36 patents
Utility
Lateral/vertical transistor structures and process of making and using same
7 Mar 23
A microfluidic device can include a base an outer surface of which forms one or more enclosures for containing a fluidic medium.
Eric D. Hobbs, Justin K. Valley
Filed: 5 Oct 20
Utility
Microfluidic devices having isolation pens and methods of testing biological micro-objects with same
31 Jan 23
A microfluidic device can comprise at least one swept region that is fluidically connected to unswept regions.
Mark P. White, Eric D. Hobbs, J. Tanner Nevill, Daniele Malleo, Steven W. Short
Filed: 14 Nov 19
Utility
Systems and methods for analyses of biological samples
6 Dec 22
Disclosed are methods, systems, and articles of manufacture for performing a process on biological samples.
Darshan Thaker, Keith J. Breinlinger, Vincent Haw Tien Pai, Christoph Andreas Neyer, Thomas M. Vetterli, Hayley M. Bennett, Elisabeth Marie Walczak, Alexander Gerald Olson, Wesley Arthur Zink, John A. Tenney, Oleksandr Tokmakov, Igor Fastnacht, Yuriy Nicheporuk, Andriy Koval, Khrystyna Andres, Alona Kostenko
Filed: 19 May 21
Utility
Well plate incubator
8 Nov 22
Incubators including an enclosure with an internal chamber configured to support a cell culture plate comprising a plurality of wells are disclosed.
Russell A. Newstrom, Andrew W. McFarland, Darcy K. Kelly-Greene, J. Tanner Nevill, Gang F. Wang
Filed: 9 Aug 19
Utility
In situ-generated microfluidic assay structures, related kits, and methods of use thereof
27 Sep 22
In situ-generated microfluidic capture structures incorporating a solidified polymer network, methods of preparation and use, compositions and kits therefor are described.
Kristin G. Beaumont, Peter J. Beemiller, Volker L. S. Kurz, Gregory G. Lavieu, Xiaohua Wang, Aathavan Karunakaran
Filed: 22 Jun 20
Utility
Well-plate incubator
6 Sep 22
Incubators are disclosed which include an enclosure with an internal chamber configured to support a cell culture plate and provide an environment suitable for maintaining and/or culturing biological cells.
Darcy K. Kelly-Greene, Russell A. Newstrom, Andrew W. McFarland, J. Tanner Nevill, Gang F. Wang
Filed: 31 May 19
Utility
Light sequencing and patterns for dielectrophoretic transport
5 Jul 22
Optically-actuated microfluidic devices permit the use of spatially-modulated light to manipulate micro-objects such as biological cells.
Troy A. Lionberger, Brandon R. Bruhn, John A. Tenney, Eric D. Hobbs
Filed: 5 Jun 20
Utility
Microfluidic cell culture
21 Jun 22
Systems, methods and kits are described for culturing one or more biological cells in a microfluidic device, including provision of nutrients and gaseous components configured to enhance cell growth, viability, portability, or any combination thereof.
Randall D. Lowe, Jr., Kristin G. Beaumont, Aathavan Karunakaran, Natalie C. Marks, Jason M. McEwen, Mark P. White, J. Tanner Nevill, Gang F. Wang, Andrew W. McFarland, Daniele Malleo, Keith J. Breinlinger, Xiao Guan, Kevin T. Chapman
Filed: 2 Jul 20
Utility
Capturing specific nucleic acid materials from individual biological cells in a micro-fluidic device
3 May 22
Individual biological cells can be selected in a micro-fluidic device and moved into isolation pens in the device.
Kevin T. Chapman, Eric D. Hobbs, Steven W. Short, Mark P. White, Daniele Malleo
Filed: 18 Dec 14
Utility
Micro-fluidic devices for assaying biological activity
19 Apr 22
Biological activity in holding pens in a micro-fluidic device can be assayed by placing in the holding pens capture objects that bind a particular material of interest produced by the biological activity.
Kevin T. Chapman, Daniele Malleo, J. Tanner Nevill, Steven W. Short, Mark P. White, M. Jimena Loureiro
Filed: 11 Jul 19
Utility
Tumor infiltrating cells engineered to express a pro-inflammatory polypeptide
15 Mar 22
The present disclosure provides methods of preparing tumor infiltrating cells engineered to express a pro-inflammatory polypeptide.
Kevin T Chapman, Xiaohua Wang, Xiao Guan Radstrom, Yelena Bronevetsky, Guido K Stadler, Gregory G Lavieu, Annamaria Mocciaro
Filed: 14 Apr 17
Utility
Methods, systems and kits for in-pen assays
21 Dec 21
Methods, systems and kits are described herein for detecting the results of an assay.
Troy A. Lionberger, Matthew E. Fowler, Phillip J. M. Elms, Kevin D. Loutherback, Randall D. Lowe, Jr., Jian Gong, J. Tanner Nevill, Gang F. Wang, Gregory G. Lavieu, John A. Tenney, Aathavan Karunakaran, Anupam Singhal, I-Jong Lin
Filed: 15 Oct 18
Utility
Actuated microfluidic structures for directed flow in a microfluidic device and methods of use thereof
7 Dec 21
A microfluidic device can comprise a plurality of interconnected microfluidic elements.
Keith J. Breinlinger, Andrew W. McFarland, J. Tanner Nevill
Filed: 12 Jul 18
Utility
DEP force control and electrowetting control in different sections of the same microfluidic apparatus
7 Dec 21
A microfluidic apparatus can comprise a dielectrophoresis (DEP) configured section for holding a first liquid medium and selectively inducing net DEP forces in the first liquid medium.
Igor Y. Khandros, J. Tanner Nevill, Steven W. Short, Ming C. Wu
Filed: 25 Apr 15
Utility
Automated detection and repositioning of micro-objects in microfluidic devices
9 Nov 21
Methods are provided for the automated detection and/or counting of micro-objects in a microfluidic device.
Hansohl E. Kim, John A. Tenney, Joshua F. Slocum
Filed: 31 May 19
Utility
Methods, systems and devices for selection and generation of genome edited clones
31 Aug 21
Methods are described herein for isolating clonal populations of cells having a defined genetic modification.
Gregory G. Lavieu, Annamaria Mocciaro, Xiao Guan Radstrom, Jason M. McEwen, Magali Soumillon, J. Tanner Nevill, Volker L. S. Kurz, Patricia A. Dyck, Ravi K. Ramenani
Filed: 28 Jan 19
Utility
Actuated microfluidic structures for directed flow in a microfluidic device and methods of use thereof
24 Aug 21
A microfluidic device can comprise a plurality of interconnected microfluidic elements.
Keith J. Breinlinger, Andrew W. McFarland, J. Tanner Nevill
Filed: 7 Aug 18
Utility
Apparatuses, systems and methods for imaging micro-objects
3 Aug 21
The present disclosure relates to an optical apparatus for imaging and/or manipulating micro-objects in a microfluidic device, such as a light-actuated microfluidic (LAMF) device, and related systems and methods.
Paul M. Lundquist, Paul M. Lebel, Phillip Ronald Thomas Jess
Filed: 17 May 19
Utility
Covalently modified surfaces, kits, and methods of preparation and use
18 May 21
In biosciences and related fields, it can be useful to modify surfaces of apparatuses, devices, and materials that contact biomaterials such as biomolecules and biological micro-objects.
Randall D. Lowe, Jr., Alexander J. Mastroianni, Mark P. White, Gregory G. Lavieu, Kristin G. Beaumont
Filed: 20 Nov 18
Utility
Freezing and archiving cells on a microfluidic device
13 Apr 21
A method of processing and storing biological cells includes introducing a flowable medium into a microfluidic device, the flowable medium including biological cells; sequestering one or more biological cells from the flowable medium in one or more isolation regions of the microfluidic device; and freezing the microfluidic device including the one or more biological cells sequestered therein.
Mark P. White, Kevin T. Chapman, Andrew W. McFarland, Eric D. Hobbs, Randall D. Lowe, Jr.
Filed: 22 Apr 16