124 patents
Utility
Flexible Metal Chip Cooling Interface
18 Jan 24
Heat transfer systems and methods are generally described.
Todd Rearick, Kyle Rearick, Jonathan C. Schultz, Philip Trioli
Filed: 13 Jul 22
Utility
Integrated Photodetector with Direct Binning Pixel
18 Jan 24
An integrated circuit includes a photodetection region configured to receive incident photons.
Jonathan M. Rothberg, Keith G. Fife, David M. Boisvert
Filed: 6 Jun 23
Utility
Systems and methods for unifying statistical models for different data modalities
16 Jan 24
Jonathan M. Rothberg, Umut Eser, Michael Meyer
Filed: 17 Oct 22
Utility
Integrated sensor for lifetime characterization
9 Jan 24
Aspects of the technology described herein relate to improved semiconductor-based image sensor designs.
Eric A. G. Webster, Changhoon Choi, Dajiang Yang, Xin Wang, Todd Rearick, Kyle Preston, Ali Kabiri, Gerard Schmid
Filed: 14 Jan 21
Utility
Integrated Sensor for Multi-dimensional Signal Analysis
4 Jan 24
Some aspects relate to an integrated circuit, comprising at least one photodetection region configured to generate charge carriers responsive to incident photons emitted from a sample, at least one charge storage region configured to receive the charge carriers from the photodetection region, and at least one controller configured to obtain information about the incident photons, the information comprising at least one member selected from the group comprising pulse duration and interpulse duration and at least one member selected from the group comprising wavelength information, luminescence lifetime information, and intensity information.
Gerard Schmid, Dajiang Yang, Eric A.G. Webster, Xin Wang, Todd Rearick, Changhoon Choi, Ali Kabiri, Kyle Preston, Brian Reed
Filed: 15 Jun 23
Utility
Directed Protein Evolution
4 Jan 24
Aspects of the disclosure provide methods and compositions for determining the identity of an analyte using molecular barcodes and single-molecule directed evolution of target biomolecules (e.g., proteins or aptamers).
Marco Ribezzi-Crivellari, Andrew Griffiths, Adeline Pichard-Kostuch, Andrea Flamm, Lisanne Spenkelink, Antonius M. van Oijen
Filed: 15 Jun 23
Utility
Integrated Device for Temporal Binning of Received Photons
21 Dec 23
An integrated circuit includes a photodetection region configured to receive incident photons.
Jonathan M. Rothberg, Keith G. Fife, David M. Boisvert
Filed: 13 Jun 23
Utility
Compact mode-locked laser module
19 Dec 23
Apparatus and methods for producing ultrashort optical pulses are described.
Jonathan M. Rothberg, Jason W. Sickler, Lawrence C. West, Faisal R. Ahmad, Paul E. Glenn, Jack Jewell, John Glenn, Jose Camara, Jeremy Christopher Jordan, Todd Rearick, Farshid Ghasemi, Jonathan C. Schultz, Keith G. Fife, Benjamin Cipriany
Filed: 16 Mar 22
Utility
Fluorescent Dye for Protein or Nucleic Acid Labelling
7 Dec 23
Roger Nani, Haidong Huang
Filed: 2 May 23
Utility
Photonic Structures and Integrated Device for Detecting and Analyzing Molecules
23 Nov 23
System and methods for analyzing single molecules and performing nucleic acid sequencing.
Jonathan M. Rothberg, Ali Kabiri, Gerard Schmid, Keith G. Fife, James Beach, Jason W. Sickler, Lawrence C. West, Paul E. Glenn, Kyle Preston, Farshid Ghasemi, Benjamin Cipriany, Jeremy Lackey
Filed: 20 Jul 23
Utility
Sliced Grating Coupler with Increased Beam Alignment Sensitivity
9 Nov 23
Apparatus and methods relating to coupling radiation from an incident beam into a plurality of waveguides with a grating coupler are described.
Gerard Schmid, Kyle Preston, Shannon Stewman
Filed: 20 Jul 23
Utility
Data acquisition control for advanced analytic instruments having pulsed optical sources
7 Nov 23
Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described.
Jonathan M. Rothberg, Benjamin Cipriany, Faisal R. Ahmad, Joseph D. Clark, Daniel B. Frier, Michael Ferrigno, Mel Davey, Tom Thurston, Brett J. Gyarfas, Todd Rearick, Jeremy Christopher Jordan
Filed: 14 Jun 19
Utility
Integrated Circuit with Sequentially-coupled Charge Storage and Associated Techniques
2 Nov 23
Described herein are techniques that improve the collection and readout of charge carriers in an integrated circuit.
Eric A.G. Webster, Todd Rearick, Thomas Raymond Thurston
Filed: 7 Jun 23
Utility
Optical and electrical secondary path rejection
31 Oct 23
Described herein are techniques to reduce or remove the impact of secondary path photons and/or charge carriers on storage bins of an integrated device to improve noise performance, and thus, sample analysis.
Dajiang Yang, Farshid Ghasemi, Keith G. Fife, Todd Rearick, Ali Kabiri, Gerard Schmid, Eric A. G. Webster
Filed: 26 Jun 20
Utility
Optical Waveguides and Couplers for Delivering Light to an Array of Photonic Elements
26 Oct 23
Optical waveguides and couplers for delivering light to an array of photonic elements in a photonic integrated device.
Kyle Preston, Bing Shen, Ali Kabiri, Gerard Schmid
Filed: 26 Jun 23
Utility
Enrichment of nucleic acid targets
24 Oct 23
Methods and apparatus providing for the isolation of an unknown mutation from a sample comprising wild type nucleic acids and mutated nucleic acids through the application of time-varying driving fields and periodically varying mobility-altering fields to the sample within in an affinity matrix.
Andrea Marziali, Milenko Despotovic, Joel Pel
Filed: 9 Apr 21
Utility
Optical waveguides and couplers for delivering light to an array of photonic elements
3 Oct 23
Optical waveguides and couplers for delivering light to an array of photonic elements in a photonic integrated device.
Kyle Preston, Bing Shen, Ali Kabiri, Gerard Schmid
Filed: 3 Jan 20
Utility
Sliced grating coupler with increased beam alignment sensitivity
5 Sep 23
Apparatus and methods relating to coupling radiation from an incident beam into a plurality of waveguides with a grating coupler are described.
Gerard Schmid, Kyle Preston, Shannon Stewman
Filed: 29 Apr 20
Utility
Ultrabright Dna Nanostructures for Biosensing
31 Aug 23
Aspects of this disclosure relate to luminescently labeled nucleic acid nanostructures and methods and compositions for the detection and/or sequencing of one or more target molecules derived from a sample.
Xinghua Shi, Haidong Huang, Hassan H. Fakih, Hanadi F. Sleiman
Filed: 19 Oct 22
Utility
Optical Coupler and Waveguide System
17 Aug 23
System and methods for optical power distribution to a large numbers of sample wells within an integrated device that can analyze single molecules and perform nucleic acid sequencing are described.
Jonathan M. Rothberg, Ali Kabir, Gerard Schmid, Jason w. Sickler, Paul E. Glenn, Lawrence C. West, Kyle Preston, Alexander Gondarenko, Benjamin Cipriany, James Beach, Keith G. Fife, Farshid Ghasemi
Filed: 24 Apr 23