Janus Henderson Global Life Sciences Fund

Fund Profile

Fund profile

Tickers

JAGLX, JFNAX, JFNCX, JFNIX, JFNSX, JNGLX, JFNNX

Fund manager

Janus Henderson Venture Fund Class T

Total assets

$4.78 bn

Liabilities

$5.17 mm

Net assets

$4.78 bn

Number of holdings

111.00

111 Holdings

As of Dec 2024

Security	$Holding	Balance	% of Fund	Category	Position	Country
LLY Eli Lilly and Company	427.93 mm	554.32 k shares	8.96	Common equity	Long	USA
UNH UnitedHealth Group Incorporated	315.60 mm	623.89 k shares	6.60	Common equity	Long	USA
Novo Nordisk A/S SER'B'DKK0.1	174.61 mm	2.03 mm shares	3.65	Common equity	Long	Denmark
AZN AstraZeneca PLC	174.46 mm	1.34 mm shares	3.65	Common equity	Long	UK
JNJ Johnson & Johnson	145.82 mm	1.01 mm shares	3.05	Common equity	Long	USA
AMGN Amgen Inc.	137.10 mm	526.02 k shares	2.87	Common equity	Long	USA
BSX Boston Scientific Corporation	135.03 mm	1.51 mm shares	2.83	Common equity	Long	USA
ABT Abbott Laboratories	131.34 mm	1.16 mm shares	2.75	Common equity	Long	USA
Sanofi EUR2	129.97 mm	1.34 mm shares	2.72	Common equity	Long	France
ABBV AbbVie Inc.	124.87 mm	702.68 k shares	2.61	Common equity	Long	USA
MRK Merck & Co., Inc.	116.91 mm	1.18 mm shares	2.45	Common equity	Long	USA
VRTX Vertex Pharmaceuticals Incorporated	113.10 mm	280.87 k shares	2.37	Common equity	Long	USA
Argenx SE SPON ADR EACH REP 1 ORD SHS	109.99 mm	178.84 k shares	2.30		Long	USA
TMO Thermo Fisher Scientific Inc.	107.38 mm	206.40 k shares	2.25	Common equity	Long	USA
NVS Novartis AG	101.80 mm	1.05 mm shares	2.13		Long	USA
ISRG Intuitive Surgical, Inc.	95.23 mm	182.45 k shares	1.99	Common equity	Long	USA
DHR Danaher Corporation	88.86 mm	387.10 k shares	1.86	Common equity	Long	USA
SYK Stryker Corporation	86.00 mm	238.86 k shares	1.80	Common equity	Long	USA
SRPT Sarepta Therapeutics, Inc.	77.28 mm	635.58 k shares	1.62	Common equity	Long	USA
PCVX Vaxcyte, Inc.	66.92 mm	817.45 k shares	1.40	Common equity	Long	USA
Teva Pharmaceutical Industries Ltd. SPON ADS EACH REP 1 ORD SHS	64.83 mm	2.94 mm shares	1.36		Long	USA
ASND Ascendis Pharma A/S	63.33 mm	460.02 k shares	1.33		Long	USA
GMED Globus Medical, Inc.	60.66 mm	733.37 k shares	1.27	Common equity	Long	USA
MDGL Madrigal Pharmaceuticals, Inc.	58.63 mm	189.99 k shares	1.23	Common equity	Long	USA
RVMD Revolution Medicines, Inc.	58.00 mm	1.33 mm shares	1.21	Common equity	Long	USA
Roche Holding AG GENUSSCHEINE NPV	57.91 mm	206.82 k shares	1.21	Preferred equity	Long	Switzerland
HCA HCA Healthcare, Inc.	56.05 mm	186.75 k shares	1.17	Common equity	Long	USA
ELV Elevance Health Inc.	54.44 mm	147.57 k shares	1.14	Common equity	Long	USA
MCK McKesson Corporation	51.20 mm	89.84 k shares	1.07	Common equity	Long	USA
UTHR United Therapeutics Corporation	47.80 mm	135.47 k shares	1.00	Common equity	Long	USA
AKRO Akero Therapeutics, Inc.	45.50 mm	1.64 mm shares	0.95	Common equity	Long	USA
BHVN Biohaven Ltd.	43.59 mm	1.17 mm shares	0.91	Common equity	Long	USA
SLNO Soleno Therapeutics, Inc.	41.95 mm	933.30 k shares	0.88	Common equity	Long	USA
LNTH Lantheus Holdings, Inc.	40.31 mm	450.61 k shares	0.84	Common equity	Long	USA
PEN Penumbra, Inc.	40.05 mm	168.66 k shares	0.84	Common equity	Long	USA
HUM Humana Inc.	38.16 mm	150.40 k shares	0.80	Common equity	Long	USA
MDT Medtronic plc	36.78 mm	460.42 k shares	0.77	Common equity	Long	USA
ZTS Zoetis Inc.	36.65 mm	224.95 k shares	0.77	Common equity	Long	USA
EW Edwards Lifesciences Corporation	35.24 mm	476.01 k shares	0.74	Common equity	Long	USA
RNA Avidity Biosciences, Inc.	35.01 mm	1.20 mm shares	0.73	Common equity	Long	USA
COR Cencora	34.35 mm	152.89 k shares	0.72	Common equity	Long	USA
DYN Dyne Therapeutics, Inc.	33.28 mm	1.41 mm shares	0.70	Common equity	Long	USA
COO The Cooper Companies, Inc.	32.10 mm	349.13 k shares	0.67	Common equity	Long	USA
MIRM Mirum Pharmaceuticals, Inc.	31.53 mm	762.42 k shares	0.66	Common equity	Long	USA
INSP Inspire Medical Systems, Inc.	29.93 mm	161.48 k shares	0.63	Common equity	Long	USA
JANX Janux Therapeutics, Inc.	28.86 mm	539.05 k shares	0.60	Common equity	Long	USA
TFX Teleflex Incorporated	28.53 mm	160.30 k shares	0.60	Common equity	Long	USA
ILMN Illumina, Inc.	28.01 mm	209.58 k shares	0.59	Common equity	Long	USA
AVDL Avadel Pharmaceuticals plc	26.71 mm	2.54 mm shares	0.56	Common equity	Long	USA
ACLX Arcellx, Inc.	25.82 mm	336.67 k shares	0.54	Common equity	Long	USA
BBIO BridgeBio Pharma, Inc.	23.37 mm	851.83 k shares	0.49	Common equity	Long	USA
Zai Lab Ltd. ADS EACH REP 1 ORD SHS	22.91 mm	874.72 k shares	0.48		Long	USA
GILD Gilead Sciences, Inc.	21.70 mm	234.94 k shares	0.45	Common equity	Long	USA
ARDX Ardelyx, Inc.	21.59 mm	4.26 mm shares	0.45	Common equity	Long	USA
ETNB 89bio, Inc.	21.59 mm	2.76 mm shares	0.45	Common equity	Long	USA
IDYA IDEAYA Biosciences, Inc.	20.99 mm	816.64 k shares	0.44	Common equity	Long	USA
PTCT PTC Therapeutics, Inc.	20.85 mm	461.96 k shares	0.44	Common equity	Long	USA
CNC Centene Corporation	19.41 mm	320.38 k shares	0.41	Common equity	Long	USA
STE STERIS plc	19.16 mm	93.22 k shares	0.40	Common equity	Long	USA
EWTX Edgewise Therapeutics, Inc.	18.81 mm	704.48 k shares	0.39	Common equity	Long	USA
NBIX Neurocrine Biosciences, Inc.	18.48 mm	135.40 k shares	0.39	Common equity	Long	USA
GPCR Structure Therapeutics Inc.	18.38 mm	677.67 k shares	0.38		Long	USA
ALNY Alnylam Pharmaceuticals, Inc.	17.70 mm	75.22 k shares	0.37	Common equity	Long	USA
CRNX Crinetics Pharmaceuticals, Inc.	17.47 mm	341.69 k shares	0.37	Common equity	Long	USA
Janus Henderson Cash Liquidity Fund LLC	17.34 mm	17.34 mm shares	0.36	Common equity	Long	USA
SHC Sotera Health Company	16.67 mm	1.22 mm shares	0.35	Common equity	Long	USA
NEO NeoGenomics, Inc.	16.11 mm	977.29 k shares	0.34	Common equity	Long	USA
HOYA Corp. NPV	16.08 mm	129.40 k shares	0.34	Common equity	Long	Japan
DXCM DexCom, Inc.	16.06 mm	206.50 k shares	0.34	Common equity	Long	USA
ICLR ICON Public Limited Company	15.27 mm	72.83 k shares	0.32	Common equity	Long	USA
LEGN Legend Biotech Corporation	15.09 mm	463.64 k shares	0.32		Long	USA
RYTM Rhythm Pharmaceuticals, Inc.	14.37 mm	256.63 k shares	0.30	Common equity	Long	USA
Takeda Pharmaceutical Co Ltd. NPV	13.97 mm	526.84 k shares	0.29	Common equity	Long	Japan
CYTK Cytokinetics, Incorporated	13.94 mm	296.33 k shares	0.29	Common equity	Long	USA
INSM Insmed Incorporated	13.94 mm	201.85 k shares	0.29	Common equity	Long	USA
XENE Xenon Pharmaceuticals Inc.	13.39 mm	341.64 k shares	0.28	Common equity	Long	USA
ALGN Align Technology, Inc.	13.17 mm	63.16 k shares	0.28	Common equity	Long	USA
FOLD Amicus Therapeutics, Inc.	12.90 mm	1.37 mm shares	0.27	Common equity	Long	USA
PRAX Praxis Precision Medicines, Inc.	11.11 mm	144.41 k shares	0.23	Common equity	Long	USA
GERN Geron Corporation	10.60 mm	2.99 mm shares	0.22	Common equity	Long	USA
IQV IQVIA Holdings Inc.	10.27 mm	52.25 k shares	0.21	Common equity	Long	USA
APGE Apogee Therapeutics, Inc.	10.09 mm	222.67 k shares	0.21	Common equity	Long	USA
TVTX Travere Therapeutics, Inc.	9.59 mm	550.54 k shares	0.20	Common equity	Long	USA
CGON CG Oncology, Inc. Common stock	9.11 mm	317.63 k shares	0.19	Common equity	Long	USA
IMNM Immunome, Inc.	8.87 mm	835.44 k shares	0.19	Common equity	Long	USA
RCKT Rocket Pharmaceuticals, Inc.	8.60 mm	683.86 k shares	0.18	Common equity	Long	USA
CRGX CARGO Therapeutics, Inc. Common Stock	7.95 mm	550.98 k shares	0.17	Common equity	Long	USA
Bicara Therapeutics	7.63 mm	437.83 k shares	0.16	Common equity	Long	USA
HeartFlow Inc - Series F	6.15 mm	1.93 mm shares	0.13	Preferred equity	Long	USA
Shoreline Biosciences Inc	5.64 mm	747.19 k shares	0.12	Preferred equity	Long	USA
Curevo Inc	5.33 mm	2.03 mm shares	0.11	Preferred equity	Long	USA
FDMT 4D Molecular Therapeutics, Inc.	5.03 mm	902.96 k shares	0.11	Common equity	Long	USA
Sonoma Biotherapeutics Inc - Series B	4.81 mm	1.26 mm shares	0.10	Preferred equity	Long	USA
LXEO Lexeo Therapeutics, Inc. Common Stock	4.49 mm	682.04 k shares	0.09	Common equity	Long	USA
Attralus Inc	3.71 mm	669.94 k shares	0.08	Preferred equity	Long	USA
Element Biosciences Inc	3.52 mm	425.02 k shares	0.07	Preferred equity	Long	USA
Magnolia Medical Technologies	3.10 mm	1.82 mm shares	0.06	Preferred equity	Long	USA
Asher Biotherapeutics - Series C	3.00 mm	2.58 mm shares	0.06	Preferred equity	Long	USA
Sonoma Biotherapeutics Inc - Series B-1	2.56 mm	669.43 k shares	0.05	Preferred equity	Long	USA
Freenome Holdings Inc - Series D	1.91 mm	342.80 k shares	0.04	Preferred equity	Long	USA
Freenome Holdings Inc - Series C	1.87 mm	337.47 k shares	0.04	Preferred equity	Long	USA
Curevo Inc. Series SAFE	1.86 mm	186.18 mm shares	0.04	Preferred equity	Long	USA
Asher Biotherapeutics Inc	1.41 mm	1.21 mm shares	0.03	Preferred equity	Long	USA
TwinStrand Biosciences Inc	1.38 mm	344.31 k shares	0.03	Preferred equity	Long	USA
BCAX Bicara Therapeutics Inc. Common Stock	757.04 k	43.46 k shares	0.02	Common equity	Long	USA
Magnolia Medical Technologies	384.51 k	384.51 k principal	0.01	Debt	Long	USA
Janus Henderson Cash Collateral Fund	235.53 k	235.53 k shares	0.00	Common equity	Long	USA
Royal Bank of Canada	58.88 k	58.88 k principal	0.00	Short-term investment vehicle	Long	USA
Magnolia Medical Technologies	37.75	37.75 k shares	0.00	Common equity	Long	USA
CMTA Clementia Pharmaceuticals Inc.	0.87	874.31 k shares	0.00		Long	USA
Magnolia Medical Technologies	0	1.00 shares	0.00	Common equity	Long	USA