140 patents
Page 6 of 7
Utility
Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate
16 Nov 20
Disclosed herein are methods of treating and preventing muscle loss using ornithine in combination with at least one of phenyl acetate and phenylbutyrate.
Christopher F. Rose, Franck Rousseau
Filed: 15 Aug 16
Utility
Systems and method for delivery of therapeutic gas to patients, in need thereof, receiving breathing gas from a ventilator that varies at least pressure and/or flow using enhanced therapeutic gas (NO) flow measurement
16 Nov 20
The present disclosure generally relates to systems and methods for delivery of therapeutic gas to patients, in need thereof, receiving breathing gas from a high frequency ventilator using at least enhanced therapeutic gas (e.g., nitric oxide, NO, etc.) flow measurement.
Jaron M. Acker, Craig R. Tolmie
Filed: 7 Aug 18
Utility
Devices, methods, and systems for priming, separating, and collecting blood components
9 Nov 20
A photopheresis system (200) is disclosed, and that may be configured to execute one or more protocols.
Dennis Briggs, Simon Do, Eric Rabeno, Abdoulaye Sangare, Mark Vandlik, Vicki Fluck, Christopher Turek
Filed: 15 Jun 16
Utility
PROCESSES FOR PREPARING MORPHINAN-6-ONE PRODUCTS WITH LOW LEVELS OF a,ß-UNSATURATED KETONE COMPOUNDS
28 Oct 20
The present invention generally relates to processes for preparing highly pure morphinan-6-one products.
Henry J. Buehler, William E. Dummitt, Anthony Mannino, Dennis C. Aubuchon, Hong Gu
Filed: 12 Jul 20
Utility
Devices, Methods, and Systems for Priming, Separating, and Collecting Blood Components
7 Oct 20
A photopheresis system (200) is disclosed, and that may be configured to execute one or more protocols.
Dennis Briggs, Simon Do, Eric Rabeno, Abdoulaye Sangare, Mark Vandlik, Vicki Fluck, Christopher Turek
Filed: 18 Jun 20
Utility
Apparatus and method for monitoring nitric oxide delivery
14 Sep 20
Described is an apparatus for monitoring nitric oxide delivery, wherein such apparatus comprises an indicator to inform a user of the apparatus when the flow of breathing gas rises above or falls below a predetermined level or range.
Robert Schnitman, Joseph J. Medicis, Jim Potenziano, Jaron Acker, Jeffrey Schmidt
Filed: 21 Aug 17
Utility
Systems and methods for providing a pulse of a therapeutic gas with a desired flow profile to maximize therapeutic effectiveness
31 Aug 20
Described are systems and methods for providing a pulse of a therapeutic gas with a desired flow profile to maximize therapeutic effectiveness.
Thomas Kohlmann, John Klaus
Filed: 18 Oct 15
Utility
Extended Release, Abuse Deterrent Dosage Forms
26 Aug 20
Extended release, abuse deterrent dosage forms comprising crush-resistant controlled-release particles that provide abuse deterrent properties to the dosage forms.
Jonathan Gaik, Jaehan Park, Ryan Lathrop, Gary Nichols, John Schallom
Filed: 12 Mar 20
Utility
Apparatus and method for filtering liquid particles from inspiratory gas flow of a patient breathing circuit affiliated with a ventilator and/or nitric oxide delivery system
17 Aug 20
The present disclosure relates to a filter apparatus for filtering liquid from a gas, the apparatus having a first housing having a gas inlet and a gas outlet; a first filter media disposed in the first housing; a second filter media disposed in the housing; and a second housing forming a first collection basin disposed in the flow path between the first filter media and the second filter media, so that a path is defined for the gas flowing from the inlet, through the first filter media, past the collection basin, through the second filter media, and to the outlet.
Scott I. Biba, John Falligant
Filed: 28 Feb 17
Utility
Apparatus and Method for Filtering Liquid Particles from Inspiratory Gas Flow of a Patient Breathing Circuit Affiliated with a Ventilator And/or Nitric Oxide Delivery System
12 Aug 20
The present disclosure relates to a filter apparatus for filtering liquid from a gas, the apparatus having a first housing having a gas inlet and a gas outlet; a first filter media disposed in the first housing; a second filter media disposed in the housing; and a second housing forming a first collection basin disposed in the flow path between the first filter media and the second filter media, so that a path is defined for the gas flowing from the inlet, through the first filter media, past the collection basin, through the second filter media, and to the outlet.
Scott I. Biba, John Falligant
Filed: 30 Apr 20
Utility
High-purity Large-scale Preparation of Stannsoporfin
12 Aug 20
Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.
George S. Drummond, Robert Caroselli, Keith A. Cooke, Daniel Levin, David G. Roe, Christopher P. Boucher
Filed: 30 Apr 20
Utility
Administration and Monitoring of Nitric Oxide In Ex Vivo Fluids
5 Aug 20
Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids.
Jim Potenziano, Douglas R. Hansell, Jeff Griebel, Eddie Costa, Lisa Cooper, David William Newman
Filed: 22 Apr 20
Utility
Method of Treating Patients with Hepatorenal Syndrome Type 1
5 Aug 20
The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease.
Khurram Jamil, Stephen Chris Pappas, Jim Potenziano
Filed: 23 Mar 20
Utility
Method of Treating Patients with Hepatorenal Syndrome Type 1
29 Jul 20
The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease.
Khurram Jamil, Stephen Chris Pappas, Jim Potenziano
Filed: 23 Mar 20
Utility
L-ornithine Phenyl Acetate and Methods of Making Thereof
29 Jul 20
Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same.
Keith Anderson, Jim Behling, Christine Henderson Dougan, Stephen William Watt, Peter Manini, Attilia Figini
Filed: 30 Jan 20
Utility
Hydroxypropyl beta-cyclodextrin compositions and methods
13 Jul 20
This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.
Bernardus Nicolaas Machielse, Allan Darling
Filed: 1 Apr 19
Utility
Intelligent Gas Source Management
8 Jul 20
Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient.
Jaron M. Acker, Craig R. Tolmie, Robin Roehl, Jeffrey Schmidt, Jeff Milsap
Filed: 19 Mar 20
Utility
Systems and Methods for Intelligent Gas Source Management
8 Jul 20
Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient.
Jaron M. Acker, Craig R. Tolmie, Robin Roehl, Jeffrey Schmidt, Jeff Milsap
Filed: 19 Mar 20
Utility
Treatment and Prevention of Neuronal Cell Loss Using L-ornithine In Combination with at Least One of Phenylacetate and Phenylbutyrate
1 Jul 20
Disclosed herein are methods of treating and preventing neuronal cell loss in a subject using ornithine in combination with phenylacetate or phenylbutyrate.
Christopher F. Rose, Marc-André Clément, Cristina R. Bosoi, Mariana Macedo Oliveira, Mélanie Tremblay, Chantal Bémeur
Filed: 21 Sep 16
Utility
Method of Identifying and Treating Premature Infants at Risk for BPD
24 Jun 20
Methods for identifying premature infants at risk for developing bronchopulmonary dysplasia and/or most likely to benefit from administration of inhaled nitric oxide for prevention of bronchopulmonary dysplasia (BPD).
Douglas Stuart Greene, Joseph J. Medicis, Jim Potenziano
Filed: 26 Feb 20