24 patents
Page 2 of 2
Utility
Methods for Synthesizing Anticoagulant Polysaccharides
13 Jan 22
The present invention includes methods for preparing anticoagulant polysaccharides using several non-naturally occurring, engineered sulfotransferase enzymes that are designed to react with aryl sulfate compounds instead of the natural substrate, PAPS, to facilitate sulfo group transfer to polysaccharide sulfo group acceptors.
Tarsis Ferreira GESTEIRA, Daniel H. LAJINESS
Filed: 15 Jul 21
Utility
Engineered Aryl Sulfate-dependent Enzymes
25 Nov 21
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira FERREIRA
Filed: 15 Jul 21
Utility
Engineered Aryl Sulfate-dependent Enzymes
25 Nov 21
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira FERREIRA
Filed: 15 Jul 21
Utility
Engineered Aryl Sulfate-dependent Enzymes
25 Nov 21
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira FERREIRA
Filed: 15 Jul 21