471 patents
Page 19 of 24
Utility
Hydroxylated and Methoxylated Pyrimidyl Cyclopentanes As Akt Protein Kinase Inhibitors
4 Nov 20
Ian S. Mitchell, James F. Blake, Rui Xu, Nicholas C. Kallan, Dengming Xiao, Keith Lee Spencer, Josef R. Bencsik, Eli M. Wallace, Stephen T. Schlachter, Anna L. Leivers, Jun Liang, Brian Safina, Birong Zhang, Christine Chabot, Steven Do
Filed: 6 Jan 20
Utility
Sodium Chloride Solution for Drug Reconstitution or Dilution
28 Oct 20
The invention provides methods for preparing pharmaceutical formulations for injection such that upon injection the formulation does not cause erythrocyte agglutination, hemolysis, and/or cell shrinkage.
Chandra A Webb, Julie Zerfas
Filed: 13 Jul 20
Utility
Aminopyrimidinyl Compounds
21 Oct 20
Andrew FENSOME, Ariamala GOPALSAMY, Brian S. GERSTENBERGER, Ivan Viktorovich EFREMOV, Zhao-Kui WAN, Betsy PIERCE, Jean-Baptiste TELLIEZ, John I. TRUJILLO, Liying ZHANG, Li XING, Eddine SAIAH
Filed: 1 Jul 20
Utility
Anti-proliferative Agents for Treating Pah
21 Oct 20
Samit Kumar Bhattacharya, Douglas Carl Behenna, Kimberly O. Cameron, Ping Chen, John M. Curto, Kevin Daniel Freeman-Cook, Mehran Jalaie, Robert Steven Kania, Yajing Lian, Sajiv Krishnan Nair, Cynthia Louise Palmer, Martin Youngjin Pettersson, Eugene Yuanjin Rui, Matthew Sammons, Qingyi Yang, Liying Zhang
Filed: 14 Apr 20
Utility
Glycoconjugation Process
21 Oct 20
The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.
Mingming Han, Rajesh Kumar Kainthan, Jin-Hwan Kim, Avvari Krishna Prasad
Filed: 7 Jul 20
Utility
Crystalline Forms of Lorlatinib Maleate
14 Oct 20
This invention relates to new crystalline forms of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3- h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile(lorlatinib) maleate.
Klimentina Dimitrova Pencheva
Filed: 26 Mar 17
Utility
Method for Controlling Streptococcus Pneumoniae Polysaccharide Molecular Weight Using Carbon Dioxide
14 Oct 20
The present invention provides improved methods for producing a solution containing high molecular weight isolated Streptococcus pneumoniae capsular polysaccharides having phosphodiester linkages between saccharide repeat units.
Jean Heather Crinean
Filed: 24 Jun 20
Utility
Combination of a PD-1 Antagonist and a Vegfr Inhibitor for Treating Cancer
14 Oct 20
The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a VEGFR inhibitor, and the use of the combination therapies for the treatment of cancer, and in particular for treating cancers that express PD-L 1.
Jean-Francois Andre Martini, Jamal Christo Tarazi, Rodolfo Fleury Perini, David J. Mauro
Filed: 13 Jan 20
Utility
Use Of Perfusion To Enhance Production Of Fed-batch Cell Culture In Bioreactors
14 Oct 20
The invention relates to methods of improving protein production, e.g., large-scale commercial protein production, e.g., antibody production, utilizing a modified fed-batch cell culture method comprising a cell growth phase and a polypeptide production phase.
Gregory Walter HILLER
Filed: 21 Jun 20
Utility
Targeted Therapeutic Nanoparticles And Methods Of Making And Using Same
30 Sep 20
Described herein are polymeric nanoparticles that include a therapeutic agent, and methods of making and using such therapeutic nanoparticles.
Hong Wang
Filed: 16 Feb 20
Utility
Immunogenic Compositions Comprising Conjugated Capsular Saccharide Antigens and Uses Thereof
30 Sep 20
The present invention relates to new immunogenic compositions comprising conjughated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof.
Emilio Anthony Emini, Wendy Jo Watson, Avvari Krishna Prasad, Mingming Han, Jin-Hwan Kim, Jianxin Gu, Yu-ying Yang, Rajesh Kumar Kainthan, David Cooper, Michael William Pride, Kathrin Ute Jansen
Filed: 11 Jun 20
Utility
Crystalline Form of Lorlatinib Free Base Hydrate
30 Sep 20
This invention relates to a crystalline form of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahy-dro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclo-tetradecine-3-carbonitrile (lorlatinib) free base hydrate (Form 24).
Paul Bowles, Peter Robert Rose
Filed: 3 Oct 18
Utility
ANTI-IL-33 Antibodies, Compositions, Methods and Uses Thereof
30 Sep 20
The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to IL-33, as well as uses, and associated methods thereof.
Laird BLOOM, Karl Henry NOCKA, James Reasoner APGAR, Matthew Allister LAMBERT, Mark A. FARMER
Filed: 28 Dec 19
Utility
SGLT-2 Inhibitors for Treating Metabolic Disorders In Patients with Renal Impairment or Chronic Kidney Disease
23 Sep 20
The present invention relates to certain SGLT-2 inhibitors, such as ertugliflozin or a co-crystal or a pharmaceutically acceptable salt thereof, for treating and/or preventing metabolic disorders, such as type 1 or type 2 diabetes mellitus or pre-diabetes, in patients with renal impairment or chronic kidney disease (CKD).
Ramachandra G. Naik, Elizabeth S. Ommen, James Michael Rusnak, Steven G. Terra
Filed: 3 Jun 20
Utility
Treatment of Abnormal Visceral Fat Deposition Using Soluble Fibroblast Growth Factor Receptor 3 (SFGFR3) Polypeptides
23 Sep 20
The invention features methods of using SFGFR3 polypeptides to treat abnormal visceral fat deposition and the conditions associated with abnormal visceral fat deposition.
Elvire Gouze, Stéphanie Garcia
Filed: 19 Sep 18
Utility
Antibodies and Antibody-drug Conjugates Specific for CD123 and Uses Thereof
9 Sep 20
The present invention provides antibodies that specifically bind to CD123.
Manoj Baburao CHARATI, Yoon-Chi HAN, Madan KATRAGADDA, Nicole Melissa PICHÉ-NICHOLAS, Lawrence Nathan TUMEY
Filed: 15 Oct 18
Utility
Heteroaromatic Compounds and Their Use As Dopamine D1 Ligands
9 Sep 20
Michael Aaron Brodney, Jennifer Elizabeth Davoren, Amy Beth Dounay, Ivan Viktorovich Efremov, David Lawrence Firman Gray, Michael Eric Green, Jaclyn Louise Henderson, Chewah Lee, Scot Richard Mente, Steven Victor O'Neil, Bruce Nelsen Rogers, Lei Zhang
Filed: 20 May 20
Utility
Antagonist Antibodies Against GDF-8 and Uses Therefor
2 Sep 20
The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies.
MICHELLE M. MADER, JAMES R. APGAR, KEVIN D. PARRIS
Filed: 12 Nov 19
Utility
EZH2 Inhibitor Combination Therapies
26 Aug 20
This invention relates to combination therapies comprising an EZH2 inhibitor and a chemotherapeutic agent, and associated pharmaceutical compositions, methods of treatment, and pharmaceutical uses.
Manfred Kraus, Pei-Pei Kung, Thomas Andrew Paul, Shikhar Sharma, Dominique Verhelle
Filed: 8 Nov 18
Utility
Recombinant Vaccinia Virus and Methods of Use Thereof
19 Aug 20
The present disclosure provides a replication-competent, recombinant oncolytic vaccinia virus, compositions comprising the vaccinia virus, and use of the vaccinia virus or composition for inducing oncolysis in an individual having a tumor.
David H. Kirn, Liliana Maruri Avidal, Prajit Limsirichai
Filed: 9 Feb 20