36 patents
Page 2 of 2
Utility
Automated detection and repositioning of micro-objects in microfluidic devices
9 Nov 20
Methods are provided for the automated detection of micro-objects in a microfluidic device.
Fenglei Du, Paul M. Lundquist, John A. Tenney, Troy A. Lionberger
Filed: 4 Jun 18
Utility
Microfluidic devices for optically-driven convection and displacement, kits and methods thereof
9 Nov 20
Apparatuses and methods are described for the use of optically driven bubble, convective and displacing fluidic flow to provide motive force in microfluidic devices.
Volker L. S. Kurz, Troy A. Lionberger, Eric K. Sackmann, Kai W. Szeto, Paul M. Lebel, Brandon R. Bruhn, Keith J. Breinlinger, Eric D. Hobbs, Andrew W. McFarland, J. Tanner Nevill, Xiaohua Wang
Filed: 14 Jun 18
Utility
Movement and selection of micro-objects in a microfluidic apparatus
2 Nov 20
A microfluidic apparatus is provided having one or more sequestration pens configured to isolate one or more target micro-objects by changing the orientation of the microfluidic apparatus with respect to a globally active force, such as gravity.
Keith J. Breinlinger, Eric D. Hobbs, Daniele Malleo, J. Tanner Nevill, Mark P. White
Filed: 25 Jul 17
Utility
Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
12 Oct 20
Microfluidic devices having an electrowetting configuration and an optimized droplet actuation surface are provided.
Randall D. Lowe, Jr., Shao Ning Pei, Jian Gong, Alexander J. Mastroianni, Jason M. McEwen, Justin K. Valley
Filed: 26 Oct 16
Utility
Exporting a selected group of micro-objects from a micro-fluidic device
12 Oct 20
A group of micro-objects in a holding pen in a micro-fluidic device can be selected and moved to a staging area, from which the micro-objects can be exported from the micro-fluidic device.
Keith J. Breinlinger, Daniele Malleo, Gaetan L. Mathieu, J. Tanner Nevill, Alexander H. Slocum, Mark P. White
Filed: 5 Sep 18
Utility
Lateral/vertical transistor structures and process of making and using same
5 Oct 20
A microfluidic device can include a base an outer surface of which forms one or more enclosures for containing a fluidic medium.
Eric D. Hobbs, Justin K. Valley
Filed: 10 Jul 19
Utility
Droplet generation in a microfluidic device having an optoelectrowetting configuration
7 Sep 20
Systems and methods are described herein for improved droplet generation within microfluidic apparatuses.
X. Robert Bao, Jason M. McEwen, Brian A. Rabkin
Filed: 28 Jun 18
Utility
Microfluidic reporter cell assay methods and kits thereof
24 Aug 20
Functional assays using reporter cell assays are described which probe the activity of at least one cell of interest.
Xiao Guan, Mark P. White, Jason M. McEwen, Gang F. Wang, Kevin T. Chapman, Xiaohua Wang, Christine E. Sun
Filed: 21 Apr 16
Utility
Microfluidic cell culture
27 Jul 20
Systems, methods and kits are described for culturing one or more biological cells in a microfluidic device, including provision of nutrients and gaseous components configured to enhance cell growth, viability, portability, or any combination thereof.
Randall D. Lowe, Jr., Kristin Beaumont, Aathavan Karunakaran, Natalie Marks, Jason M. McEwen, Mark P. White, J. Tanner Nevill, Gang F. Wang, Andrew W. McFarland, Daniele Malleo, Keith J. Breinlinger, Xiao Guan, Kevin T. Chapman
Filed: 21 Apr 16
Utility
Methods of producing patient-specific anti-cancer therapeutics and methods of treatment therefor
13 Jul 20
A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells.
Kevin T. Chapman, George L. Fox, Peggy A. Radel, Mark P. White, Xiaohua Wang, Minha Park, Guido K. Stadler, Randall D. Lowe, Jr., Xiao Guan Radstrom, Jason M. McEwen, Gang F. Wang
Filed: 12 Jan 17
Utility
In situ-generated microfluidic assay structures, related kits, and methods of use thereof
6 Jul 20
In situ-generated microfluidic capture structures incorporating a solidified polymer network, methods of preparation and use, compositions and kits therefor are described.
Kristin G. Beaumont, Peter J. Beemiller, Volker L. S. Kurz, Gregory G. Lavieu, Xiaohua Wang, Aathavan Karunakaran
Filed: 6 Dec 16
Utility
Pens for biological micro-objects
22 Jun 20
Individual biological micro-objects can be deterministically selected and moved into holding pens in a micro-fluidic device.
Kevin T. Chapman, Igor Y. Khandros, Gaetan L. Mathieu, J. Tanner Nevill, Ming C. Wu
Filed: 13 Dec 17
Utility
Light sequencing and patterns for dielectrophoretic transport
8 Jun 20
Optically-actuated microfluidic devices permit the use of spatially-modulated light to manipulate micro-objects such as biological cells.
Troy A. Lionberger, Brandon R. Bruhn, John A. Tenney, Eric D. Hobbs
Filed: 13 Apr 17
Utility
Microfluidic devices having isolation pens and methods of testing biological micro-objects with same
11 May 20
A microfluidic device can comprise at least one swept region that is fluidically connected to unswept regions.
Mark P. White, Eric D. Hobbs, J. Tanner Nevill, Daniele Malleo, Steven W. Short
Filed: 24 May 18
Utility
Automated identification of assay areas in a microfluidic device and detection of assay positive areas based on rate of change of image light intensity
2 Mar 20
Methods are provided for the automated detection of assay-positive assay areas in a microfluidic device.
Fenglei Du
Filed: 8 Dec 15
Utility
Single-sided light-actuated microfluidic device with integrated mesh ground
24 Feb 20
Single-sided optoelectrowetting (SSOEW)-configured substrates are provided, as well as microfluidic devices that include such substrates.
Ming-Chiang Wu, Jodi Tsu-An Loo, Shao Ning Pei, Gaetan L. Mathieu, Jian Gong, Randall D. Lowe, Jr., Justin K. Valley
Filed: 16 Oct 17