67 patents
Page 2 of 4
Utility
Monoclonal antibodies and cocktails for treatment of Ebola infections
9 Aug 22
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 9 Jun 20
Utility
Monoclonal antibodies and cocktails for treatment of Ebola infections
9 Aug 22
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Z. Wec, Laura Walker
Filed: 9 Jun 20
Utility
Polyclonal mixtures of antibodies, and methods of making and using them
19 Jul 22
A method of broadening epitopic coverage of an antigen of interest, wherein a first sample of the antigen of interest is contacted with a first plurality of host cells collectively expressing a first library of antibodies.
Laura M. Walker, Eric Krauland, Karl Dane Wittrup
Filed: 9 Apr 20
Utility
Anti-IL-27 antibodies and uses thereof
17 May 22
The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof.
Jonathan Hill, Scott Chappel, Michael Gladstone, Bianka Prinz, Andrew Lake, Christine Miller, Kerry White, Jing Hua, Pamela M. Holland, Matthew Rausch, Devapregasan Moodley
Filed: 22 Mar 19
Utility
Anti-respiratory Syncytial Virus Antibodies, and Methods of Their Generation and Use
12 May 22
Anti-RSV antibodies with neutralizing potency against RSV subtype A and RSV subtype B are provided, as well as methods for their identification, isolation, generation, and methods for their preparation and use are provided.
Laura M. Walker
Filed: 27 Jan 22
Utility
Anti-respiratory syncytial virus antibodies, and methods of their generation and use
26 Apr 22
Anti-RSV antibodies with neutralizing potency against RSV subtype A and RSV subtype B are provided, as well as methods for their identification, isolation, generation, and methods for their preparation and use are provided.
Laura M. Walker
Filed: 20 Oct 17
Utility
Monoclonal antibodies and cocktails for treatment of Ebola infections
22 Feb 22
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 9 Jun 20
Utility
Monoclonal antibodies and cocktails for treatment of Ebola infections
8 Feb 22
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 9 Jun 20
Utility
Monoclonal antibodies and cocktails for treatment of Ebola infections
8 Feb 22
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 9 Jun 20
Utility
Anti-crimean-congo Hemorrhagic Fever Virus Antibodies, and Methods of Their Generation and Use
18 Nov 21
Anti-CCHFV antibodies with neutralizing potency and protective efficacy against CCHFV are provided, as well as methods for their identification, isolation, generation, and methods for their preparation and use are provided.
Zachary A. Bornholdt, Akaash Mishra, Laura M. Walker, Noel T. Pauli, Daniel Maurer, Kartik Chandran, Jens Maximilian Fels, Dafna Abelson, Jason Scott McLellan, Jonathan R. Lai, Ariel Wirchnianski, Olivia Vergnolle
Filed: 5 May 21
Utility
ALK7 binding proteins and uses thereof
13 Jul 21
This disclosure provides ALK7-binding proteins such as anti-ALK7 antibodies, and compositions and methods for making the ALK7-binding proteins.
John Knopf, Jonathan Belk, Nathan J. Sharkey, Ravindra Kumar, Asya Grinberg, Dianne Sako, Roselyne Castonguay, Yossi Dagon
Filed: 26 Nov 19
Utility
Antibodies Against BACE1 and Use Thereof for Neural Disease Immunotherapy
8 Jul 21
The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders
Yichin Liu, Jasvinder Atwal, Cecilia Pui Chi Chiu, Ryan J. Watts, Yan Wu, Eric Krauland, Michael Feldhaus
Filed: 7 Dec 20
Utility
Polyspecificity Reagents, Methods for Their Preparation and Use
27 May 21
The present invention relates, inter alia, to polyspecificity reagents, methods of making the same, and methods of using the same in, inter alia, the selection, screening, enrichment, and identification of non-polyspecific, and thus developable, polypeptides.
Piotr Bobrowicz, Amber D. Hanna, Jerry M. Thomas
Filed: 3 Dec 20
Utility
Rationally designed, synthetic antibody libraries and uses therefor
18 May 21
The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
Maximiliano Vasquez, Michael Feldhaus, Tillman U. Gerngross, K. Dane Wittrup
Filed: 10 Dec 18
Utility
Anti-transferrin receptor / anti-BACE1 multispecific antibodies and methods of use
18 May 21
The present invention relates to bispecific antibodies that bind to transferrin receptor and BACE1 and methods of using the same.
Yichin Liu, Jasvinder Atwal, Cecilia Pui Chi Chiu, Ryan J. Watts, Yan Wu, Eric Krauland, Michael Feldhaus, Yin Zhang, Joy Yu Zuchero, Jessica Couch, Mark S Dennis, James A Ernst, Gregory A Lazar
Filed: 18 Nov 15
Utility
Rationally designed, synthetic antibody libraries and uses therefor
18 May 21
The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
Maximiliano Vasquez, Michael Feldhaus, Tillman U. Gerngross, K. Dane Wittrup
Filed: 28 Dec 18
Utility
Methods of increasing muscle mass by administration of activin type 2 receptor antibodies
11 May 21
This disclosure provides ActRII-binding proteins such as anti-ActRIIA and anti-ActRIIB antibodies, and compositions and methods for making the ActRII-binding proteins.
Ravindra Kumar, Jonathan Belk, Asya Grinberg, Dianne Sako, Roselyne Castonguay
Filed: 22 Apr 19
Utility
Antibody Libraries
6 May 21
The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
Maximiliano Vasquez, Arvind Sivasubramanian, Michael Feldhaus
Filed: 2 Nov 20
Utility
FC Variants with Reduced Effector Function
25 Mar 21
The present invention provides Fc variants and polypeptides, e.g., antibodies and Fc fusion proteins, comprising such Fc variants.
Robert Pejchal, Eric Krauland, Maximiliano Vasquez, Michael Brown, Anthony Cooper
Filed: 18 Sep 20
Utility
Methods for Purifying Heterodimeric Multispecific Antibodies from Parental Homodimeric Antibody Species
18 Feb 21
Methods for purifying multispecific antibodies on interest (MAIs) that co-engage at least two different antigens or epitopes (also referred to targets, used interchangeably throughout), from compositions comprising the MAI and parental homodimeric antibody species are provided, as well as reagents which may be used to practice such methods.
Juergen Hermann Nett, K. Dane Wittrup, Maximiliano Vasquez
Filed: 21 Aug 20