187 patents
Page 3 of 10
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Chemokine Receptor Binding Heterocyclic Compounds with Enhanced Efficacy
29 Dec 22
The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings.
Gary J. Bridger, Renato T. Skerlj, Al Kaller, Curtis Harwig, David Bogucki, Trevor R. Wilson, Jason B. Crawford, Ernest J. McEachern, Bem Atsma, Siqiao Nan, Yuanxi Zhou, Dominique Schols, Christopher Dennis Smith, Maria Rosaria Di Fluri
Filed: 13 Jan 22
Utility
Glucosylceramide Synthase Inhibitors
29 Dec 22
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy.
John P. LEONARD, Jean-François DELEUZE, Jean-Michel ITIER, Cécile ORSINI, Gwénaëlle RET-LECUELLE, Sandra VIALE
Filed: 25 May 22
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rjaaaf287ac5w6yn ragfbpvfp1ppfbi5a2a5394fkt34
22 Dec 22
Anti-CD73 antigen-binding proteins are provided.
Dana LORD, Katarina RADOSEVIC, James E. STEFANO, Yenfang ZHOU
Filed: 13 Nov 20
Utility
t79m4b6b1lpfyf7k9xf1k8zyxi hc349z6rrxiiiyl8rqspvr
15 Dec 22
John L. Kane, JR., Claude Barberis, Mark Czekaj, Paul Erdman, Barret Giese, Michael Kothe, Tieu-Binh Le, Jinyu Liu, Liang Ma, Markus Metz, Vinod Patel, Andrew Scholte, Patrick Shum, Linli Wei
Filed: 9 Feb 22
Utility
6agj wnb8mj55fh3qyxakxhvu0r5zvq6vbs
15 Dec 22
Provided herein are novel methods for delivering recombinant adeno-associated viral (rAAV) particles to the central nervous system of a mammal (e.g., a human).
Lisa M. STANEK, Lamya S. SHIHABUDDIN
Filed: 29 Jul 22
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0unanehdis8ufxtj4qkwtgzrwuwgkitt31oqg
24 Nov 22
The present technology relates to a novel sanitization method for chromatography media and supporting equipment comprising treatment with a sanitization/sterilization solution comprising acetic acid and hexylene glycol.
Joseph P. Kutzko, Ryan F. Wollensak
Filed: 6 May 22
Utility
v90a0bexvz9nupdzzfcykm78r 1d0xykwvnzuye
24 Nov 22
Neurological diseases, including lysosomal storage diseases, can be successfully treated using intraventricular delivery of the therapeutic agents to bypass the blood-brain barrier.
James C. DODGE, Marco A. PASSINI, Lamya S. SHIHABUDDIN, Seng H. CHENG
Filed: 10 Jan 22
Utility
41lfbla3ry6pevrv0cfjw24d8zaj1ipfp8sk kiwttntkmpa6rlqithject
17 Nov 22
An scFv-Fc dimer binds and neutralizes TGFβ1 selectively and with high affinity and avidity.
Huawei Qiu, Clark Pan, Julie Bird
Filed: 4 Apr 22
Utility
hh7zmaijoxl91ycigt54bz454v5imlj6776q7wbinde3b37
17 Nov 22
Methods for separating AAV empty capsids from mixtures of AAV vector particles and AAV empty capsids are described.
Guang QU, John Fraser WRIGHT
Filed: 19 Jan 22
Utility
dwi2hpw2qnl eulh92cq388eorxl45k
27 Oct 22
The use of iNOS inhibitors, including aurintricarboxylic acid, dexamethasone and valproic acid, to increase the yield of a variety of viruses in culture, including recombinant herpesviruses is described.
Peter PECHAN, Jeffery ARDINGER, Abraham SCARIA, Samuel WADSWORTH
Filed: 3 Mar 22
Utility
jedddlurqp4rjv8dt00q e44sa6gssdren4ergsgomb896d0pl97
20 Oct 22
Provided herein are methods of perfusion culturing a mammalian cell that include: providing a vessel containing a mammalian cell disposed in a first liquid culture medium having an osmolality of about 270 mOsm/kg to about 380 mOsm/kg; incubating the mammalian cell for a period of time at about 32° C. to about 39° C.; and during the period of time, continuously or periodically removing a first volume of the first liquid culture medium and adding to the first liquid culture medium a second volume of a second liquid culture medium, wherein the first and second volumes are about equal and the osmolality of the first and second liquid culture medium in the vessel is maintained at about 270 mOsm/kg to about 380 mOsm/kg over the period of time.
Shawn L. Barrett, Charles Budde, Daryl Powers
Filed: 14 Apr 22
Utility
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6 Oct 22
A modified IgG antibody binds and neutralizes TGFβ1 selectively and with high affinity and avidity.
Huawei Qiu, Julie Bird
Filed: 11 Apr 22
Utility
gp4ar0lhsjmzfb59yb43bv
29 Sep 22
The invention relates to dose escalation enzyme replacement therapy using acid sphingomyelinase (ASM) for the treatment of human subjects having acid sphingomyelinase deficiency (ASMD), and, in particular, patients with non-neurological manifestations of Niemann-Pick Disease (NPD), and in certain embodiments, NPD type B.
Edward H. Schuchman, Robert J. Desnick, Gerald F. Cox, Laura P. Andrews, James M. Murray
Filed: 18 Feb 22
Utility
5xyiliys3ysllwdgaivlag6gz54bg6k yech2qi
29 Sep 22
Provided herein are methods of predicting the effect of a concentration of a sensitizer on cell viability in a production bioreactor, methods of improving cell viability in a production bioreactor, methods of predicting cell viability in a production bioreactor, and methods for culturing a cell in a production bioreactor.
Jonathan Wang, Neha Shah, Jason Walther, Jiuyi Lu, Timothy Johnson, Yukun Ren, Jean McLarty
Filed: 16 Jun 22
Utility
la1drtzv6zrqqg0c1whgulwtz864y
15 Sep 22
Compositions and methods for treating macular degeneration are disclosed.
Abraham SCARIA
Filed: 25 Feb 22
Utility
fyz9003h9p3ohx2in5n25nxkdvjl3lfhtw6x9nnropafyoe86uc
11 Aug 22
The present invention relates to a novel analytical method for detecting one or more analytes in a source sample by continuous flow 2D LC-MS/MS using a single LC system.
Wei-Lien Chuang, Felipe Gazos Lopes, Joshua Pacheco, Gerard Sanderink
Filed: 29 May 20
Utility
4yrpp65xvug1685xi3znhuep5l0r1a ishjdjr0cu
4 Aug 22
Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI.
Luis Z. AVILA, Clark Q. PAN, Patrick FINN, John HARRAHY, Qun ZHOU, Yunxiang ZHU, Paul A. KONOWICZ, Duncan E. PATERSON, Andreas PEER, Joseph P. KUTZKO, Michael R. REARDON, James E. STEFANO, Xiaoyang ZHENG, Robert J. MILLER, Lauren YOUNG
Filed: 14 Feb 22
Utility
ie7s2fr3fdwj8lnjtcq9qu4kbh5f w91rxw0oito3713q5z2xmu
4 Aug 22
Provided herein are methods relating to the purification of a polypeptide comprising an Fc region (e.g., an antibody) via protein A chromatography; methods relating to the use of a wash solution comprising a benzoate salt and/or benzyl alcohol during protein A chromatography; and methods of adjusting a harvest using sodium benzoate prior to protein A chromatography.
Carl A. BEIGIE
Filed: 17 Dec 21
Utility
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30 Jun 22
John L. Kane, JR., Nellwyn A. Hagan, Maria A. Fitzgerald
Filed: 11 Feb 22
Utility
1s68dx8hbmcoa2klis5u2kccs3f2syieoj5qkwa4s5v
30 Jun 22
The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group.
Yunxiang ZHU, Seng H. CHENG, Canwen JIANG, Luis Z. AVILA
Filed: 10 Sep 21