49 patents
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Utility
Optimized Bacteria Engineered to Treat Disorders Involving the Catabolism of Leucine, Isoleucine, And/or Valine
17 Nov 22
The present disclosure provides recombinant bacterial cells that have been engineered with genetic circuitry which allow the recombinant bacterial cells to sense a patients internal environment and respond by turning an engineered metabolic pathway on or off.
Ning Li, Jian-Rong Gao, Philippa Jane Reeder Morrison, Christopher George Bergeron, Dylan Alexander Carlin, Laura K. Stone, Alex C. Tucker, Patrick M. Boyle
Filed: 19 Jun 20
Utility
Increasing lipid production in oleaginous yeast
8 Nov 22
Disclosed are methods and compositions for increasing the triacylglycerol content of a cell by increasing the activity of a type 1 diacylglycerol acyltransferase (i.e., DGA2) and increasing the activity of a type 2 diacylglycerol acyltransferase (i.e., DGA1).
Vasiliki Tsakraklides, Elena E. Brevnova
Filed: 5 Apr 19
Utility
Rare Earth Element (Ree)-binding Proteins
3 Nov 22
Described in this disclosure are rare earth element (REE)-binding proteins (e.g., lanthanide-binding proteins), host cells expressing the REE-binding proteins, and methods of recovering REEs.
Patrick Boyle, Ramya L. Prathuri, Nathan W. Schmidt, Emily E. Wrenbeck, Mark David Simon
Filed: 19 Jun 20
Utility
Protective Enzymes
3 Nov 22
The present invention relates to methods and compositions that include enzymes and/or binding polypeptides useful for protecting polymers from damage caused by fatty acids from secreted biological fluids such as sebum or sweat.
Patrick Magannig Boyle, Jeffery Ian Boucher, Michael Gregory Napolitano
Filed: 13 May 22
Utility
Biosynthesis of Enzymes for Use In Treatment of Maple Syrup Urine Disease (Msud)
3 Nov 22
Provided in this disclosure, in some embodiments, are methods and compositions for treating maple syrup urine disease (MSUD) and other conditions characterized by excessive branched-chain amino acids.
Patrick Boyle, Dylan Alexander Carlin, Rishi Jain, Ryan Putman, Laura Stone, Alex C. Tucker, Kolea Zimmerman
Filed: 19 Jun 20
Utility
Heterologous Production of 10-METHYLSTEARIC Acid by Cells Expressing Recombinant Methyltransferase
27 Oct 22
Disclosed herein are cells, nucleic acids, and proteins that can be used to produce branched (methyl)lipids, such as 10-methylstearic acids, and compositions that include such lipids.
Arthur J. Shaw, Hannah Blitzblau, Donald V. Crabtree
Filed: 30 Jan 22
Utility
Methods and systems for methylotrophic production of organic compounds
25 Oct 22
The present disclosure identifies pathways, mechanisms, systems and methods to confer production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in engineered and/or evolved methylotrophs such that these organisms efficiently convert C1 compounds, such as formate, formic acid, formaldehyde or methanol, to organic carbon-based products of interest, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
Reshma P. Shetty, Curt R. Fischer
Filed: 27 Mar 18
Utility
Compositions and methods for the production of compounds
25 Oct 22
The present disclosure provides proteins, nucleic acids, vectors, and host molecules useful for the production of compounds of interest, and methods for their use.
Daniel C. Gray, Brian R. Bowman, Gregory L. Verdine, Mathew Edward Sowa
Filed: 27 Oct 17
Utility
Biosynthesis of Cannabinoids and Cannabinoid Precursors
29 Sep 22
The disclosure relates to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro comprising the use of disclosed prenyltransferase variants.
Kim Cecelia Anderson, Dylan Alexander Carlin, Nicholas Flores, Katrina Forrest, Ramya L. Prathuri, Gabriel Rodriguez, Michelle Spencer
Filed: 18 Aug 20
Utility
Biosynthesis of Cannabinoids and Cannabinoid Precursors
29 Sep 22
Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
Kim Cecelia Anderson, Elena Brevnova, Dylan Alexander Carlin, Brian Carvalho, Nicholas Flores, Katrina Forrest, Matthew McMahon, Massimo Merighi, Gabriel Rodriguez, Emily E. Wrenbeck
Filed: 9 Mar 22
Utility
Compositions and methods for the production of compounds
20 Sep 22
The present disclosure provides nucleic acids encoding a Large ATP-binding regulator of the LuxR family (LAL) of transcription factors, vectors and host cells including such nucleic acids, and methods for producing compounds (e.g., polyketides or β-lactam compounds) with such nucleic acids, vectors, and/or host cells.
Brian R. Bowman, Joshua A. V. Blodgett, Gregory L. Verdine, Daniel C. Gray, Jay P. Morgenstern, Lucy Foulston, Keith Robison
Filed: 29 Jan 21
Utility
Biosynthesis of Cannabinoids and Cannabinoid Precursors
23 Jun 22
Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
Kim Cecelia Anderson, Elena Brevnova, Dylan Alexander Carlin, Brian Carvalho, Nicholas Flores, Katrina Forrest, Massimo Merighi, Gabriel Rodriguez, Emily E. Wrenbeck
Filed: 4 Feb 22
Utility
Protective enzymes
14 Jun 22
The present invention relates to methods and compositions that include enzymes and/or binding polypeptides useful for protecting polymers from damage caused by fatty acids from secreted biological fluids such as sebum or sweat.
Patrick Magannig Boyle, Jeffrey Ian Boucher, Michael Gregory Napolitano
Filed: 12 Sep 18
Utility
Diacylglycerol acyltransferase (DGA1) polynucleotides, and methods of increasing yeast cell lipid production by overexpression of heterologous DGA1
7 Jun 22
DGA1 catalyzes the final enzymatic step for converting acyl-CoA and 1,2-diacylglycerol to triacylglycerols (TAG) and CoA in yeast.
Elena E. Brevnova, Arthur J. Shaw, IV, Emily H. Greenhagen
Filed: 28 Feb 19
Utility
Derivatives of 10-METHYLENE Lipids, Process for Preparing Such Derivatives and Use Thereof
2 Jun 22
The present invention relates to derivatives of 10-methylene lipids, their preparation and their use.
Jean-Christophe RABOIN, Henri STRUB
Filed: 26 Mar 20
Utility
Biosynthesis of cannabinoids and cannabinoid precursors
15 Mar 22
Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
Kim Cecelia Anderson, Elena Brevnova, Dylan Alexander Carlin, Brian Carvalho, Nicholas Flores, Katrina Forrest, Massimo Merighi, Gabriel Rodriguez, Emily E. Wrenbeck
Filed: 23 Oct 20
Utility
Heterologous production of 10-methylstearic acid by cells expressing recombinant methyltransferase
1 Feb 22
Disclosed herein are cells, nucleic acids, and proteins that can be used to produce branched (methyl)lipids, such as 10-methylstearic acids, and compositions that include such lipids.
Arthur J. Shaw, Hannah Blitzblau, Donald V. Crabtree
Filed: 20 Sep 18
Utility
Biosynthesis of Mogrosides
30 Dec 21
Described in this application are enzymes (e.g., cucurbitadienol synthases (CDS), UDP-glycosyltransferases (UGT), C11 hydroxylases, epoxide hydrolases (EPH), squalene epoxidases, and/or cytochrome P450 reductases), host cells expressing the enzymes, and methods of producing mogrol precursors, mogrol, and/or mogrosides using such host cells.
Kim Cecelia Anderson, Jeffrey Ian Boucher, Nicholas Flores, Jaide Jensen, Scott Marr, Matthew McMahon, Dayal Saran, Jue Wang, Jie Zhu
Filed: 9 Nov 19
Utility
Microorganisms Engineered to Use Unconventional Sources of Nitrogen
9 Dec 21
Disclosed are genetically engineered organisms, such as yeast and bacteria, that have the ability to metabolize atypical nitrogen sources, such as melamine and cyanamide.
Colin R. South, Arthur J. Shaw, IV
Filed: 16 Jun 21
Utility
Heterologous Production of 10-METHYLSTEARIC Acid
2 Sep 21
Nucleic acids and cells comprising a methyltransferase gene and/or a reductase gene are disclosed.
Arthur J. Shaw, Hannah Blitzblau, Donald V. Crabtree
Filed: 10 Mar 21