61 patents
Page 3 of 4
Utility
Method for Preparing Particles Comprising Metal Oxide Coating and Particles with Metal Oxide Coating
14 Jan 21
The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer.
Ofer TOLEDANO, Haim Bar-Simantov, Nissim Bilman, Leora Shapiro, Raed Abu-Reziq, Hanan Sertchook
Filed: 10 Sep 20
Utility
Treatment of Ocular Diseases with Ophthalmic Tapinarof Compositions
6 Jan 21
The present invention relates to the treatment of an ocular inflammatory disease or an ocular degeneration disease by ophthalmic administration of a composition comprising tapinarof and optionally at least one additional active agent.
Moshe ARKIN, Marcel ZIGHELBOIM
Filed: 14 Jul 20
Utility
Pharmaceutical Compositions Comprising Silica Microspheres
6 Jan 21
Topical vaginal compositions are disclosed herein which include silica microspheres and an active ingredient in the amount of 0.001 to 15.0% w/w selected from estradiol, metronidazole, clindamycin, butoconazole, and combinations thereof.
MARINA SHEVACHMAN, AMIRA ZE' EVI, EILON ASCULAI, BATELLA BENYAMINOVICH, NIR AVRAM, CHAIM ASCHKENASY
Filed: 16 Sep 20
Utility
Methods for the Treatment of Rosacea
30 Dec 20
The present invention relates to pharmaceutical compositions for topical use (including also dermatological compositions), for treating skin conditions and afflictions, such as rosacea and symptoms and conditions associated there from.
Hanan SERTCHOOK, Ofer Toledano, Haim Bar-Simantov
Filed: 9 Sep 20
Utility
Treatment of Ocular Diseases with Ophthalmic Tapinarof Compositions
16 Dec 20
The present invention relates to the treatment of an ocular inflammatory disease or an ocular degeneration disease by ophthalmic administration of a composition comprising tapinarof and optionally at least one additional active agent.
Moshe ARKIN, Marcel ZIGHELBOIM
Filed: 21 Jul 20
Utility
Treatment of Ocular Diseases with Ophthalmic Tapinarof Compositions
16 Dec 20
The present invention relates to the treatment of an ocular inflammatory disease or an ocular degeneration disease by ophthalmic administration of a composition comprising tapinarof and optionally at least one additional active agent.
Moshe ARKIN, Marcel ZIGHELBOIM
Filed: 16 Aug 20
Utility
Method for Preparing Particles Comprising Metal Oxide Coating and Particles with Metal Oxide Coating
9 Dec 20
The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer.
Ofer TOLEDANO, Haim BAR-SIMANTOV, Nissim BILMAN, Leora SHAPIRO, Raed ABU-REZIQ, Hanan SERTCHOOK
Filed: 24 Aug 20
Utility
Process for the Preparation of Glycopyrrolate Tosylate
2 Dec 20
The present application provides novel process for the preparation of glycopyrrolate tosylate.
Stephen CHERKEZ, Veera Reddy ARAVA, Madhusudhanarao RAYAPUREDDI, Venkateswarlu JASTI
Filed: 11 Mar 18
Utility
Process for the Preparation of Glycopyrrolate Tosylate
2 Dec 20
This invention is directed to a process for the preparation of glycopyrrolate tosylate comprising the step of reacting a halogen salt of glycopyrrolate with tosylic acid or a salt thereof in the presence of hydrogen peroxide and at least one unsaturated organic agent.
Veera Reddy ARAVA, Madhusudhanarao RAYAPUREDDI, Venkateswarlu JASTI
Filed: 25 Jul 18
Utility
Methods and Compositions for the Treatment of Acne
7 Oct 20
The present application is directed to regimens, methods of treatment, and compositions for the treatment of acne in a subject suffering therefrom.
Ofer Toledano, Ori Nov
Filed: 9 Jun 20
Utility
Method for Therapeutic Treatment of Rosacea
19 Aug 20
A regimen and a pharmaceutical composition for the treatment of rosacea are described.
Ofer TOLEDANO, Ori NOV
Filed: 18 Feb 20
Utility
Method for Treatment of Rosacea Including Patient Reported Outcomes Thereof
19 Aug 20
A regimen is described for the therapeutic treatment of rosacea including topically applying to the skin of a subject in need of the treatment a pharmaceutical composition.
Ofer TOLEDANO, Ofra LEVY-HACHAM, Ori NOV, Vered RAM
Filed: 18 Feb 20
Utility
Method for Providing Early Onset of Action In the Treatment of Rosacea
19 Aug 20
A regimen is described for providing early onset of action in the therapeutic treatment of rosacea including topically applying a pharmaceutical composition to the skin of a subject in need of said treatment.
Ofer TOLEDANO, Ofra LEVY-HACHAM, Ori NOV, Vered RAM
Filed: 18 Feb 20
Utility
Method for First-line Treatment of Rosacea
19 Aug 20
A first-line treatment regimen is described for the therapeutic treatment of rosacea.
Moshe ARKIN, Karine NEIMANN, Ofer TOLEDANO
Filed: 18 Feb 20
Utility
Method for Long-term Treatment of Rosacea
19 Aug 20
A regimen for the long-term therapeutic treatment of rosacea.
Ofer TOLEDANO, Ofra LEVY-HACHAM, Ori NOV, Vered RAM
Filed: 18 Feb 20
Utility
Method for Treatment of Rosacea
19 Aug 20
A regimen for the therapeutic treatment of rosacea, which includes topically applying to the skin of a subject a pharmaceutical composition.
Ofer TOLEDANO, Ofra LEVY-HACHAM, Ori NOV, Vered RAM
Filed: 18 Feb 20
Utility
Method for Treatment of Rosacea In Patients Aged 65 Years and Older
19 Aug 20
A regimen for the therapeutic treatment of rosacea in subjects aged 65 years and older, the regimen comprising topically applying to the skin of a subject aged 65 years and older in need of said treatment a pharmaceutical composition, the pharmaceutical composition comprising about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient, wherein the benzoyl peroxide is the only active ingredient in said pharmaceutical composition, wherein said pharmaceutical composition is applied once daily for a period of at least about 2 weeks, to achieve, in a group of such subjects, a success rate of at least about 15%, wherein the success rate is defined as the number of subjects achieving clear or almost clear skin on the investor global assessment (IGA) scale after treatment with the pharmaceutical composition.
Ofer TOLEDANO, Ofra LEVY-HACHAM, Ori NOV, Vered RAM
Filed: 18 Feb 20
Utility
Method for Treatment of Moderate to Severe Erythema Symptoms In Rosacea Patients
19 Aug 20
A regimen for the therapeutic treatment of moderate to severe erythema symptoms in rosacea patients, the regimen comprising topically applying to the skin of a subject in need of said treatment a pharmaceutical composition, the pharmaceutical composition comprising about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient, wherein the benzoyl peroxide is the only active ingredient in said pharmaceutical composition, wherein said pharmaceutical composition is applied once daily for a period of at least about 12 weeks, to achieve a percentage decrease of about 60% in a population exhibiting moderate to severe erythema symptoms when measured at about 12 weeks after initial treatment of the population with the pharmaceutical composition.
Ofer TOLEDANO, Ofra LEVY-HACHAM, Ori NOV, Vered RAM
Filed: 18 Feb 20
Utility
Treatment of Skin Disorders with Compositions Comprising an Egfr Inhibitor
24 Jun 20
This invention relates to compositions and methods of treatment of skin or mucosal disorders by administration of compositions comprising at least one EGFR inhibitor, such as topical compositions comprising erlotinib.
Moshe Arkin, Marcel Zighelboim, Ori Nov, Ofer Toledano, Karine Neimann
Filed: 7 Jan 20
Utility
Microcapsules Comprising Active Ingredients and a Metal Oxide Shell, a Method for Their Preparation and Uses Thereof
15 Apr 20
The present invention provides a process for preparing microcapsules comprising a core material encapsulated by a metal oxide shell, microcapsules obtained therewith and uses thereof.
Ofer TOLEDANO Olfer TOLEDANO, Hanan Sertchook, Natalia Loboda, Raed Abu-Reziq
Filed: 11 Dec 19