Janus Henderson Global Life Sciences Fund

Fund Profile

Fund profile

Tickers

JAGLX, JFNAX, JFNCX, JFNIX, JFNSX, JNGLX, JFNNX

Fund manager

Janus Henderson Venture Fund Class T

Total assets

$5.73 bn

Liabilities

$5.43 mm

Net assets

$5.73 bn

Number of holdings

114.00

114 Holdings

As of Sep 2024

Security	$Holding	Balance	% of Fund	Category	Position	Country
LLY Eli Lilly and Company	483.98 mm	546.29 k shares	8.45	Common equity	Long	USA
UNH UnitedHealth Group Incorporated	392.60 mm	671.48 k shares	6.85	Common equity	Long	USA
Novo Nordisk A/S SER'B'DKK0.1	265.19 mm	2.26 mm shares	4.63	Common equity	Long	Denmark
AZN AstraZeneca PLC	208.97 mm	1.35 mm shares	3.65	Common equity	Long	UK
ABBV AbbVie Inc.	206.47 mm	1.05 mm shares	3.60	Common equity	Long	USA
AMGN Amgen Inc.	185.50 mm	575.72 k shares	3.24	Common equity	Long	USA
Sanofi EUR2	158.92 mm	1.39 mm shares	2.77	Common equity	Long	France
MRK Merck & Co., Inc.	146.86 mm	1.29 mm shares	2.56	Common equity	Long	USA
BSX Boston Scientific Corporation	144.11 mm	1.72 mm shares	2.52	Common equity	Long	USA
JNJ Johnson & Johnson	142.12 mm	876.96 k shares	2.48	Common equity	Long	USA
ABT Abbott Laboratories	136.40 mm	1.20 mm shares	2.38	Common equity	Long	USA
NVS Novartis AG	129.85 mm	1.13 mm shares	2.27		Long	USA
VRTX Vertex Pharmaceuticals Incorporated	128.47 mm	276.23 k shares	2.24	Common equity	Long	USA
TMO Thermo Fisher Scientific Inc.	113.32 mm	183.20 k shares	1.98	Common equity	Long	USA
ARGX argenx SE	111.79 mm	206.22 k shares	1.95		Long	USA
PCVX Vaxcyte, Inc.	108.42 mm	948.85 k shares	1.89	Common equity	Long	USA
DHR Danaher Corporation	106.67 mm	383.69 k shares	1.86	Common equity	Long	USA
SYK Stryker Corporation	106.11 mm	293.74 k shares	1.85	Common equity	Long	USA
ISRG Intuitive Surgical, Inc.	96.10 mm	195.62 k shares	1.68	Common equity	Long	USA
SRPT Sarepta Therapeutics, Inc.	85.93 mm	688.06 k shares	1.50	Common equity	Long	USA
HCA HCA Healthcare, Inc.	83.35 mm	205.09 k shares	1.46	Common equity	Long	USA
ELV Elevance Health Inc.	82.36 mm	158.39 k shares	1.44	Common equity	Long	USA
ASND Ascendis Pharma A/S	73.97 mm	495.42 k shares	1.29		Long	USA
Roche Holdings AG GENUSSCHEINE NPV	71.09 mm	222.31 k shares	1.24	Preferred equity	Long	Switzerland
GMED Globus Medical, Inc.	64.99 mm	908.49 k shares	1.13	Common equity	Long	USA
BHVN Biohaven Ltd.	59.28 mm	1.19 mm shares	1.03	Common equity	Long	USA
AKRO Akero Therapeutics, Inc.	57.94 mm	2.02 mm shares	1.01	Common equity	Long	USA
UTHR United Therapeutics Corporation	55.46 mm	154.76 k shares	0.97	Common equity	Long	USA
Madrigal Pharmaceuticals, Inc.	53.72 mm	253.14 k shares	0.94	Common equity	Long	USA
RVMD Revolution Medicines, Inc.	53.11 mm	1.17 mm shares	0.93	Common equity	Long	USA
DYN Dyne Therapeutics, Inc.	51.33 mm	1.43 mm shares	0.90	Common equity	Long	USA
HUM Humana Inc.	47.19 mm	148.99 k shares	0.82	Common equity	Long	USA
ZTS Zoetis Inc.	47.15 mm	241.35 k shares	0.82	Common equity	Long	USA
TFX Teleflex Incorporated	46.52 mm	188.11 k shares	0.81	Common equity	Long	USA
MCK McKesson Corporation	44.94 mm	90.90 k shares	0.78	Common equity	Long	USA
LNTH Lantheus Holdings, Inc.	44.93 mm	409.37 k shares	0.78	Common equity	Long	USA
MDT Medtronic plc	43.54 mm	483.64 k shares	0.76	Common equity	Long	USA
RNA Avidity Biosciences, Inc.	42.74 mm	930.48 k shares	0.75	Common equity	Long	USA
COO The Cooper Companies, Inc.	42.02 mm	380.78 k shares	0.73	Common equity	Long	USA
ACLX Arcellx, Inc.	40.56 mm	485.65 k shares	0.71	Common equity	Long	USA
PEN Penumbra, Inc.	39.73 mm	204.45 k shares	0.69	Common equity	Long	USA
COR Cencora	38.76 mm	172.20 k shares	0.68	Common equity	Long	USA
Teva Pharmaceutical Industries Ltd. SPON ADS EACH REP 1 ORD SHS	38.05 mm	2.11 mm shares	0.66		Long	USA
REGN Regeneron Pharmaceuticals, Inc.	36.30 mm	34.53 k shares	0.63	Common equity	Long	USA
INSP Inspire Medical Systems, Inc.	35.19 mm	166.73 k shares	0.61	Common equity	Long	USA
AVDL Avadel Pharmaceuticals plc	35.16 mm	2.68 mm shares	0.61	Common equity	Long	USA
STE STERIS plc	34.05 mm	140.41 k shares	0.59	Common equity	Long	USA
EW Edwards Lifesciences Corporation	34.02 mm	515.47 k shares	0.59	Common equity	Long	USA
Zai Lab Ltd. ADS EACH REP 1 ORD SHS	33.96 mm	1.41 mm shares	0.59		Long	USA
GPCR Structure Therapeutics Inc.	32.66 mm	744.12 k shares	0.57		Long	USA
SLNO Soleno Therapeutics, Inc.	32.39 mm	641.49 k shares	0.57	Common equity	Long	USA
MIRM Mirum Pharmaceuticals, Inc.	32.30 mm	828.13 k shares	0.56	Common equity	Long	USA
ARDX Ardelyx, Inc.	31.66 mm	4.59 mm shares	0.55	Common equity	Long	USA
ILMN Illumina, Inc.	29.48 mm	226.08 k shares	0.51	Common equity	Long	USA
IDYA IDEAYA Biosciences, Inc.	27.22 mm	859.28 k shares	0.48	Common equity	Long	USA
CNC Centene Corporation	27.05 mm	359.38 k shares	0.47	Common equity	Long	USA
LEGN Legend Biotech Corporation	24.84 mm	509.68 k shares	0.43		Long	USA
SHC Sotera Health Company	23.25 mm	1.39 mm shares	0.41	Common equity	Long	USA
ICLR ICON Public Limited Company	23.18 mm	80.69 k shares	0.40	Common equity	Long	USA
HOYA Corp. NPV	22.90 mm	166.30 k shares	0.40	Common equity	Long	Japan
ALNY Alnylam Pharmaceuticals, Inc.	22.75 mm	82.73 k shares	0.40	Common equity	Long	USA
MDGL Madrigal Pharmaceuticals, Inc.	21.95 mm	2.97 mm shares	0.38	Common equity	Long	USA
GILD Gilead Sciences, Inc.	21.83 mm	260.35 k shares	0.38	Common equity	Long	USA
RPRX Royalty Pharma plc	21.10 mm	745.86 k shares	0.37	Common equity	Long	USA
CYTK Cytokinetics, Incorporated	19.62 mm	371.68 k shares	0.34	Common equity	Long	USA
JANX Janux Therapeutics, Inc.	19.53 mm	429.99 k shares	0.34	Common equity	Long	USA
CRNX Crinetics Pharmaceuticals, Inc.	19.23 mm	376.27 k shares	0.34	Common equity	Long	USA
PTCT PTC Therapeutics, Inc.	18.45 mm	497.35 k shares	0.32	Common equity	Long	USA
FOLD Amicus Therapeutics, Inc.	17.36 mm	1.63 mm shares	0.30	Common equity	Long	USA
ALGN Align Technology, Inc.	17.30 mm	68.01 k shares	0.30	Common equity	Long	USA
NBIX Neurocrine Biosciences, Inc.	17.11 mm	148.48 k shares	0.30	Common equity	Long	USA
Takeda Pharmaceutical Co Ltd. NPV	16.19 mm	567.14 k shares	0.28	Common equity	Long	Japan
INSM Insmed Incorporated	15.86 mm	217.26 k shares	0.28	Common equity	Long	USA
EWTX Edgewise Therapeutics, Inc.	15.62 mm	585.18 k shares	0.27	Common equity	Long	USA
NEO NeoGenomics, Inc.	15.55 mm	1.05 mm shares	0.27	Common equity	Long	USA
DXCM DexCom, Inc.	14.93 mm	222.76 k shares	0.26	Common equity	Long	USA
RYTM Rhythm Pharmaceuticals, Inc.	14.91 mm	284.69 k shares	0.26	Common equity	Long	USA
IQV IQVIA Holdings Inc.	13.36 mm	56.36 k shares	0.23	Common equity	Long	USA
BBIO BridgeBio Pharma, Inc.	13.20 mm	518.59 k shares	0.23	Common equity	Long	USA
XENE Xenon Pharmaceuticals Inc.	12.76 mm	324.00 k shares	0.22	Common equity	Long	USA
CATX Perspective Therapeutics, Inc.	12.73 mm	953.83 k shares	0.22	Common equity	Long	USA
IMNM Immunome, Inc.	11.69 mm	799.55 k shares	0.20	Common equity	Long	USA
NGNE Neurogene Inc.	11.67 mm	278.17 k shares	0.20	Common equity	Long	USA
CGON CG Oncology, Inc. Common stock	11.42 mm	302.66 k shares	0.20	Common equity	Long	USA
Bicara Therapeutics - Series C	11.15 mm	437.83 k shares	0.19	Common equity	Long	USA
GERN Geron Corporation	11.02 mm	2.43 mm shares	0.19	Common equity	Long	USA
FDMT 4D Molecular Therapeutics, Inc.	10.99 mm	1.02 mm shares	0.19	Common equity	Long	USA
CRGX CARGO Therapeutics, Inc. Common Stock	10.08 mm	546.47 k shares	0.18	Common equity	Long	USA
RCKT Rocket Pharmaceuticals, Inc.	9.90 mm	536.20 k shares	0.17	Common equity	Long	USA
Janus Henderson Cash Collateral Fund	9.64 mm	9.64 mm shares	0.17	Common equity	Long	USA
Bridgebio Pharma Inc	9.06 mm	355.70 k shares	0.16	Common equity	Long	USA
LXEO Lexeo Therapeutics, Inc. Common Stock	6.61 mm	731.18 k shares	0.12	Common equity	Long	USA
HeartFlow Inc - Series F	6.15 mm	1.93 mm shares	0.11	Preferred equity	Long	USA
Curevo Inc	5.71 mm	2.03 mm shares	0.10	Preferred equity	Long	USA
Shoreline Biosciences Inc	5.64 mm	747.19 k shares	0.10	Preferred equity	Long	USA
BCAX Bicara Therapeutics Inc. Common Stock	5.22 mm	205.13 k shares	0.09	Common equity	Long	USA
Attralus Inc	5.20 mm	669.94 k shares	0.09	Preferred equity	Long	USA
Sonoma Biotherapeutics Inc - Series B	4.81 mm	1.26 mm shares	0.08	Preferred equity	Long	USA
Element Biosciences Inc	4.14 mm	425.02 k shares	0.07	Preferred equity	Long	USA
Magnolia Medical Technologies	3.01 mm	1.82 mm shares	0.05	Preferred equity	Long	USA
Asher Biotherapeutics - Series C	3.00 mm	2.58 mm shares	0.05	Preferred equity	Long	USA
Sonoma Biotherapeutics Inc - Series B-1	2.56 mm	669.43 k shares	0.04	Preferred equity	Long	USA
Royal Bank of Canada	2.41 mm	2.41 mm principal	0.04	Short-term investment vehicle	Long	USA
Freenome Holdings Inc - Series D	1.91 mm	342.80 k shares	0.03	Preferred equity	Long	USA
Freenome Holdings Inc - Series C	1.87 mm	337.47 k shares	0.03	Preferred equity	Long	USA
Asher Biotherapeutics Inc	1.41 mm	1.21 mm shares	0.02	Preferred equity	Long	USA
TwinStrand Biosciences Inc	1.38 mm	344.31 k shares	0.02	Preferred equity	Long	USA
Janus Henderson Cash Liquidity Fund LLC	1.20 mm	1.20 mm shares	0.02	Common equity	Long	USA
Curevo Inc. Series SAFE	874.61 k	87.46 mm shares	0.02	Preferred equity	Long	USA
Arbor Biotechnologies Inc	642.91 k	156.43 k shares	0.01	Preferred equity	Long	USA
Magnolia Medical Technologies	384.51 k	384.51 k principal	0.01	Debt	Long	USA
Magnolia Medical Technologies	37.75	37.75 k shares	0.00	Common equity	Long	USA
CMTA Clementia Pharmaceuticals Inc.	0.87	874.31 k shares	0.00		Long	USA
Magnolia Medical Technologies	0	1.00 shares	0.00	Common equity	Long	USA