17 patents
Utility
PI3K-ALPHA Inhibitors and Methods of Use Thereof
2 Nov 23
The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-α enzymes with the compounds and compositions of the disclosure.
Lucian V. DIPIETRO, Kelley C. SHORTSLEEVES, Thomas H. MCLEAN, Alexandre LARIVEE, Fabrizio GIORDANETTO
Filed: 9 Jun 23
Utility
FGFR inhibitors and methods of use thereof
10 Oct 23
The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of FGFR enzymes with the compounds and compositions of the disclosure.
Bakary-Barry Touré, Heike Schoenherr, Fabrizio Giordanetto, Demetri T. Moustakas, Brandi M. Hudson
Filed: 31 Jan 23
Utility
SHP2 Phosphatase Inhibitors and Methods of Use Thereof
27 Jul 23
Alexander M. Taylor, Andre Lescarbbeau, Elizabeth H. Kelley, Kelley C. Shortsleeves, W. Patrick Walters, Mark Andrew Murcko, Thomas H. McLean, Hakan Gunaydin, Fabrizio Giordanetto, Eric Therrien
Filed: 15 Dec 22
Utility
Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors
18 Jul 23
Cellular biological activities are tightly controlled by intracellular signaling processes initiated by extracellular signals.
Alexander M. Taylor, W. Patrick Walters, Mark Andrew Murcko, Fabrizio Giordanetto, Eric Therrien, Sathesh Bhat, Markus Kristofer Dahlgren
Filed: 28 Sep 18
Utility
SHP2 phosphatase inhibitors and methods of use thereof
18 Apr 23
The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the invention.
Fabrizio Giordanetto, Jack Benjamin Greisman, Paul Maragakis, Alexander M. Taylor, Lucian V. Dipietro, Elizabeth H. Kelley, André Lescarbeau, Mark Andrew Murcko, Levi Charles Thomas Pierce, Kelley C. Shortsleeves, W. Patrick Walters, Sathesh Bhat, Eric Therrien, Markus Kristofer Dahlgren
Filed: 24 Oct 17
Utility
FGFR Inhibitors and Methods of Use Thereof
6 Apr 23
The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of FGFR enzymes with the compounds and compositions of the disclosure.
Bakary-Barry TOURÉ, Heike SCHOENHERR, Alexander M. TAYLOR, Fabrizio GIORDANETTO, Demetri T. MOUSTAKAS, Thomas H. MCLEAN, Brandi M. HUDSON, Mary M. MADER, Pelin AYAZ, Dina A. SHARON, Ravi KURUKULASURIYA, Alessandro BOEZIO
Filed: 12 May 20
Utility
Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors
28 Feb 23
Alexander M. Taylor, André Lescarbeau, Elizabeth H. Kelley, Kelley C. Shortsleeves, Lucian V. DiPietro, W. Patrick Walters, Mark Andrew Murcko, Levi Charles Thomas Pierce, Yong Tang, Fabrizio Giordanetto, Jack Benjamin Greisman, Paul Maragakis, Sathesh Bhat, Markus Kristofer Dahlgren, Eric Therrien
Filed: 25 May 18
Utility
SHP2 phosphatase inhibitors and methods of use thereof
20 Dec 22
Brian K. Albrecht, Fabrizio Giordanetto, Jack Benjamin Greisman, Paul Maragakis, Alexander M. Taylor, W. Patrick Walters
Filed: 22 Sep 17
Utility
Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors
20 Dec 22
Cellular biological activities are tightly controlled by intracellular signaling processes initiated by extracellular signals.
Alexander M. Taylor, W. Patrick Walters, Mark Andrew Murcko, Fabrizio Giordanetto, Eric Therrien, Sathesh Bhat, Markus Kristofer Dahlgren
Filed: 28 Sep 18
Utility
SHP2 Phosphatase Inhibitors and Methods of Use Thereof
27 Oct 22
Alexander M. Taylor, André Lescarbeau, Elizabeth H. Kelley, Kelley C. Shortsleeves, W. Patrick Walters, Mark Andrew Murcko, Thomas H. McLean, Hakan Gunaydin, Fabrizio Giordanetto, Eric Therrien
Filed: 17 Nov 20
Utility
SHP2 Phosphatase Inhibitors and Methods of Use Thereof
6 Oct 22
Alexander M. Taylor, André Lescarbeau, Elizabeth H. Kelley, Kelley C. Shortsleeves, W. Patrick Walters, Mark Andrew Murcko, Thomas H. McLean, Hakan Gunaydin, Fabrizio Giordanetto, Eric Therrien
Filed: 21 Mar 19
Utility
FGFR Inhibitors and Methods of Making and Using the Same
23 Jun 22
The disclosure is in part directed to crystalline forms of N-(4-(4-amino-5-(3-fluoro-4-(4-methylpyrimidin-2-yl)oxy)phenyl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)methacrylamide, its salts, its cocrystals, and variants thereof.
André LESCARBEAU, Jethro BEAMISH-COOK, Zoe PRENTICE, Thomas KENDALL, Aaron DUMAS, Elisabeth ISAAK, Piera TRINCHERA, Oleksandr ZHURAKOVSKYI, Osama SULEIMAN
Filed: 18 Nov 21
Utility
SHP2 Phosphatase Inhibitors and Methods of Making and Using the Same
25 Mar 21
The disclosure is in part directed to crystalline forms of (R)-1′-(3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3H-spiro[benzofuran-2,4′-piperidin]-3-amine, its salt, and variants thereof.
Alexander M. Taylor, André Lescarbeau, Jing Wang, Yanyan Zhang, Gaodeng Lian
Filed: 23 Sep 20
Utility
PYRAZOLO[3,4-B]PYRAZINE SHP2 Phosphatase Inhibitors and Methods of Use Thereof
11 Mar 21
Alexander M. Taylor, Fabrizio Giordanetto, Jack Benjamin Greisman, Paul Maragakis, Heike Schoenherr
Filed: 21 Mar 19
Utility
SHP2 phosphatase inhibitors and methods of use thereof
2 Mar 21
The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure.
Alexander M. Taylor, André Lescarbeau, Elizabeth H. Kelley, Kelley C. Shortsleeves, W. Patrick Walters, Mark Andrew Murcko, Fabrizio Giordanetto, Eric Therrien
Filed: 28 May 20
Utility
SHP2 Phosphatase Inhibitors and Methods of Use Thereof
16 Dec 20
The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure.
W. Patrick Walters, André Lescarbeau, Elizabeth H. Kelley, Kelley C. Shortsleeves, Alexander M. Taylor, Levi Charles Thomas Pierce, Mark Andrew Murcko, Fabrizio Giordanetto, Jack Benjamin Greisman, Paul Maragakis, Sathesh Bhat, Kyle Konze, Markus Kristofer Dahlgren, Eric Therrien
Filed: 20 Feb 19
Utility
PYRAZOLO[3,4-B]PYRAZINE Derivatives As SHP2 Phosphatase Inhibitors
12 Aug 20
Alexander M. Taylor, W. Patrick Walters, Mark Andrew Murcko, Fabrizio Giordanetto, Eric Therrien, Sathesh Bhat, Markus Kristofer Dahlgren
Filed: 27 Sep 18
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