130 patents
Page 3 of 7
Utility
Modulators of Chemokine Receptors
13 Jan 22
Xi CHEN, Dean R. DRAGOLI, Junfa FAN, Jaroslaw KALISIAK, Antoni KRASINSKI, Manmohan Reddy LELETI, Venkat MALI, Jeffrey McMAHON, Rajinder SINGH, Hiroko TANAKA, Ju YANG, Chao YU, Penglie ZHANG
Filed: 4 Mar 21
Utility
Methods of Treating Pancreatic Cancer
30 Dec 21
The present disclosure describes methods of treating pancreatic cancer and limiting over-expression of oncogenes, activating tumor suppressor genes or regulating signaling proteins in patients comprising administering compounds and pharmaceutical combinations as described herein.
Petrus BEKKER, Shichang MIAO, Israel CHARO, Tom SCHALL
Filed: 23 Aug 21
Utility
Methods of treating generalized pustular psoriasis with an antagonist of CCR6 or CXCR2
28 Dec 21
James J. Campbell, Karen Ebsworth, Antoni Krasinski, Venkat Reddy Mali, Jeffrey McMahon, Rajinder Singh, Ju Yang, Chao Yu, Penglie Zhang
Filed: 7 Jan 19
Utility
Methods of Treating Cancer Using Heteroaryl-biphenyl Amide Derivatives
23 Dec 21
Shijie LI, Marta VILALTA-COLOMER, Yibin ZENG, Penglie ZHANG
Filed: 22 Jun 21
Utility
Dosing and effect of C5a antagonist with ANCA-associated vasculitis
7 Dec 21
Jun Deng, Petrus Bekker, Jan Hillson
Filed: 6 Jun 19
Utility
Methods of Treating Solid Tumors with CCR2 Antagonists
11 Nov 21
James J. CAMPBELL, Rajinder SINGH, Samuel HWANG, Xuesong WU
Filed: 21 Dec 20
Utility
Methods of treating solid tumors with CCR2 antagonists
26 Oct 21
James J. Campbell, Rajinder Singh, Samuel Hwang, Xuesong Wu
Filed: 7 Jan 19
Utility
Compositions and Methods for Treating Inflammatory Bowel Disease Using a Combination Therapy of Small Molecule Inhibitors of C-C Chemokine Receptor Type 9 (CCR9) and ANTI-ALPHA4BETA7 Integrin Blocking Antibodies
21 Oct 21
Provided herein are compositions, methods and kits for treating inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis in a mammal in need thereof.
James CAMPBELL, Israel CHARO, Thomas SCHALL, Karen EBSWORTH, Yu WANG, Yibin ZENG, Penglie ZHANG, Joanne TAN
Filed: 24 May 21
Utility
Substituted anilines as CCR(4) antagonists
12 Oct 21
Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
Trevor T. Charvat, Junfa Fan, Christopher W. Lange, Manmohan Reddy Leleti, Yandong Li, Venkat Reddy Mali, Jeffrey P. McMahon, Jay Powers, Sreenivas Punna, Ju Yang
Filed: 30 Jul 19
Utility
Compositions and Methods for Treating Inflammatory Bowel Disease Using CCR9 Inhibitor and ANTI-IL-23 Blocking Antibodies
7 Oct 21
Provided herein are compositions, methods and kits for treating inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis in a mammal in need thereof.
James CAMPBELL, Israel CHARO, Thomas SCHALL, Rajinder SINGH, Yibin ZENG, Penglie ZHANG
Filed: 31 Mar 21
Utility
Indane-amines as PD-L1 antagonists
5 Oct 21
Christopher Lange, Sreenivas Punna, Rajinder Singh, Ju Yang, Penglie Zhang
Filed: 14 Jan 20
Utility
Methods of treating pancreatic cancer
14 Sep 21
The present disclosure describes methods of treating pancreatic cancer and limiting over-expression of oncogenes, activating tumor suppressor genes or regulating signaling proteins in patients comprising administering compounds and pharmaceutical combinations as described herein.
Petrus Bekker, Shichang Miao, Israel Charo, Tom Schall
Filed: 14 Feb 20
Utility
Deuterated Compounds As Immunomodulators
9 Sep 21
Pingchen FAN, Rebecca M. LUI, Venkat Reddy MALI, Rajinder SINGH, Yibin ZENG, Penglie ZHANG
Filed: 9 Oct 20
Utility
C5AR Antagonists
2 Sep 21
Compounds are provided that are modulators of the C5a receptor.
Pingchen Fan, Kevin Lloyd Greenman, Manmohan Reddy Leleti, Yandong Li, Jay Powers, Hiroko Tanaka, Ju Yang, Yibin Zeng
Filed: 20 Oct 20
Utility
Methods of Treating Cancer with Small Molecule PD-L1 Inhibitors
5 Aug 21
The present disclosure provides, inter alia, methods of treating cancer by administering an effective amount of a com-pound of Formula (I).
Shijie LI, Marta VILALTA-COLOMER, Sreenivas PUNNA, Viengkham MALATHONG, Rajinder SINGH, Penglie ZHANG
Filed: 28 Aug 19
Utility
CXCR7 antagonists
13 Jul 21
Junfa Fan, Antoni Krasinski, Christopher W. Lange, Rebecca M. Lui, Jeffrey P. McMahon, Jay P. Powers, Yibin Zeng, Penglie Zhang
Filed: 9 Apr 19
Utility
Macrocyclic immunomodulators
13 Jul 21
Viengkham Malathong, Jeffrey McMahon, Darren J. McMurtrie, Sreenivas Punna, Howard S. Roth, Rajinder Singh, Penglie Zhang
Filed: 8 Jul 19
Utility
Compositions and methods for treating inflammatory bowel disease using a combination therapy of small molecule inhibitors of C-C chemokine receptor type 9 (CCR9) and anti-α4β7 integrin blocking antibodies
29 Jun 21
Provided herein are compositions, methods and kits for treating inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis in a mammal in need thereof.
James Campbell, Israel Charo, Thomas Schall
Filed: 14 May 20
Utility
Inhibitors of CXCR2
22 Jun 21
Xi Chen, Dean R. Dragoli, Junfa Fan, Jaroslaw Kalisiak, Manmohan Reddy Leleti, Viengkham Malathong, Jeffrey McMahon, Hiroko Tanaka, Ju Yang, Chao Yu, Penglie Zhang, Venkat Mali
Filed: 12 Jun 19
Utility
Free base crystalline form of a complement component C5a receptor
8 Jun 21
Rajinder Singh, Kwok Yau, Yibin Zeng, Penglie Zhang, Rebecca M. Lui, Antoni Krasinski
Filed: 6 Nov 20