471 patents
Page 17 of 24
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LFA3 Variants and Compositions and Uses Thereof
4 Feb 21
The invention provides LFA3 polypeptide molecules, e.g., variant LFA3 fusion polypeptide molecules.
Natasha Kay CRELLIN, Lauren Kate ELY, Jason Robles REYES, Chia Chi HO, Jeffrey A. BLUESTONE, Eleonora TROTTA, Qizhi TANG
Filed: 28 Sep 20
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Methods of Administering Chimeric Antigen Receptor Immunotherapy In Combination with 4-1BB Agonist
28 Jan 21
The disclosure provides a method of treatment of a B-cell lymphoma or leukemia, including diffuse large B-cell lymphoma (DLBCL) comprising a CD19-directed chimeric antigen receptor (CAR) genetically modified T-cell immunotherapy in combination with a 4-IBB (CD137) agonist.
William Y. GO, Adrian WOOLFSON
Filed: 15 Jan 19
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28 Jan 21
The invention relates to activated Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides and processes for their preparation.
Jianxin Gu, Rajesh Kumar Kainthan, Jin-Hwan Kim, Avvari Krishna Prasad, Yu-Ying Yang
Filed: 1 Oct 20
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28 Jan 21
The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.
Ye Che, Philip Ralph Dormitzer, Alexey Vyacheslavovich Gribenko, Luke David Handke, Avvari Krishna Prasad, Xiayang Qiu, Mark Edward Ruppen, Xi Song, Kena Anne Swanson, Srinivas Kodali, Xin Xu, KariAnn Sweeney Efferen, Ping Cai, Kristin Rachael Tompkins, Lorna del Pilar Nunez
Filed: 1 Oct 20
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28 Jan 21
Lei Zhang, Erik Alphie LaChapelle, Christopher Ryan Butler, Natasha Mariam Kablaoui, Michael Aaron Brodney, Laura Ann McAllister, Qingyi Yang, Christopher John Helal, Damien Webb
Filed: 25 Mar 19
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28 Jan 21
Samit Kumar Bhattacharya, Leanne Marie Buzon, Kevin James Filipski, David Andrew Griffith, Bethany Lyn Kormos, Luis Angel Martinez-Alsina, Russell Alan Miller, Matthew Richard Reese, Rachel Jane Roth Flach, Yuan Zhang
Filed: 26 Jun 20
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28 Jan 21
In one aspect, the invention relates to a non-lipidated and non-pyruvylated Neisseria meningitidis serogroup B polypeptide and methods of use thereof.
Annaliesa Sybil Anderson, Susan Kay Hoiseth, Kathrin Ute Jansen, Justin Keith Moran, Mark Edward Ruppen
Filed: 30 Sep 20
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28 Jan 21
In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B.
Jason Arnold Lotvin, Annaliesa Sybil Anderson, Robert G. K. Donald, Michael James Flint, Narender Kumar Kalyan, Kathrin Ute Jansen, Maninder K. Sidhu, Justin Keith Moran, Mark Edward Ruppen, Weiqiang Sun
Filed: 7 Jul 20
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21 Jan 21
The present invention relates to imidazo-pyridinyl compounds, or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject.
Omar Ahmad, Andrew Fensome, Erik Alphie LaChapelle, Ethan Lawrence Fisher, Rayomand J. Unwalla, Jun Xiao, Lei Zhang
Filed: 13 Jul 20
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21 Jan 21
Tamim Fehme Braish, Matthew Frank Brown, Ye Che, Richard Andrew Ewin, Timothy Allan Johnson, Michael Joseph Melnick, Justin Ian Montgomery, Mark Stephen Plummer, Loren Michael Price, Usa Reilly, Daniel Uccello
Filed: 14 Mar 19
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21 Jan 21
Methods for the purification of antibodies are provided.
Timothy ISKRA, Ashley Margaret SACRAMO
Filed: 25 Feb 19
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21 Jan 21
Matthew Frank Brown, Ye Che, Anthony Marfat, Michael Joseph Melnick, Justin Ian Montgomery, Timothy Allan Johnson, Richard Andrew Ewin, Daniel Paul Uccello, Usa Reilly, Tamim Fehme Braish
Filed: 14 Mar 19
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21 Jan 21
The invention relates to a method of cell culture where the cells are modified to reduce the level of synthesis of growth and/or productivity inhibitors by the cell.
Gregory Walter HILLER, Jeffrey Joseph MITCHELL, Bhanu Chandra MULUKUTLA, Pamela Mary PEGMAN
Filed: 30 Jun 20
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14 Jan 21
Joseph P. LYSSIKATOS, Julie Marie HICKS, Fredrik P. MARMSATER, Qian ZHAO
Filed: 27 Jul 20
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14 Jan 21
The present invention relates to a manufacturing process and intermediates for preparing a crystalline or non-crystalline form of N-((1S,3S)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide.
Kapildev Kashmirilal Arora, Jacob Cole DeForest, Andrew Kevern Hills, Brian Patrick Jones, Kris Nicole Jones, Chad Arthur Lewis, Anil Mahadeo Rane
Filed: 29 Sep 20
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14 Jan 21
The invention features soluble FGF decoy polypeptides and fusion polypeptides comprising an FGF decoy polypeptide linked to a heterologous polypeptide, such as an aggrecan binding protein.
Elvire Gouze, Stéphanie Garcia
Filed: 20 Feb 20
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6 Jan 21
John Robert Springer, Balekudru Devadas, Danny James Garland, Margaret Lanahan Grapperhaus, Seungil Han, Susan Landis Hockerman, Robert Owen Hughes, Eddine Saiah, Mark Edward Schnute, Shaun Raj Selness, Daniel Patrick Walker, Zhao-Kui Wan, Li Xing, Christoph Wolfgang Zapf, Michelle Ann Schmidt
Filed: 17 Sep 20
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6 Jan 21
The disclosure provides compositions and methods for counteracting the effects of direct activated Factor X (FXa) inhibitors in a subject by administering a variant of FXa.
Debra D. Pittman, Rodney M. Camire, Joachim Fruebis
Filed: 15 Mar 20
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6 Jan 21
The present invention relates generally to the field of pharmaceutical formulations of antibodies.
Syed Saleem AHMED, Bryan Mark BALTHAZOR, Anjali Pramod MEHTA, Tihami QURESHI
Filed: 3 Mar 19
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6 Jan 21
Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
Julia Haas, Steven W. Andrews, Yutong Jiang, Gan Zhang
Filed: 13 Sep 20