BlackRock Health Sciences Opportunities Portfolio

Fund Profile

Fund profile

Tickers

SHSSX, SHISX, SHSAX, SHSCX

Fund manager

BlackRock 20/80 Target Allocation Fund, Investor A

Total assets

$8.13 bn

Liabilities

$108.56 mm

Net assets

$8.02 bn

Number of holdings

140.00

140 Holdings

As of Nov 2024

Security	$Holding	Balance	% of Fund	Category	Position	Country
UNH UnitedHealth Group Incorporated	725.57 mm	1.19 mm shares	9.04	Common equity	Long	USA
LLY Eli Lilly and Company	703.81 mm	884.90 k shares	8.77	Common equity	Long	USA
BSX Boston Scientific Corporation	554.85 mm	6.12 mm shares	6.91	Common equity	Long	USA
ISRG Intuitive Surgical, Inc.	395.06 mm	728.89 k shares	4.92	Common equity	Long	USA
ABBV AbbVie Inc.	345.57 mm	1.89 mm shares	4.31	Common equity	Long	USA
ABT Abbott Laboratories	302.86 mm	2.55 mm shares	3.77	Common equity	Long	USA
SYK Stryker Corporation	263.63 mm	672.26 k shares	3.29	Common equity	Long	USA
DHR Danaher Corporation	260.66 mm	1.09 mm shares	3.25	Common equity	Long	USA
TMO Thermo Fisher Scientific Inc.	222.98 mm	421.01 k shares	2.78	Common equity	Long	USA
AMGN Amgen Inc.	203.56 mm	719.63 k shares	2.54	Common equity	Long	USA
GILD Gilead Sciences, Inc.	193.39 mm	2.09 mm shares	2.41	Common equity	Long	USA
VRTX Vertex Pharmaceuticals Incorporated	182.18 mm	389.17 k shares	2.27	Common equity	Long	USA
JNJ Johnson & Johnson	177.40 mm	1.14 mm shares	2.21	Common equity	Long	USA
Cigna Holding Co	173.11 mm	512.48 k shares	2.16	Common equity	Long	USA
ARGX argenx SE	136.59 mm	221.54 k shares	1.70	Common equity	Long	Netherlands
ELV Elevance Health Inc.	131.58 mm	323.32 k shares	1.64	Common equity	Long	USA
ALNY Alnylam Pharmaceuticals, Inc.	124.21 mm	490.80 k shares	1.55	Common equity	Long	USA
MRK Merck & Co., Inc.	116.76 mm	1.15 mm shares	1.46	Common equity	Long	USA
BLACKROCK LIQUIDITY FUNDS T-FUND PORTFOLIO	116.40 mm	116.40 mm shares	1.45	Short-term investment vehicle	Long	USA
MCK McKesson Corporation	106.60 mm	169.61 k shares	1.33	Common equity	Long	USA
BDX Becton, Dickinson and Company	102.22 mm	460.64 k shares	1.27	Common equity	Long	USA
EW Edwards Lifesciences Corporation	100.58 mm	1.41 mm shares	1.25	Common equity	Long	USA
ZTS Zoetis Inc.	97.64 mm	557.15 k shares	1.22	Common equity	Long	USA
COR Cencora	94.85 mm	377.05 k shares	1.18	Common equity	Long	USA
BlackRock Cash Funds - Institutional	90.25 mm	90.20 mm shares	1.12	Short-term investment vehicle	Long	USA
MDT Medtronic plc	86.73 mm	1.00 mm shares	1.08	Common equity	Long	Ireland
GEHC GE HealthCare Technologies Inc.	85.66 mm	1.03 mm shares	1.07	Common equity	Long	USA
PFE Pfizer Inc.	79.61 mm	3.04 mm shares	0.99	Common equity	Long	USA
REGN Regeneron Pharmaceuticals, Inc.	76.05 mm	101.37 k shares	0.95	Common equity	Long	USA
HUM Humana Inc.	75.84 mm	255.89 k shares	0.95	Common equity	Long	USA
BIIB Biogen Inc.	72.38 mm	450.62 k shares	0.90	Common equity	Long	USA
WAT Waters Corporation	68.88 mm	179.04 k shares	0.86	Common equity	Long	USA
COO The Cooper Companies, Inc.	67.72 mm	648.30 k shares	0.84	Common equity	Long	USA
NTRA Natera, Inc.	63.55 mm	378.78 k shares	0.79	Common equity	Long	USA
SRPT Sarepta Therapeutics, Inc.	63.40 mm	475.46 k shares	0.79	Common equity	Long	USA
DXCM DexCom, Inc.	63.21 mm	810.44 k shares	0.79	Common equity	Long	USA
SAN Banco Santander, S.A.	58.39 mm	601.22 k shares	0.73	Common equity	Long	France
ROG Rogers Corporation	56.23 mm	193.52 k shares	0.70	Common equity	Long	Switzerland
AZN AstraZeneca PLC	47.08 mm	347.84 k shares	0.59	Common equity	Long	UK
INSM Insmed Incorporated	46.69 mm	621.16 k shares	0.58	Common equity	Long	USA
WST West Pharmaceutical Services, Inc.	45.98 mm	141.19 k shares	0.57	Common equity	Long	USA
RYTM Rhythm Pharmaceuticals, Inc.	42.83 mm	690.35 k shares	0.53	Common equity	Long	USA
PEN Penumbra, Inc.	41.26 mm	169.04 k shares	0.51	Common equity	Long	USA
IDXX IDEXX Laboratories, Inc.	38.31 mm	90.83 k shares	0.48	Common equity	Long	USA
NUVL Nuvalent, Inc.	37.21 mm	384.89 k shares	0.46	Common equity	Long	USA
BPMC Blueprint Medicines Corporation	35.37 mm	366.99 k shares	0.44	Common equity	Long	USA
STE STERIS plc	29.15 mm	133.06 k shares	0.36	Common equity	Long	USA
A Agilent Technologies, Inc.	29.04 mm	210.46 k shares	0.36	Common equity	Long	USA
GKOS Glaukos Corporation	28.64 mm	199.36 k shares	0.36	Common equity	Long	USA
RGEN Repligen Corporation	28.56 mm	189.70 k shares	0.36	Common equity	Long	USA
HCA HCA Healthcare, Inc.	27.87 mm	85.17 k shares	0.35	Common equity	Long	USA
Novo Nordisk A/S	27.08 mm	252.67 k shares	0.34	Common equity	Long	Denmark
EXAS Exact Sciences Corporation	26.84 mm	432.37 k shares	0.33	Common equity	Long	USA
DGX Quest Diagnostics Incorporated	26.44 mm	162.54 k shares	0.33	Common equity	Long	USA
ALGN Align Technology, Inc.	26.19 mm	112.52 k shares	0.33	Common equity	Long	USA
ACLX Arcellx, Inc.	24.86 mm	282.23 k shares	0.31	Common equity	Long	USA
UCB United Community Banks, Inc.	22.91 mm	116.82 k shares	0.29	Common equity	Long	Belgium
LH Laboratory Corporation of America Holdings	22.66 mm	93.97 k shares	0.28	Common equity	Long	USA
XENE Xenon Pharmaceuticals Inc.	20.97 mm	491.96 k shares	0.26	Common equity	Long	Canada
ONC BeiGene, Ltd.	20.83 mm	96.87 k shares	0.26	Common equity	Long	USA
PCVX Vaxcyte, Inc.	20.58 mm	218.16 k shares	0.26	Common equity	Long	USA
MTD Mettler-Toledo International Inc.	20.28 mm	16.20 k shares	0.25	Common equity	Long	USA
BMRN BioMarin Pharmaceutical Inc.	19.43 mm	294.33 k shares	0.24	Common equity	Long	USA
IQV IQVIA Holdings Inc.	18.64 mm	92.79 k shares	0.23	Common equity	Long	USA
NBIX Neurocrine Biosciences, Inc.	17.89 mm	141.17 k shares	0.22	Common equity	Long	USA
ASND Ascendis Pharma A/S	17.68 mm	129.95 k shares	0.22	Common equity	Long	Denmark
TECH Bio-Techne Corporation	17.32 mm	229.86 k shares	0.22	Common equity	Long	USA
INSP Inspire Medical Systems, Inc.	16.17 mm	83.91 k shares	0.20	Common equity	Long	USA
Daiichi Sankyo Co Ltd	16.02 mm	504.50 k shares	0.20	Common equity	Long	Japan
INCY Incyte Corporation	15.87 mm	212.73 k shares	0.20	Common equity	Long	USA
BHVN Biohaven Ltd.	15.54 mm	337.77 k shares	0.19	Common equity	Long	USA
MRUS Merus N.V.	14.11 mm	314.74 k shares	0.18	Common equity	Long	Netherlands
NRIX Nurix Therapeutics, Inc.	13.70 mm	619.56 k shares	0.17	Common equity	Long	USA
PTCT PTC Therapeutics, Inc.	12.62 mm	287.58 k shares	0.16	Common equity	Long	USA
BNTX BioNTech SE	12.40 mm	104.74 k shares	0.15	Common equity	Long	Germany
Zealand Pharma A/S	12.16 mm	117.41 k shares	0.15	Common equity	Long	Denmark
DNLI Denali Therapeutics Inc.	12.14 mm	485.67 k shares	0.15	Common equity	Long	USA
PTGX Protagonist Therapeutics, Inc.	12.05 mm	275.15 k shares	0.15	Common equity	Long	USA
GH Guardant Health, Inc.	12.04 mm	338.16 k shares	0.15	Common equity	Long	USA
RVMD Revolution Medicines, Inc.	11.84 mm	204.58 k shares	0.15	Common equity	Long	USA
STOK Stoke Therapeutics, Inc.	11.74 mm	969.34 k shares	0.15	Common equity	Long	USA
LARONDE INC	10.82 mm	386.52 k shares	0.13	Common equity	Long	USA
RNA Avidity Biosciences, Inc.	10.56 mm	245.37 k shares	0.13	Common equity	Long	USA
DYN Dyne Therapeutics, Inc.	10.33 mm	337.55 k shares	0.13	Common equity	Long	USA
ROIV Roivant Sciences Ltd.	10.08 mm	793.28 k shares	0.13	Common equity	Long	USA
RARE Ultragenyx Pharmaceutical Inc.	9.70 mm	203.61 k shares	0.12	Common equity	Long	USA
SRRK Scholar Rock Holding Corporation	9.48 mm	237.47 k shares	0.12	Common equity	Long	USA
IONS Ionis Pharmaceuticals, Inc.	9.29 mm	259.92 k shares	0.12	Common equity	Long	USA
SLNO Soleno Therapeutics, Inc.	8.87 mm	168.27 k shares	0.11	Common equity	Long	USA
HLXB Helix Acquisition Corp. II	8.86 mm	850.72 k shares	0.11	Common equity	Long	Cayman Islands
LBPH Longboard Pharmaceuticals, Inc.	8.29 mm	138.29 k shares	0.10	Common equity	Long	USA
MLTX MoonLake Immunotherapeutics	7.89 mm	144.88 k shares	0.10	Common equity	Long	Switzerland
BEAM Beam Therapeutics Inc.	7.81 mm	285.43 k shares	0.10	Common equity	Long	USA
KARTOS THERAPEUTICS INC	7.79 mm	1.23 mm shares	0.10	Common equity	Long	USA
NGNE Neurogene Inc.	7.22 mm	284.04 k shares	0.09	Common equity	Long	USA
ADARX PHARMACEUTICALS INC	6.92 mm	769.23 k shares	0.09	Common equity	Long	USA
VKTX Viking Therapeutics, Inc.	6.59 mm	124.54 k shares	0.08	Common equity	Long	USA
NVCR NovoCure Limited	6.53 mm	326.09 k shares	0.08	Common equity	Long	Jersey
QUANTA DIALYSIS TECHNOLOGIES LTD	6.52 mm	80.02 mm shares	0.08	Common equity	Long	UK
GPCR Structure Therapeutics Inc.	6.50 mm	196.10 k shares	0.08	Common equity	Long	USA
IRON Disc Medicine, Inc.	6.42 mm	101.26 k shares	0.08	Common equity	Long	USA
BBIO BridgeBio Pharma, Inc.	6.28 mm	231.97 k shares	0.08	Common equity	Long	USA
LEGN Legend Biotech Corporation	6.17 mm	146.62 k shares	0.08	Common equity	Long	USA
IMCR Immunocore Holdings plc	5.94 mm	181.36 k shares	0.07	Common equity	Long	UK
GENESIS THERAPEUTICS INC	5.19 mm	823.87 k shares	0.06	Common equity	Long	USA
NARI Inari Medical, Inc.	5.06 mm	97.49 k shares	0.06	Common equity	Long	USA
INSITRO INC	5.01 mm	592.64 k shares	0.06	Common equity	Long	USA
CGON CG Oncology, Inc. Common stock	4.62 mm	132.96 k shares	0.06	Common equity	Long	USA
WVE Wave Life Sciences Ltd.	3.98 mm	263.89 k shares	0.05	Common equity	Long	USA
RCKT Rocket Pharmaceuticals, Inc.	3.83 mm	266.18 k shares	0.05	Common equity	Long	USA
EXO IMAGING INC	3.78 mm	1.91 mm shares	0.05	Common equity	Long	USA
ACIU AC Immune SA	3.68 mm	1.08 mm shares	0.05	Common equity	Long	Switzerland
ALLO Allogene Therapeutics, Inc.	3.67 mm	1.48 mm shares	0.05	Common equity	Long	USA
NYXH Nyxoah S.A.	3.39 mm	411.25 k shares	0.04	Common equity	Long	Belgium
TCRX TScan Therapeutics, Inc.	3.25 mm	681.02 k shares	0.04	Common equity	Long	USA
VYGR Voyager Therapeutics, Inc.	3.06 mm	445.89 k shares	0.04	Common equity	Long	USA
AUTL Autolus Therapeutics plc	2.95 mm	889.96 k shares	0.04	Common equity	Long	UK
CELLARITY INC	2.64 mm	858.33 k shares	0.03	Common equity	Long	USA
RGNX REGENXBIO Inc.	2.57 mm	259.10 k shares	0.03	Common equity	Long	USA
IMTX Immatics N.V.	2.49 mm	298.70 k shares	0.03	Common equity	Long	Germany
SEPN Septerna, Inc. Common Stock	2.24 mm	88.76 k shares	0.03	Common equity	Long	USA
SGMT Sagimet Biosciences Inc.	1.72 mm	302.93 k shares	0.02	Common equity	Long	USA
CABA Cabaletta Bio, Inc.	1.60 mm	419.92 k shares	0.02	Common equity	Long	USA
CARBON HEALTH TECHNOLOGIES INC	1.57 mm	1.67 mm shares	0.02	Common equity	Long	USA
OBIO Orchestra BioMed Holdings, Inc.	1.48 mm	262.31 k shares	0.02	Common equity	Long	USA
EXO IMAGING INC	1.45 mm	541.37 k principal	0.02	Debt	Long	USA
GOLDFINCH BIO INC	1.37 mm	3.52 mm shares	0.02	Common equity	Long	USA
Carbon Health Technologies Inc	1.27 mm	1.21 k shares	0.02	Common equity	Long	USA
FDMT 4D Molecular Therapeutics, Inc.	1.27 mm	161.49 k shares	0.02	Common equity	Long	USA
PRME Prime Medicine, Inc.	1.19 mm	360.98 k shares	0.01	Common equity	Long	USA
AFFINIVAX INC	1.16 mm	122.82 k shares	0.01	Common equity	Long	USA
KYTX Kyverna Therapeutics, Inc.	768.81 k	133.24 k shares	0.01	Common equity	Long	USA
CRVO CervoMed Inc.	675.59 k	62.56 k shares	0.01	Common equity	Long	USA
ABIOMED Inc	526.27 k	243.64 k shares	0.01		Long	USA
MRTX Mirati Therapeutics Inc	171.38 k	228.51 k shares	0.00	Common equity	Long	USA
NUVB Nuvation Bio Inc.	12.72 k	77.35 k contracts	0.00	Equity derivative	N/A	USA
CMAXQ CareMax, Inc.	442.16	88.43 k contracts	0.00	Equity derivative	N/A	USA
AFFERENT PHARMACEUTICAL	34.21	3.42 mm shares	0.00	Preferred equity	Long	USA
SWIFT HEALTH SYSTEMS INC	17.00	1.70 mm shares	0.00	Common equity	Long	USA
FREQUENCY THERAPEUTICS CVR	4.28	428.01 k shares	0.00	Common equity	Long	USA