229 patents
Page 10 of 12
Utility
Monoclonal antibodies and cocktails for treatment of ebola infections
16 Nov 20
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 16 Feb 18
Utility
Monoclonal Antibodies and Cocktails for Treatment of Ebola Infections
11 Nov 20
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 8 Jun 20
Utility
Monoclonal Antibodies and Cocktails for Treatment of Ebola Infections
11 Nov 20
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 8 Jun 20
Utility
High Resolution Intravital Imaging and Uses Thereof
11 Nov 20
Methods and apparatus are provided for high resolution intravital imaging and for chronic optical imaging of tissues such as lung.
David Entenberg, John S. Condeelis, Sonia E. Voiculescu
Filed: 31 Jul 18
Utility
BTNL9 and Ermap As Novel Inhibitors of the Immune System for Immunotherapies
28 Oct 20
Provided are methods of treating a tumor in a subject with a BTNL9-binding antibody.
Xingxing ZANG, Kaya GHOSH
Filed: 4 May 20
Utility
Fidgetin-like 2 as a target to enhance wound healing
19 Oct 20
Methods of treating a wound in a subject are provided comprising administering to the subject an amount of an inhibitor of Fidgetin-like 2.
David J. Sharp, Rabab Charafeddine
Filed: 21 Feb 19
Utility
Methods and devices for intraoperative viewing of patient 3D surface images
19 Oct 20
Methods and devices are disclosed for intra-operative viewing of pre- and intra-operative 3D patient images.
Oren Mordechai Tepper, Jillian Schreiber, Cesar Colasante
Filed: 25 Sep 16
Utility
PAK1 Inhibitors and Uses Thereof
14 Oct 20
Methods are disclosed for treating acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) using compounds that inhibit p21 protein (Cdc42/Rac)-activated kinase (PAK1).
Ulrich Steidl, Ashley M. Eckel, Robert F. Stanley, Boris Rogovoy, Ilya Okun
Filed: 2 Apr 17
Utility
Methods of determining levels of exposure to radiation and uses thereof
12 Oct 20
Provided herein are methods of determining a subject's level of exposure to radiation and methods of determining a subject's risk of subsequent development of radiation disease or risk of poor prognosis from radiation exposure that include determining a level of one or more miRNAs selected from the group consisting of mouse and human homologues of mouse miR-130a-3p, miR-150-5p, miR-17-3p, miR-187-3p, miR-194-5p, miR-27a-3p, miR-30a-3p, miR-30c-5p, miR-142-5p, miR-342-3p, miR-34b-3p, miR-126-3p, miR-320-3p, miR-136-5p, miR-33-5p, miR-142a-3p, miR-706, miR-375-3p, miR-29a-5p, miR-193a-3p, miR-99b-5p, miR-151-3p, miR-let-7d-3p, miR-486-5p, miR-423-5p, miR-30b-5p, miR-191-5p, miR-497a-5p, miR-32-5p, miR-214-5p, miR-326-3p, miR-1195, miR-122-5p, miR-1839-3p, miR-500-3p, miR-30e-3p, miR-322-3p, miR-709, miR-486-3p, miR-133a-3p, miR-676-3p, miR-744-5p, miR-29a-3p, miR-1839-5p, miR-30a-5p, miR-199b-5p, miR-125a-5p, miR-133b-3p, miR-24-3p, miR-21a-5p, miR-503-5p, miR-328-3p, miR-let-7g-5p, miR-362-3p, miR-199a-5p, miR-15a-3p, miR-139-5p, miR-149-5p, miR-29b-3p, miR-1a-3p, miR-23b-3p, miR-215-5p, miR-204-5p, miR-200b-5p, miR-25-3p, miR-338-3p, and miR-196b-5p, in a sample including a biological fluid from the subject.
Dipanjan Chowdhury, Chandan Guha
Filed: 8 Feb 16
Utility
Antibodies to CENTRIN-1, Methods of Making, and Uses Thereof
7 Oct 20
Provided herein are antibodies that specifically bind Centrin-1 and methods of making the same, for use the treatment, prevention, detection, imaging, and diagnosis of cancers including pancreatic and prostate cancer.
David J. RICKLES, Ekaterina DADACHOVA, Ruth A. BRYAN
Filed: 19 Dec 18
Utility
Methods and Compositions for Assessing Germline Risk of Cancer
30 Sep 20
Heritable mutations in the BRCA1 and BRCA2 and other genes in the DNA double-strand break (DSB) repair pathway increase risk of breast, ovarian and other cancers.
Harry OSTRER, Johnny C. LOKE, Alexander PEARLMAN
Filed: 11 Jun 20
Utility
Monoclonal Antibodies and Cocktails for Treatment of Ebola Infections
23 Sep 20
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 8 Jun 20
Utility
Monoclonal Antibodies and Cocktails for Treatment of Ebola Infections
23 Sep 20
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 8 Jun 20
Utility
Monoclonal Antibodies and Cocktails for Treatment of Ebola Infections
23 Sep 20
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 8 Jun 20
Utility
Programmed cargo release using nucleic acid-stabilized micelles
21 Sep 20
Methods and compositions for serum-stabilizing micelles for drug delivery or imaging agent delivery are provided, as well as methods and compositions to enhance micelle-mediated drug delivery.
Samantha E. Wilner, Matthew Levy
Filed: 6 Oct 15
Utility
Dengue virus glycoprotein E DIII variants and uses thereof
14 Sep 20
Specific Dengue virus glycoprotein subunit E DIII variants and their uses in preventing and treating Dengue virus infection are disclosed.
Jonathan R. Lai, Margaret C. Kielian, Julia C. Frei
Filed: 12 Feb 17
Utility
PU.1 inhibitors
14 Sep 20
Disclosed herein are inhibitors of PU.1.
W. David Wilson, David W. Boykin, Gregory Poon, Ulrich Steidl, Iléana Anthony-Debré
Filed: 19 Dec 18
Utility
Methods and compositions for treating and preventing arthritis
14 Sep 20
Methods and formulations are provided for treating or preventing arthritis, in particular osteoarthritis, where the formulation to be administered to a subject for treating or preventing arthritis comprises carvacrol, curcumin, epigallocatechin-3-gallate and oligomeric procyanidins.
Hui B. Sun, Daniel J. Leong, Neil J. Cobelli, David M. Hirsh, John A. Hardin, Karen E. Sperling, Sun Jin Kim, David C. Spray, Chandan Guha, Marwa Choudhury
Filed: 1 Nov 15
Utility
Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof
7 Sep 20
Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RARα) in subjects in need thereof.
Ana Maria Cuervo, Evripidis Gavathiotis, Qisheng Xin, Bhaskar C. Das
Filed: 4 Dec 18
Utility
Methods and Compositions to Inhibit Metastasis and to Treat Fibrosis and to Enhance Wound Healing
2 Sep 20
Methods and compositions are provided for inhibiting or treating metastasis based on discoveries regarding Kif19 and Cep192.
David SHARP, Brian O'ROURKE
Filed: 8 Jan 20