end of the period Acquisition value at the end of the period Movements during the period ..................................................... ................... xxxxxxxxxxxxxxx ..................................................... ................... Amortisations and amounts written down at the end of the period ............................................ ............................ Amortisations and amounts written down at the end of the period ............ ............ ............ ............ ............ ............ ............ ............ .... NET BOOK VALUE AT THE END OF THE PERIOD xxxxxxxxxxxxxxx OTHER TANGIBLE FIXED ASSETS Revaluation surpluses at the end of the period Movements during the period Revaluation surpluses at the end of the period ........................................... ............................ Movements during the period xxxxxxxxxxxxxxx ......................................... ............................... ............ ............ ............ ............ ............ ............ ............ ............ .... 234.556,79 234.556,79 102.831,55 37.241,11 140.072,66 94.484,13 8175 8185 8195 8255P 8215 8195P 8165 8235 8245 8225 8325P 8275 8255 8285 8305 8315 8295 8325 (26) Acquisitions, including produced fixed assets ........................................... Transfers from one heading to another ............................................(+)/(-) Sales and disposals .................................................................................. Recorded .................................................................................................. Written back .............................................................................................. Acquisitions from third parties ................................................................... Cancelled owing to sales and disposals .................................................... Transferred from one heading to another ..........................................(+)/(-) Cancelled .................................................................................................. Recorded .................................................................................................. Acquisitions from third parties ................................................................... Transferred from one heading to another ..........................................(+)/(-) NYXOAH 16/47

N°. 0817.149.675 C-c 6.3.6 Codes Period Preceding period Acquisition value at the end of the period Acquisition value at the end of the period Movements during the period ..................................................... ................... xxxxxxxxxxxxxxx ..................................................... ................... Amortisations and amounts written down at the end of the period ............................................ ............................ Amortisations and amounts written down at the end of the period ............. ............. ............. ............. ............. ............. ............. ........ NET BOOK VALUE AT THE END OF THE PERIOD xxxxxxxxxxxxxxx ASSETS UNDER CONSTRUCTION AND ADVANCE PAYMENTS Revaluation surpluses at the end of the period Movements during the period Revaluation surpluses at the end of the period ........................................... ............................ Movements during the period xxxxxxxxxxxxxxx ......................................... ............................... ............. ............. ............. ............. ............. ............. ............. ........ 691.477,99 26.216,24 717.694,23 717.694,23 8176 8186 8196 8256P 8216 8196P 8166 8236 8246 8226 8326P 8276 8256 8286 8306 8316 8296 8326 (27) Acquisitions, including produced fixed assets ........................................... Transfers from one heading to another ............................................(+)/(-) Sales and disposals .................................................................................. Recorded .................................................................................................. Written back .............................................................................................. Acquisitions from third parties ................................................................... Cancelled owing to sales and disposals .................................................... Transferred from one heading to another ..........................................(+)/(-) Cancelled .................................................................................................. Recorded .................................................................................................. Acquisitions from third parties ................................................................... Transferred from one heading to another ..........................................(+)/(-) NYXOAH 17/47

N°. 0817.149.675 C-c 6.4.1 Codes Period Preceding period Acquisition value at the end of the period Acquisition value at the end of the period Movements during the period ..................................................... ................... xxxxxxxxxxxxxxx ..................................................... ................... Amounts written down at the end of the period ............................................ ............................ Amounts written down at the end of the period ............................................ ............................................ ...... xxxxxxxxxxxxxxx AFFILIATED COMPANIES - PARTICIPATING INTERESTS AND SHARES Revaluation surpluses at the end of the period Movements during the period Revaluation surpluses at the end of the period ........................................... ............................ Movements during the period xxxxxxxxxxxxxxx ............................................ ............................................ ...... STATEMENT OF FINANCIAL FIXED ASSETS Uncalled amounts at the end of the period ................................................... ......................................... Movements during the period ...............................................................(+)/(-) Uncalled amounts at the end of the period ................................................... ......................................... NET BOOK VALUE AT THE END OF THE PERIOD......................................... .......................................... .......... AFFILIATED COMPANIES - AMOUNTS RECEIVABLE NET BOOK VALUE AT THE END OF THE PERIOD......................................... .......................................... Movements during the period ......... Appropriations ............................................................................................ Repayments ............................................................................................... Amounts written down ................................................................................ Amounts written back ................................................................................. Exchange differences ........................................................................(+)/(-) Other movements ..............................................................................(+)/(-) NET BOOK VALUE AT THE END OF THE PERIOD ACCUMULATED AMOUNTS WRITTEN DOWN ON AMOUNTS RECEIVABLE AT END OF THE PERIOD......................................................... ................................... .......................................... .......................................... .......... xxxxxxxxxxxxxxx xxxxxxxxxxxxxxx 64,48 64,48 64,48 1.042.385,47 1.042.385,47 5.861.516,29 8371 8381 8391 8451P 8411 8391P 8361 8431 8441 8421 8521P 8471 8451 8481 8501 8511 8491 8521 8551P 8541 8581 8601 8611 8591 8621 8631 8551 (280) 281P (281) 8651 Acquisitions ............................................................................................... Transfers from one heading to another ............................................(+)/(-) Sales and disposals .................................................................................. Recorded .................................................................................................. Written back .............................................................................................. Acquisitions from third parties ................................................................... Cancelled owing to sales and disposals .................................................... Transferred from one heading to another ..........................................(+)/(-) Cancelled .................................................................................................. Recorded .................................................................................................. Acquisitions from third parties ................................................................... Transferred from one heading to another ..........................................(+)/(-) NYXOAH 18/47

N°. 0817.149.675 C-c 6.4.3 Codes Period Preceding period Acquisition value at the end of the period Acquisition value at the end of the period Movements during the period .................................................... .................... xxxxxxxxxxxxxxx .................................................... .................... Amounts written down at the end of the period ............................................ ............................ Amounts written down at the end of the period ............................................ ............................................ ...... xxxxxxxxxxxxxxx OTHER COMPANIES - PARTICIPATING INTERESTS AND SHARES Revaluation surpluses at the end of the period Movements during the period Revaluation surpluses at the end of the period ........................................... ............................ Movements during the period xxxxxxxxxxxxxxx ............................................ ............................................ ...... Uncalled amounts at the end of the period ................................................... ......................................... Movements during the period ...............................................................(+)/(-) Uncalled amounts at the end of the period ................................................... ......................................... NET BOOK VALUE AT THE END OF THE PERIOD......................................... .......................................... .......... OTHER COMPANIES - AMOUNTS RECEIVABLE NET BOOK VALUE AT THE END OF THE PERIOD......................................... .......................................... Movements during the period ......... NET BOOK VALUE AT THE END OF THE PERIOD ACCUMULATED AMOUNTS WRITTEN DOWN ON AMOUNTS RECEIVABLE AT END OF THE PERIOD......................................................... ................................... .......................................... .......................................... .......... xxxxxxxxxxxxxxx xxxxxxxxxxxxxxx 24.098,96 1.272,36 22.826,60 8373 8383 8393 8453P 8413 8393P 8363 8433 8443 8423 8523P 8473 8453 8483 8503 8513 8493 8523 8553P 8543 8583 8603 8613 8593 8623 8633 8553 (284) 285/8P (285/8) 8653 Acquisitions ............................................................................................... Transfers from one heading to another ............................................(+)/(-) Sales and disposals .................................................................................. Recorded .................................................................................................. Written back .............................................................................................. Acquisitions from third parties ................................................................... Cancelled owing to sales and disposals .................................................... Transferred from one heading to another ..........................................(+)/(-) Cancelled .................................................................................................. Recorded .................................................................................................. Acquisitions from third parties ................................................................... Transferred from one heading to another ..........................................(+)/(-) Appropriations ............................................................................................ Repayments ............................................................................................... Amounts written down ................................................................................ Amounts written back ................................................................................. Exchange differences ........................................................................(+)/(-) Other movements ..............................................................................(+)/(-) NYXOAH 19/47

N°. 0817.149.675 NYXOAH C-c 6.5.1 PARTICIPATING INTERESTS AND OTHER RIGHTS IN OTHER COMPANIES PARTICIPATING INTERESTS INFORMATION The following list mentions the companies in which the company holds a participating interest (recorded in headings 280 and 282 of assets), as well as the companies in which the company holds rights (recorded in headings 284 and 51/53 of assets) for an amount of at least 10% of the capital, the equity or a class of shares of the company. NAME, full address of the REGISTERED OFFICE and, for an entity governed by Belgian law, the COMPANY REGISTRATION NUMBER Rights held Directly Subs-idiaries Number % % Data extracted from the most recent annual accounts Annual accounts as per Cur-rency code Equity Net result (in units) (+) or (-) Nature NYXOAH LTD 31/12/2022 ILS 8.613.655 1.511.459 Yigal Alon st 126 64074 Tel Aviv Israel shares 100 100,00 0,00 NYXOAH PTY LTD FC 31/12/2022 AUD -9.719.961 -2.379.549 GIPPS STREET 58 VIC3066 COLLINGWOOD Australia shares 100 100,00 0,00 NYXOAH INC 31/12/2022 USD 1.327.461 1.197.445 LITTLE FALLS DRIVE 251 19808 DELAWARE United States of America Shares 1.000 100,00 0,00 20/47

N°. 0817.149.675 C-c 6.6 CURRENT INVESTMENTS AND ACCRUALS AND DEFERRED INCOME NYXOAH Codes Period Preceding period Shares – Book value increased with the uncalled amount ....................... With a remaining term or notice Shares and investments other than fixed income investments Fixed-income securities Fixed income securities issued by credit institutions ................................ CURRENT INVESTMENTS - OTHER INVESTMENTS Shares – Uncalled amount ...................................................................... Term accounts with credit institutions up to one month ................................................................................. over one year ..................................................................................... between one month and one year ...................................................... Other investments not mentioned above 76.968.116,35 58.968.116,35 18.000.000,00 8681 8682 52 8684 51 53 8686 8687 8688 8689 ................. ................. ................. ................. ................. ................. ................. ..... ................................................................................ ...................................... ........................................................ ........................................................ .. .................................................... .................................................... ............... Precious metals and works of art ............................................................. 8683 Allocation of account 490/1 of assets if the amount is significant ACCRUALS AND DEFERRED INCOME Period Deffered charges 999.862,56 Acquired product 259.026,46 21/47

N°. 0817.149.675 NYXOAH C-c 6.7.1 STATEMENT OF CAPITAL Capital Codes Period Preceding period Issued capital at the end of the period .................................................... Issued capital at the end of the period .................................................... 100P (100) XXXXXXXXXXXXXX 4.427.369,69 4.440.069,16 STATEMENT OF CAPITAL AND SHAREHOLDERS’ STURCTURE Codes Period Number of shares Modifications during the period Capital increase 12.699,47 73.920 Composition of the capital Share types Ordinary 4.427.369,69 25.846.279 8702 8703 XXXXXXXXXXXXXX 13.598.702 12.247.577 XXXXXXXXXXXXXX Registered shares .................................................................................. Shares dematerialized ........................................................................... Uncalled amount Called up amount, unpaid Unpaid capital Codes Uncalled capital ...................................................................................... Called up capital, unpaid ........................................................................ (101) 8712 XXXXXXXXXXXXXX XXXXXXXXXXXXXX Shareholders that still need to pay up in full Own shares Period Held by the company itself Amount of capital held ....................................... ....................................... ..................... Number of shares Held by a subsidiary Codes 8722 8731 8732 8721 Amount of capital held Number of shares Commitments to issuing shares Owing to the exercise of conversion rights Amount of outstanding convertible loans Amount of capital to be subscribed 8741 8740 Corresponding maximum number of shares to be issued 8742 Owing to the exercise of subscription rights Number of outstanding subscription rights 8746 8745 2.578.750 443.029,25 8747 2.578.750 Authorised capital not issued 8751 Amount of capital to be subscribed Corresponding maximum number of shares to be issued ................................................................................................................... ...................... ........................................................................................................................... .............. ................................................................................................................... ...................... ........................................................................................................................... .............. ........................................................................................ ................................................. ............................................................................................... .......................................... ............................................................. ............................................................. ................ ..................................................................................... .................................................... ............................................................................................... .......................................... ............................................................. ............................................................. ................ ................................................................................................................ ......................... 22/47

N°. 0817.149.675 NYXOAH C-c 6.7.1 Shares issued, non-representing capital Period Distribution Number of shares Number of voting rights attached thereto Allocation by shareholder Number of shares held by the company itself Number of shares held by its subsidiaries Codes 8762 8771 8781 ........................................................................................................................... 8761 .............. ...................................................................................... ................................................... ................................................................................ ......................................................... ..................................................................................... .................................................... Period ADDITIONAL NOTES REGARDING CONTRIBUTIONS (INCLUDING CONTRIBUTIONS IN THE FORM OF SERVICES OR KNOW-HOW) 23/47

N°. 0817.149.675 C-c 6.7.2 SHAREHOLDERS' STRUCTURE OF THE COMPANY AT YEAR-END CLOSING DATE NYXOAH As reflected in the notifications received by the company pursuant to article 7:225 of the Belgian Companies and Associations Code, article 14 fourth paragraph of the law of 2 May 2007 on the publication of major holdings and article 5 of the Royal Decree of 21 August 2008 on further rules for certain multilateral trading facilities. 24/47

N°. 0817.149.675 NYXOAH C-c 6.9 Codes Period STATEMENT OF AMOUNTS PAYABLE AND ACCRUALS AND DEFERRED INCOME (LIABILITIES) Leasing and other similar obligations ............................................................................................ Advance payments on contracts in progress ....................................................................................... Other loans ................................................................................................................................... Suppliers ...................................................................................................................................... Bills of exchange payable ............................................................................................................. Total current portion of amounts payable after more than one year falling due within one year Trade debts ........................................................................................................................................ .. Amounts payable with a remaining term of more than one year, yet less than 5 years Financial debts .................................................................................................................................... Subordinated loans ....................................................................................................................... Unsubordinated debentures .......................................................................................................... ........ ........ ........ ........ ........ ........ ........ ........ ........ ....... Total amounts payable with a remaining term of more than one year, yet less than 5 years Amounts payable with a remaining term of more than 5 years BREAKDOWN OF AMOUNTS PAYABLE WITH AN ORIGINAL TERM OF MORE THAN ONE YEAR, ACCORDING TO THEIR RESIDUAL MATURITY Current portion of amounts payable after more than one year falling due within one year Credit institutions .......................................................................................................................... Other amounts payable ....................................................................................................................... .............. .............. .............. .............. .............. .............. .............. .............. .............. .............. .............. .............. ....... Amounts payable with a remaining term of more than 5 years ............................................................. .............................................................. ............................. 343.347,53 343.347,53 343.347,53 923.471,64 923.471,64 923.471,64 8811 8821 8831 8841 8801 8851 8861 8871 8881 8891 (42) 8901 8802 8812 8822 8832 8842 8852 8862 8872 8882 8892 8902 8912 8803 8813 8823 8833 8843 8853 8863 8873 8883 8893 8903 8913 Leasing and other similar obligations ............................................................................................ Advance payments on contracts in progress ....................................................................................... Other loans ................................................................................................................................... Suppliers ...................................................................................................................................... Bills of exchange payable ............................................................................................................. Trade debts ........................................................................................................................................ .. Financial debts .................................................................................................................................... Subordinated loans ....................................................................................................................... Unsubordinated debentures .......................................................................................................... Credit institutions .......................................................................................................................... Other amounts payable ....................................................................................................................... Leasing and other similar obligations ............................................................................................ Advance payments on contracts in progress ....................................................................................... Other loans ................................................................................................................................... Suppliers ...................................................................................................................................... Bills of exchange payable ............................................................................................................. Trade debts ........................................................................................................................................ .. Financial debts .................................................................................................................................... Subordinated loans ....................................................................................................................... Unsubordinated debentures .......................................................................................................... Credit institutions .......................................................................................................................... Other amounts payable ....................................................................................................................... 25/47

N°. 0817.149.675 NYXOAH C-c 6.9 Codes Period Total of the amounts payable guaranteed by the Belgian government agencies Amounts payable guaranteed by real securities given or irrevocably promised by the company on its own assets ................................ ................................ ........ Taxes AMOUNTS PAYABLE GUARANTEED Amounts payable guaranteed by the Belgian government agencies (included in accounts 17 and 42/48 of liabilities) Remuneration and social security ...................................................................................................... Total amounts payable guaranteed by real securities given or irrevocably promised by the company on its own assets.................................................................................................................... .......... TAXES, REMUNERATION AND SOCIAL SECURITY (headings 450/3 and 178/9 of liabilities) Outstanding tax debts ........................................................................................................................ Accruing taxes payable ...................................................................................................................... Estimated taxes payable .................................................................................................................... Remuneration and social security (headings 454/9 and 178/9 of liabilities) Amounts due to the National Social Security Office ............................................................................ Other amounts payable in respect of remuneration and social security .............................................. 183.463,36 1.344.697,74 8931 8941 8951 8961 8921 8971 8981 8991 9001 9011 9051 9021 9061 8922 8932 8942 8952 8962 8972 8982 8992 9002 9022 9062 9012 9072 9073 450 9076 9077 9052 Taxes .......................................................................................................................................... Remuneration and social security ................................................................................................ 9042 9032 Leasing and other similar obligations ............................................................................................ Advance payments on contracts in progress ...................................................................................... Other loans ................................................................................................................................... Suppliers ...................................................................................................................................... Bills of exchange payable ............................................................................................................. Trade debts ........................................................................................................................................ Financial debts ................................................................................................................................... Subordinated loans ....................................................................................................................... Unsubordinated debentures ......................................................................................................... Credit institutions .......................................................................................................................... Other amounts payable ...................................................................................................................... Taxes, remuneration and social security ............................................................................................ Leasing and other similar obligations ............................................................................................ Advance payments on contracts in progress ...................................................................................... Other loans ................................................................................................................................... Suppliers ...................................................................................................................................... Bills of exchange payable ............................................................................................................. Trade debts ........................................................................................................................................ .. Financial debts ................................................................................................................................... Subordinated loans ....................................................................................................................... Unsubordinated debentures ........................................................................................................... Credit institutions .......................................................................................................................... Other amounts payable ...................................................................................................................... Codes Period 26/47

N°. 0817.149.675 NYXOAH C-c 6.9 Period Allocation of heading 492/3 of liabilities if the amount is significant ACCRUALS AND DEFERRED INCOME expenses to be charged 112.903,10 27/47

N°. 0817.149.675 NYXOAH C-c 6.10 Codes Period Preceding period OPERATING RESULTS OPERATING INCOME Net turnover Allocation by categories of activity Genio System 3.095.389,42 862.859,70 Allocation by geographical market Germany 2.817.047,51 818.584,70 Rest of Europe 44.275,00 Finland 40.550,00 Zwitzerland 213.791,91 Spain 24.000,00 Operating subsidies and compensatory amounts received from public authorities ...................................................................................... 740 149.803,00 Other operating income OPERATING CHARGES Employees for whom the company submitted a DIMONA declaration or who are recorded in the general personnel register Total number at the closing date ............................................................... Average number of employees calculated in full-time equivalents ............. Number of actual hours worked ................................................................. 35 34,0 45.839 24 31.749 18,5 9088 9087 9086 Remuneration and direct social benefits .................................................... Employers' contribution for social security ................................................. Personnel costs Employers' premiums for extra statutory insurance ................................... Other personnel costs ............................................................................... Retirement and survivors' pensions ........................................................... 3.558.014,93 728.796,22 171.063,74 659.878,98 2.613.238,18 714.726,24 174.354,78 429.428,32 620 621 622 623 624 28/47

N°. 0817.149.675 NYXOAH C-c 6.10 Appropriations (uses and write-backs) ............................................. (+)/(-) On stock and contracts in progress Provisions for pensions and similar obligations Recorded ............................................................................................ Written back ....................................................................................... Depreciations On trade debtors 29.043,00 635 9110 9111 9112 9113 Recorded ............................................................................................ Written back ....................................................................................... Codes Period Preceding period Other ......................................................................................................... Provisions for liabilities and charges Appropriations ........................................................................................... Uses and write-backs ................................................................................ Other operating charges Taxes related to operation ......................................................................... 47.370,88 18.073,47 9.697,34 868,15 284.267,58 11.626,06 9.760,76 9115 9116 640 641/8 Hired temporary staff and personnel placed at the company’s disposal Costs to the company ............................................................................... 0,5 853 34.716,61 0,6 988 72.007,86 9096 9097 9098 617 Total number at the closing date ............................................................... Average number calculated in full-time equivalents ................................... Number of actual hours worked ................................................................. 29/47

N°. 0817.149.675 C-c 6.11 FINANCIAL RESULTS NYXOAH Codes Period Preceding period Other financial income RECURRING FINANCIAL INCOME Subsidies paid by public authorities, added to the profit and loss account Capital subsidies .............................................................................. Interest subsidies ............................................................................... 9126 9125 Allocation of other financial income Exchange differences realized .......................................................... 754 2.716.304,66 8.759,21 Other RECURRING FINANCIAL CHARGES Depreciation of loan issue expenses Depreciations on current assets Amount of the discount borne by the company, as a result of negotiating amounts receivable .................................................................................. Appropriations .......................................................................................... Uses and write-backs .............................................................................. Provisions of a financial nature Other financial charges Recorded ................................................................................................. Written back ............................................................................................ Capitalised interests 12.973,83 9.209,13 9.351,00 6502 6501 6511 6510 6561 6560 653 ........................................................... ................................ ...................................................................................... ...... Allocation of other financial costs 30/47

N°. 0817.149.675 C-c 6.12 INCOME AND CHARGES OF EXCEPTIONAL SIZE OR FREQUENCY NYXOAH Codes Period Preceding period ........................................................................... .............................................. NON-RECURRING INCOME Write-back of depreciation and of amounts written off intangible and tangible fixed assets ................................................................................ Write-back of provisions for extraordinary operating liabilities and charges ................................................................................................... Capital profits on disposal of intangible and tangible fixed assets ............ 76 760 7620 7630 .................................................................. ....................................................... Non-recurring operating income (76A) Other non-recurring operating income ..................................................... 764/8 Write-back of amounts written down financial fixed assets ....................... Write-back of provisions for extraordinary financial liabilities and charges .................................................................................................... Capital profits on disposal of financial fixed assets .................................. 761 7621 7631 ................................................................... ...................................................... Non-recurring financial income (76B) Other non-recurring financial income ....................................................... 769 ....................................................................... .................................................. NON-RECURRING CHARGES Non-recurring depreciation of and amounts written off formation expenses, intangible and tangible fixed assets ........................................ Provisions for extraordinary operating liabilities and charges: appropriations (uses) ..................................................................... (+)/(-) Capital losses on disposal of intangible and tangible fixed assets ............ 66 1.042.385,47 -5.768.391,64 660 6620 6630 .................................................................. ....................................................... Non-recurring operating charges (66A) -7.587.260,00 Other non-recurring operating charges ...................................................... 664/7 Amounts written off financial fixed assets ................................................ Provisions for extraordinary financial liabilities and charges - appropriations (uses) ..................................................................... (+)/(-) Capital losses on disposal of financial fixed assets ................................. 661 1.042.385,47 1.818.868,36 6621 6631 ................................................................... ...................................................... Non-recurring financial charges (66B) 1.042.385,47 1.818.868,36 Other non-recurring financial charges ..................................................... 668 Non-recurring operating charges carried to assets as restructuring costs ....................................................................................................(-) 6690 -7.587.260,00 Non-recurring financial charges carried to assets as restructuring costs ................................................................................................... (-) 6691 31/47

N°. 0817.149.675 C-c 6.13 TAXES NYXOAH Codes Period INCOME TAXES Income taxes on the result of the period Income taxes paid and withholding taxes due or paid ........................................................................ Income taxes on the result of prior periods Additional income taxes due or paid .................................................................................................. Excess of income tax prepayments and withholding taxes paid recorded under assets ..................... Estimated additional taxes ................................................................................................................. Additional income taxes estimated or provided for ............................................................................. 32.353,36 32.353,36 3.204,91 3.204,91 9135 9134 9137 9136 9139 9138 9140 ............................................................................................... ........................................ .......................................................................................... ............................................... Major reasons for the differences between pre-tax profit, as it results from the annual accounts, and estimated taxable profit Disallowed expenses 1.432.513,19 Influence of non-recurring results on income taxes on the result of the period Period Sources of deferred taxes Codes Period Deferred taxes representing assets .................................................................................................... Accumulated tax losses deductible from future taxable profits ..................................................... 108.782.966,46 9142 108.782.966,46 9141 Deferred taxes representing liabilities ................................................................................................. 9144 Allocation of deferred taxes representing liabilities Codes Period Preceding period VALUE-ADDED TAXES AND TAXES BORNE BY THIRD PARTIES Value-added taxes charged To the company (deductible) .................................................................... By the company ........................................................................................ Amounts withheld on behalf of third party by way of Payroll withholding taxes ........................................................................... Withholding taxes on investment income .................................................. 1.081.640,78 1.786.455,10 1.782,75 1.238.739,61 768.239,18 9146 9145 9148 9147 32/47

N°. 0817.149.675 NYXOAH C-c 6.14 RIGHTS AND COMMITMENTS NOT REFLECTED IN THE BALANCE SHEET Codes Period PERSONAL GUARANTEES PROVIDED OR IRREVOCABLY PROMISED BY THE COMPANY AS SECURITY FOR DEBTS AND COMMITMENTS OF THIRD PARTIES Of which Real guarantees provided or irrevocably promised by the company on its own assets as security of debts and commitments of the company Amount of registration ................................................................................................................... Mortgages Book value of the immovable properties mortgaged ...................................................................... Bills of exchange in circulation endorsed by the company .................................................................... REAL GUARANTEES Maximum amount up to which the debt is secured and which is the subject of registration ..................................................................................................................................... For irrevocable mandates to pledge goodwill, the amount for which the agent can take the inscription ...................................................................................................................................... 9150 9149 91611 91721 91621 91711 .................................................. .................................................. .................................................. ................. Bills of exchange in circulation drawn or guaranteed by the company .................................................. 9151 Maximum amount for which other debts or commitments of third parties are guaranteed by the company .............................................................................................................................................. 9153 For irrevocable mortgage mandates, the amount for which the agent can take registration ..................................................................................................................................... 91631 Pledging of goodwill Pledging of other assets or irrevocable mandates to pledge other assets Book value of the immovable properties mortgaged ...................................................................... Maximum amount up to which the debt is secured ........................................................................ 91811 91821 Guarantees provided or irrevocably promised on future assets Amount of assets in question ......................................................................................................... Maximum amount up to which the debt is secured ......................................................................... 91911 91921 Vendor’s privilege Book value of sold goods ............................................................................................................... Amount of the unpaid price ............................................................................................................ 92011 92021 33/47

N°. 0817.149.675 NYXOAH C-c 6.14 Real guarantees provided or irrevocably promised by the company on its own assets as security of debts and commitments of third parties Amount of registration ................................................................................................................... Mortgages Book value of the immovable properties mortgaged ...................................................................... Maximum amount up to which the debt is secured and which is the subject of registration ........... For irrevocable mandates to pledge goodwill, the amount for which the agent can take the inscription ...................................................................................................................................... 91612 91722 91622 91712 For irrevocable mortgage mandates, the amount for which the agent can take registration ..................................................................................................................................... 91632 Pledging of goodwill Pledging of other assets or irrevocable mandates to pledge other assets Book value of the immovable properties mortgaged ...................................................................... Maximum amount up to which the debt is secured ........................................................................ 91812 91822 Guarantees provided or irrevocably promised on future assets Amount of assets in question ......................................................................................................... Maximum amount up to which the debt is secured ......................................................................... 91912 91922 Vendor’s privilege Book value of sold goods ............................................................................................................... Amount of the unpaid price ............................................................................................................ 92012 92022 Codes Period GOODS AND VALUES, NOT REFLECTED IN THE BALANCE SHEET, HELD BY THIRD PARTIES IN THEIR OWN NAME BUT FOR THE BENEFIT AND AT THE RISK OF THE COMPANY Codes Period SUBSTANTIAL COMMITMENTS TO ACQUIRE FIXED ASSETS SUBSTANTIAL COMMITMENTS TO DISPOSE OF FIXED ASSETS Goods purchased (to be received) FORWARD TRANSACTIONS .......................................................................................................... 9213 ........................................................... Goods sold (to be delivered) .................................................................................................................. 9214 .................................................. Currencies purchased (to be received) .................................................................................................. 9215 920.978,97 .................................................................. Currencies sold (to be delivered) ........................................................................................................... 9216 ......................................................... Period COMMITMENTS RELATING TO TECHNICAL GUARANTEES IN RESPECT OF SALES OR SERVICES 34/47

N°. 0817.149.675 NYXOAH C-c 6.14 Period AMOUNT, NATURE AND FORM CONCERNING LITIGATION AND OTHER IMPORTANT COMMITMENTS Variable part RCA région wallonne 7.585.045,00 SETTLEMENT REGARDING THE COMPLEMENTARY RETIREMENT OR SURVIVORS’ PENSION FOR PERSONNEL AND BOARD MEMBERS Brief description Pension plan The company Nyxoah has set up an additional pension plan for the benefit of all its employees since the year 2012. This pension plan is a so-called "defined contribution" plan and is outsourced and financed by a group insurance contract (a pension fund). This plan defines the payment of contributions paid by the employer. The goal is to finance a capital that will be paid out to employees in case of life at the age of 65. Employer's allowances and personal contributions are paid periodically to the organization responsible for financing the pensions. According to Belgian legislation, the employer must guarantee a minimum return on both the employer's allowances and the personal contributions. At the balance sheet date, the insurance company informed us that there is no underfunding of the legal reserves compared to the mathematical reserves. The calculation method corresponds to the underfunding determined according to the intrinsic value method. This method consists of comparing the reserves defined in the pension plan and available in the individual contracts at the balance sheet date with the individual minimum reserve calculated at the balance sheet date. The negative difference determines the individual underfunding at the balance sheet date. The total underfunding is the sum of the individual underfunding. Measures taken to cover the related charges Code Period PENSIONS FUNDED BY THE COMPANY ITSELF Methods of estimation Estimated amount of the commitments resulting from past services ................................................. 9220 .................................................. .................................................. ................. Period NATURE AND FINANCIAL IMPACT OF SIGNIFICANT EVENTS AFTER THE CLOSING DATE not reflected in the balance sheet or income statement Period COMMITMENTS TO PURCHASE OR SALE AVAILABLE TO THE COMPANY AS ISSUER OF OPTIONS FOR SALE OR PURCHASE Period NATURE, COMMERCIAL OBJECTIVE AND FINANCIAL CONSEQUENCES OF TRANSACTIONS NOT REFLECTED IN THE BALANCE SHEET If the risks and benefits resulting from such transactions are of any meaning and if publishing such risks and benefits is necessary to appreciate the financial situation of the company 35/47

N°. 0817.149.675 NYXOAH C-c 6.14 Period OTHER RIGHTS AND COMMITMENTS NOT REFLECTED IN THE BALANCE SHEET (including those that cannot be calculated) 36/47

N°. 0817.149.675 C-c 6.15 RELATIONSHIPS WITH AFFILIATED COMPANIES, ASSOCIATED COMPANIES AND OTHER COMPANIES LINKED BY PARTICIPATING INTERESTS NYXOAH Codes Period Preceding period AFFILIATED COMPANIES Participating interests ............................................................................... Provided or irrevocably promised by affiliated companies as security for debts or commitments of the company ................................................... Subordinated amounts receivable ............................................................ .................................................................................... ..................................... Financial fixed assets Other amounts receivable ........................................................................ Amounts receivable...................................................................................... .......................................... Over one year .......................................................................................... Within one year ....................................................................................... Current investments Shares ..................................................................................................... ..................................................................................... ............................................ Amounts receivable ................................................................................. Amounts payable .......................................................................................... ...................................... Personal and real guarantees Provided or irrevocably promised by the company as security for debts or commitments of affiliated companies .................................................. Other significant financial commitments .................................................... ..................................................... Financial results ....................... Income from financial fixed assets ........................................................... ............................................................ .......... Income from current assets ...................................................................... .......................................................... Other financial income .............................................................................. .................................................. Debt charges ........................................................................................... ..................................... Other financial charges ............................................................................ .................................................... 64,48 64,48 233.498,43 233.498,43 342.459,74 342.459,74 64,48 64,48 1.226.873,58 1.226.873,58 1.613.952,95 1.613.952,95 Disposal of fixed assets Capital profits realised Capital losses realised ............................................................................... .................................................. .............................................................................. ................................................... (280/1) (280) 9271 9281 9291 9301 9311 9321 9331 9351 9341 9361 9371 9381 9391 9401 9421 9431 9441 9461 9471 9481 9491 Over one year .......................................................................................... Within one year ....................................................................................... 37/47

N°. 0817.149.675 C-c 6.15 RELATIONSHIPS WITH AFFILIATED COMPANIES, ASSOCIATED COMPANIES AND OTHER COMPANIES LINKED BY PARTICIPATING INTERESTS NYXOAH Codes Period Preceding period ASSOCIATED COMPANIES Participating interests ............................................................................... COMPANIES LINKED BY PARTICIPATING INTERESTS Provided or irrevocably promised by affiliated companies as security for debts or commitments of the company ................................................... Subordinated amounts receivable ........................................................... .................................................................................... ..................................... Financial fixed assets Other amounts receivable ........................................................................ Amounts receivable...................................................................................... .......................................... Over one year .......................................................................................... Within one year ....................................................................................... Amounts payable Over one year .......................................................................................... ............................................................................................ ..................................... Within one year ....................................................................................... Personal and real guarantees Provided or irrevocably promised by the company as security for debts or commitments of affiliated companies .................................................. Other significant financial commitments .................................................... ..................................................... ........................ Financial fixed assets 9253 9263 9273 9283 9293 9303 9313 9353 9363 9373 9383 9393 9403 9262 ................................................................................... 9252 .............................................. Participating interests ............................................................................... Amounts receivable...................................................................................... .......................................... Amounts payable........................................................................................... ..................................... 9362 9372 9272 9282 9292 9302 9352 9312 Subordinated amounts receivable ........................................................... Other amounts receivable ........................................................................ Over one year .......................................................................................... Within one year ....................................................................................... Over one year .......................................................................................... Within one year ....................................................................................... Period TRANSACTIONS WITH AFFILIATED PARTIES BEYOND NORMAL MARKET CONDITIONS Mention of these transactions if they are significant, including the amount of the transactions, the nature of the link, and all information about the transactions that should be necessary to get a better understanding of the financial situation of the company Nihil 38/47

N°. 0817.149.675 C-c 6.16 FINANCIAL RELATIONSHIPS WITH NYXOAH Codes Period DIRECTORS AND MANAGERS, INDIVIDUALS OR LEGAL PERSONS WHO CONTROL THE COMPANY DIRECTLY OR INDIRECTLY WITHOUT BEING ASSOCIATED THEREWITH, OR OTHER COMPANIES CONTROLLED DIRECTLY OR INDIRECTLY BY THESE PERSONS Amounts receivable from these persons ............................................................................................... 9500 .................................. Principal conditions regarding amounts receivable, rate of interest, duration, any amounts repaid, cancelled or written off Guarantees provided in their favour ...................................................................................................... 9501 ........................... Other significant commitments undertaken in their favour .................................................................. 9502 ............................................................... Amount of direct and indirect remunerations and pensions, reflected in the income statement, as long as this disclosure does not concern exclusively or mainly, the situation of a single identifiable person To directors and managers ................................................................................................................. To former directors and former managers ........................................................................................... 945.932,31 9504 9503 Codes Period THE AUDITOR(S) AND THE PERSONS WHOM HE (THEY) IS (ARE) COLLABORATING WITH Auditors' fees Fees for exceptional services or special assignments executed within the company by the auditor Other audit assignments Tax consultancy assignments Other assignments beyondthe audit 527.000,00 18.000,00 45.000,00 9505 95061 95062 95063 ........................................................................................................................................... ...................................................................................................................... .................................................. .............................................................................................................. .......................................................... ..................................................................................................... ................................................................... Fees for exceptional services or special assignments executed within the company by people the auditor(s) is (are collaborating with 95081 95082 95083 Other audit assignments Tax consultancy assignments Other assignments beyondthe audit ...................................................................................................................... .................................................. .............................................................................................................. .......................................................... ..................................................................................................... ................................................................... Mentions related to article 3:64, § 2 and § 4 of the Belgian Companies and Associations Code 39/47

N°. 0817.149.675 C-c 6.18.1 DECLARATION WITH REGARD TO THE CONSOLIDATED ANNUAL ACCOUNTS NYXOAH INFORMATION TO DISCLOSE BY EACH COMPANY GOVERNED BY THE BELGIAN COMPANIES AND ASSOCIATIONS CODE ON THE CONSOLIDATED ANNUAL ACCOUNTS The company has prepared and published consolidated annual accounts and a consolidated annual report* The company has not prepared consolidated annual accounts and a consolidated annual report, because of an exemption for the following reason(s)* The company and its subsidiaries exceed, on a consolidated basis, not more than one of the criteria mentioned in article 1:26 of the Belgian Companies and Associations Code* The company itself is a subsidiary of a parent company that prepares and publishes consolidated annual accounts, in which the annual accounts are integrated by consolidation* The company only has subsidiaries that, considering the evaluation of the consolidated capital, the consolidated financial position or the consolidated result, individually or together, are of negligible interestError! Bookmark not defined. (article 3:23 of the Belgian Companies and Associations Code) Name, full address of the registered office and, if it concerns companies under Belgian law, the company registration number of the parent company(ies) and the indication if this (these) parent company(ies) prepares (prepare) and publishes (publish) consolidated annual accounts, in which the annual accounts are included by means of consolidation**: If the parent company(ies) is (are) (a) company(ies) governed by foreign law, the location where the abovementioned annual accounts are available**: * Strike out what does not apply. ** Where the annual accounts of the company are consolidated at different levels, the information should be given, on the one hand at the highest and on the other at the lowest level of companies of which the company is a subsidiary and for which consolidated accounts are prepared and published. 40/47

N°. 0817.149.675 NYXOAH C-c 6.18.2 Codes Period FINANCIAL RELATIONSHIPS OF THE GROUP THE COMPANY IS IN CHARGE OF IN BELGIUM WITH THE AUDITOR(S) AND THE PERSONS WITH WHOM HE (THEY) IS (ARE) LINKED Fees to auditors according to the mandate at the group level led by the company publishing the information Other audit assignments Tax consultancy assignments Other assignments beyondthe audit 18.000,00 20.654,00 45.000,00 ................................................................................................................................................ 567.000,00 ........................ 9507 95072 95071 95073 95091 95092 95093 Fees for exceptional services or special missions executed by the auditor(s) at this group ...................................................................................................................... ................................................... ............................................................................................................... ......................................................... ..................................................................................................... ................................................................... Fees for exceptional services or special assignments executed at this group by people the auditor(s) is (are) linked to ...................................................................................................................... .................................................. ............................................................................................................... ......................................................... ..................................................................................................... ................................................................... ....................................................................................................... ................................................................. 9509 Fees to people auditors are linked to according to the mandate at the group level led by the company publishing the information Mentions related to article 3:65, § 4 and § 5 of the Belgian Companies and Associations Code Other audit assignments Tax consultancy assignments Other assignments beyond the audit Mentions related to article 3:64, § 2 and § 4 of the Belgian Companies and Associations Code 41/47

N°. 0817.149.675 C-c 6.19 VALUATION RULES NYXOAH VALUATION RULES The annual accounts have been drawn up in accordance with the Royal Decree of 29 April 2019 regarding the implementation of the Code of Companies and Associations. The annual accounts give a true and fair view of the assets, liabilities, financial position and results of the company. The amounts relating to the financial year are established in a consistent way with those of the previous financial year. Assets and liabilities are valued in accordance with article 3:108 of the Royal Decree of 29 April 2019 on the assumption that the company will continue as a going concern. Each component of the assets and liabilities is valued separately. Depreciations, write-off and revaluations are specific to each asset to which they relate. Provisions for liabilities and charges are individualized. Valuations, depreciations, write-off and provisions for liabilities and charges meet the requirements of prudence, sincerity and good faith. Formation expenses amortized over a period of 5 years. Formation expenses will be amortized over a period of 5 years as from the finalization of the capital round. Intangible assets Intangible fixed assets are stated at net book value, i.e. the acquisition value less depreciations and write-downs recorded. If they were set up by the company itself, they are recorded at the lower of cost or production cost, or at a conservative estimate of their value in use, with an estimate of future yield acting as a ceiling. Intangible assets are amortized on a straight-line basis. The following amortization percentage applies: 20% Research and development expenses - Patents The development costs are capitalized as intangible asset on the balance sheet if the potential profitability are identifiable and probable. Development expenses will be capitalized for the first time in the year in which the CE mark is obtained. Research and development expenses - Device treating Obstructive Sleep Apnea. The development costs were capitalized as intangible asset on the balance sheet if the potential profitability are identifiable and probable. Part of the capitalization will stop following the sales made. Nevertheless, part of the capitalization will continue, i.e.: indirect and direct costs of clinical studies conducted in Europe, United-States and Australia ; Development costs incurred in Israel. Research and development costs are amortized over the estimated life of the Genio system based on the expiration of the last patent of this technology. The company concludes that the useful life of the technology and related improvements is at least 14 years from January 1, 2021. In accordance with the accounting principle, the intangible assets are tested annually for impairment during the development period. The Genio® system is currently a unique product line developed by the Company and the Company determined that it has two cash generating units, Genio® system in Europe and Genio® system in the United States, for which a value in use analysis has been performed. The discount rates have been determined by reference to the analyst reports covering the Company which are available. A sensitivity analysis has been performed concluding that a reasonable change in the WACC and/or the long-term growth rate would not lead to an impairment. ? Property, plant and equipment Fixed assets are stated at net book value, i.e. the acquisition value less depreciations and impairments. Fixed assets are depreciated using the straight-line method. Additional costs are immediately recognized in the income statement. The following depreciation percentages apply: Computer hardware: 33%. Fitting-out of rented buildings 20% Machinery and tools 20%. Furniture 10% Interest expenses are not included in the acquisition value . Property, plant and equipment that are no longer in use or that have no planned use on a long-term basis for the company's business are, where applicable, subject to exceptional depreciation or impairment to bring their valuation into line with their probable realizable value. Long-term financial assets Financial fixed assets are valued at their acquisition cost and impairments are accounted for in case sustainable minus values are identified considering applicable circumstances, considering expected profitability or perspectives for which the investment or shares are held. Guarantees are booked at their nominal value. Write-off are applied to receivables included in financial fixed assets in the event of uncertainty regarding the payment of those on the due date. Receivables Receivables are recorded in the balance sheet at their nominal value. Receivables are subject to write-off in the event of uncertainty as to the payment of all or part of the receivable on the due date. ? VALUATION RULES Receivables are recorded in the balance sheet at their nominal value taking into consideration liabilities recorded in accruals and deferred income on the basis of pro rata temporis of interest: a. interest conventionally included in the nominal value of the receivables; b. the difference between the acquisition value and the nominal value of the receivables; c. the discounting of non-interest-bearing or abnormally low-interest receivables, Cash and cash equivalents Cash and cash equivalents are recorded at their nominal value. Write-off are applied if their realizable value is lower than their nominal value on the closing date of the financial year. Additional write-off are booked in the same way as for investments. Accrued charges and deferred income Income and expenses relating to the financial year or to the previous financial years are taken into account, regardless of the date of payment or collection of such income and expenses, unless the actual collection of such income is uncertain. If income or expenses are significantly influenced by income or expenses attributable to another financial year, this is mentioned in the notes to the accounts. Statement of liabilities Recoverable advances Recoverable advances contracted with the Direction Générale d'Aide à la Recherche de la Région Wallonne (DGO6) are recognized as other operating income in the fiscal year in which the Company obtains confirmation of the settlement of the DGO6's claims. When the 42/47

N°. 0817.149.675 C-c 6.19 VALUATION RULES NYXOAH Company decides to use the results of the research or development project (decision subject to written notification by the Company to DGO6), the portion of the recoverable cash advance that is repayable at the time of the decision to start using the results of the research or development project independently of sales (i.e. 30% of the recoverable advance) will be recognized as a debt on the balance sheet. The remaining 70% of the amount of the recoverable advance, which is repayable based on sales, will be recorded as an off-balance sheet item. Accrued charges and deferred revenues These debts are valued at their nominal value. These debts do not include any long-term debts, either interest-free or with a low interest rate. If this is the case, a discount must be applied to these debts that should be capitalized. Transactions in foreign currencies Transactions in foreign currencies are translated at the exchange rate applicable at the date of the transaction. Non-current assets and shareholders' equity are translated into euros at the historical exchange rate. Other assets and liabilities in foreign currencies are translated into euros at the exchange rate applicable at the balance sheet date. Realized and unrealized exchange differences are immediately recognized in the income statement. Cash flow hedges The effects of changes in the fair value of cash flow hedges are recognized as off-balance sheet commitments and disclosed in the notes to the financial statements. In the case of cash flow hedges (Call & Put; Swaps); premiums received are recorded in an accrual account; changes in financial instruments are recorded in the income statement. Income and expense recognition Income and expenses related to the disposal of an asset will be recognized in the year in which the main risks and rewards on the asset are transferred to the purchaser. In principle, the transfer of the main risks and rewards correspond to the transfer of ownership of the asset or, if it is separated from it, to the transfer of the risks of loss or deterioration of the asset. With respect to the provision of services, the income and expenses related to the provision of services will be allocated to the financial year in which the essential part of the service is performed. Expenses will be recognized as they are incurred. Invoiced expenses that are related to the following financial year will be accounted for on an deferred charges account on the assets side of the balance sheet. Justification of the application of the continuity accounting rules As at December 31, 2022, the Company had cash and cash equivalents of €12 million and financial assets of €77.0 million. Based on cash flow forecasts for the upcoming years, which include significant expenses and cash outflows in relation to -among others- the ongoing clinical trials, the continuation of research and development projects, and the scaling-up of the Company's manufacturing facilities, the Company believes that this cash position will be sufficient to meet the Company's capital requirements and fund its operations for at least 12 months as from the date of this Annual Report. In view of the above, and notwithstanding a loss brought forward of €112 million as of December 31, 2022, the Board of Directors has decided, after due consideration, that the application of the valuation rules in the assumption of a "going concern" is justified. 43/47

N°. 0817.149.675 NYXOAH C-c 10 Numbers of the joint industrial committees competent for the company: SOCIAL BALANCE SHEET 218 STATEMENT OF THE PERSONS EMPLOYED EMPLOYEES FOR WHOM THE COMPANY SUBMITTED A DIMONA DECLARATION OR WHO ARE RECORDED IN THE GENERAL PERSONNEL REGISTER 1001 27,2 1002 1003 .................................................................. ................................................................... .................................................................. During the period Average number of employees Full-time Part-time Total in full-time equivalents (FTE) Codes Total 1. Men 2. Women 13,2 14,0 2,0 1,3 0,7 28,1 13,6 14,5 1011 44.348 1012 1013 Number of actual hours worked Full-time Part-time Total 21.765 22.583 1.491 519 972 45.839 22.284 23.555 1021 3.195.644,74 1022 1023 Personnel costs Full-time Part-time Total 196.384,05 3.392.028,79 2.078.595,02 1.313.433,77 Benefits in addition to wages 1033 39.235,85 19.220,33 20.015,52 18,5 1003 1013 1023 During the preceding period Average number of employees in FTE Number of actual hours worked Personnel costs P. Total 1P. Men 2P. Women 11,2 7,3 31.749 19.296 12.453 2.903.908,01 2.391.309,87 512.598,14 Codes Benefits in addition to wages 1033 27.727,03 17.006,15 10.720,88 ................................................................... .................................................................. .................................................................. ................................................................... ................................................................... ................................................................... ................................................................... ................................................................... ................................................................... ................................................................... ................................................................... 44/47

N°. 0817.149.675 NYXOAH C-c 10 Codes 1. Full-time 3. Total in full-time equivalents 2. Part-time At the closing date of the period Number of employees By nature of the employment contract Contract for an indefinite period ....................................... Contract for a definite period ............................................ Contract for the execution of a specifically assigned work .. Replacement contract ...................................................... According to gender and study level By professional category 105 110 111 112 120 113 121 133 130 134 132 33 2 34,0 33 2 34,0 14 19 1 32 2 15,0 19,0 2 1,0 33,0 .......................................................... .................................. primary education ...................................................... secondary education .................................................. higher non-university education ................................. university education ................................................... 1200 1201 1202 1203 1 4 9 2 1,0 4,0 10,0 primary education ...................................................... secondary education .................................................. higher non-university education ................................. university education ................................................... 1210 1211 1212 1213 1 5 3 10 1,0 5,0 3,0 10,0 Management staff ............................................................................... Salaried employees ....................................................................... Hourly employees ........................................................................ Other ............................................................................... Men ................................................................................... Women ............................................................................. HIRED TEMPORARY STAFF AND PERSONNEL PLACED AT THE DISPOSAL OF THE COMPANY Codes 1. Hired temporary staff 2. Hired temporary staff and personnel placed at the company’s disposal During the period Average number of persons employed Number of actual hours worked Costs to the company 0,5 853 34.716,61 150 151 152 ................................................................... ......................... .............................................................................. .............. ........................................................................................... EMPLOYEES FOR WHOM THE COMPANY SUBMITTED A DIMONA DECLARATION OR WHO ARE RECORDED IN THE GENERAL PERSONNEL REGISTER (continuation) 45/47

N°. 0817.149.675 NYXOAH C-c 10 LIST OF PERSONNEL MOVEMENTS DURING THE PERIOD ENTRIES Codes 1. Full-time 3. Total in full-time equivalents 2. Part-time By nature of the employment contract 17 14 3 2 1 1 18,6 14,8 3,8 205 210 211 212 213 Contract for the execution of a specifically assigned work ................................................................................. Replacement contract ................................................................................. Contract for a definite period .................................................................................... Number of employees for whom the company submitted a DIMONA declaration or who have been recorded in the general personnel register during the period ....................................................................................................... Contract for an indefinite period ...................................................................................... DEPARTURES 1. Full-time Codes 2. Part-time 3. Total in full-time equivalents Number of employees whose contract-termination date has been included in the DIMONA declaration or in the general personnel register during the period By nature of the employment contract By reason of termination of contract 6 3 3 2 1 1 7,2 3,8 3,4 1 5 1 1 1,8 5,4 310 305 311 312 313 340 341 342 343 350 ...................... ...................... ....... Retirement ............................................................................. Unemployment with extra allowance from enterprise ........................................................................ Dismissal ............................................................................. Other reason ........................................................................ Of which: the number of persons who continue to render services to the company at least half-time on a self-employment basis ................................. Contract for an indefinite period ............................................................................. Contract for a definite period ........................................................................ Contract for the execution of a specifically assigned work . Replacement contract ........................................................................ 46/47

N°. 0817.149.675 NYXOAH C-c 10 INFORMATION ON TRAINING PROVIDED TO EMPLOYEES DURING THE PERIOD Codes Men Codes Women 5802 5801 5803 5811 5812 5813 58031 58032 58033 58131 58132 58133 5821 5822 5823 5841 5842 5843 5831 5832 5833 5851 5852 5853 Number of employees involved ..................................................................... Total of initiatives of formal professional training at the expense of the employer Number of actual training hours .................................................................. Net costs for the company ............................................................................ of which gross costs directly linked to training ............................................................................... of which contributions paid and payments to collective funds ............................................................................... of which grants and other financial advantages received (to deduct) ............................................................................... Total of initiatives of less formal or informal professional training at the expense of the employer Total of initial initiatives of professional training at the expense of the employer Number of employees involved ..................................................................... Number of actual training hours .................................................................. Net costs for the company ............................................................................ Number of employees involved ..................................................................... Number of actual training hours .................................................................. Net costs for the company .............................................................................. 47/47

Nyxoah (NYXH) 6-KCurrent report (foreign)