110 patents
Page 6 of 6
Utility
Microbial Strain Improvement by a HTP Genomic Engineering Platform
12 Feb 20
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zach Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 27 Oct 19
Utility
Liquid Based Selection and Cell Isolation
29 Jan 20
Aspects of this disclosure relate to liquid-based workflows for strain engineering.
Sean Poust, Vytas SunSpiral, William Serber, Matthew Jonathan Myers, Sara da Luz Areosa Cleto, Philip Weyman
Filed: 1 Jul 19
Utility
Bioreachable Prediction Tool
25 Dec 19
Systems and methods for predicting the viability of producing target molecules in a host organism are provided.
Erik Jedediah Dean, Alexander G. Shearer, Michelle L. Wynn
Filed: 11 Aug 19
Utility
Engineered Biosynthetic Pathways for Production of Tyramine by Fermentation
25 Dec 19
The present disclosure describes the engineering of microbial cells for fermentative production of tyramine and provides novel engineered microbial cells and cultures, as well as related tyramine production methods.
Michael Shareef Siddiqui, Stefan de Kok, Alexander Glennon Shearer, Franklin Lu, Cara Ann Tracewell, Steven M. Edgar
Filed: 25 Jun 19
Utility
Nepetalactol Oxidoreductases, Nepetalactol Synthases, and Microbes Capable of Producing Nepetalactone
25 Dec 19
The present disclosure provides isolated nepetalactone oxidoreductase polypeptides (NORs), nepetalactol synthases (NEPSs), and related polynucleotides, engineered host cells, and cultures, as well as methods for producing NORs and NEPSs, and for using them to produce nepetalactol, nepetalactone, and dihydronepetalactone.
Grayson Wawrzyn, Christine Roche, Patrick J. Westfall, Warren Lau, Savita Ganesan, Fern R. McSorley, Zach Serber
Filed: 6 Aug 19
Utility
Manipulation of Genes Involved In Signal Transduction to Control Fungal Morphology During Fermentation and Production
11 Dec 19
The present disclosure provides a microbial genomic engineering method and system for transforming, screening, and selecting filamentous fungal cells that have altered morphology and/or growth under specific growth conditions.
Kenneth S. Bruno, Sachin Jain, Brandon Pfannenstiel, Edyta Szewczyk
Filed: 5 Jun 19
Utility
Engineered Biosynthetic Pathways for Production of (6E)-8-HYDROXYGERANIOL by Fermentation
6 Nov 19
The present disclosure describes the engineering of microbial cells for fermentative production of (6E)-8-hydroxygeraniol and provides novel engineered microbial cells and cultures, as well as related (6E)-8-hydroxygeraniol production method.
Cara Ann Tracewell, Steven M. Edgar, Stepan Tymoshenko, Alexander Glennon Shearer
Filed: 23 Jun 19
Utility
Scarless Dna Assembly and Genome Editing Using CRISPR/CPF1 and Dna Ligase
30 Oct 19
The disclosure describes a scarless DNA assembly and genome editing methodology termed “CLIC” (CRISPR and Ligase Cloning), which utilizes a CRISPR/Cpf1 complex and DNA ligase to perform programmable gene editing and nucleotide assembly.
William C. DeLoache, Hendrik Marinus van Rossum, Kedar Gautam Patel
Filed: 13 Jul 17
Utility
Method to Build Fungal Production Strains Using Automated Steps for Genetic Manipulation and Strain Purification
23 Oct 19
The present disclosure provides a high-throughput (HTP) microbial genomic engineering method and system for transforming, screening, and selecting filamentous fungal cells that utilizes automation.
Kenneth S. BRUNO, Patrick WESTFALL, Edyta SZEWCZYK, Kyle ROTHSCHILD-MANCINELLI
Filed: 25 Jun 19
Utility
Microbial Strain Improvement by a HTP Genomic Engineering Platform
16 Oct 19
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zach Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 30 Jun 19