2
a
a
Country
Shares
a
Value
a
a
a
a
a
a
Common
Stocks
96.4%
Biotechnology
80.0%
a
89bio,
Inc.
...........................................
United
States
284,400
$
6,586,704
a
ACADIA
Pharmaceuticals,
Inc.
...........................
United
States
294,600
13,684,170
a
Acceleron
Pharma,
Inc.
.................................
United
States
158,700
16,596,846
a,b
ADMA
Biologics,
Inc.
...................................
United
States
437,264
870,155
a,b
Akouos
,
Inc.
.........................................
United
States
157,600
3,059,016
a
Albireo
Pharma,
Inc.
...................................
United
States
102,400
3,231,744
a
Alector
,
Inc.
..........................................
United
States
331,600
3,120,356
a
Alexion
Pharmaceuticals,
Inc.
............................
United
States
260,000
29,936,400
a
Alnylam
Pharmaceuticals,
Inc.
............................
United
States
52,300
6,431,331
a
ALX
Oncology
Holdings,
Inc.
.............................
United
States
86,100
3,401,811
Amgen,
Inc.
.........................................
United
States
318,700
69,138,778
a,b
Applied
Molecular
Transport,
Inc.
.........................
United
States
59,800
1,757,522
a
Applied
Therapeutics,
Inc.
...............................
United
States
154,857
2,519,523
a
Arcus
Biosciences,
Inc.
.................................
United
States
311,000
6,779,800
a
Argenx
SE,
ADR
......................................
Netherlands
57,325
14,224,052
a
Ascendis
Pharma
A/S,
ADR
.............................
Denmark
214,400
35,022,240
a
Assembly
Biosciences,
Inc.
..............................
United
States
381,295
5,620,288
a
Athenex
,
Inc.
.........................................
United
States
406,200
4,630,680
a
Autolus
Therapeutics
plc,
ADR
...........................
United
Kingdom
232,430
2,512,568
a
Biogen,
Inc.
.........................................
United
States
159,875
40,299,691
a
BioMarin
Pharmaceutical,
Inc.
............................
United
States
142,456
10,603,000
a
Black
Diamond
Therapeutics,
Inc.
.........................
United
States
127,800
4,026,978
a
Bluebird
Bio,
Inc.
......................................
United
States
30,900
1,597,839
a
Blueprint
Medicines
Corp.
...............................
United
States
117,200
11,987,216
a,b
Bridgebio
Pharma,
Inc.
.................................
United
States
118,800
4,559,544
a
Cardiff
Oncology,
Inc.
..................................
United
States
174,312
2,757,616
a
Codiak
Biosciences,
Inc.
................................
United
States
107,500
926,650
a
CRISPR
Therapeutics
AG
...............................
Switzerland
166,314
15,270,952
a
Deciphera
Pharmaceuticals,
Inc.
..........................
United
States
572,854
33,265,632
c,d
Dyne
Therapeutics,
Inc.
................................
United
States
115,139
2,172,481
a
Dyne
Therapeutics,
Inc.
................................
United
States
100,400
2,076,272
a,b
Equillium
,
Inc.
........................................
United
States
294,800
1,871,980
a
Fate
Therapeutics,
Inc.
.................................
United
States
456,793
20,281,609
a
Forte
Biosciences,
Inc.
.................................
United
States
445,464
16,998,906
Gilead
Sciences,
Inc.
..................................
United
States
1,511,900
87,916,985
a
Global
Blood
Therapeutics,
Inc.
...........................
United
States
391,500
20,702,520
a
Gossamer
Bio,
Inc.
....................................
United
States
361,833
3,003,214
a
Heron
Therapeutics,
Inc.
................................
United
States
1,739,677
28,374,132
a,b
Inhibrx
,
Inc.
..........................................
United
States
84,100
1,433,064
a
Insmed
,
Inc.
.........................................
United
States
890,600
29,336,364
c,d
Intarcia
Therapeutics,
Inc.,
DD
...........................
United
States
80,195
—
a
Iovance
Biotherapeutics
,
Inc.
.............................
United
States
1,502,101
53,594,964
a
iTeos
Therapeutics,
Inc.
................................
United
States
36,700
835,659
a
KalVista
Pharmaceuticals,
Inc.
...........................
United
States
103,300
1,777,793
a
Kezar
Life
Sciences,
Inc.
................................
United
States
853,550
4,370,176
a
Kronos
Bio,
Inc.
......................................
United
States
82,400
2,314,616
a
Legend
Biotech
Corp.,
ADR
.............................
United
States
196,800
5,091,216
a
LogicBio
Therapeutics,
Inc.
..............................
United
States
661,200
3,649,824
c,d
Metacrine
,
Inc.
.......................................
United
States
260,919
2,163,123
a
Metacrine
,
Inc.
.......................................
United
States
251,900
2,292,290
a
Mirati
Therapeutics,
Inc.
................................
United
States
108,715
23,606,375
a
Neurocrine
Biosciences,
Inc.
.............................
United
States
163,800
16,162,146
a,b
Nkarta
,
Inc.
..........................................
United
States
238,955
6,860,398
a
Novavax
,
Inc.
........................................
United
States
360,800
29,120,168
a
PMV
Pharmaceuticals,
Inc.
..............................
United
States
83,100
2,912,655
a
Praxis
Precision
Medicines,
Inc.
..........................
United
States
103,600
3,626,000
a
Protara
Therapeutics,
Inc.
...............................
United
States
145,500
2,610,270
a
PTC
Therapeutics,
Inc.
.................................
United
States
765,900
39,972,321