104 patents
Page 5 of 6
Utility
an Apparatus for Anastomosing a Cut Vessel
3 Aug 23
An apparatus for anastomosing a cut vessel is provided.
Kent K. HIGDON, Stephane A. BRAUN
Filed: 3 Jun 21
Utility
CorrectedMethods for Identification of Ligand-blocking Antibodies and for Determining Antibody Potency
3 Aug 23
The present disclosure relates to high-throughput systems and methods for the detection of ligand-blocking antibodies and for determining antibody potency.
Marion Francis Setliff, Ivelin Stefanov Georgiev, Andrea Shiakolas, Kelsey PILEWSKI, Rohit VENKAT
Filed: 22 Jan 21
Utility
Meta-optic Accelerators for Object Classifiers
27 Jul 23
A system for identifying objects in images is provided.
Jason Valentine, Yuankai Huo, Hanyu Zheng, Quan Liu
Filed: 26 Jan 23
Utility
Clutch Mechanisms and Uses of the Same
27 Jul 23
A clutch mechanism includes a spool that is configured to receive a cable, a disk with elasticity, a mechanism configured for locking and unlocking the movement of the disk, and at least one sensor.
Karl E. Zelik, Michael Goldfarb, Paul R. Slaughter, Shane T. King, Cameron A. Nurse, Chad C. Ice
Filed: 20 Jan 23
Utility
Engineered Probes for Sialoglycan Binding
27 Jul 23
Disclosed are compositions and methods related to the use of sialoglycan as markers for the diagnosis and prognosis of cancers and inflammatory conditions.
Tina IVERSON, Barbara BENSING, Paul SULLAM
Filed: 11 Jun 21
Utility
Generation of human allergen- and helminth-specific IgE monoclonal antibodies for diagnostic and therapeutic use
25 Jul 23
The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom.
Scott A. Smith
Filed: 26 May 22
Utility
Annulated 2-AMINO-3-CYANO Thiophenes and Derivatives for the Treatment of Cancer
20 Jul 23
Joachim BROEKER, Jason ABBOTT, Jianwen CUI, Stephen W. FESIK, Julian FUCHS, Andreas GOLLNER, Lorenz HERDEIS, Tim HODGES, Andrew LITTLE, Andreas MANTOULIDIS, Jason PHAN, Juergen RAMHARTER, Dhruba SARKAR, Christian Alan Paul SMETHURST, Kevin SOKOL, Heinz STADTMUELLER, Qi SUN, Matthias TREU, Alex WATERSON, Birgit WILDING, Tobias WUNBERG
Filed: 30 Nov 22
Utility
Filterless Non-dispersive Infrared Sensing Devices and Methods
13 Jul 23
Devices and methods for non-dispersive infrared (NDIR) sensing are disclosed.
Joshua D. Caldwell, Edward Sachet, Christopher Shelton, Thomas G. Folland
Filed: 12 Jan 23
Utility
Compounds and methods for scavenging dicarbonyl electrophiles
11 Jul 23
Keith T. Wilson, John A. Oates, Olivier Boutaud, Venkataraman Amarnath, Erica J. Carrier, Alain P. Gobert
Filed: 4 Jun 20
Utility
Self-antigen specific T-cells as vaccines for augmenting engraftment and stability of autologous transfer
11 Jul 23
Disclosed are compositions and methods relating to genetically modified cells for the long-term expression of an antigen of interest.
Richard Thomas O'Neil, Matthew Hunter Wilson
Filed: 23 Jan 19
Utility
Annulated 2-AMINO-3-CYANO Thiophenes and Derivatives for the Treatment of Cancer
6 Jul 23
Jason ABBOTT, Joachim BROEKER, Jianwen CUI, Stephen W. FESIK, Andreas GOLLNER, Tim HODGES, Jale KAROLYI-OEZGUER, Andrew LITTLE, Andreas MANTOULIDIS, Jason PHAN, Dhruba SARKAR, Christian Alan Paul SMETHURST, Qi SUN, Matthias TREU, Alex WATERSON
Filed: 1 Jun 21
Utility
Methods for identifying treatments that reduce the actions of substances of abuse and addiction
4 Jul 23
Based on the discovery that MBLAC1 is a specific, high-affinity target for Ceftriaxone (Cef), MBLAC1 may be used for identifying treatments for addiction to substances of abuse.
Randy D. Blakely, Maureen K. Hahn
Filed: 7 Aug 18
Utility
Human zika virus antibodies and methods of use therefor
4 Jul 23
The present disclosure is directed to antibodies binding to and neutralizing Zika virus and methods for use thereof.
James E. Crowe, Jr.
Filed: 17 May 21
Utility
Nucleoside-modified mRNA-lipid nanoparticle lineage vaccine for hepatitis C virus
30 May 23
The present invention relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject.
Drew Weissman, George M. Shaw, Justin R. Bailey, Stuart C. Ray, James Crowe, Jr., Andrew Flyak
Filed: 27 Apr 18
Utility
Methods and Apparatus for Intraoperative Assessment of Parathyroid Gland Vascularity Using Laser Speckle Contrast Imaging and Applications of Same
25 May 23
One aspect of the invention relates to a method for intraoperative detection of parathyroid gland viability in a surgery, comprising obtaining speckle contrast images of a parathyroid gland of a patent; and displaying the speckle contrast images of the parathyroid gland in real-time.
Emmanuel A. Mannoh, Anita Mahadevan-Jansen
Filed: 14 Dec 22
Utility
Cleavable Agents
18 May 23
The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon.
Boyd M. Goodson, Eduard Y. Chekmenev, Bryce E. Kidd, Jamil A. Mashni, Miranda Limbach, Yuqing Hou, Fan Shi
Filed: 4 Jan 23
Utility
Antagonists of the Muscarinic Acetylcholine Receptor M4
18 May 23
Disclosed herein are 2,3,5-trifluorophenyl-pyridazine substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4) Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
Craig W. Lindsley, P. Jeffrey Conn, Aaron M. Bender, Katrina A. Bollinger, Trever R. Carter, Jerri M. Rook, Jonathan W. Dickerson, Julie L. Engers, Kayla J. Temple, Changho Han, Matthew Spock, Logan A. Baker, Thomas M. Bridges
Filed: 10 Dec 20
Utility
Method and Apparatus for Intraoperative Nerve Visualization Using Polarized Diffuse Reflectance Spectroscopy and Applications of Same
18 May 23
An apparatus for intraoperative nerve identification and/or visualization of a target of interest of a living subject comprises a light source; an imaging head configured to acquire a polarized diffuse reflectance spectral image from the illuminated target of interest; and a controller configured to control the imaging head and to process the acquired polarized diffuse reflectance spectral image.
Justin Baba, Anita Mahadevan-Jansen, Graham Throckmorton
Filed: 9 Jan 23
Utility
Active Titration of One or More Nerve Stimulators to Treat Obstructive Sleep Apnea
18 May 23
The present disclose generally relates to systems and methods for active titration of one or more cranial or peripheral nerve stimulators to treat obstructive sleep apnea.
David T. KENT
Filed: 5 Jan 23
Utility
Double Offsets and Powers Magnetization Transfer Ratio for Specific Magnetization Transfer Magnetic Resonance Imaging
18 May 23
Imaging methods for assessing the macromolecular content, such as myelin, are of great interest for understanding brain tissue microstructure, and have shown potentials in diagnosing and prognosing demyelinating diseases. for example.
ZhongLiang Zu
Filed: 7 Nov 22