290 patents
Page 12 of 15
Utility
Integrated Continuous Manufacturing of Therapeutic Protein Drug Substances
7 Oct 20
Provided herein are integrated continuous biomanufacturing processes for producing a therapeutic protein drug substance.
Konstantin Konstantinov, Rahul Godawat, Veena Warikoo, Sujit Jain
Filed: 21 Jun 20
Utility
Continuous Production of Recombinant Proteins
7 Oct 20
The present disclosure relates to methods and systems for the continuous production of recombinant proteins.
Michael Coolbaugh, Tarl Vetter, Chad Varner, Kevin Brower
Filed: 31 Mar 20
Utility
6dqgrv9snvqai2cshdcmpt4y8mq22pxy0v7fiokd5tlwya
5 Oct 20
Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described.
James Stefano
Filed: 26 Jul 18
Utility
jbj96v1q6vx 0nsa0ii3u4tez
30 Sep 20
The disclosure pertains to methods and compositions for treating disorders affecting the central nervous system (CNS).
Marco A. PASSINI, James DODGE
Filed: 2 Mar 20
Utility
zz9y45pwykn9e963mljdyijizd7qloij05s
23 Sep 20
The present invention relates to treatment of relapsing and progressive forms of multiple sclerosis using a humanized anti-human CD52 IgG1 monoclonal antibody.
David H. MARGOLIN
Filed: 19 Apr 18
Utility
rjdo1h5 7r6xpwgwy8knrq0u57wxdlerz6
23 Sep 20
Disclosed herein are methods that have been developed to control the formation of disulfide bonds between polypeptides of a multimeric protein produced by a bioprocess.
Kevin P. Brower, Chris Hwang, Rao Koduri, Konstantin B. Konstantinov, Veena Warikoo, Jin Yin, Marcella Yu
Filed: 7 Apr 20
Utility
tw3553gwigle7a87c5omjj25xx96f1wp4yvz69mmcywk0dww
23 Sep 20
Provided herein are methods for selecting a population of cells expressing a target polypeptide.
Victor R. Cairns, Christine DeMaria, Jason Vitko
Filed: 13 Nov 19
Utility
z4l6xw 9fylx1qgmkm7btcjuji54obkig2tn8a6gdog7h3zpujthewokl4
21 Sep 20
The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof.
Steven R. Ledbetter, Celia Patricia Hart, Robert G. Holgate, Lutz U. Jermutus, Catriona L. Buchanan, Alexander R. Duncan, Donna K. Finch
Filed: 20 Nov 18
Utility
jrhoyad7cq02 bh3679ru68ti0q74gl5tzu90gle8pgt0ugql
16 Sep 20
Viral filters include a filter member featuring a first surface and a second surface and having a thickness extending between the first and second surfaces in a first direction, and a plurality of channels formed in the filter member, each of the channels having a channel axis, where during use, a solution carrying a viral load flows in a direction parallel to the first surface, and at least a portion of the viral load enters the membrane through the first surface and propagates in the first direction, and where for at least 50% of the channels in the filter member, the channel axis is oriented at an angle of between 5 degrees and 85 degrees relative to the first direction.
Tarl Vetter, Kevin Brower
Filed: 10 Mar 20
Utility
6gfl0lzstq8mofnpeyso6z sgd58jd
31 Aug 20
Provided herein are RNAi molecules including a first strand containing a guide sequence and a second strand comprising a non-guide sequence where the non-guide sequence contains a bulge opposite the seed region of the guide sequences; e.g., opposite the cleavage sequence.
Lisa M. Stanek, Adam Palermo, Brenda Richards, Sergio Pablo Sardi, Catherine O'Riordan, Antonius Song
Filed: 9 Sep 19
Utility
8q0xgxvw9ry64f44556x5ovtw2fe pnrumcw10y
19 Aug 20
Provided herein are recombinant adeno-associated virus (rAAV) vectors comprising nucleic acid encoding N-acetyl-glucosamine-1-phosphate transferase, alpha and beta subunits (GNPTAB) and at least one AAV inverted terminal repeat (ITR).
Nelson YEW, Dong-Kyu JIN
Filed: 13 Dec 16
Utility
t8ahuq5y2gpazfdem1ddkwoltrvzyi5l4uun7uuin660hdsik 5rtf
19 Aug 20
Andrew Peter Thomas, Elaine Sophie Elizabeth Stokes, Laurent Francois Andre Hennequin
Filed: 24 Sep 19
Utility
ogh1ozyaseaeypcakbd5995g25iupfl dqbb85h6rw8mtad5zze
17 Aug 20
This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject.
James Dodge, Lamya Shihabuddin, Marco Passini, Seng H. Cheng, Catherine O'Riordan
Filed: 1 Nov 07
Utility
k91azoew6ormhvgljp7zy rwq02d67wxu1dq
12 Aug 20
The invention relates, in part, to antibodies with increased ADCC activity.
Daniel Schindler, Harry M. Meade, Timothy Edmunds, John McPherson
Filed: 20 Feb 20
Utility
ei8m2o4jnvidh ubgkbtrp0
12 Aug 20
Provided herein are methods of perfusion culturing an adherent mammalian cell using a shake flask and a plurality of microcarriers, and various methods that utilize these culturing methods.
Jianguo Yang, Yang Yang, Jennifer Tengtrakool, Weichang Zhou
Filed: 1 Mar 20
Utility
wls7e170jvic537wfowqtkgjzjela4sk2dxzdfwjv5d6dy4tb kv4y414
3 Aug 20
Antibodies or antigen-binding fragments thereof are engineered to bind Transforming Growth Factor-β (TGFβ).
Ronnie Wei, Aaron Moulin, Magali Mathieu, Clark Pan, Sunghae Park, Huawei Qiu
Filed: 6 Aug 17
Utility
eeyhe9k8ylwn36u0m htcyv9820xhs5s57yf562
22 Jul 20
The present disclosure relates to recombinant viral vectors, to pharmaceutical compositions comprising such recombinant vectors, and to methods for prevention and treatment of osteoarthritis in mammals.
Monica DIAS FIGUEIREDO, Sirkka RM KYOSTIO-MOORE, Patricia BERTHELETTE
Filed: 28 Jul 19
Utility
qsrgl ga39qfa6s5c36za5gyccs
15 Jul 20
Provided herein are methods to characterize preparations of recombinant viral particles using analytical ultracentrifugation.
Catherine R. O'RIORDAN, Brenda BURNHAM
Filed: 20 Aug 19
Utility
yn22mi a3vvze4gcx5pzv
13 Jul 20
Provided herein are integrated continuous biomanufacturing processes for producing a therapeutic protein drug substance.
Konstantin Konstantinov, Rahul Godawat, Veena Warikoo, Sujit Jain
Filed: 20 Apr 17
Utility
0gjo22oy69rfceri23710dik83e6er2 o2ostbiux4nt
8 Jul 20
Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI.
Luis Z. AVILA, Clark Q. PAN, Patrick FINN, John HARRAHY, Qun ZHOU, Yunxiang ZHU, Paul A. KONOWICZ, Duncan E. PATERSON, Andreas PEER, Joseph P. KUTZKO, Michael R. REARDON, James E. STEFANO, Xiaoyang ZHENG, Robert J. MILLER, Lauren YOUNG
Filed: 23 Sep 19