67 patents
Page 3 of 4
Utility
Antibody libraries
12 Jan 21
The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
Maximiliano Vasquez, Arvind Sivasubramanian, Michael Feldhaus
Filed: 10 Sep 18
Utility
Antibodies against BACE1 and use thereof for neural disease immunotherapy
4 Jan 21
The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders.
Yichin Liu, Jasvinder Atwal, Cecilia Pui Chi Chiu, Ryan J. Watts, Yan Wu, Eric Krauland, Michael Feldhaus
Filed: 17 Nov 15
Utility
Polyspecificity reagents, methods for their preparation and use
4 Jan 21
The present invention relates, inter alia, to polyspecificity reagents, methods of making the same, and methods of using the same in, inter alia, the selection, screening, enrichment, and identification of non-polyspecific, and thus developable, polypeptides.
Piotr Bobrowicz, Amber D. Hanna, Jerry M. Thomas
Filed: 19 Nov 18
Utility
ALK7 Binding Proteins and Uses Thereof
16 Dec 20
This disclosure provides ALK7-binding proteins such as anti-ALK7 antibodies, and compositions and methods for making the ALK7-binding proteins.
Ravindra Kumar, Roselyne Castonguay, Dianne Sako, Jonathan Belk, Nathan J. Sharkey
Filed: 24 Oct 18
Utility
Monoclonal antibodies and cocktails for treatment of ebola infections
16 Nov 20
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 16 Feb 18
Utility
Monoclonal Antibodies and Cocktails for Treatment of Ebola Infections
11 Nov 20
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 8 Jun 20
Utility
Monoclonal Antibodies and Cocktails for Treatment of Ebola Infections
11 Nov 20
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 8 Jun 20
Utility
Anti-coagulation Factor XI Antibodies
7 Oct 20
Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
Zhu Chen, Kenneth Ellsworth, James Milligan, Elizabeth Oldham, Dietmar Seiffert, Vaishnavi Ganti, Mohammad Tabrizifard, Bianka Prinz
Filed: 30 Apr 20
Utility
Anti-coagulation Factor XI Antibodies
30 Sep 20
Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
Zhu Chen, Kenneth Ellsworth, James Milligan, Elizabeth Oldham, Dietmar Seiffert, Vaishnavi Ganti, Mohammad Tabrizifard, Bianka Prinz
Filed: 30 Apr 20
Utility
Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species
28 Sep 20
Methods for purifying multispecific antibodies on interest (MAIs) that co-engage at least two different antigens or epitopes (also referred to targets, used interchangeably throughout), from compositions comprising the MAI and parental homodimeric antibody species are provided, as well as reagents which may be used to practice such methods.
Juergen Hermann Nett, K. Dane Wittrup, Maximiliano Vasquez
Filed: 7 Apr 16
Utility
Monoclonal Antibodies and Cocktails for Treatment of Ebola Infections
23 Sep 20
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 8 Jun 20
Utility
Monoclonal Antibodies and Cocktails for Treatment of Ebola Infections
23 Sep 20
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 8 Jun 20
Utility
Monoclonal Antibodies and Cocktails for Treatment of Ebola Infections
23 Sep 20
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 8 Jun 20
Utility
Polyclonal Mixtures of Antibodies, and Methods of Making and Using Them
2 Sep 20
A method of broadening epitopic coverage of an antigen of interest, wherein a first sample of the antigen of interest is contacted with a first plurality of host cells collectively expressing a first library of antibodies.
Laura M. Walker, Eric Krauland, Karl Dane Wittrup
Filed: 8 Apr 20
Utility
Anti-coagulation Factor XI Antibodies
26 Aug 20
Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
Zhu Chen, Kenneth Ellsworth, James Milligan, Elizabeth Oldham, Dietmar Seiffert, Vaishnavi Ganti, Mohammad Tabrizifard, Bianka Prinz
Filed: 30 Apr 20
Utility
Anti-coagulation Factor XI Antibodies
12 Aug 20
Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
Zhu Chen, Kenneth Ellsworth, James Milligan, Elizabeth Oldham, Dietmar Seiffert, Vaishnavi Ganti, Mohammad Tabrizifard, Bianka Prinz
Filed: 30 Apr 20
Utility
Anti-respiratory Syncytial Virus Antibodies, Methods of Their Generation and Use
29 Jul 20
Provided are antibodies or antigen binding polypeptides characterized by the ability to neutralize respiratory syncytial virus (RSV).
Laura M. Walker
Filed: 11 Oct 18
Utility
Multispecific Antibody Analogs Comprising a Common Light Chain, and Methods of Their Preparation and Use
15 Jul 20
Multispecific antibody analogs that co-engage at least two different antigens or epitopes (also referred to targets, used interchangeably throughout), said analogs comprising a common light chain, are provided, as well as methods for their production and use.
Hemanta Baruah, Robert Mabry
Filed: 8 Jan 20
Utility
ANTI-CD3-BINDING Domains and Antibodies Comprising Them, and Methods for Their Generation and Use
17 Jun 20
Anti-CD3 binding domains and antibodies comprising them, including multispecific antibodies, with, inter alia, desirable T-cell activation and (re)directed target cell killing potency and developability, profiles are provided, as well as methods for their identification, isolation, and generation, and methods for their preparation and use.
Laura M. Walker, Robert Pejchal, Eric Krauland, Maximiliano Vasquez, Monica Wai Ling Leung
Filed: 7 May 18
Utility
Polyclonal mixtures of antibodies, and methods of making and using them
15 Jun 20
A method of broadening epitopic coverage of an antigen of interest, wherein a first sample of the antigen of interest is contacted with a first plurality of host cells collectively expressing a first library of antibodies.
Laura M. Walker, Eric Krauland, Karl Dane Wittrup
Filed: 8 Dec 14