87 patents
Utility
High intensity labeled reactant compositions and methods for sequencing
28 Mar 23
Compositions useful for the detection of single molecules in a sample are provided.
Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang, David Dodd
Filed: 23 Jan 20
Utility
Polymerizing Enzymes for Sequencing Reactions
23 Feb 23
Compositions comprising modified recombinant polymerizing enzymes are provided, along with nucleic acid molecules encoding the modified polymerizing enzymes.
Brian Reed, Mohammad Wadud Bhuiya, Manjula Pandey, Jeremy Lackey, Jonathan M. Rothberg, Thomas Christian
Filed: 9 Mar 22
Utility
Systems and Methods for Unifying Statistical Models for Different Data Modalities
9 Feb 23
Techniques for performing a prediction task using a multi-modal statistical model configured to receive input data from multiple modalities including input data from a first modality and input data from a second modality different from the first modality.
Jonathan M. Rothberg, Umut Eser, Michael Meyer
Filed: 17 Oct 22
Utility
Integrated sensor with reduced skew
7 Feb 23
Aspects of the present disclosure relate to techniques for reducing skew in an integrated device, such as a CMOS imaging device.
Eric A. G. Webster, Dajiang Yang, Xin Wang, Zhaoyu He, Changhoon Choi, Peter J. Lim, Todd Rearick
Filed: 7 Apr 21
Utility
Optical sources for fluorescent lifetime analysis
31 Jan 23
Compact optical sources and methods for producing short and ultrashort optical pulses are described.
Jonathan M. Rothberg, Jason W. Sickler, Lawrence C. West, Faisal R. Ahmad, Brendan Huang, Paul E. Glenn, Jonathan C. Schultz, Jose Camara
Filed: 23 Jan 20
Utility
Machine learning enabled pulse and base calling for sequencing devices
27 Dec 22
A method includes obtaining, from one or more sequencing devices, raw data detected from luminescent labels associated with nucleotides during nucleotide incorporation events; and processing the raw data to perform a comparison of base calls produced by a learning enabled, automatic base calling module of the one or more sequencing devices with actual values associated with the raw data, wherein the base calls identify one or more individual nucleotides from the raw data.
Jonathan M. Rothberg, Michael Meyer, Umut Eser
Filed: 25 Jan 19
Utility
Optical Microdisks for Integrated Devices
15 Dec 22
Apparatus and methods for improving optical signal collection in an integrated device are described.
Ali Kabiri, Bing Shen, Gerard Schmid, James Beach, Kyle Preston, Sharath Hosali
Filed: 22 Aug 22
Utility
Inter-pixel Substrate Isolation
8 Dec 22
Aspects of the technology described herein relate to improved semiconductor-based image sensor designs.
Eric A.G. Webster
Filed: 2 Jun 22
Utility
Integrated Device with External Light Source for Probing Detecting and Analyzing Molecules
17 Nov 22
Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing.
Jonathan M. Rothberg, Ali Kabiri, Jason W. Sickler, Brett J. Gyartas, Jeremy Lackey, Gerard Schmid, Benjamin Cipriany, Jack Jewell, Lawrence C. West, Michael Ferrigno, Paul E. Glenn, Anthony Bellofiore
Filed: 29 Jul 22
Utility
Universal Adaptor for Sequencing
10 Nov 22
Methods and compositions for preparing nucleic acid libraries for nucleic acid sequencing are provided.
Jeffrey Sabina, Jonathan M. Rothberg, John H. Leamon
Filed: 29 Apr 22
Utility
Systems and methods for unifying statistical models for different data modalities
8 Nov 22
Techniques for performing a prediction task using a multi-modal statistical model configured to receive input data from multiple modalities including input data from a first modality and input data from a second modality different from the first modality.
Jonathan M. Rothberg, Umut Eser, Michael Meyer
Filed: 8 Mar 21
Utility
Photonic Structures and Integrated Device for Detecting and Analyzing Molecules
3 Nov 22
System and methods for analyzing single molecules and performing nucleic acid sequencing.
Jonathan M. Rothberg, Ali Kabiri, Gerard Schmid, Keith G. Fife, James Beach, Jason W. Sickler, Lawrence C. West, Paul E. Glenn, Kyle Preston, Farshid Ghasemi, Benjamin Cipriany, Jeremy Lackey
Filed: 11 Jul 22
Utility
Devices and Methods for Loading of Fluidic Receptacles
27 Oct 22
Aspects of this disclosure relate to systems, devices, and methods for the transfer of fluid to fluidic receptacles.
Xiaoxiao Ma, Jonathan C. Schultz, Caixia Lv, Brittany Lathrop
Filed: 20 Apr 22
Utility
Devices and Methods for Loading of Fluidic Receptacles
27 Oct 22
Aspects of this disclosure relate to systems, devices, and methods for the transfer of fluid to fluidic receptacles.
Xiaoxiao Ma, Jonathan C. Schultz, Caixia Lv, Brittany Lathrop
Filed: 20 Apr 22
Utility
Photodetector Circuit with Indirect Drain Coupling
27 Oct 22
Aspects of the technology described herein relate to improved semiconductor-based image sensor designs.
Xin Wang, Le Huang
Filed: 21 Apr 22
Utility
Protein-wide Modification of Aspartates and Glutamates
13 Oct 22
The present disclosure is related to peptides comprising modified aspartic acid and glutamic acid moieties, methods of making such peptides, and methods of using such modified peptides to selectively direct cleavage of peptide bonds.
Omer Ad, Haidong Huang
Filed: 31 Mar 22
Utility
Optical Pulse Stretcher
13 Oct 22
Disclosed herein are aspects of an optical pulse stretcher for temporally stretching a short duration pulsed light signal to reduce its peak power, thus reducing the risk of causing damage to components that receives the pulsed light signal.
Michael Bellos, Faisal R. Ahmad
Filed: 12 Apr 22
Utility
Integrated Circuit Having Mirrored Pixel Configuration
13 Oct 22
Aspects of the technology described herein relate to improved semiconductor-based image sensor designs.
Xin Wang, Eric A.G. Webster, Todd Rearick
Filed: 8 Apr 22
Utility
Integrated Circuit Having Mirrored Pixel Configuration
13 Oct 22
Aspects of the technology described herein relate to improved semiconductor-based image sensor designs.
Xin Wang, Eric A.G. Webster, Todd Rearick
Filed: 8 Apr 22
Utility
Pulsed laser and bioanalytic system
11 Oct 22
Apparatus and methods for producing ultrashort optical pulses are described.
Jonathan M. Rothberg, Jason W. Sickler, Lawrence C. West, Faisal R. Ahmad, Paul E. Glenn, Jack Jewell, John Glenn, Jose Camara, Jeremy Christopher Jordan, Todd Rearick, Farshid Ghasemi, Jonathan C. Schultz, Keith G. Fife
Filed: 15 Feb 19