130 patents
Page 4 of 7
Utility
Compositions and methods for treating inflammatory bowel disease using a combination therapy of small molecule inhibitors of C—C chemokine receptor type 9 (CCR9) and anti-α4β7 integrin blocking antibodies
1 Jun 21
Provided herein are compositions, methods and kits for treating inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis in a mammal in need thereof.
Yibin Zeng, Penglie Zhang, Thomas Schall, Israel Charo, James J. Campbell
Filed: 9 Dec 19
Utility
Compositions and Methods for Treating CCR9-Mediated Diseases using CCR9 Inhibitor and Anti-TNF-Alpha Blocking Antibodies
27 May 21
Provided herein are compositions, methods and kits for a CCR9-mediated disease in a mammal in need thereof.
Thomas SCHALL, James J. CAMPBELL
Filed: 6 Oct 20
Utility
Immunomodulator Compounds
20 May 21
Christopher LANGE, Viengkham MALATHONG, Venkat Reddy MALI, Jeffrey McMAHON, Darren J. McMURTRIE, Sreenivas PUNNA, Howard S. ROTH, Rajinder SINGH, Yu WANG, Ju YANG, Penglie ZHANG
Filed: 30 Nov 20
Utility
FREE BASE CRYSTALLINE FORM OF A COMPLEMENT COMPONENT C5a RECEPTOR
13 May 21
Rajinder SINGH, Kwok YAU, Yibin ZENG, Penglie ZHANG, Rebecca M. LUI, Antoni KRASINSKI
Filed: 6 Nov 20
Utility
AMORPHOUS FORM OF A COMPLEMENT COMPONENT C5a RECEPTOR
13 May 21
Kwok YAU, Kenken LUONG, Rajinder SINGH, Yibin ZENG, Penglie ZHANG, Manmohan Reddy LELETI, Rebecca M. LUI
Filed: 6 Nov 20
Utility
Salt Forms of a Complement Component C5A Receptor
13 May 21
Rajinder SINGH, Kwok YAU, Yibin ZENG, Penglie ZHANG, Rebecca M. LUI, Ju YANG, Howard S. ROTH
Filed: 6 Nov 20
Utility
Heteroaryl-biphenyl Amides for the Treatment of PD-L1 Diseases
6 May 21
Pingchen FAN, Christopher W. LANGE, Rebecca M. LUI, Darren J. McMURTRIE, Ryan J. SCAMP, Ju YANG, Yibin ZENG, Penglie ZHANG
Filed: 15 Oct 20
Utility
Heteroaryl-biphenyl Amines for the Treatment of PD-L1 Diseases
6 May 21
Pingchen FAN, Christopher W. LANGE, Rebecca M. LUI, Darren J. McMURTRIE, Ryan J. SCAMP, Ju YANG, Yibin ZENG, Penglie ZHANG
Filed: 15 Oct 20
Utility
Modulators of chemokine receptors
27 Apr 21
Xi Chen, Dean R. Dragoli, Junfa Fan, Jaroslaw Kalisiak, Antoni Krasinski, Manmohan Reddy Leleti, Venkat Mali, Jeffrey McMahon, Rajinder Singh, Hiroko Tanaka, Ju Yang, Chao Yu, Penglie Zhang
Filed: 16 May 19
Utility
Method of treating focal segmental glomerulosclerosis
13 Apr 21
A method of treating focal segmental glomerulosclerosis with a compound of Formula I is provided.
Zhenhua Miao, Thomas Schall, Rajinder Singh
Filed: 22 Nov 17
Utility
2-OXINDOLE Compounds
8 Apr 21
Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.
Xi CHEN, Dean R. DRAGOLI, Pingchen FAN, Manmohan Reddy LELETI, Rebecca M. LUI, Viengkham MALATHONG, Jay P. POWERS, Rajinder SINGH, Hiroko TANAKA, Ju YANG, Chao YU, Penglie ZHANG
Filed: 17 Jul 20
Utility
Diazole Lactams
1 Apr 21
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity.
Xi CHEN, Pingchen FAN, Yandong LI, Jay P. POWERS, Viengkham MALATHONG, Sreenivas PUNNA, Hiroko TANAKA, Penglie ZHANG, Dean DRAGOLI
Filed: 8 Jul 20
Utility
Immunomodulator Compounds
25 Feb 21
Christopher LANGE, Viengkham MALATHONG, Darren J. McMURTRIE, Sreenivas PUNNA, Rajinder SINGH, Ju YANG, Penglie ZHANG
Filed: 23 Jan 20
Utility
PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS
25 Feb 21
Pingchen FAN, Rebecca M. LUI, Rajinder SINGH, Venkat Reddy MALI, Yibin ZENG, Penglie ZHANG
Filed: 1 Apr 19
Utility
Immunomodulator compounds
16 Feb 21
Christopher Lange, Viengkham Malathong, Venkat Reddy Mali, Jeffrey McMahon, Darren J. McMurtrie, Sreenivas Punna, Howard S. Roth, Rajinder Singh, Yu Wang, Ju Yang, Penglie Zhang
Filed: 27 Jul 18
Utility
Fused heteroaryl pyridyl and phenyl benzenesuflonamides as CCR2 modulators for the treatment of inflammation
26 Jan 21
Antoni Krasinski, Sreenivas Punna, Solomon Ungashe, Qiang Wang, Yibin Zeng
Filed: 11 Jan 19
Utility
Indanes As PD-L1 Inhibitors
14 Jan 21
Viengkham MALATHONG, Venkat Reddy MALI, Darren J. McMURTRIE, Sreenivas PUNNA, Howard S. ROTH, Rajinder SINGH, Ju YANG, Penglie ZHANG
Filed: 9 Jul 20
Utility
5-5 FUSED RINGS AS C5a INHIBITORS
14 Jan 21
Pingchen FAN, Christopher W. LANGE, Rebecca M. LUI, Viengkham MALATHONG, Venkat Reddy MALI, Sreenivas PUNNA, Yibin ZENG, Penglie ZHANG
Filed: 4 May 20
Utility
DIARYL SUBSTITUTED 5,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS
14 Jan 21
Pingchen FAN, Christopher W. LANGE, Rebecca M. LUI, Viengkham MALATHONG, Venkat Reddy MALI, Sreenivas PUNNA, Rajinder SINGH, Yibin ZENG, Penglie ZHANG
Filed: 27 Jul 20
Utility
Treatment of Focal Segmental Glomerulosclerosis with CCR2 Antagonists
6 Jan 21
Provided herein are methods of treating focal segmental glomerulosclerosis, said methods include administering to a subject in need thereof a therapeutically effective amount of a CCR2 antagonist.
Zhenhua MIAO, Thomas J. SCHALL, Rajinder SINGH
Filed: 10 Aug 20