187 patents
Page 5 of 10
Utility
Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline
3 Feb 22
The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof.
Jorgen Blixt, Michael David Golden, Philip John Hogan, David Michael Glanville Martin, Francis Joseph Montgomery, Zakariya Patel, John David Pittam, George Joseph Sependa, Christopher John Squire, Nicholas Cartwright Alexander Wright
Filed: 2 Nov 20
Utility
Pharmaceutical Compositions Comprising Venglustat
27 Jan 22
The present disclosure relates to pharmaceutical compositions, including dosage forms, such as tablets or capsules, comprising venglustat, in free base, or pharmaceutically acceptable salt form, a diluent/filler and a lubricant, optionally in combination with one or more additional therapeutic agents, to processes for manufacture thereof, and to methods of use in the treatment or prevention of disease.
Audrey JEANJEAN, Danielle COMBESSIS, David RIGAL, Chris HO, Pankaj TANEJA
Filed: 23 Jul 21
Utility
hb6l7lt7qbq2wwsoizg5gtiqr6u6x7oc cibc5zq46id09g
27 Jan 22
This disclosure to methods for treating or preventing particular symptoms and disorders which are associated with lysosomal storage diseases using quinuclidine compounds of formula (I), optionally in combination with enzyme replacement therapy.
Nigel Patrick Somerville CRAWFORD, Tanya Zaremba FISCHER
Filed: 3 Feb 20
Utility
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20 Jan 22
This disclosure to methods for treating or preventing particular symptoms and disorders which are associated with lysosomal storage diseases using quinuclidine compounds of formula (I), optionally in combination with enzyme replacement therapy.
Nigel Patrick Somerville CRAWFORD, Tanya Zaremba FISCHER
Filed: 3 Feb 20
Utility
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20 Jan 22
The invention relates to iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and to treat subjects having a Serpinc1-associated disease, e.g., a bleeding disorder, such as a hemophilia.
Akin Akinc, Benny Sorensen, Pushkal Garg, Gabriel Robbie
Filed: 14 Jul 21
Utility
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20 Jan 22
Methods of making and using recombinant AAV virions with decreased immunoreactivity are described.
Alejandra E. ARBETMAN, Peter C. COLOSI, Michael A. LOCHRIE, Richard T. SUROSKY
Filed: 23 Jun 21
Utility
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13 Jan 22
The present invention relates to humanized immunoglobulins, mouse monoclonal antibodies and chimeric antibodies that have binding specificity for human CD52.
Bruce L. Roberts, Srinivas Shankara, William Harold Brondyk, William M. Siders
Filed: 3 Mar 21
Utility
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6 Jan 22
Provided are methods for quantitating an amount of a polypeptide that comprises a portion of an antibody present in a sample (e.g., a plasma or serum sample) wherein the antibody comprises a constant region (e.g., a heavy chain or light chain constant region) that comprises an engineered mutation.
Christopher MORGAN, Xiaokui ZHANG
Filed: 16 Jun 21
Utility
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23 Dec 21
The present disclosure provides using a double-stranded oligonucleotide compound as a novel therapy to improve the quality of life and joint function of patients with hemophilia A and hemophilia B.
Baisong Mei, Shauna Andersson, Qifeng Yu, Pronabesh DasMahapatra
Filed: 22 Jun 21
Utility
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23 Dec 21
Hanlan LIU, Chris WILLIS, Renu BHARDWAJ, Diane P. COPELAND, Abizer HARIANAWALA, Jeffrey SKELL, John MARSHALL, Jianmei KOCHLING, Gerard PALACE, Judith PETERSCHMITT, Craig SIEGEL, Seng CHENG
Filed: 3 Sep 21
Utility
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9 Dec 21
Provided herein are methods for determining the efficacy of treatment for polycystic kidney disease (PKD) in a patient, diagnosing PKD in a patient, staging PKD in a patient, and monitoring PKD in a patient.
Nikolai Bukanov, Sarah Moreno, Timothy E. Weeden
Filed: 17 Aug 21
Utility
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9 Dec 21
The present invention provides a bispecific biologic comprising a ligand specific for CTLA-4 and a ligand specific for a pMHC complex.
Yunxiang Zhu, Jozsef Karman, Ronnie Wei, Canwen Jiang, Seng Cheng
Filed: 3 May 21
Utility
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9 Dec 21
This disclosure anti-human IgG antibodies and antigen-binding portions thereof derived from rabbits and methods of using these antibodies and portions.
Ruiyin CHU
Filed: 1 Jun 21
Utility
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2 Dec 21
Hanlan LIU, Chris WILLIS, Renu BHARDWAJ, Diane P. COPELAND, Abizer HARIANAWALA, Jeffrey SKELL, John MARSHALL, Jianmei KOCHLING, Gerard PALACE, Judith PETERSCHMITT, Craig SIEGEL, Seng CHENG
Filed: 7 Jan 21
Utility
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18 Nov 21
One aspect of the present invention provides a method for the treatment of lithiasis, which mitigates the risk of damage to surrounding body tissue when removing a calculi (e.g., biological concretions, such as urinary, biliary, and pancreatic stones) that obstructs or may otherwise be present within a body's anatomical lumen.
Jean-Marie Vogel, James A. Wilkie
Filed: 26 Feb 21
Utility
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11 Nov 21
Provided herein are variant phenylalanine hydroxylase (PAH) polypeptides which are more stable and have greater activity than wild-type human PAH.
Sirkka KYOSTIO-MOORE, Partha MANAVALAN
Filed: 11 Oct 19
Utility
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28 Oct 21
Provided herein are humanized anti-factor Bb antibodies, methods of producing the antibodies and methods of using the antibodies.
Graham Parry, Stephen Moore, Michael Storek, Nina C. Leksa
Filed: 19 Apr 21
Utility
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28 Oct 21
Methods for treating Gaucher disease in patients with renal or hepatic impairment.
Jing LI, M. Judith PETERSCHMITT, Vanaja KANAMALURU, Jun CHEN, Sebastiaan J.M. GAEMERS, Dan RUDIN
Filed: 7 Dec 20
Utility
zbwromshc54zhxjov3pg0hxn6wou8bucxx2v129tf9ouz9nrjangrj60xfj6
21 Oct 21
Provided herein are methods of culturing a mammalian cell and various methods that utilize these culturing methods.
Agata Villiger-Oberbek, Jianguo Yang, Yang Yang, Gabrielle Lorenzo
Filed: 25 Jun 21
Utility
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7 Oct 21
Provided herein are RNAi molecules for treating neurodegenerative synucleinopathies.
Bradford ELMER, Brenda RICHARDS, Martine LATTA-MAHIEU, Maria Carmen OBINU, Véronique TAUPIN, Véronique BLANCHARD
Filed: 2 Aug 19