154 patents
Page 6 of 8
Utility
Methods for Treating Visceral Pain by Administering Antagonist Antibodies Directed Against Calcitonin Gene-related Peptide
18 Feb 21
The invention features methods for preventing or treating visceral pain, including pain associated with functional bowel disorder, inflammatory bowel disease and interstitial cystitis, by administering an anti-CGRP antagonist antibody.
Ariel Ates Pios, Kristian Todd Poulsen, David Louis Shelton, Joerg Zeller
Filed: 14 Feb 20
Utility
Compliance monitoring module for a breath-actuated inhaler
16 Feb 21
A compliance monitoring module for a breath-actuated inhaler comprising: a miniature pressure sensor, a sensor port of said sensor being pneumatically coupled to a flow channel through which a user can inhale; a processor configured to: receive a signal originating from a dosing mechanism of the inhaler indicating that medication has been released; receive data from a sensing element of the sensor; and based on said signal from said dosing mechanism and said data from said sensing element, make a determination that inhalation of a breath containing medication through said flow channel complies with one or more predetermined requirements for successful dosing; and a transmitter configured to, responsive to said determination, issue a dosing report.
Mark Steven Morrison, Douglas E. Weitzel, Enrique Calderon Oliveras, Daniel Buck
Filed: 1 Oct 18
Utility
Treating Refractory Migraine
11 Feb 21
Disclosed herein are methods of treating or reducing incidence of migraine and/or at least one secondary symptom associated with refractory migraine in a subject having refractory migraine comprising administering to the subject a monoclonal antibody that modulates the CGRP pathway.
Marcelo Bigal, Ernesto Aycardi
Filed: 21 Oct 20
Utility
Treating Refractory Migraine
11 Feb 21
Disclosed herein are methods of treating or reducing incidence of migraine and/or at least one secondary symptom associated with refractory migraine in a subject having refractory migraine comprising administering to the subject a monoclonal antibody that modulates the CGRP pathway.
Marcelo Bigal, Ernesto Aycardi
Filed: 21 Oct 20
Utility
Compliance monitoring module for an inhaler
2 Feb 21
A compliance monitoring module for an inhaler comprising: a miniature pressure sensor, a sensor port of said sensor being configured to be pneumatically coupled to a flow channel of said inhaler through which a user can inhale; a processor configured to: receive data from a sensing element of the pressure sensor; receive data from a mode sensor configured to detect when the inhaler changes from an inactive mode to an active mode; and based on said data from said pressure sensor sensing element and said data from said mode sensor, compile a compliance report; and a transmitter configured to issue said compliance report.
Mark Steven Morrison, Douglas E. Weitzel, Enrique Calderon Oliveras, Daniel Buck
Filed: 28 Aug 15
Utility
Pharmaceutical compositions for an anti-CGRP antagonist antibody
26 Jan 21
The present disclosure provides pharmaceutical compositions including a plurality of IgG2 anti-CGRP antagonist antibodies comprising a high content of particular IgG2 disulfide isomers, and methods of using the same.
Jason Bock, John Kim
Filed: 12 Sep 19
Utility
Breath Actuated Inhaler
21 Jan 21
A breath actuated metered dose inhaler may comprise a canister fire system configured to fire a medicament containing canister in response to patient inhalation.
Declan Walsh, Paul Prendergast, Daniel Buck, Trevor Kent, Niall Thompson
Filed: 2 Oct 20
Utility
Dose Counter for Inhaler Having An Anti-Reverse Rotation Actuator
21 Jan 21
An inhaler includes a main body having a canister housing, a medicament canister retained in a central outlet port of the canister housing, and a dose counter having an actuation member for operation by movement of the medicament canister.
Declan Walsh, Derek Fenlon, Simon Kaar, Jan Geert Hazenberg, Daniel Buck, Paul Clancy, Robert Charles Uschold, Jeffrey A. Karg
Filed: 29 Jun 20
Utility
Solid State Forms of Relugolix
21 Jan 21
The present disclosure provides solid state forms of Relugolix, crystalline forms of Relugolix, pharmaceutical compositions thereof, and pharmaceutical formulations thereof.
Hana Kantor, Roman Gabriel, Pavel Kolesa, Alexandr Jegorov
Filed: 14 Mar 19
Utility
Drug Delivery Device with Electronics and Power Management
6 Jan 21
A system may limit the number of times an inhalation device transmits inhalation data to a single time to reduce the battery usage of the inhalation device.
Enrique Calderon Oliveras, Amir Kesten
Filed: 5 Jul 20
Utility
Pre-filled Syringe
2 Dec 20
The invention relates to a pre-filled syringe, an auto-injector device comprising such pre-filled syringe, a method of administering a pharmaceutical composition with such auto-injector device, and a manufacturing method for such auto-injector device.
Vijay Joguparthi, Rosario LoBrutto
Filed: 19 Aug 20
Utility
Antagonist Antibodies Directed Against Calcitonin Gene-Related Peptide and Methods Using Same
2 Dec 20
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms and/or headaches (e.g., migraine, cluster headache, and tension headache) by administering an anti-CGRP antagonist antibody.
Marcelo Bigal, Sarah Walter, Henry Stern, Michael Chang
Filed: 11 Dec 19
Utility
Drug Delivery Device with Electronics
18 Nov 20
A system may include an external device and an inhaler.
Enrique Calderon Oliveras, Daniel Buck
Filed: 14 May 20
Utility
Pre-filled syringe
16 Nov 20
The invention relates to a pre-filled syringe, an auto-injector device comprising such pre-filled syringe, a method of administering a pharmaceutical composition with such auto-injector device, and a manufacturing method for such auto-injector device.
Vijay Joguparthi, Rosario LoBrutto
Filed: 12 Jan 17
Utility
Inhaler System
4 Nov 20
Provided is a system (10) for determining a probability of an asthma exacerbation in a subject.
Mark Milton-Edwards, Guilherme Safioti, Lena Granovsky, Michael Reich
Filed: 1 Jul 20
Utility
Antagonist Antibodies Directed Against Calcitonin Gene-Related Peptide and Methods Using Same
21 Oct 20
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms and/or headaches (e.g., migraine, cluster headache, and tension headache) by administering an anti-CGRP antagonist antibody.
Marcelo Bigal, Sarah Walter, Henry Stern, Michael Chang
Filed: 6 Nov 19
Utility
Processes and intermediates for the preparation of Pimavanserin
19 Oct 20
The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes.
Tomislav Biljan, Jasna Dogan, Leonid Metsger, Sara Morasi Pipercic, Marina Ratkaj, Maja Matanovic Skugor, Yi Wang
Filed: 27 May 19
Utility
Rasagiline for the Treatment of Restless Legs Syndrome
14 Oct 20
Disclosed are methods for the treatment of Restless Legs Syndrome comprising administering an amount of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof.
Eran Blaugrund, Ruth Levy
Filed: 25 Jun 20
Utility
Breath actuated inhaler
5 Oct 20
A breath actuated metered dose inhaler may include a canister fire system configured to fire a medicament containing canister in response to patient inhalation.
Declan Walsh, Paul Prendergast, Daniel Buck, Trevor Kent, Niall Thompson
Filed: 24 Jan 19
Utility
Solid State Forms of Neratinib and Salts Thereof
30 Sep 20
Solid state forms of Neratinib and salts thereof, processes for preparation thereof and pharmaceutical compositions thereof are disclosed.
Igor AVDEJEV, Edi TOPIC, Dijana Skalec SAMEC, Lidija LERMAN, Vitomir VUSAK
Filed: 26 Jun 17