769 patents
Page 10 of 39
Utility
Dimerization Switches and Uses Thereof
1 Dec 22
Andreas Loew, Brian Edward Vash
Filed: 22 Jul 22
Utility
Crizanlizumab Containing Antibody Formulations
1 Dec 22
The present invention relates to novel pharmaceutical formulations of an antibody against human P-selectin, especially SEG101, or an antibody having at most 3 amino acid difference from crizanlizumab, and processes for the preparation thereof and uses of the formulations.
Fabian BICKEL, Lina BOADO, Dirk CHELIUS, Francois GRIAUD, Caroline HILBERT, Frieder KROENER, Juergen SIGG, Rajsekhar PAUL, Maja ANKO, Aljosa JELENKO
Filed: 29 Oct 20
Utility
Methods for Radiolabelling GRPR Antagonists and Their Kits
1 Dec 22
The present invention relates to methods for radiolabelling GRPR antagonists such as NeoB, and their kits.
Elena CASTALDI, Lorenza FUGAZZA, Maurizio F. MARIANI, Francesca ORLANDI, Mattia TEDESCO
Filed: 16 Sep 20
Utility
MLL1 Inhibitors and Anti-cancer Agents
1 Dec 22
Ming LI, Kevin Kun Chin LIU, Chunliang LU, Zhuming SUN, Jichen ZHAO, Yihui ZHU
Filed: 18 Sep 20
Utility
Method for Delivering the Fluid Formulation As a Spray or a Jet of Droplets to a Target Area on an Eye
24 Nov 22
A package (1) for a fluid formulation (2) to be delivered as a spray or a jet of droplets to an eye (4), comprising an enclosed container (5) a storage recess (6) containing a fluid formulation (2); and a delivery recess (7), adjacent to the storage recess (6).
Matt CHANDLER, Graeme DAVIES, Adrian HORRELL, Rachel MYERS, Grant SMETHAM, Gabrielle WHITWORTH-SMITH, Ben WICKS
Filed: 30 Oct 20
Utility
Polyomavirus Neutralizing Antibodies
17 Nov 22
The present invention relates to anti-VP 1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.
Johanna ABEND, Zorica DRAGIC, Adam Lloyd FEIRE, Mark KNAPP, Steven KOVACS, Elisabetta TRAGGIAI, Lichun WANG, Yongqiang WANG, Danqing WU, Qilong WU, Fangmin Xu
Filed: 15 Oct 21
Utility
Pyrazolyl derivatives useful as anti-cancer agents
17 Nov 22
Simona Cotesta, Marc Gerspacher, Catherine Leblanc, Edwige Liliane Jeanne Lorthiois, Bo Liu, Rainer Machauer, Robert Mah, Christophe Mura, Pascal Rigollier, Nadine Schneider, Stefan Stutz, Andrea Vaupel, Nicolas Warin, Rainer Wilcken
Filed: 17 Dec 20
Utility
Glue Degraders and Methods of Use Thereof
17 Nov 22
Described herein are glue degrader compounds, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment or prevention of conditions, diseases, and disorders mediated by various target proteins.
Jake AXFORD, Rohan Eric John BECKWITH, Simone BONAZZI, Nicole BUSCHMANN, Artiom CERNIJENKO, Janetta DEWHURST, Aleem FAZAL, Matthew James HESSE, Lauren HOLDER, Viktor HORNAK, Hidetomo IMASE, Rama JAIN, Xianming JIN, John Ryan KERRIGAN, Julie LACHAL, Fupeng MA, Hasnain Ahmed MALIK, James R. MANNING, Daniel MCKAY, Robert Joseph MOREAU, Pierre NIMSGERN, Gary O'BRIEN, Anna VULPETTI, Ken YAMADA, Junping ZHAO
Filed: 16 Sep 20
Utility
Methods of Treating Autoimmune Diseases Using INTERLEUKIN-17 (IL-17) Antagonists
17 Nov 22
The present disclosure relates to methods for treating patients having autoimmune diseases, e.g., methods for treating psoriatic arthritis (PsA) or axial spondyloarthritis (axSpA), e.g., non-radiographic axial spondyloarthritis (nr-axSpA) or ankylosing spondylitis (AS), using IL-17 antagonists, e.g., IL-17 antibodies, such as secukinumab.
Abhijit BAPAT, Thomas DUMORTIER, Meryl MENDELSON, Shephard MPOFU, Luminita PRICOP
Filed: 18 Sep 20
Utility
Methods of Making Chimeric Antigen Receptor-expressing Cells
17 Nov 22
The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.
Louise Treanor, Michael R. Greene, Jennifer Brogdon, Boris Engels, Glenn Dranoff, Olja Kodrasi, Hyungwook Lim, Akash Sohoni, Elizabeth Dorothy Pratico, Anniesha Hack, Aida Abujoub, Tony Fleming, Lu Huang, Connie Hong, John Blankenship, Brian Holmberg, Chonghui Zhang, Dexiu Bu, Andrew Price, Xu Zhu, Andrew Stein, Attilio Bondanza
Filed: 30 Aug 19
Utility
CorrectedComplexes of IL-15 and IL-15RALPHA In Combination with ANTI-PD-1 Antibody Molecules and Uses Thereof
10 Nov 22
Dosing regimens for the administration of complexes comprising IL-15/IL-15Ra in combination with an anti-PD-1 antibody molecule to patients are disclosed.
Nancy LEWIS
Filed: 19 Jan 18
Utility
Anti-betacellulin Antibodies, Fragments Thereof, and Multi-specific Binding Molecules
10 Nov 22
The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies.
Chad Eric BIGELOW, Ana Maria CARRION, James Edgar CHASTAIN, Kirk Lee CLARK, Bijan Alexandre ETEMAD-GILBERTSON, Joy Gispati GHOSH, Shawn Michael HANKS, Nicole HAUBST, Ganesh Rajan IYER, Nina MOKER, Andrew Anh NGUYEN, Stephen Hendrick POOR, Yubin QIU, Nalini Velamur RANGASWAMY, Michael STEFANIDAKIS, Engin TOKSOZ, Michael Zbigniew TWAROG
Filed: 30 Jun 22
Utility
Natriuretic Peptide Receptor 1 Antibodies and Methods of Use
10 Nov 22
This disclosure relates to anti-Natriuretic Peptide Receptor 1 (NPR1) antibodies including agonist antibodies which are able to activate the NPR1 receptor, pharmaceutical compositions comprising the same, and methods of treatment comprising the same.
John Louis DIENER, Lars GADTKE, Felix HARTLEPP, Tiancen HU, Kathrin LADETZKI-BAEHS, Michael John ROMANOWSKI, Cesare RUSSO, Xenia WEZLER, Xiaoling XIE
Filed: 16 Jun 21
Utility
Treatment for Sjögren's Syndrome
10 Nov 22
The present disclosure relates to methods for treating Sjögren's Syndrome disease using therapeutically effective doses of anti-BAFFR antibody, such as ianalumab.
Irina BALTCHEVA, Wolfgang HUEBER, Stephen OLIVER, Olivier PETRICOUL
Filed: 23 Oct 20
Utility
Solubilized Apyrases, Methods and Use
10 Nov 22
The invention relates to design and therapeutic use of solubilized apyrase polypeptides, pharmaceuticals compositions, therapeutic uses and methods useful for preventing and treating tissue damage.
Agostino CIRILLO, Hilmar EBERSBACH, Boerje HARALDSSON, Thomas HUBER, Guido JUNGE, Regina LINK, Max WARNCKE, Chao ZOU
Filed: 17 Jul 19
Utility
Treatment Comprising FXR Agonists
3 Nov 22
The invention provides, FXR agonists for the treatment of a condition mediated by Farnesoid X receptor (FXR), in particular liver disease or intestinal disease, in a subject in need thereof, to reduce drug-induced adverse side effects inpatients suffering from such diseases or conditions.
Michael Badman, Clifford Brass, Bryan Laffitte, Iwona KSIAZEK
Filed: 18 Sep 20
Utility
1-PYRIDAZIN-/TRIAZIN-3-YL-PIPER(-AZINE)/IDINE/PYROLIDINE Derivatives and Compositions Thereof for Inhibiting the Activity of SHP2
3 Nov 22
Christine Hiu-Tung Chen, Zhuoliang Chen, Jorge Garcia Fortanet, Denise Grunenfelder, Rajesh Karki, Mitsunori Kato, Matthew J. LaMarche, Lawrence Blas Perez, Travis Matthew Stams, Sarah Williams
Filed: 24 Jun 22
Utility
Novel Heteroaryl Aminopropanol Derivatives
3 Nov 22
Andreas Kordikowski, Yugang Liu, Rainer Martin Lüönd, Christian Markert, Wolfgang Miltz, Till Roehn, Carsten Spanka, Gebhard Thoma, Tian XIE
Filed: 8 Apr 22
Utility
NKG2D Fusion Proteins and Uses Thereof
3 Nov 22
Provided are NKG2D fusion proteins and their uses for the treatment of various diseases.
Ryan Sullivan, Hilmar Ebersbach, Emilie Ramondou, Philip Egger
Filed: 16 Sep 20
Utility
Anti-betacellulin Antibodies, Fragments Thereof, and Multi-specific Binding Molecules
3 Nov 22
The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies.
Chad Eric BIGELOW, Ana Maria CARRION, James Edgar CHASTAIN, Kirk Lee CLARK, Bijan Alexandre ETEMAD-GILBERTSON, Joy Gispati GHOSH, Shawn Michael HANKS, Nicole HAUBST, Ganesh Rajan IYER, Nina MOKER, Andrew Anh NGUYEN, Stephen Hendrick POOR, Yubin QIU, Nalini Velamur RANGASWAMY, Michael STEFANIDAKIS, Engin TOKSOZ, Michael Zbigniew TWAROG
Filed: 30 Jun 22