471 patents
Page 15 of 24
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Therapeutic Antibodies and Their Uses
24 Jun 21
The present invention relates bispecific antibodies that specific binds to BCMA (B-Cell Maturation Antigen) and CD3 (Cluster of Differentiation 3).
Tracy Chia-Chien KUO, Javier Fernando CHAPARRO RIGGERS, Wei CHEN, Amy Shaw-Ru CHEN, Edward Derrick PASCUA, Thomas John VAN BLARCOM, Leila Marie BOUSTANY, Weihsien HO, Yik Andy YEUNG, Pavel STROP, Arvind RAJPAL
Filed: 21 Dec 20
Utility
Anti-proliferative Agents for Treating Pah
24 Jun 21
Pulmonary hypertension and related diseases, like pulmonary arterial hypertension, can be treated by administering an effective dose of a CDK inhibitor, including palbociclib, 6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, or pharmaceutically acceptable salt thereof.
Steven Martin Evans
Filed: 4 Nov 20
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Orally Administered Combinations of Amoxicillin and Avibactam Derivatives for Treating Mycobacterial Infections
24 Jun 21
Pharmaceutical compositions comprise amoxicillin and an avibactam derivative and methods of treating bacterial infections using the pharmaceutical compositions.
JOAQUIM TRIAS
Filed: 16 Dec 20
Utility
Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using the Same
17 Jun 21
The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid and a therapeutic agent (1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea), or pharmaceutically acceptable salts thereof, and a polymer.
Shubha Bagrodia, Jennifer Lafontaine, Zach Lovatt, Eyoung Shin, Young Ho Song, Greg Troiano, Hong Wang
Filed: 24 Feb 21
Utility
Antibodies Specific for CD47, PD-L1, and Uses Thereof
17 Jun 21
Antibodies that specifically bind to CD47 and antibodies that specifically bind to PD-L1 are provided, as well as CD47/PD-L1 bispecific antibodies.
Javier Fernando CHAPARRO RIGGERS, Shih-Hsun CHEN, Sheng DING, Pawel Kamil DOMINIK, Shahram SALEK-ARDAKANI, Jessica Lynn Stanfield, Thomas John VAN BLARCOM
Filed: 14 Dec 20
Utility
Media and Fermentation Methods for Producing Polysaccharides In Bacterial Cell Culture
17 Jun 21
The present invention relates to media and fermentation methods for producing polysaccharides in bacterial cell culture.
Sunil Gururao Desai, Michael Allen Hanson, Jonathan Patrick Kinross, Daniel R. Lasko, Scott Ellis Lomberk, Jason Arnold Lotvin, Sujata Kaushikbhai Patel-Brown, Weiqiang Sun, Peter Anthony Tomasello
Filed: 8 Feb 21
Utility
GLP-1 Receptor Agonists and Uses Thereof
3 Jun 21
Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
Gary Erik Aspnes, Scott W. Bagley, John M. Curto, David James Edmonds, Mark E. Flanagan, Kentaro Futatsugi, David A. Griffith, Kim Huard, Yajing Lian, Chris Limberakis, Allyn T. Londregan, Alan M. Mathiowetz, David W. Piotrowski, Roger B. Ruggeri
Filed: 9 Feb 21
Utility
Interferon Beta Antibodies and Uses Thereof
3 Jun 21
The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to interferon beta (IFNβ).
Stefano V. Gulla, Christine Huard, Janet Elizabeth Buhlmann, Juan Carlos Almagro, Sreekumar R. Kodangattil, Steven A. Greenberg, Edward Roland Lavallie, Eric M. Bennett, Lidia Mosyak, James Perry Hall, Anthony John Coyle
Filed: 9 Nov 20
Utility
Group B Streptococcus Polysaccharide-protein Conjugates, Methods for Producing Conjugates, Immunogenic Compositions Comprising Conjugates, and Uses Thereof
20 May 21
The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B. streptococcus (GBS), and a carrier protein, wherein the CP is selected from the group consisting of serotypes Ia, Ib, II, III, IV, V, VI, VII, VIII, and IX, and wherein the CP has a sialic acid level of greater than about 60%.
Annaliesa Sybil Anderson, Amardeep Singh Bhupender Bhalla, Robert G.K. Donald, Jianxin Gu, Kathrin Ute Jansen, Rajesh Kumar Kainthan, Lakshmi Khandke, Jin-Hwan Kim, Paul Liberator, Avvari Krishna Prasad, Mark Edward Ruppen, Ingrid Lea Scully, Suddham Singh, Cindy Xudong Yang
Filed: 28 Jan 21
Utility
Mutant Antibodies and Conjugation Thereof
20 May 21
The present invention relates to a polypeptide comprising 7 β-strands A, B, C, D, E, F, and G sequentially connected together by connecting chains of amino acids, and a first α-helix sequentially located on the EF chain between β-strands E and F, wherein the β-strands are arranged so as to form a first β-sheet comprising β-strands A, B, D, and E, and a second β-sheet comprising β-strands C, F and G, said first and second β-sheets being covalently bonded together so as to form a first Ig domain; wherein the EF chain between β-strands E and F comprises the sequence X1-X2-X3-X4-K5H6 (SEQ ID NO:98), and X1, X3 and X4 are each independently any amino acid residue, characterized in that X2 is selected from the group consisting of A, G, I, V, L, R, S, T, Q, P, N, M, H, W, and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, and prodrugs thereof
Olivier Alexandre Laurent, Alice Lee, Richard Ryan Preston, David Tumelty, Wei Hong Yu, Abhijit Suresh Bhat, Anna Tempczyk-Russell
Filed: 9 Jun 20
Utility
Apixaban Formulations
20 May 21
Apixaban pharmaceutical formulation is provided.
Sherif Ibrahim Farag BADAWY, Timothy D. STEVENS, Daniel KUNTZ, Brett WAYBRANT
Filed: 15 Apr 19
Utility
Stable Aqueous Antibody Formulation
6 May 21
The present invention relates to the field of pharmaceutical formulations of antibodies.
REBECCA LEE INGRAM, SARAH ELIZABETH WEISER
Filed: 6 Jan 21
Utility
Streptococcus Pneumoniae Capsular Polysaccharides and Conjugates Thereof
29 Apr 21
The invention relates to isolated Streptococcus pneumoniae serotype 15B capsular polysaccharide and processes for their preparation.
Mingming Han, Avvari Krishna Prasad, David Cooper, Wendy Jo Watson
Filed: 17 Dec 20
Utility
Engineered Polypeptide Conjugates and Methods for Making Thereof Using Transglutaminase
22 Apr 21
The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents.
Pavel STROP, Magdalena Grazyna DORYWALSKA, Arvind RAJPAL, David SHELTON, Shu-Hui LIU, Jaume PONS, Russell DUSHIN
Filed: 18 Nov 20
Utility
Methods of Glycoengineering Proteoglycans with Distinct Glycan Structures
22 Apr 21
Disclosed herein are methods of generating proteoglycans with distinct glycan structures in engineered, non-naturally occurring eukaryotic cells.
Michelle Chang, Leonid A. Gaydukov, Giyoung Jung, Nevin M. Summers, Timothy Kuan-Ta Lu, Ron Weiss, John Scarcelli, Richard Cornell, Jeffrey Marshall, Bruno Figueroa, Wen Allen Tseng
Filed: 20 Jun 19
Utility
Diacylglycerol Acyl Transferase 2 Inhibitor
8 Apr 21
David James Edmonds, Kevin James Filipski, Kentaro Futatsugi, Michelle Renee Garnsey, Jack Chang Hung Lee, Daniel Jonathan Smaltz
Filed: 5 Oct 20
Utility
Diacylglycerol Acyl Transferase 2 Inhibitor
8 Apr 21
David James Edmonds, Kevin James Filipski, Kentaro Futatsugi, Michelle Renee Garnsey, Jack Chang Hung Lee, Daniel Jonathan Smaltz
Filed: 5 Nov 20
Utility
Aqueous Pharmaceutical Formulation Comprising ANTI-PD-L1 Antibody Avelumab
8 Apr 21
The present invention relates to a novel anti-PD-L1 antibody formulation.
Gianluca RINALDI, Alessandra DEL RIO, Silvia FRATAR-CANGELI, Senta VOSS, Markus WEIGANDT
Filed: 9 Dec 20
Utility
Neisseria Meningitidis Compositions and Methods Thereof
8 Apr 21
In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2.
Annaliesa Sybil Anderson, Rasappa Gounder Arumugham, John Erwin Farley, Leah Diane Fletcher, Shannon Lea Harris, Kathrin Ute Jansen, Thomas Richard Jones, Lakshmi Khandke, Bounthon Loun, John Lance Perez, Gary Warren Zlotnick
Filed: 18 Dec 20
Utility
ANTI-CXCR5 Antibodies and Compositions and Uses Thereof
8 Apr 21
The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to CXCR5.
Rachel Groth, William Brian Snyder, Xianjun Cao, Robert Joseph Dunn, Joseph Dal Porto, Michael Karin
Filed: 20 Nov 20