229 patents
Page 11 of 12
Utility
Synthetic antibodies to BAX and uses thereof
31 Aug 20
Synthetic fragment antigen-binding (Fab) antibodies are disclosed that bind to an N-terminal activation site of BCL-2-associated X-protein (BAX) and inhibit BAX activation.
Evripidis Gavathiotis, Jonathan R. Lai, Sachdev Sidhu
Filed: 29 Jan 19
Utility
Methods of Treatment by Targeting VCAM1 and Maea
26 Aug 20
Antibodies and antibody fragments that inhibit the activity of vascular cell adhesion molecule 1 (VCAM1) and/or macrophage erythroblast attacher (MAEA) are provided, along with formulations and kits comprising these antibodies and antibody fragments and the use of the disclosed compositions, formulations, and kits to treat cancers, sickle cell disease, and Polycythemia Vera.
Paul S. FRENETTE, Sandra PINHO, Qiaozhi WEI, Sung Kyun LEE
Filed: 26 Jan 20
Utility
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24 Aug 20
Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors, virions thereof, compositions and vaccines comprising such, and methods of use thereof are each provided.
William Jacobs, Jr., Pablo A. Gonzalez Munoz, Betsy Herold, Christopher Petro
Filed: 29 Jul 19
Utility
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19 Aug 20
Activators of mitofusins and their uses in treatment of diseases and disorders are disclosed.
Evripidis Gavathiotis, Richard N. Kitsis, Nikolaos Biris, Emmanouil Zacharioudakis
Filed: 15 Oct 18
Utility
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29 Jul 20
Disclosed are methods for chemoenzymatic synthesis of S-Nucleosyl Amino acid probes (SNA), analogs of S-adeno-syl-L-methionine and S-adenosyl-L-homo-cysteine, analogs synthesized by the methods, and uses thereof.
Emmanuel Sebastien Burgos, David Shechter
Filed: 24 Jan 17
Utility
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20 Jul 20
Disclosed are tumor necrosis factor receptor 1B (TNFR-1B) signaling targets and TNFR-1B mutants and their uses for treatment of diseases and disorders.
Steven C. Almo, Sarah Garrett-Thomson, Ron Seidel
Filed: 4 Apr 18
Utility
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20 Jul 20
Heritable mutations in the BRCA1 and BRCA2 and other genes in the DNA double-strand break (DSB) repair pathway increase risk of breast, ovarian and other cancers.
Harry Ostrer, Johnny C. Loke, Alexander Pearlman
Filed: 18 Aug 15
Utility
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8 Jul 20
The application discloses methods and compositions for the inhibition of the alternative complement pathway.
Carl Erickson, Christopher P. Rusconi, Kevin G. McLure, Matthew Levy, Arijit Bhowmick
Filed: 14 Aug 19
Utility
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6 Jul 20
A method of treating a tumor in a subject, or reducing or preventing metastasis of a tumor in a subject, is provided comprising administering to the subject an amount of a bacteria labelled with, or comprising, one or more radionuclides so as to treat the tumor in the subject, or so as to reduce or prevent metastasis of the tumor in the subject.
Ekaterina Dadachova, Claudia Gravekamp, Arturo Casadevall
Filed: 2 Feb 12
Utility
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29 Jun 20
Disclosed are piston actuator devices and their uses for magnetic resonance elastography (MRE).
Mark Elliott Wagshul
Filed: 30 Mar 16
Utility
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22 Jun 20
Methods are disclosed for preventing and/or treating cardiovascular diseases comprising administering B7x or a derivative of B7x to a patient in need thereof.
Xingxing Zang, Hyungjun Jeon
Filed: 8 Dec 14
Utility
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10 Jun 20
Provided are chemically modified ribonucleic acid (RNA) aptamers comprising one or more of 2′F guanylate, 2′OMe cytidylate, 2′OMe adenylate, and a deoxy pyrimidine nucleotide with a moiety on the 5 position of the pyrimidine; and methods of making the aptamers.
Matthew LEVY, Arijit BHOWMICK
Filed: 5 Oct 17
Utility
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11 May 20
Methods and systems for identifying inhibitors of Equilibrative Nucleoside Transporters are provided.
Myles Akabas, Ithiel James Frame, Roman Deniskin
Filed: 7 Jan 14
Utility
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6 May 20
A method for revitalizing mesenchymal stem cells (MSC) maintained in culture by transducing the MSC with vectors encoding a specific gene combination, as well as methods of use of MSC so revitalized in co-culturing hematopoietic stem cells.
Paul S. FRENETTE, Fumio NAKAHARA
Filed: 6 Jun 18
Utility
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6 May 20
Methods of treating a wound in a subject are provided comprising administering to the subject an amount of an inhibitor of Fidgetin-like 2.
David J. SHARP, Rabab CHARAFEDDINE
Filed: 9 Dec 19
Utility
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25 Mar 20
Activators of BAX and their uses in cancer therapy are disclosed.
Evripidis Gavathiotis, Denis E. Reyna, Felix Kopp, Ulrich G. Steidl
Filed: 23 May 18
Utility
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11 Mar 20
Nucleic acid molecules encoding monomeric near-infrared fluorescent proteins, variants and derivatives thereof are provided, as well as proteins and peptides encoded by these nucleic acids.
Vladislav V. Verkhusha, Daria M. Shcherbakova, Mikhail Baloban
Filed: 10 Sep 19
Utility
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12 Feb 20
Methods of determining the erythroid prognosis of an anemia, methods of treating a blood disorder in a subject comprising an anemia, and methods of treating a blood disorder in a subject comprising an expanded erythron are all provided.
Andrew Chow, Paul S. Frenette, Miriam Merad
Filed: 9 Jul 19
Utility
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12 Feb 20
Methods and devices are disclosed for non-invasive optogenetic stimulation of autonomic efferent fibers to regulate glucose metabolism in the liver and brown adipose tissue and to treat metabolic disorders.
Young-Hwan Jo, Jae Hoon Jeong, Streamson Chua, JR.
Filed: 1 Apr 18
Utility
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29 Jan 20
Disclosed herein is a delivery platform for the preparation of versatile sol-gel/hydrogel based nano and micro particles that can be loaded with small molecules.
JOEL FRIEDMAN, ANDREW DRAGANSKI, ADAM FRIEDMAN, MAHANTESH NAVATI, PARIMALA NACHARAJU
Filed: 8 Feb 18