426 patents
Page 3 of 22
Utility
Matching thermally modulated variable restrictors to chromatography separation columns
22 Aug 23
Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column.
Michael O. Fogwill, Joseph D. Michienzi, Geoff Gerhardt, James P. Murphy
Filed: 30 Jun 20
Utility
High Purity Chromatographic Materials Comprising an Ionizable Modifier for Retention of Acidic Analytes
17 Aug 23
The present invention provides the use of charged surface reversed phase chromatographic materials along with standard reversed-phase LC and mass spectrometry compatible conditions for the retention, separation, purification, and characterization of acidic, polar molecules, including, but not limited to, organic acids, α-amino acids, phosphate sugars, nucleotides, other acidic, polar biologically relevant molecules.
Matthew A. Lauber, Paul Rainville, Jacob N. Fairchild, Babjide Okandeji, Nicole L. Lawrence, Dimple Shah
Filed: 25 Apr 23
Utility
Hydrophobicity Shifted Enzyme
17 Aug 23
The present invention relates to a method for analyzing a sample, the method comprising: (a) incubating a sample comprising an analyte with at least one enzyme to produce a digestion mixture comprising fragments of the analyte; (b) loading the digestion mixture onto a reversed-phase chromatography column; and (c) performing reversed-phase chromatography on the digestion mixture, wherein the at least one enzyme is hydrophobically modified to increase a retention time of the at least one enzyme such that the at least one enzyme elutes from the reversed-phase chromatography column later than the fragments of the analyte.
Matthew Lauber, Wenjing Li
Filed: 10 Feb 23
Utility
Liquid-chromatography Apparatus Having Diffusion-bonded Titanium Components
10 Aug 23
A liquid chromatography apparatus includes a diffusion-bonded separation column comprising a lower substrate comprising titanium, an upper substrate comprising titanium, and a titanium patterned foil disposed between the lower substrate and the upper substrate.
Theodore A. Dourdeville
Filed: 21 Apr 23
Utility
Variable fluidic restrictor having selective restriction
8 Aug 23
A variable fluidic restrictor of a liquid chromatography system including a stator body, the stator body include a plurality of fluidic channels located within the stator body, wherein each fluidic channel of the plurality of fluidic channels includes a restrictor element, wherein a flow of a fluid through the variable fluidic restrictor is selectively restricted based on a position of an external element coupled to the stator body is provided.
Zongren Shang, Stanislaw Koziol, Joseph D. Michienzi, Michael Eggertson, Keith Fadgen
Filed: 8 Apr 22
Utility
Rotor for rheological measurements of material with variable volume
8 Aug 23
A rheological system includes a sample chamber, a compressed air system configured to provide compressed air to pressurize the sample chamber, and a rotor configured for rheological measurement of a material with variable volume, the rotor including an elongated shaft extending to a measurement portion having a widened geometry relative to the elongated shaft.
Reginald Lee, Amit Ahuja, Sally Childears
Filed: 8 Oct 20
Utility
Nanospray Reactive Sprayer
3 Aug 23
Described are an apparatus for generating and collecting nanospray reactive droplets and a method for analyzing a protein digestion.
Lindsay Morrison
Filed: 12 Jan 23
Utility
Method and apparatus for high pressure sealing
25 Jul 23
The present technology generally relates to devices, systems and methods for providing robust sealing between surfaces in a pressurized system, such as a chromatography system.
Emily J. Berg, Joshua A. Shreve
Filed: 13 May 20
Utility
Method for determining a dwell volume of a chromatographic system
25 Jul 23
Described is a method for determining a dwell volume of a liquid chromatography system and a liquid chromatography system that can determined the system dwell volume.
Jason F. Hill, Martin Gilar, Abhijit Tarafder, Christopher DesJardins
Filed: 19 Aug 20
Utility
Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
25 Jul 23
Matthew A. Lauber, Mathew H. DeLano, Scott A. McCall, Jonathan L. Belanger, Theodore A. Dourdeville, Kerri M. Smith, Paul D. Rainville, Dimple D. Shah, Stephen J. Shiner, Catalin Doneanu, Michael Donegan
Filed: 17 Sep 18
Utility
Use of vapor deposition coated flow paths for improved analytical analysis
25 Jul 23
Xiaoxiao Liu, Anna Boardman, Mathew H. DeLano, Matthew A. Lauber
Filed: 17 Jan 20
Utility
an Atmospheric Pressure Ionisation Source
6 Jul 23
An atmospheric pressure ionisation source comprising: an ionisation chamber, comprising an aperture for receiving at least the distal end of a capillary into the ionisation chamber in use, the aperture having a capillary axis; a desolvation heater having a nozzle, for directing a stream of heated gas onto the distal end of the capillary in use, the nozzle having a nozzle axis; a corona discharge device including a corona pin having a corona axis, the corona pin for ionizing a sample in the ionisation chamber in use; and an inlet cone of a mass spectrometer arranged in the ionisation chamber, the inlet cone defining a cone entrance having a cone axis, wherein the cone axis is substantially coaxial with the corona axis and the capillary axis is substantially perpendicular to and intersects with the nozzle axis.
Arvind Rangan, Carl Chen, Steven Rocha, Enchen Guo, Nicola Lumley, David Douce, Richard Gallagher, Kate Whyatt
Filed: 5 May 21
Utility
Rheometer having resistance heater and cooling device
4 Jul 23
Described are a method and device for controlling a temperature of a sample.
Scott Merrullo, Nigel Doe, Peter Foster
Filed: 21 May 21
Utility
Solid Phase Extraction Methods for Enhanced Removal of Phospholipids from Biological Samples
29 Jun 23
In various aspects, the present disclosure pertains to methods of performing a sample enrichment procedure, which comprise: adding a sample fluid that comprises at least one phospholipid and at least one target analyte to a sorbent that comprises a hydrophobic component and a cation exchange component, thereby resulting in sorbent with bound phospholipid and bound target analyte; adding an aqueous solution comprising an acidic compound and a salt; adding an organic solution to the sorbent thereby desorbing at least a portion of the bound phospholipid from the sorbent; and adding an elution solution to the sorbent, thereby desorbing at least a portion of the bound target analyte from the sorbent and forming a solution of the target analyte in the elution solution.
Bonnie A. Alden, Kenneth Berthelette, Jon Finch, Donna Osterman, Thomas Swann, Thomas H. Walter
Filed: 9 Feb 23
Utility
Sample Preparation Devices, Kits and Methods
29 Jun 23
The present disclosure pertains to sample preparation devices useful for affinity capture and purification that include one or more internal structures that comprise a reservoir, a well, a fluid passageway, sorbent particles, and a filter element that blocks passage of the affinity sorbent particles, which sample preparation devices combine the attributes of both dispersive and flow through designs into a single sample preparation device.
Raymond P. Fisk, Timothy J. Becker, Mary Elizabeth Lame, Frank John Marszaikowski, Matthew A. Lauber
Filed: 7 Mar 23
Utility
Multi-injection mode valve module
23 May 23
A chromatography system includes a gradient delay volume defined as an overall fluid volume between where gradient is proportioned until an inlet of a chromatography column, a pump pumping a flow of gradient; and at least one valve located downstream from the pump, the at least one valve having a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the at least one valve, the at least one valve having at least two positions.
Sylvain Cormier, Richard W. Andrews, Peyton C. Beals
Filed: 19 Mar 21
Utility
Link chain, chain system and method
23 May 23
Described is a chain including a plurality of links pivotally connected to each other such that the chain is configured to bend in one direction without back-bending.
Jeffrey Musacchio
Filed: 28 Jul 20
Utility
Method of Operating a Liquid Chromatography Arrangement, a Liquid Chromatography Arrangement, and a Chromatography System
18 May 23
There is provided a method of operating a liquid chromatography arrangement, the liquid chromatography arrangement comprising: a solvent pump arranged to flow a liquid solvent over a liquid chromatography column; a restrictor arranged to restrict the liquid solvent from leaving the liquid chromatography column; and a liquid pump arranged to provide liquid flow between the liquid chromatography column and the restrictor, the method comprising: flowing the liquid solvent through the liquid chromatography column using the solvent pump; and controlling a liquid pressure within the liquid chromatography column by providing a liquid flow between the liquid chromatography column and the restrictor using the liquid pump.
Szabolcs Fekete, Michael O. Fogwill, Matthew A. Lauber
Filed: 16 Nov 22
Utility
Light-guiding Flow Cell Technologies
18 May 23
A flow cell for a liquid chromatography detector comprises a substrate formed of a glass material; a fluidic channel extending through the substrate; and at least one gas filled region formed in the substrate along at least a portion of a length of the fluidic channel.
Michael O. Fogwill, Joseph D. Michienzi, Sebastien Besner, Brett G. Cook, Peter O'Brien
Filed: 18 Nov 22
Utility
Determination of dynamic parameters for adaptive actuator control
16 May 23
An actuator control system, mechanical testing system, and method for adaptive control of an actuator of a mechanical testing device is provided.
Kevin Alstrin
Filed: 25 Aug 21