74 patents
Page 3 of 4
Utility
Variant Nucleic Acid Libraries for Coronavirus
23 Dec 21
Provided herein are methods and compositions relating to libraries of optimized antibodies having nucleic acids encoding for an antibody comprising modified sequences.
Aaron SATO, Qiang LIU, Tom YUAN
Filed: 27 Apr 21
Utility
Variant Nucleic Acid Libraries for Coronavirus
18 Nov 21
Provided herein are methods and compositions relating to libraries of optimized antibodies having nucleic acids encoding for an antibody comprising modified sequences.
Aaron SATO, Qiang LIU, Tom YUAN
Filed: 27 Apr 21
Utility
Polynucleotide Libraries Having Controlled Stoichiometry and Synthesis Thereof
11 Nov 21
Provided herein are compositions, methods and systems relating to libraries of polynucleotides having preselected stoichiometry with regard to species of polynucleotides such that the libraries allow for predetermined application outcomes, e.g., controlled representation after amplification and uniform enrichment after binding to target sequences.
Ramsey Ibrahim ZEITOUN, Siyuan CHEN
Filed: 17 Jun 21
Utility
Compositions and Methods for Nucleic Acid Amplification
28 Oct 21
The present disclosure provides compositions, methods and systems for the efficient removal of a non-target nucleic acid sequence from a double stranded nucleic acid amplification product.
Cheng-Hsien WU
Filed: 8 Jul 21
Utility
Compositions and Methods for Next Generation Sequencing
8 Jul 21
Provided herein are compositions and methods for next generation sequencing using universal polynucleotide adapters.
Richard GANTT, Siyuan CHEN
Filed: 21 Jan 21
Utility
Variant Nucleic Acid Libraries for Adenosine Receptors
17 Jun 21
Provided herein are methods and compositions relating to adenosine A2A receptor libraries having nucleic acids encoding for a scaffold comprising an adenosine A2A binding domain. adenosine A2A receptor libraries described herein encode for immunoglobulins including antibodies and single domain antibodies.
Aaron SATO, Ray TABIBIAZAR, Pankaj GARG, Qiang LIU
Filed: 9 Dec 20
Utility
De Novo Synthesized Nucleic Acid Libraries
17 Jun 21
Disclosed herein are methods for the generation of nucleic acid libraries encoding for gRNA sequences.
Anthony COX, Siyuan CHEN
Filed: 23 Feb 21
Utility
Functionalized Surfaces and Preparation Thereof
10 Jun 21
Compositions, devices, methods and systems are provided for differential functionalization of a surface of a structure to support biopolymer synthesis.
Bill James PECK, Pierre INDERMUHLE, Eugene P. MARSH, Andres FERNANDEZ, David STERN
Filed: 19 Feb 21
Utility
Dna-based Digital Information Storage with Sidewall Electrodes
13 May 21
Provided herein are compositions, devices, systems and methods for generation and use of biomolecule-based information for storage.
Brian Wayne BRAMLETT, Bill James PECK
Filed: 21 Jan 21
Utility
Heated Nanowells for Polynucleotide Synthesis
6 May 21
Devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein.
Eugene P. Marsh, Pierre F. Indermuhle, Bill James Peck
Filed: 15 Dec 20
Utility
Variant Libraries of the Immunological Synapse and Synthesis Thereof
22 Apr 21
Disclosed herein are methods for the generation of highly accurate nucleic acid libraries encoding for predetermined variants of a nucleic acid sequence.
Anthony COX, Siyuan CHEN
Filed: 23 Dec 20
Utility
Variant Nucleic Acid Libraries for Single Domain Antibodies
8 Apr 21
Provided herein are methods and compositions relating to variant nucleic acid libraries encoding for antibodies including single domain antibodies.
Aaron SATO, Pankaj GARG, Qiang LIU, Tom YUAN
Filed: 23 Sep 20
Utility
Variant Nucleic Acid Libraries for CRTH2
8 Apr 21
Provided herein are methods and compositions relating to prostaglandin D2 receptor 2 (DP2 or CRTH2R) libraries having nucleic acids encoding for a scaffold comprising a CRTH2R binding domain.
Ray TABIBIAZAR, Aaron SATO, Pankaj GARG, Qiang LIU
Filed: 23 Sep 20
Utility
Variant Libraries of the Immunological Synapse and Synapse and Synthesis Thereof
8 Apr 21
Disclosed herein are methods for the generation of highly accurate nucleic acid libraries encoding for predetermined variants of a nucleic acid sequence.
Anthony COX, Siyuan CHEN
Filed: 11 Dec 20
Utility
Barcode-based Nucleic Acid Sequence Assembly
11 Mar 21
Provided herein are methods, systems, and compositions for efficient nucleic acid assembly.
Rebecca NUGENT, Siyuan CHEN, Ross KETTLEBOROUGH, Elian LEE, Nathan RAYNARD
Filed: 19 Jun 20
Utility
Oligonucleic Acid Variant Libraries and Synthesis Thereof
11 Feb 21
Disclosed herein are methods for the generation of highly accurate oligonucleic acid libraries encoding for predetermined variants of a nucleic acid sequence.
Anthony COX, Sebastian Treusch, Siyuan CHEN
Filed: 12 Oct 20
Utility
Compositions and Methods for Next Generation Sequencing
6 Jan 21
Provided herein are compositions and methods for next generation sequencing using universal polynucleotide adapters.
Richard GANTT, Siyuan CHEN
Filed: 20 Feb 20
Utility
Nucleic Acid Based Data Storage
28 Oct 20
Provided herein are compositions, devices, systems and methods for the generation and use of biomolecule-based information for storage.
Bill James PECK
Filed: 12 Jul 20
Utility
Devices and Methods for Oligonucleic Acid Library Synthesis
21 Oct 20
Devices and methods for de novo synthesis of large and highly accurate libraries of oligonucleic acids are provided herein.
William BANYAI, Bill James PECK, Andres FERNANDEZ, Siyuan CHEN, Pierre INDERMUHLE, Eugene P. MARSH
Filed: 5 Jul 20
Utility
Variant Nucleic Acid Libraries for GLP1 Receptor
14 Oct 20
Provided herein are methods and compositions relating to glucagon-like peptide-1 receptor (GLP1R) libraries having nucleic acids encoding for a scaffold comprising a GLP1R binding domain.
Ray TABIBIAZAR, Aaron SATO, Pankaj GARG, Qiang LIU, Fumiko AXELROD
Filed: 25 Feb 20