61 patents
Page 2 of 4
Utility
Topical Minocycline Foamable Compositions
14 Apr 22
Disclosed are simple yet stable and effective compositions comprising from about 1% to about 5% by weight of the composition of a minocycline or mixtures thereof and pharmaceutically acceptable ingredients comprising from about 60% to about 99% by weight of the composition of at least one hydrophobic oil, and from about 5% to about 25% by weight of the composition of at least one fatty alcohol, wherein the at least one hydrophobic oil and the at least one fatty alcohol are sufficient to ensure the pharmaceutically acceptable assay stability of the minocycline in the composition under 3 months accelerated stability conditions at 40° C./75% RH.
Karine NEIMANN, Danil FINKEL-MOISEEV, Moshe ARKIN, Adina HAIMOV
Filed: 28 Oct 19
Utility
Treatment of Ocular Diseases with Ophthalmic Tapinarof Compositions
10 Mar 22
The present invention relates to the treatment of an ocular inflammatory disease or an ocular degeneration disease by ophthalmic administration of a composition comprising tapinarof and optionally at least one additional active agent.
Moshe ARKIN, Marcel ZIGHELBOIM
Filed: 16 Nov 21
Utility
Method of Treating a Skin Disorder with Egfr Inhibitor
3 Mar 22
The present invention, in some embodiments, relates to a method of treatment, prevention or alleviation of Palmoplantar Keratoderma (PPK) or Olmsted syndrome in a patient in need thereof, comprising a debridement step followed by topical administration of a composition comprising at least one Epidermal Growth Factor Receptor (EGFR) inhibitor.
Moshe ARKIN, Marcel ZIGHELBOIM, Ofra LEVY-HACHAM, Ori NOV
Filed: 9 Nov 21
Utility
Treatment of Psoriasis with Topical Tapinarof-tazarotene Combination Compositions
24 Feb 22
Provided herein is a topical combination composition comprising from about 0.25% w/w to about 2.0% w/w tapinarof, from about 0.025% w/w to about 0.1% w/w tazarotene and a carrier suitable for topical administration.
Moshe ARKIN
Filed: 25 Feb 20
Utility
High Purity Cantharidin Manufacturing Process and Compositions
27 Jan 22
Disclosed are topical compositions and methods of treatment of skin disorders selected from Molluscum contagiosum, verrucae and warts by topical administration to a subject in need thereof of a composition comprising between about 0.5%-1.0% w/w high-purity cantharidin.
Stephen CHERKEZ
Filed: 26 Jul 21
Utility
Treatment of Skin Disorders with Topical Tapinarof Combination Compositions
13 Jan 22
Provided herein are topical combination compositions comprising a therapeutically effective dose of tapinarof and a therapeutically effective dose of at least one additional active agent, selected from at least one corticosteroid, calcipotriene, at least one JAK inhibitor and combinations thereof, and a carrier suitable for topical administration.
Moshe ARKIN
Filed: 27 Jan 20
Utility
Stabilized Microcapsules, Method of Their Preparation and Uses Thereof
25 Nov 21
The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.
Ofer Toledano, Karine Neimann, Danil Finkel-Moiseev, Maya Erlich, Dorit MARCO
Filed: 23 May 21
Utility
Stabilized Microcapsules, Method of Their Preparation and Uses Thereof
25 Nov 21
The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.
Ofer TOLEDANO, Karine NEIMANN, Danil FINKEL-MOISEEV, Maya ERLICH, Dorit MARCO
Filed: 23 May 21
Utility
Stabilized Microcapsules, Method of Their Preparation and Uses Thereof
25 Nov 21
The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.
Ofer TOLEDANO, Karine NEIMANN, Danil FINKEL-MOISEEV, Maya ERLICH, Dorit MARCO
Filed: 23 May 21
Utility
Compositions Comprising Tapinarof for the Treatment of Pruritis
11 Nov 21
The present invention, in some embodiments thereof, relates to a topical composition for use in treating, preventing, alleviating and/or ameliorating pruritus, wherein the composition comprises tapinarof and the pruritus is not associated with atopic dermatitis, psoriasis or any combination thereof.
Marcel ZIGHELBOIM, Moshe ARKIN, Karine NEIMANN, Hila HAKAK DJERBI
Filed: 6 May 21
Utility
Treatment of Skin Disorders with Compositions Comprising an Egfr Inhibitor
11 Nov 21
This invention relates to compositions and methods of treatment of skin or mucosal disorders by administration of compositions comprising at least one EGFR inhibitor, such as topical compositions comprising erlotinib.
Moshe ARKIN, Marcel ZIGHELBOIM, Ori NOV, Ofer TOLEDANO, Karine NEIMANN, Asher Cachlon
Filed: 20 Jun 21
Utility
Treatment of Alopecia
14 Oct 21
The present invention is directed to a composition comprising aryl hydrocarbon receptor (AhR) agonists and combinations for the prevention and treatment of alopecia and hair loss, e.g. when such conditions are caused by chemotherapy, radiation therapy or hormone replacement therapy.
Ori Nov, Marcel Zighelboim, Karine Neimann
Filed: 12 Apr 21
Utility
Core Stabilized Microcapsules, Method of Their Preparation and Uses Thereof
23 Sep 21
The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.
Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook, Sharon Fireman-Shoresh, Dorit Marco
Filed: 7 Jun 21
Utility
Compositions Comprising Benzoyl Peroxide for the Treatment of Gastrointestinal Disorder
16 Sep 21
The present invention relates to the treatment, prevention or alleviation of a gastrointestinal disorder caused by one or more intestinal helminths, said treatment, prevention or alleviation comprises administering a topical composition comprising a peroxide to a subject in need thereof.
Ori NOV, Karine NEIMANN, Asher CACHLON
Filed: 16 Mar 21
Utility
Treatment of Skin Disorders with Topical Roflumilast Combination Compositions
5 Aug 21
Moshe ARKIN, Marcel ZIGHELBOIM, Karine NEIMANN
Filed: 3 Feb 21
Utility
Compositions Comprising Roflumilast for Treating Hidradenitis Suppurativa and Prurigo Nodularis
5 Aug 21
Moshe Arkin, Marcel Zighelboim, Karine Neimann, Hila Hakak Djerbi
Filed: 3 Feb 21
Utility
Methods and Compositions for the Treatment of Granuloma Annulare or Subcutaneous Inflammation and Non-infection Granulomatous Diseases
15 Jul 21
The present invention, in some embodiments thereof, relates to topical compositions and methods of treatment, prevention and/or amelioration of granuloma annulare, a non-infection granulomatous disease, or a subcutaneous inflammation by topical or intralesional administration of compositions comprising tapinarof.
Marcel Zighelboim, Hila Hakak Djerbi, Karine Neimann
Filed: 13 Jan 21
Utility
Method for Treatment of Rosacea In Patients Aged 65 Years and Older
10 Jun 21
A regimen for the therapeutic treatment of rosacea in subjects aged 65 years and older, the regimen comprising topically applying to the skin of a subject aged 65 years and older in need of said treatment a pharmaceutical composition, the pharmaceutical composition comprising about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient, wherein the benzoyl peroxide is the only active ingredient in said pharmaceutical composition, wherein said pharmaceutical composition is applied once daily for a period of at least about 2 weeks, to achieve, in a group of such subjects, a success rate of at least about 15%, wherein the success rate is defined as the number of subjects achieving clear or almost clear skin on the investor global assessment (IGA) scale after treatment with the pharmaceutical composition.
Ofer TOLEDANO, Ofra LEVY-HACHAM, Ori NOV, Vered RAM
Filed: 21 Jan 21
Utility
Method for Providing Early Onset of Action In the Treatment of Rosacea
20 May 21
A regimen is described for providing early onset of action in the therapeutic treatment of rosacea including topically applying a pharmaceutical composition to the skin of a subject in need of said treatment.
Ofer TOLEDANO, Ofra LEVY-HACHAM, Ori NOV, Vered RAM
Filed: 25 Jan 21
Utility
Methods and Compositions for the Treatment of Acne
22 Apr 21
The present application is directed to regimens, methods of treatment, and compositions for the treatment of acne in a subject suffering therefrom.
Ofer Toledano, Ofra Levy-Hacham, Rinat Mizrahi
Filed: 30 Dec 20