60 patents
Page 2 of 3
Utility
Apparatus and method for cell kill confirmation
30 Aug 22
A method and related apparatus for confirming whether a kill laser successfully destroys an undesired population of cells includes introducing fluorescent dye into cells, exciting the cells with a detection laser or a light emitting diode to cause the cell to fluoresce for a first time, measuring the amount of fluorescence in the cells with a detector capable of emitting a detection pulse, classifying the cells via embedded processing as undesired or desired cells based on the amount of fluorescence, firing a kill beam with a kill laser at any undesired cells, measuring the amount of fluorescence in the cells a second time to determine whether a fluorescent event was generated from the kill beam striking the cells, and providing feedback to an operator of the kill laser as to whether any fluorescent events were generated from the kill beam striking the cells.
Frederick Hershel Savage, David Appleyard, Zheng Xia, Matthew Ebersole, Daniel McAda
Filed: 14 Jun 19
Utility
Hybrid dairy cattle and systems for maximizing hybrid advantage
23 Aug 22
Systems for selecting, generating, and breeding hybrid dairy cattle are described, as are methods for maintaining herds of hybrid cattle.
Jon Lightner, Richard Williams
Filed: 13 Nov 18
Utility
Multiple laminar flow-based particle and cellular separation with laser steering
23 Aug 22
The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing.
Daniel Mueth, Joseph Plewa, Jessica Shireman, Amy Anderson, Lewis Gruber, Neil Rosenbaum
Filed: 27 Aug 21
Utility
Microfluidic system and method with focused energy apparatus
16 Aug 22
A method of inseminating an animal including flowing a stream of a population of sperm cells through a channel, differentiating the sperm cells into two subpopulations of X-chromosome containing sperm cells and Y-chromosome containing sperm cells, selecting a desired subpopulation, ablating an undesired subpopulation, and collecting both the subpopulations of sperm cells including the desired subpopulation and the ablated undesired subpopulation together, wherein the collected population of sperm cells is used to fertilize an egg.
David Appleyard, Jeff Betthauser, Marjorie Faust, John Larsen, Guocheng Shao, Zheng Xia, Yu Zhou
Filed: 7 Oct 21
Utility
Multiple laminar flow-based particle and cellular separation with laser steering
16 Aug 22
The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing.
Daniel Mueth, Joseph Plewa, Jessica Shireman, Amy Anderson, Lewis Gruber, Neil Rosenbaum
Filed: 26 Aug 21
Utility
Methods of Sperm Cell Sensing Utilizing an Avalanche Photodiode and Cytometer Apparatus
4 Aug 22
A cytometer includes an avalanche photodiode, a switching power supply, a filter, and voltage adjustment circuitry.
Frederick Savage, Glenn J. Szejna, Zheng Xia
Filed: 25 Apr 22
Utility
Hybrid dairy cattle and systems for maximizing hybrid advantage
2 Aug 22
Systems for selecting, generating, and breeding hybrid dairy cattle are described, as are methods for maintaining herds of hybrid cattle.
Jon Lightner, Richard Williams
Filed: 13 Nov 18
Utility
Systems and Methods for Particle Focusing In Microchannels
21 Jul 22
A microfluidic system configured to focus particles suspended in a fluid.
Gerson Aguirre, Zheng Xia, Gopakumar Kamalakshakurup
Filed: 5 Apr 22
Utility
Cryopreserving Ungulate Embryos
16 Jun 22
Technologies for cryopreserving ungulate embryos for implantation into recipient females are described.
Bruno Valente SANCHES
Filed: 2 Mar 22
Utility
Modular Flow Cytometry Systems and Methods of Processing Samples
26 May 22
Modular flow cytometry systems and methods for processing samples are described herein.
Gary Klas, Daniel McAda, Zheng Xia, Matthew Ebersole, Brian Lena, David Appleyard, Richard Lu, Scott Buckley, Mark Abermoske
Filed: 12 Nov 21
Utility
Methods of sperm cell sensing utilizing an avalanche photodiode and cytometer apparatus
24 May 22
A cytometer includes an avalanche photodiode, a switching power supply, a filter, and voltage adjustment circuitry.
Frederick Savage, Glenn J. Szejna, Zheng Xia
Filed: 20 Nov 20
Utility
Systems and methods for particle focusing in microchannels
17 May 22
A microfluidic system configured to focus particles suspended in a fluid.
Gerson Aguirre, Zheng Xia, Gopakumar Kamalakshakurup
Filed: 22 May 19
Utility
Porcine Sexed Semen and Methods of Use
21 Apr 22
The present disclosure relates generally to methods for using porcine sex-sorted sperm cells for the efficient dissemination of desirable traits in multi-level swine production systems.
Matthew CULBERTSON, Daniel HAMILTON, Matthew EBERSOLE, William HERRING
Filed: 14 Oct 21
Utility
Methods and Systems for Processing Genetic Samples to Determine Identity or Detect Contamination
21 Apr 22
Methods and systems for processing semen samples from straws for determining genetic identity, testing the purity of the sample, detecting errors or contamination, calculating an amount of contamination, and determining the identity of the contaminant.
Jennifer Dzelil, Matthew Campbell, Steve Rounsley, Patrice Linel
Filed: 21 Oct 21
Utility
Microfluidic System and Method with Focused Energy Apparatus
31 Mar 22
A method of inseminating an animal including flowing a stream of a population of sperm cells through a channel, differentiating the sperm cells into two subpopulations of X-chromosome containing sperm cells and Y-chromosome containing sperm cells, selecting a desired subpopulation, ablating an undesired subpopulation; and collecting both the subpopulations of sperm cells including the desired subpopulation and the ablated undesired subpopulation together, wherein the collected population of sperm cells is used to fertilize an egg.
David Appleyard, Jeff Betthauser, Marjorie Faust, John Larsen, Guocheng Shao, Zheng Xia, Yu Zhou
Filed: 7 Oct 21
Utility
System and Methods for Sub-population Identification
3 Mar 22
Systems and methods are provided for identification and discrimination of subpopulations within a mixture of particles.
Jim HARRINGTON, Dan ANTONUK, Fred SAVAGE, David APPLEYARD, Matthew EBERSOLE
Filed: 21 Dec 18
Utility
Multiple laminar flow-based particle and cellular separation with laser steering
8 Feb 22
The invention, provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing.
Daniel Mueth, Joseph Plewa, Jessica Shireman, Amy Anderson, Lewis Gruber, Neil Rosenbaum
Filed: 3 Jan 19
Utility
Microfluidic System and Method with Focused Energy Apparatus
27 Jan 22
A method of inseminating an animal including flowing a stream of a population of sperm cells through a channel, differentiating the sperm cells into two subpopulations of X-chromosome containing sperm cells and Y-chromosome containing sperm cells, selecting a desired subpopulation, ablating an undesired subpopulation, and collecting both the subpopulations of sperm cells including the desired subpopulation and the ablated undesired subpopulation together, wherein the collected population of sperm cells is used to fertilize an egg.
David Appleyard, Jeff Betthauser, Marjorie Faust, John Larsen, Guocheng Shao, Zheng Xia, Yu Zhou
Filed: 7 Oct 21
Utility
Multiple Laminar Flow-based Particle and Cellular Separation with Laser Steering
23 Dec 21
The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing.
Daniel Mueth, Joseph Plewa, Jessica Shireman, Amy Anderson, Lewis Gruber, Neil Rosenbaum
Filed: 27 Aug 21
Utility
Multiple Laminar Flow-based Particle and Cellular Separation with Laser Steering
16 Dec 21
The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing.
Daniel Mueth, Joseph Plewa, Jessica Shireman, Amy Anderson, Lewis Gruber, Neil Rosenbaum
Filed: 26 Aug 21