Exhibit 21 - MERCK & CO., INC. SUBSIDIARIES
changes as of 12/31/2022
The following is a list of subsidiaries of the Company, doing business under the name stated.
| | | | | |
| Name | Country or State of Incorporation |
| 7728026 Canada Inc. | Canada |
| Abmaxis Inc. | Delaware |
| Acceleron Pharma Inc. | Delaware |
| Afferent Pharmaceuticals, Inc. | Delaware |
| Agrident GmbH | Germany |
| Agro Verhen B.V. | Netherlands |
| Aleis Pty Ltd | Australia |
| Allflex Argentina S.A. | Argentina |
| Allflex Australia Pty. Ltd. | Australia |
| Allflex dan-mark ApS | Denmark |
| Allflex Europe Holdings 1 B.V. | Netherlands |
| Allflex Europe Holdings 2 B.V. | Netherlands |
| Allflex Europe Holdings 3 B.V. | Netherlands |
| | | | | |
| Allflex Europe S.A.S. | France |
| Allflex Group Germany GmbH | Germany |
| Allflex Holdings 1 Inc. | Delaware |
| Allflex Holdings 2 Inc. | Delaware |
| Allflex Holdings 3 Inc. | Delaware |
| Allflex India Private Limited | India |
| Allflex International do Brasil Ltda. | Brazil |
| Allflex Maroc S.A.R.L. | Morocco |
| Allflex New Zealand Limited | New Zealand |
| Allflex Polska Spolka z ograniczona odpowiedzialnoscia | Poland |
| Allflex SCR Vostok | Belarus |
| Allflex Services S.A.R.L. | France |
| Allflex UK Group Limited | United Kingdom |
| Allflex USA, LLC | Delaware |
| Antelliq Finance, Inc. | Delaware |
| Antelliq Holdings France S.A.S | France |
| Antimicrobial Stewardship LLC | Delaware |
| | | | | |
| ArQule, Inc. | Delaware |
| Beijing Allflex Plastic Products Co. Ltd | China |
| Beijing Protection Science & Technology Co., Ltd. | China |
| Biomark LLC | Idaho |
| BRC Ltd. | Bermuda |
| Burgwedel Biotech GmbH | Germany |
| Calporta Therapeutics, Inc. | Delaware |
| Cambridge Resonant Technologies Ltd | United Kingdom |
| Canji, Inc. | Delaware |
| cCam Biotherapeutics Ltd. | Israel |
| Cherokee Pharmaceuticals LLC | Delaware |
| Chevillot S.A.S. | France |
| Controladora MSD Mexicana Sociedad de Responsabilidad Limitada de Capital Variable | Mexico |
| Cooper Veterinary Products (Proprietary) Limited | South Africa |
| Corporation Allflex, Inc. | Canada |
| Cosmas B.V. | Netherlands |
| Cubist Pharmaceuticals LLC | Delaware |
| | | | | |
| Dialstat Trading 91 Pty Ltd T/A Allflex SA | South Africa |
| Digital Angel S.A. | Argentina |
| Diosynth France S.A.S. | France |
| Diosynth Holding B.V. | Netherlands |
| Diosynth Produtos Farmo-quimicos Ltda. | Brazil |
| Drovers ID Pty Ltd | Australia |
| DSD Holding ApS | Denmark |
| Elastec S.R.L | Argentina |
| Essex Pharmaceuticals, Inc. | Philippines |
| Essexfarm, S.A. | Ecuador |
| Farmacox - Companhia Farmaceutica, Lda | Portugal |
| Farmasix-Produtos Farmaceuticos, Lda | Portugal |
| Financiere MSD | France |
| Fontelabor-Produtos Farmaceuticos, Lda. | Portugal |
| Frosst Laboratories, Inc. | Delaware |
| Frosst Portuguesa - Produtos Farmaceuticos, Lda. | Portugal |
| Global Farm S.A. | Argentina |
| | | | | |
| GlycoFi, Inc. | Delaware |
Hangzhou MSD Pharmaceutical Co., Ltd.1 | China |
| Harrisvaccines LLC | Iowa |
| Hawk and Falcon L.L.C. | Delaware |
| Healthcare Services and Solutions, LLC | Delaware |
| Heptafarma Companhia Farmaceutica, Lda | Portugal |
| Hydrochemie GmbH | Germany |
| Idenix GmbH | Switzerland |
| IdentiGEN Canada Ltd. | Canada |
| IdentiGEN Deutschland GmbH | Germany |
| IdentiGEN Limited | Ireland |
| IdentiGEN North America Inc. | Delaware |
| IdentiGEN Switzerland AG | Switzerland |
| Immune Design Corp. | Delaware |
| International Indemnity Ltd. | Bermuda |
| Intervet (Ireland) Limited | Ireland |
| Intervet (Israel) Ltd. | Israel |
| | | | | |
| Intervet (M) Sdn. Bhd. | Malaysia |
| Intervet (Proprietary) Limited | South Africa |
| Intervet (Thailand) Ltd. | Thailand |
| Intervet AB | Sweden |
| Intervet Agencies B.V. | Netherlands |
| Intervet Animal Health Taiwan Limited | China |
| Intervet Argentina S.A. | Argentina |
| Intervet Australia Pty Limited | Australia |
| Intervet Canada Corp. | Canada |
| Intervet Central America S. de R.L. | Panama |
| Intervet Deutschland GmbH | Germany |
| Intervet Ecuador S.A. | Ecuador |
| Intervet Egypt for Animal Health SAE | Egypt |
| Intervet GesmbH | Austria |
| Intervet Hellas A.E. | Greece |
| Intervet Holding B.V. | Netherlands |
| Intervet Holdings France SAS | France |
| | | | | |
| Intervet Hungaria Értékesítő Kft | Hungary |
| Intervet Inc. | Delaware |
| Intervet India Pvt Limited | India |
| Intervet International B.V. | Netherlands |
| Intervet International GmbH | Germany |
| Intervet International Sarl | France |
| Intervet LLC | Russian Federation |
| Intervet Maroc S.A. | Morocco |
| Intervet Mexico S.A. de C.V. | Mexico |
| Intervet Middle East Limited | Cyprus |
| Intervet Nederland B.V. | Netherlands |
| Intervet Philippines, Inc. | Philippines |
| Intervet Productions S.A. | France |
| Intervet Productions S.r.l. | Italy |
| Intervet Romania SRL | Romania |
| Intervet S.A. | Peru |
| Intervet SAS | France |
| | | | | |
| Intervet Schering-Plough Animal Health Pty. Ltd. | Australia |
| Intervet South Africa (Proprietary) Limited | South Africa |
| Intervet Sp. z.o.o. | Poland |
| Intervet UK Production Limited | United Kingdom |
| Intervet Venezolana S.A. | Venezuela |
| Intervet Veterinaria Chile Ltda | Chile |
| Intervet Veteriner Ilaclari Pazarlama ve Ticaret Ltd. Sirketi | Turkey |
| Intervet, s.r.o. | Czech Republic |
| Interveterinaria SA de CV | Mexico |
| IOmet Pharma Limited | United Kingdom |
| Laboratoires Merck Sharp & Dohme | France |
| Laboratorios Abello, S.A. | Spain |
| Laboratorios Quimico-Farmaceuticos Chibret, Lda | Portugal |
| Lemifar S. A. | Uruguay |
Matsuken Yakuhin Kogyo K.K.1 | Japan |
| Maya Tibbi Ürünler Ticaret Limited Sirketi | Turkey |
MCM Vaccine B.V.1 | Netherlands |
| | | | | |
| Merck and Company LLC | Delaware |
| Merck Canada Inc. | Canada |
Merck Capital Ventures, LLC1 | Delaware |
| Merck Frosst Canada & Co. | Canada |
| Merck Frosst Company | Canada |
| Merck Global Health Innovation Fund, LLC | Delaware |
| Merck Global Health Innovation, Private Equity, LLC | Delaware |
| Merck HDAC Research, LLC | Delaware |
| Merck Holdings II Corp. | Delaware |
| Merck Holdings IV Corp. | Delaware |
| Merck Holdings LLC | Delaware |
| Merck International Holdings Corp. | Delaware |
Merck Lumira Biosciences Fund L.P.1 | Canada |
| Merck Registry Holdings, Inc. | New Jersey |
| Merck Research Investments LLC | Delaware |
| Merck Research Laboratories Massachusetts, LLC | Delaware |
| Merck Sharp & Dohme (Argentina) LLC | Delaware |
| | | | | |
| Merck Sharp & Dohme (Asia) Limited | Hong Kong |
| Merck Sharp & Dohme (Australia) Pty. Limited | Australia |
| Merck Sharp & Dohme (Chile) Ltda. | Chile |
| Merck Sharp & Dohme (China) Limited | Hong Kong |
| Merck Sharp & Dohme (Enterprises) B.V. | Netherlands |
| Merck Sharp & Dohme (Europe) Inc. | Delaware |
| Merck Sharp & Dohme (Holdings) Pty Ltd | Australia |
| Merck Sharp & Dohme (I.A.) LLC | Delaware |
| Merck Sharp & Dohme (International) Limited | Bermuda |
| Merck Sharp & Dohme (Israel - 1996) Company Ltd. | Israel |
| Merck Sharp & Dohme (Malaysia) SDN. BHD. | Malaysia |
| Merck Sharp & Dohme (New Zealand) Limited | New Zealand |
| Merck Sharp & Dohme (Sweden) A.B. | Sweden |
| Merck Sharp & Dohme (Switzerland) GmbH | Switzerland |
| Merck Sharp & Dohme (UK) Limited | United Kingdom |
| Merck Sharp & Dohme Animal Health, S.L. | Spain |
| Merck Sharp & Dohme Asia Pacific Services Pte. Ltd. | Singapore |
| | | | | |
| Merck Sharp & Dohme B.V. | Netherlands |
| Merck Sharp & Dohme BH d.o.o. | Bosnia |
| Merck Sharp & Dohme Bulgaria EOOD | Bulgaria |
| Merck Sharp & Dohme Colombia S.A.S. | Colombia |
| Merck Sharp & Dohme Comercializadora, S. de R.L. de C.V. | Mexico |
| Merck Sharp & Dohme Cyprus Limited | Cyprus |
| Merck Sharp & Dohme d.o.o. | Croatia |
| Merck Sharp & Dohme d.o.o. Belgrade | Serbia |
| Merck Sharp & Dohme de Espana SAU | Spain |
| Merck Sharp & Dohme Farmaceutica Ltda. | Brazil |
| Merck Sharp & Dohme Finance Europe Limited | United Kingdom |
| Merck Sharp & Dohme Gesellschaft m.b.H. | Austria |
| Merck Sharp & Dohme Holdings Corp. | Delaware |
| Merck Sharp & Dohme IDEA GmbH | Switzerland |
| Merck Sharp & Dohme inovativna zdravila d.o.o. | Slovenia |
| Merck Sharp & Dohme International Services B.V. | Netherlands |
| Merck Sharp & Dohme Ireland (Human Health) Ltd | Ireland |
| | | | | |
| Merck Sharp & Dohme Latvija | Latvia |
| Merck Sharp & Dohme Limitada | Bolivia |
| Merck Sharp & Dohme LLC | New Jersey |
| Merck Sharp & Dohme Manufacturing Unlimited Company | Ireland |
| Merck Sharp & Dohme OU | Estonia |
| Merck Sharp & Dohme Peru SRL | Peru |
| Merck Sharp & Dohme Pharmaceutical Industrial and Commercial Societe Anonyme | Greece |
| Merck Sharp & Dohme Research GmbH | Switzerland |
| Merck Sharp & Dohme Romania SRL | Romania |
| Merck Sharp & Dohme S.A. | Morocco |
| Merck Sharp & Dohme s.r.o. | Czech Republic |
| Merck Sharp & Dohme Salud Animal Colombia S.A.S. | Colombia |
| Merck Sharp & Dohme Saude Animal Ltda. | Brazil |
| Merck Sharp & Dohme Singapore Trading Pte. Ltd. | Singapore |
| Merck Sharp & Dohme Tunisie SARL | Tunisia |
| Merck Sharp & Dohme, Limitada | Portugal |
| Merck Sharp & Dohme, S. de R.L. de C.V. | Mexico |
| | | | | |
| Merck Sharp & Dohme, s.r.o. | Slovakia |
| Merck Sharp Dohme Ilaclari Limited Sirketi | Turkey |
| Merck Teknika LLC | Delaware |
| Merko Acquisition S.A. | Belgium |
| Merko Dalton B.V. | Netherlands |
| Merko N.V. | Belgium |
| ML Holdings (Canada) Inc. | Canada |
| MRL San Francisco, LLC | Delaware |
| MRL Ventures Fund LLC | Delaware |
| MSD (I.A.) B.V. | Netherlands |
| MSD (L-SP) Unterstützungskasse GmbH | Germany |
| MSD (Ningbo) Animal Health Technology Co., Ltd. | China |
| MSD (Nippon Holdings) B.V. | Netherlands |
| MSD (Norge) AS | Norway |
| MSD (Proprietary) Limited | South Africa |
| MSD (Shanghai) Pharmaceuticals Consultancy Co., Ltd. | China |
| MSD (Thailand) Ltd. | Thailand |
| | | | | |
| MSD Agencies B.V. | Netherlands |
| MSD Animal Health UK Limited | United Kingdom |
| MSD Animal Health (Phils.), Inc | Philippines |
| MSD Animal Health (Shanghai) Trading Co., Ltd. | China |
| MSD Animal Health A/S | Denmark |
| MSD Animal Health B.V. | Belgium |
| MSD Animal Health Danube Biotech GmbH | Austria |
| MSD Animal Health FZ-LLC | United Arab Emirates |
| MSD Animal Health GmbH | Switzerland |
| MSD Animal Health Holdings BV | Netherlands |
| MSD Animal Health Innovation AS | Norway |
| MSD Animal Health Innovation GmbH | Germany |
| MSD Animal Health Innovation Pte. Ltd. | Singapore |
| MSD Animal Health Innovation SAS | France |
| MSD Animal Health K.K. | Japan |
| MSD Animal Health Korea Ltd. | Korea |
| MSD Animal Health Norge AS | Norway |
| | | | | |
| MSD Animal Health Oy | Finland |
| MSD Animal Health Pension Trustee Limited | United Kingdom |
| MSD Animal Health S.r.l. | Italy |
| MSD Animal Health Vietnam Co. Limited | Vietnam |
| MSD Animal Health, Lda. | Portugal |
| MSD Argentina Holdings B.V. | Netherlands |
| MSD Argentina SRL | Argentina |
| MSD Asia Holdings Pte. Ltd. | Singapore |
| MSD Belgium BV – SRL | Belgium |
| MSD Biotech B.V. | Netherlands |
| MSD Brazil Investments B.V. | Netherlands |
| MSD Central America Services S. de R.L. | Panama |
| MSD China (Investments) B.V. | Netherlands |
| MSD China B.V. | Netherlands |
| MSD China Holding Co., Ltd. | China |
| MSD Cubist Holdings BV | Switzerland |
| MSD Cubist Holdings Unlimited Company | Ireland |
| | | | | |
| MSD Czech Republic s.r.o. | Czech Republic |
| MSD Danmark ApS | Denmark |
| MSD Egypt LLC | Egypt |
| MSD EIC Unlimited Company | Ireland |
| MSD Eurofinance | Bermuda |
| MSD Europe Belgium BV | Belgium |
| MSD Farmaceutica C.A. | Venezuela |
| MSD FI BV | Netherlands |
| MSD Finance B.V. | Netherlands |
| MSD Finance Company | Bermuda |
| MSD Finland Oy | Finland |
| MSD France | France |
| MSD Global Holdings B.V. | Netherlands |
| MSD HH Vietnam Ltd | Vietnam |
| MSD Holdings 2 G.K. | Japan |
| MSD Human Health Holding B.V. | Netherlands |
| MSD Human Health Holding II B.V. | Netherlands |
| | | | | |
| MSD IDEA Algerie SPA | Algeria |
| MSD IDEA Pharmaceuticals Nigeria Limited | Nigeria |
| MSD IDEA Tunisie SARL | Tunisia |
| MSD Innovation & Development GmbH | Switzerland |
| MSD International B.V. | Netherlands |
| MSD International Business GmbH | Switzerland |
| MSD International Finance B.V. | Netherlands |
| MSD International Finance LLC | Delaware |
| MSD International GmbH | Switzerland |
| MSD International Manufacturing GmbH | Switzerland |
| MSD Italia s.r.l. | Italy |
| MSD Japan Holdings B.V. | Netherlands |
| MSD Japan Holdings GK | Japan |
| MSD K.K. | Japan |
| MSD KSA GmbH | Switzerland |
| MSD Korea Co., Ltd. | Korea |
| MSD Laboratories India LLC | Delaware |
| | | | | |
| MSD Latin America Services S. de R.L. | Panama |
| MSD Latin America Services S. de R.L. de C.V. | Mexico |
| MSD Limited | United Kingdom |
| MSD Luxembourg S.a.r.l. | Luxembourg |
| MSD Merck Sharp & Dohme AG | Switzerland |
| MSD NL 4 B.V. | Netherlands |
| MSD Panama International Services S. de R.L. | Panama |
| MSD Participations B.V. | Netherlands |
| MSD Pharma (Singapore) Pte. Ltd. | Singapore |
| MSD Pharma GmbH | Germany |
| MSD Pharma Hungary Korlatolt Felelossegu Tarsasag | Hungary |
| MSD Pharmaceuticals Investments 1 Unlimited Company | Ireland |
| MSD Pharmaceuticals Investments 3 Unlimited Company | Ireland |
| MSD Pharmaceuticals Ireland Unlimited Company | Ireland |
| MSD Pharmaceuticals LLC | Russian Federation |
| MSD Pharmaceuticals Private Limited | India |
| MSD Polska Dystrybucja Sp. z.o.o. | Poland |
| | | | | |
| MSD Polska Sp.z.o.o. | Poland |
| MSD R&D (China) Co., Ltd. | China |
| MSD R&D Innovation Centre Limited | United Kingdom |
| MSD RDC Costa Rica Sociedad de Responsabilidad Limitada | Cost Rica |
| MSD Registry Holdings, Inc. | New Jersey |
| MSD Shared Business Services EMEA Limited | Ireland |
| MSD Sharp & Dohme Gesellschaft mit beschränkter Haftung | Germany |
| MSD Switzerland Investments 1 Unlimited Company | Ireland |
| MSD Switzerland Investments 4 Unlimited Company | Ireland |
| MSD Switzerland Investments 5 Unlimited Company | Ireland |
| MSD Ukraine Limited Liability Company | Ukraine |
| MSD Unterstutzungskasse GmbH | Germany |
| MSD Vaccines Limited | United Kingdom |
| MSD Vaccins | France |
| MSD Vaccins Holdings | France |
| MSD Venezuela Holding GmbH | Switzerland |
| MSD Verwaltungs GmbH | Germany |
| | | | | |
| MSD Vietnam Company Limited | Vietnam |
| MSD Vietnam Holdings B.V. | Netherlands |
| MSDIG Holdings Unlimited Company | Ireland |
| MSDRG LLC | Delaware |
| MSP Singapore Company, LLC | Delaware |
MSP Vaccine Company1 | Pennsylvania |
| Multilan AG | Switzerland |
| Nanjing Organon Pharmaceutical Co., Ltd. | China |
| Nihon MSD G.K. | Japan |
| Nourifarma - Produtos Quimicos e Farmaceuticos, Sociedade Uniperssoal, Lda | Portugal |
| O.PI.VI S.R.L. | Italy |
| OBS Holdings B.V. | Netherlands |
| Oncoethix GmbH | Switzerland |
| OncoImmune, Inc. | Delaware |
| Organon China B.V. | Netherlands |
| Organon Egypt Ltd | Egypt |
| Organon Latin America S.A. | Uruguay |
| | | | | |
| Organon Middle East S.A.L. | Lebanon |
| OS ID AS | Norway |
| OS ID Hellas M.I.K.E | Greece |
| P.T. Merck Sharp & Dohme Indonesia | Indonesia |
| Pandion Therapeutics, Inc. | Delaware |
| Pandion Operations, Inc. | Delaware |
| Peloton Therapeutics, Inc. | Delaware |
| Polnet ID Spolka z ograniczona odpowiedzialnoscia | Poland |
| PrognostiX-Poultry Limited | United Kingdom |
| Prondil Sociedad Anónima | Uruguay |
| PT Intervet Indonesia | Indonesia |
| PT Organon Indonesia | Indonesia |
| Putexin Investments Limited | New Zealand |
| Rigontec GmbH | Germany |
| Rosetta Inpharmatics LLC | Delaware |
| S.C. Allflex Romania S.R.L. | Romania |
| S.C.R. (Engineers) Limited | Israel |
| | | | | |
| Schering-Plough, S.A.S. | France |
| Schering-Plough (Ireland) Unlimited Company | Ireland |
| Schering-Plough Animal Health Limited | New Zealand |
| Schering-Plough Canada Inc. | Canada |
| Schering-Plough Corporation | Philippines |
| Schering-Plough Corporation, U.S.A. | Delaware |
| Schering-Plough del Peru S.A. | Peru |
| Schering-Plough Holdings Limited | United Kingdom |
| Schering-Plough S.A. | Panama |
| Schering-Plough S.A. | Paraguay |
| Schering-Plough S.A. | Spain |
| Schering-Plough S.A. | Uruguay |
| SCR Allflex Management, Ltd | Israel |
| Sentipharm AG | Switzerland |
| Servicios Veternarios Servet, Sociedad Anónima | Costa Rica |
| Shanghai MSD Pharmaceutical Trading Co., Ltd. | China |
| Siren Merger Sub Inc. | Delaware |
| | | | | |
| Sistemas de Identificacao Animal Ltda | Brazil |
| SmartCells, Inc. | Delaware |
| SOL Limited | Bermuda |
| Stallmastaren AB | Sweden |
| SureFlap (NZ) Limited | New Zealand |
| SureFlap Limited | United Kingdom |
| Tag ID Investments, Inc. | Delaware |
| Themis Bio Holdings LLC | Delaware |
| Themis Bio Holdings B.V. | Netherlands |
| Themis BioScience GmbH | Austria |
| Theriak B.V. | Netherlands |
| Tilos Therapeutics, Inc. | Delaware |
| UAB Merck Sharp & Dohme | Lithuania |
| Vaki Aquaculture Systems ehf. | Iceland |
| VelosBio Inc. | Delaware |
| VelosBio Canada Inc. | Canada |
| Vence Corp | Delaware |
| | | | | |
| Vence Corp AU Pty Ltd | Australia |
| Venco Farmaceutica S.A. | Venezuela |
| Venco Holding GmbH | Switzerland |
| Vet Pharma Friesoythe GmbH | Germany |
| Veterinaria Premium, Sociedad Anonima | Guatemala |
| VetInvent, LLC | Delaware |
| Vetrex B.V. | Netherlands |
| Vetrex Egypt L.L.C. | Egypt |
| Vilsan Veteriner Ilaclari Ticaret ve Sanayi Anonim Sirketi | Turkey |
| Viralytics Limited | Australia |
| Vocaltag Limited | Israel |
| Vree Health Italia S.r.l. | Italy |
| Werthenstein Biopharma GmbH | Switzerland |
| Zoöpharm B.V. | Netherlands |
___________
1 own less than 100%
