21 patents
Utility
Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases
6 Sep 22
Armen Manoukian, Fabrizio Mastronardi, Sam Scanga, Frank Mercurio, Kyle W. H. Chan
Filed: 7 Oct 16
Utility
Aminoamide compounds
2 Aug 22
Compounds with amino amide linkers and pharmaceutical compositions and medicaments comprising such compounds are disclosed.
Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, Frank Mercurio, Robert W. Sullivan
Filed: 1 Feb 21
Utility
Substituted isoindolinones
7 Jun 22
Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah M. Fung, Imelda Lam, Frank Mercurio, Robert W. Sullivan, Eduardo Torres
Filed: 25 Jun 20
Utility
Protein-targeting compounds and pharmaceutical compositions thereof, and their therapeutic applications
31 May 22
Kyle W. H. Chan, Paul E. Erdman, Leah Fung, David Aaron Hecht, Imelda Lam, Robert Sullivan, Eduardo Torres
Filed: 26 May 20
Utility
Compounds targeting proteins, compositions, methods, and uses thereof
31 May 22
The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK1α, GSPT1, aiolos, and/or ikaros activity, and cell-cell adhesion.
Kyle W. H. Chan, Paul E. Erdman, Leah M. Fung, Frank Mercurio, Robert W. Sullivan, Eduardo Torres
Filed: 11 Jan 21
Utility
Bifunctional compounds
1 Feb 22
The present application provides compounds that modulate CDK protein function.
Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, David Aaron Hecht, Frank Mercurio, Robert Sullivan, Joseph P. Vacca
Filed: 25 Jul 19
Utility
Bicyclic compounds and methods of use
1 Feb 22
The present invention provides compounds that modulate protein function, specifically phosphodiesterase 4 (PDE4).
Robert Sullivan, Paul E. Erdman, Eduardo Torres, Leah Fung, Kyle W. H. Chan, Frank Mercurio
Filed: 11 Feb 20
Utility
Fused thiophene compounds
7 Dec 21
The present disclosure provides compounds that modulate protein function, to restore protein homeostasis, and cell-cell adhesion.
Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, Frank Mercurio, Robert Sullivan
Filed: 11 Jun 19
Utility
Pyrazole compounds and uses thereof
27 Jul 21
Dansu Li, Irit Snir-Alkalay, Joseph Vacca, Yinon Ben-Neriah, Avanthika Venkatachalam
Filed: 30 Jan 18
Utility
Pyrazole pyrimidine derivative and uses thereof
30 Mar 21
The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAKI) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.
Yinon Ben Neriah, Guy Brachya, Ido Burstain, Waleed Minzel, Irit Snir-Alkalay, Joseph Vacca, Dansu Li
Filed: 12 Aug 19
Utility
Ether compounds and uses thereof
23 Feb 21
The present invention provides compounds that modulate protein function, to restore protein homeostasis and/or cell-cell adhesion.
Kyle W. H. Chan, Frank Mercurio, Aparajita Hoskote Chourasia, Leah Fung, Robert Sullivan
Filed: 18 Dec 19
Utility
Aminoamide compounds
2 Feb 21
Compounds with amino amide linkers and pharmaceutical compositions and medicaments comprising such compounds are disclosed.
Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, Frank Mercurio, Robert Sullivan
Filed: 11 Jun 19
Utility
Compounds targeting proteins, compositions, methods, and uses thereof
12 Jan 21
The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK1α, GSPT1, aiolos, and/or ikaros activity, and cell-cell adhesion.
Kyle W. H. Chan, Paul E. Erdman, Leah Fung, Frank Mercurio, Robert Sullivan, Eduardo Torres
Filed: 28 Jun 19
Utility
Compounds targeting proteins, compositions, methods, and uses thereof
7 Dec 20
The present invention provides modulators of protein function, to restore protein homeostasis, including GSPT1 activity.
Kyle W. H. Chan, Paul E. Erdman, Leah Fung, Frank Mercurio, Robert Sullivan
Filed: 12 Aug 19
Utility
Substituted isoindolinones
23 Nov 20
Substituted isoindolinones of Formula (I), methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat or ameliorate diseases, disorders, or conditions associated with protein malfunction, such as cancer, are provided.
Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, Imelda Lam, Frank Mercurio, Robert Sullivan, Eduardo Torres
Filed: 11 Nov 19
Utility
Compounds targeting proteins, compositions, methods, and uses thereof
1 Jun 20
The present invention provides modulators of protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros activity, and cell-cell adhesion.
Kyle W. H. Chan, Leah Fung, Robert Sullivan, Paul E. Erdman, Frank Mercurio
Filed: 31 Oct 17
Utility
Pyridinethiones, pharmaceutical compositions thereof, and their therapeutic use for treating a proliferative, inflammatory, neurodegenerative, or immune-mediated disease
18 May 20
Leah Fung, Robert Sullivan, Kyle W. H. Chan, Frank Mercurio, Armen Manoukian, Sam Scanga, Fabrizio Mastronardi
Filed: 10 Mar 19
Utility
Thienopyrimidinone compounds
9 Mar 20
The present disclosure provides compounds that modulate protein function and/or restore protein homeostasis.
Kyle W. H. Chan, Aparajita Hoskote Chourasia, Paul E. Erdman, Leah Fung, Imelda Lam, Frank Mercurio, Robert Sullivan, Eduardo Torres
Filed: 27 Mar 19
Utility
Bicyclic compounds and methods of use
24 Feb 20
The present invention provides compounds that modulate protein function, specifically phosphodiesterase 4 (PDE4).
Robert Sullivan, Paul E. Erdman, Eduardo Torres, Leah Fung, Kyle W. H. Chan, Frank Mercurio
Filed: 4 Jun 18
Utility
Chimeric compounds targeting proteins, compositions, methods, and uses thereof
17 Feb 20
The present invention provides chimeric compounds that modulate protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros activity, TNF-alpha activity, CK1-alpha activity and cell-cell adhesion.
Kyle W. H. Chan, Leah Fung, Robert Sullivan, Paul E. Erdman, Frank Mercurio, Eduardo Torres
Filed: 7 Feb 18